Maxidex

Pemphigus, Macular Edema, Iridocyclitis + 102 more

Treatment

57 FDA approvals

20 Active Studies for Maxidex

Treatment for

Pemphigus

What is Maxidex

DexamethasoneThe Generic name of this drug

Treatment SummaryDexamethasone, also known as MK-125, is a steroid medication used to treat a variety of conditions such as endocrine, rheumatic, and allergic disorders. It was first developed in 1957 and approved by the FDA in 1958. Recently, dexamethasone has been recommended for use in COVID-19 patients with severe respiratory symptoms as it can reduce deaths by one third in patients requiring ventilation and one fifth in those requiring oxygen.

Decadronis the brand name

image of different drug pills on a surface

Maxidex Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Decadron

Dexamethasone

1958

452

Approved as Treatment by the FDA

Dexamethasone, also known as Decadron, is approved by the FDA for 57 uses which include Epicondylitis and Ankylosing Spondylitis .

Epicondylitis

Helps manage Epicondylitis

Ankylosing Spondylitis

Helps manage Ankylosing Spondylitis (AS)

anterior eye segment inflammation

Helps manage anterior eye segment inflammation

Congenital Hypoplastic Anemia

Helps manage Congenital Hypoplastic Anemia

Rosacea

Helps manage Rosacea

Hypercalcemia

Helps manage Hypercalcemia

Loeffler's syndrome

Helps manage Loeffler's syndrome

Allergic Conjunctivitis (AC)

Helps manage Allergic Conjunctivitis (AC)

Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor

Used to treat Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor in combination with Isatuximab

Perennial Allergic Rhinitis (PAR)

Helps manage Perennial Allergic Rhinitis (PAR)

Stevens-Johnson Syndrome

Helps manage Stevens-Johnson Syndrome

acquired immune hemolytic anemia

Helps manage acquired immune hemolytic anemia

Optic Neuritis

Helps manage Optic Neuritis

Bursitis

Helps manage Bursitis

Pemphigus

Helps manage Pemphigus

Synovitis

Helps manage Synovitis

Ophthalmia, Sympathetic

Helps manage Ophthalmia, Sympathetic

Psoriasis

Helps manage severe Psoriasis

Adrenal cortical hypofunctions

Helps manage Adrenal cortical hypofunctions

exfoliative erythroderma

Helps manage exfoliative erythroderma

Rheumatoid Arthritis, Juvenile

Helps manage Rheumatoid Arthritis, Juvenile

Congenital adrenal hyperplasia

Helps manage Congenital Adrenal Hyperplasia (CAH)

Lupus

Helps manage Systemic Lupus Erythematosus (SLE)

Crohn Disease

Helps manage Regional Enteritis

Acute Myeloid Leukemia (AML)

Helps manage Acute Leukemia (Category)

Drug Allergy

Helps manage Drug hypersensitivity reaction

Brain

Helps manage Edema of the cerebrum

Malignant Lymphomas

Helps manage Malignant Lymphomas

Ulcerative Colitis

Helps manage Ulcerative Colitis

Berylliosis

Helps manage Berylliosis

Bullous dermatitis herpetiformis

Helps manage Bullous dermatitis herpetiformis

Tuberculosis (TB)

Helps manage Tuberculosis (TB)

Mycosis Fungoides (MF)

Helps manage Mycosis Fungoides (MF)

Inflammation

Hay Fever

Helps manage Seasonal Allergic Rhinitis

Cushing's Syndrome

Asthma

Helps manage Asthma

Trichinosis

Helps manage Trichinosis

Iritis

Helps manage Iritis

Degenerative polyarthritis

Helps manage Posttraumatic Osteoarthritis

Iridocyclitis

Helps manage Iridocyclitis

Rheumatoid Arthritis

Helps manage Rheumatoid Arthritis

Acute Coryza

Helps manage acute rheumatic carditis

Choroiditis

Helps manage Choroiditis

varicella-zoster virus acute retinal necrosis

Helps manage varicella-zoster virus acute retinal necrosis

Arthritis, Gouty

Helps manage Acute Gouty Arthritis

Chorioretinitis

Helps manage Chorioretinitis

Erythroblastopenia

Helps manage Erythroblastopenia

Multiple Myeloma

Used to treat Multiple Myeloma (MM) in combination with Isatuximab

Adrenocortical Hyperfunction

Seborrheic dermatitis

Helps manage Severe Seborrheic Dermatitis

Serum Sickness

Helps manage Serum Sickness

Secondary thrombocytopenia

Helps manage Secondary thrombocytopenia

Sarcoidosis

Helps manage Sarcoidosis

Uveitis

Helps manage Uveitis

Thyroiditis

Helps manage non-suppurative Thyroiditis

Aspiration Pneumonitis

Helps manage Aspiration Pneumonitis

Effectiveness

How Maxidex Affects PatientsCorticosteroids work by blocking signals that cause inflammation and promoting signals that reduce inflammation. The amount of time they have an effect can vary depending on how they are taken. Corticosteroids can be taken in larger doses than what the body produces naturally. People using corticosteroids should be aware that they may suppress the body's natural hormone production and could be more vulnerable to infections.

