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What is Macrobid
NitrofurantoinThe Generic name of this drug
Treatment SummaryNitrofurantoin is an antibiotic used to treat simple urinary tract infections. The drug works by blocking the production of proteins, DNA and RNA, which stops bacteria from multiplying. Nitrofurantoin is generally used as a second-line treatment after other antibiotics, such as trimethoprim/sulfamethoxazole, have failed. It was approved by the FDA in 1953 and has proven to be more resistant to bacteria becoming resistant to it.
Furadantinis the brand name
Macrobid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Furadantin
Nitrofurantoin
1953
247
Approved as Treatment by the FDA
Nitrofurantoin, otherwise called Furadantin, is approved by the FDA for 2 uses such as Urinary Tract Infection and Cystitis .Urinary Tract Infection
Cystitis
Effectiveness
How Macrobid Affects PatientsNitrofurantoin works by disrupting important processes in bacteria, causing them to die. It is quickly absorbed and cleared out of the body, making it an effective treatment.
How Macrobid works in the bodyNitrofurantoin is changed by bacteria in the body into substances that stop the citric acid cycle and the creation of DNA, RNA, and protein.
When to interrupt dosage
The advocated dosage of Macrobid is contingent upon the identified condition. The measure of dosage may differ, in line with the method of delivery (e.g. Capsule or Capsule - Oral) indicated in the table beneath.Condition
Dosage
Administration
Cystitis
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 75.0 mg, 105.7 mg, 80.7 mg, 5.0 mg/mL
, Oral, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral
Urinary Tract Infection
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 75.0 mg, 105.7 mg, 80.7 mg, 5.0 mg/mL
, Oral, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral
Warnings
Macrobid has nine contraindications, so it should not be taken when dealing with the situations given in the table below.Macrobid ContraindicationsCondition
Risk Level
Notes
Anuria
Do Not Combine
Pulse Frequency
Do Not Combine
imminent onset of labor
Do Not Combine
Term Birth (Pregnancy)
Do Not Combine
Jaundice, Obstructive
Do Not Combine
Liver Dysfunction
Do Not Combine
Oliguria
Do Not Combine
Parturition
Do Not Combine
Labour
Do Not Combine
Common Macrobid Drug Interactions
Drug Name
Risk Level
Description
Cinoxacin
Major
The therapeutic efficacy of Cinoxacin can be decreased when used in combination with Nitrofurantoin.
Ciprofloxacin
Major
The therapeutic efficacy of Ciprofloxacin can be decreased when used in combination with Nitrofurantoin.
Delafloxacin
Major
The therapeutic efficacy of Delafloxacin can be decreased when used in combination with Nitrofurantoin.
Difloxacin
Major
The therapeutic efficacy of Difloxacin can be decreased when used in combination with Nitrofurantoin.
Enoxacin
Major
The therapeutic efficacy of Enoxacin can be decreased when used in combination with Nitrofurantoin.
Macrobid Toxicity & Overdose RiskSome of the symptoms of an overdose of nitrofurantoin include vomiting. To treat an overdose, you should induce vomiting if it has not already occurred and drink more fluids to help flush the drug out of your system. In serious cases, nitrofurantoin can be removed from the bloodstream with dialysis.
Macrobid Novel Uses: Which Conditions Have a Clinical Trial Featuring Macrobid?
10 active trials are currently assessing the potential of Macrobid to alleviate symptoms of Urinary Tract Infection.Condition
Clinical Trials
Trial Phases
Urinary Tract Infection
8 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Cystitis
0 Actively Recruiting
Macrobid Reviews: What are patients saying about Macrobid?
5Patient Review
6/3/2022 I'm grateful that I haven't had any side effects from this medication. The UTI was so painful that I went to the ER early Wednesday morning. By Wednesday evening, the symptoms had subsided almost completely. Thursday midday, I felt back to normal (besides my sleep schedule being totally screwed up).
3Patient Review
6/30/2022 Though this drug was effective in treating my burning, I experienced some very intense side effects a few hours later. Thankfully, they didn't last too long and I woke up feeling better the next day.
3Patient Review
9/18/2022 I had a really terrible experience with this medication. The first dose gave me a headache, and the second made me feel like I was dying. I went to the ER, but they couldn't find anything wrong with me. I'm having awful nightmares now and I'm not even sure if I can finish the full course of treatment.
2.7Patient Review
9/24/2022 Almost immediately after taking this drug, I started experiencing a range of concerning symptoms like joint pain, sweating, fever, chills, exhaustion, vision problems, dizziness, nausea, and shortness of breath. Thankfully, I didn't wind up going to the ER--but only because the side effects abated a few days later.
2Patient Review
5/26/2022 I was prescribed this antibiotics twice for the last 2 UTI's that I had. The first time, my only side effects were headaches and fatigue. Now, the second time I was prescribed this, I felt awful - nothing like the first time. Migraines, nausea/vomiting, and overall body weakness. I wasn't able to go to work or get out of the bed. I am currently on day 3 of 7 and I still feel discomfort in my pelvic area. Please inform yourself of this before you take it..
2Patient Review
9/8/2022 I took Macrobid twice for a mild UTI. The second time I didn't remember which antibiotic I had. Both times I had fever, chills, body aches. There are other antibiotics that also treat UTIs effectively and with fewer side effects. This was a terrible experience and I will never take this medication again.
1.7Patient Review
11/10/2022 I had a UTI with no symptoms and discovered it through a routine urine test. I took one macrobid 100mg and now feel awful--body aches, headaches (but no fever), my skin hurts to the touch, dizzy and chilly. This is by far the worst antibiotic I've ever taken.
1.3Patient Review
7/15/2022 After taking this medication for just three days, I started experiencing intense leg pain and neuropathy. This was despite the fact that I'm retired from a medical field where I treated patients with urinary tract infections! Needless to say, I stopped taking the pills and will never use them again.
1Patient Review
7/25/2022 I would rather suffer from a UTI than take this medication again. I had terrible chills, body aches, and a headache. This antibiotic is poison and should not be on the market.
1Patient Review
8/27/2022 I was really sick after taking just two doses of this medication. I had a raging headache, body aches, and joint pain. I thought I was coming down with the flu but it turns out that these are all side effects of the medication!
1Patient Review
11/5/2022 I was really sick after taking this medication. It gave me a severe headache, chills, made me sleepy and dizzy, and caused serious nausea.
1Patient Review
6/24/2022 I had a terrible experience with this medicine. I felt like I had a severe kidney infection after only taking it for 2.5 days. If you don't feel right while taking this medication, definitely talk to your doctor. I was told that I could be on the verge of a stroke when I spoke with the prescriber.
Patient Q&A Section about macrobid
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Macrobid a penicillin?
"Macrobid is an antibiotic that is part of the nitrofuran class. Augmentin, on the other hand, is a combination of a penicillin-type antibiotic and a beta-lactamase inhibitor."
Answered by AI
What is Macrobid antibiotic good for?
"This medication is an antibiotic used to treat bladder infections (acute cystitis) by stopping the growth of bacteria. It will not work for viral infections (such as common cold, flu)."
Answered by AI
How quickly does Macrobid work for UTI?
"It's sold under the brand names Macrobid, Macrodantin, and Furadantin.
Nitrofurantoin is used to treat urinary tract infections. It should start working within three to five days, although it may take up to a week for symptoms to clear. Be sure to complete the full course of medication."
Answered by AI
Is Macrobid the best antibiotic for UTI?
"Nitrofurantoin is an antibiotic that is only effective in treating UTIs. It works by preventing bacteria from being able to create the DNA and proteins they need to survive."
Answered by AI