How Maxidex works in the bodyCorticosteroids work in the body to reduce inflammation. They work by binding to a receptor and changing how some genes are expressed. Corticosteroids stop white blood cells from moving to sites of inflammation, stop the creation of molecules that increase inflammation, and promote molecules that reduce inflammation. Low doses of corticosteroids reduce inflammation without affecting the immune system, while higher doses suppress the immune system and can raise sodium levels and lower potassium levels.

When to interrupt dosage

The prescribed dosage of Maxidex is contingent upon the ascertained condition, including Pink Eye, Brain and Keloids Scars. The quantity of dosage can be found in the table below, subject to the means of delivery.

Condition

Dosage

Administration

Macular Edema

, 0.7 mg, 0.001 mg/mg, 10.0 mg/mL, 4.0 mg/mL, 1.5 mg, 1.0 mg/mL, 4.0 mg, 0.75 mg, 1.0 mg, 2.0 mg, 6.0 mg, 0.5 mg, 0.5 mg/mL, 0.1 %, 40.0 mg, 0.0005 mg/mg, 517.0 mg/mL, 0.0015 mg/mg, 0.4 mg, 20.0 mg, 0.1 mg/mL, 0.5 mg/units

, Implant, Implant - Intravitreal, Intravitreal, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Injection, solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Suspension / drops, Solution, Solution - Ophthalmic, Auricular (otic), Suspension - Auricular (otic), Intramuscular, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Injection, Intra-articular; Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Elixir, Elixir - Oral, Liquid, Liquid - Intramuscular; Intravenous, Intramuscular; Intrasynovial; Intravenous, Liquid - Intramuscular; Intrasynovial; Intravenous, Liquid - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Auricular (otic); Ophthalmic, Solution / drops - Auricular (otic); Ophthalmic, Solution - Intramuscular; Intrasynovial; Intravenous, Solution - Auricular (otic); Ophthalmic, Solution - Intra-articular; Intramuscular; Intravenous, Topical, Solution / drops - Topical, Ophthalmic; Topical, Liquid - Ophthalmic; Topical, Ointment - Topical, Liquid - Auricular (otic); Ophthalmic, Ointment - Auricular (otic); Ophthalmic, Solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Solution - Intramuscular; Intravenous, Liquid - Intra-articular; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Oral, Suspension / drops - Auricular (otic), Injection - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Dental, Liquid - Dental, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Epidural; Infiltration; Intramuscular; Intravenous, Injection - Intramuscular, Solution - Parenteral, Parenteral, Injection, solution - Ophthalmic, Intraocular, Injection, solution - Intraocular, Injection, suspension, Injection, suspension - Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Intramuscular; Intravenous; Topical, Kit - Intramuscular; Intravenous; Topical, Injection, emulsion, Injection, emulsion - Intramuscular; Intravenous, Insert, Insert - Ophthalmic, Solution - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Perineural, Suspension / drops - Topical

Chorioretinitis

Ophthalmia, Sympathetic

Iritis

Sarcoidosis

Inflammation

Berylliosis

Hypercalcemia

acquired immune hemolytic anemia

Necrobiosis lipoidica diabeticorum

Uveitis

Choroiditis

Pink Eye

Synovitis

Thyroiditis

Lupus

Secondary thrombocytopenia

exfoliative erythroderma

Granuloma Annulare

Rosacea

Warnings

Maxidex Contraindications

Condition

Risk Level

Notes

active periocular infections

Do Not Combine

Eye

Do Not Combine

Tympanic membrane structure

Do Not Combine

suspected periocular infections

Do Not Combine

Eye Infections, Fungal

Do Not Combine

Viral Conjunctivitis

Do Not Combine

Communicable Diseases

Do Not Combine

Eye Infection

Do Not Combine

Mycoses

Do Not Combine

acute infectious stages of varicella

Do Not Combine

External auditory canal structure

Do Not Combine

epithelial herpes simplex keratitis

Do Not Combine

External Ear

Do Not Combine

torn posterior lens

Do Not Combine

Open-angle glaucoma

Do Not Combine

Cornea

Do Not Combine

active ocular infections

Do Not Combine

ruptured posterior lens

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Dexamethasone may interact with Pulse Frequency

There are 20 known major drug interactions with Maxidex.

Common Maxidex Drug Interactions

Drug Name

Risk Level

Description

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be increased when combined with Dexamethasone.

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Dexamethasone is combined with 2-Methoxyethanol.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Dexamethasone.

6-O-benzylguanine

Major

The metabolism of 6-O-benzylguanine can be increased when combined with Dexamethasone.

7-ethyl-10-hydroxycamptothecin

Major

The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Dexamethasone.

Maxidex Toxicity & Overdose RiskThe lethal dose of this drug in female mice is 6.5g/kg when taken orally, and 794mg/kg when taken intravenously. Long-term use of this medication can cause cataracts, glaucoma, high blood pressure, water retention, high cholesterol, ulcers, pancreatitis, muscle pain, emotional changes, skin thinning and hair growth, weakened immune system, and slowed growth in children. If an overdose occurs, the dose may be adjusted or stopped, and any symptoms should be treated.

Maxidex Novel Uses: Which Conditions Have a Clinical Trial Featuring Maxidex?

345 active trials are being conducted to explore the capability of Maxidex to provide relief from Eye Infections, Stevens-Johnson Syndrome and Chorioretinitis.

Condition

Clinical Trials

Trial Phases

Chorioretinitis

0 Actively Recruiting

swelling of the eyes

0 Actively Recruiting

Acute Otitis Media (AOM)

3 Actively Recruiting

Not Applicable

Open-angle glaucoma

84 Actively Recruiting

Phase 3, Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1

Necrobiosis lipoidica diabeticorum

0 Actively Recruiting

Urinary Tract Infection (UTI)

24 Actively Recruiting

Phase 2, Phase 1, Phase 4, Phase 3, Not Applicable

Ulcerative Colitis

99 Actively Recruiting

Phase 2, Not Applicable, Phase 3, Phase 1, Phase 4, Early Phase 1

Psoriasis

0 Actively Recruiting

anterior eye segment inflammation

0 Actively Recruiting

Granuloma Annulare

0 Actively Recruiting

Middle ear inflammation

0 Actively Recruiting

Bullous dermatitis herpetiformis

0 Actively Recruiting

Phlyctenular keratoconjunctivitis

0 Actively Recruiting

Bacterial Infections

0 Actively Recruiting

Trichinosis

0 Actively Recruiting

Keloids Scars

1 Actively Recruiting

Not Applicable

Inflammation

170 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4

Thyroiditis

0 Actively Recruiting

Ophthalmia, Sympathetic

0 Actively Recruiting

Otitis Externa

0 Actively Recruiting

Maxidex Reviews: What are patients saying about Maxidex?

3.7Patient Review

9/12/2022

Maxidex for Inflammation of the Eye Following Surgery

Maxidex is great for temporarily alleviating inflammation, but it only lasts a few days once you stop using it.

3Patient Review

2/17/2016

Maxidex for Inflammation of the Iris - the Colored Part of the Eyeball

I had retina surgery a while back and have been using these drops for the past two months. My eye still feels itchy and gritty, so I'm not sure if this medication is actually doing anything.

2Patient Review

12/12/2021

Maxidex for Inflammation of the Eye

My husband has been prescribed Maxidex three times a day. Three days after using it, he's developed an upset stomach. We've both eaten the same things and I've been okay, so I'm wondering if there's a connection.

1.7Patient Review

7/15/2014

Maxidex for Infection of the Cornea of the Eye due to Herpes Zoster

My son was given maxidex to help with kerataconus after two laser surgeries. However, now he's developed cataracts and has to go back for monitoring frequently. We weren't warned about this possibility by the surgeon and it's frustrating.

1.7Patient Review

12/7/2021

Maxidex for Inflammation of the Eye Following Surgery

My husband was prescribed Maxidex drops after cataract surgery. He experienced EXTREME pain in his eye immediately after having the drops administered. After approximately 1 week of using these drops we had to call 911 because the pain was unbearable.

1.3Patient Review

4/17/2011

Maxidex for Inflammation of the Eye Following Surgery

I used this before my cataract surgery and now I need LASIK. Not sure if it was the medicine or the doctor...

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about maxidex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it safe to use Maxidex?

"Do not take Maxidex if you are allergic to it, have an eye infection, or have had glaucoma or cataracts in the past."

Answered by AI

How long should I use Maxidex eye drops?

"Use the drops every 30 to 60 minutes that you're awake for the first 24 to 48 hours, then reduce to every four hours. Follow your doctor's instructions."

Answered by AI

What is Maxidex used to treat?

"MAXIDEX is a corticosteroid eye drop used to treat inflammation of the surface of the eye and the front portion inside the eye, as well as to prevent inflammation following surgery on the eye."

Answered by AI

What are the side effects of Maxidex eye drops?

"Glaucoma refers to a group of eye conditions that damage the optic nerve. Symptoms may include eye discomfort, grittiness, itchiness, irritation, pain, dry or watery eyes, red eye, inflammation of the eye, secondary eye infection, staining front part of the eye, drooping eyelid."

Answered by AI