Macrobid

Urinary Tract Infections, Cystitis
Treatment
2 FDA approvals
6 Active Studies for Macrobid

What is Macrobid

NitrofurantoinThe Generic name of this drug
Treatment SummaryNitrofurantoin is an antibiotic used to treat simple urinary tract infections. The drug works by blocking the production of proteins, DNA and RNA, which stops bacteria from multiplying. Nitrofurantoin is generally used as a second-line treatment after other antibiotics, such as trimethoprim/sulfamethoxazole, have failed. It was approved by the FDA in 1953 and has proven to be more resistant to bacteria becoming resistant to it.
Furadantinis the brand name
image of different drug pills on a surface
Macrobid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Furadantin
Nitrofurantoin
1953
247

Approved as Treatment by the FDA

Nitrofurantoin, otherwise called Furadantin, is approved by the FDA for 2 uses such as Cystitis and Urinary Tract Infections .
Cystitis
Urinary Tract Infections

Effectiveness

How Macrobid Affects PatientsNitrofurantoin works by disrupting important processes in bacteria, causing them to die. It is quickly absorbed and cleared out of the body, making it an effective treatment.
How Macrobid works in the bodyNitrofurantoin is changed by bacteria in the body into substances that stop the citric acid cycle and the creation of DNA, RNA, and protein.

When to interrupt dosage

The advocated dosage of Macrobid is contingent upon the identified condition. The measure of dosage may differ, in line with the method of delivery (e.g. Capsule or Capsule - Oral) indicated in the table beneath.
Condition
Dosage
Administration
Urinary Tract Infections
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 75.0 mg, 105.7 mg, 80.7 mg, 5.0 mg/mL
, Oral, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral
Cystitis
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 75.0 mg, 105.7 mg, 80.7 mg, 5.0 mg/mL
, Oral, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral

Warnings

Macrobid has nine contraindications, so it should not be taken when dealing with the situations given in the table below.Macrobid Contraindications
Condition
Risk Level
Notes
Anuria
Do Not Combine
Pulse Frequency
Do Not Combine
imminent onset of labor
Do Not Combine
Term Birth (Pregnancy)
Do Not Combine
Jaundice, Obstructive
Do Not Combine
Liver Dysfunction
Do Not Combine
Oliguria
Do Not Combine
Parturition
Do Not Combine
Labour
Do Not Combine
There are 20 known major drug interactions with Macrobid.
Common Macrobid Drug Interactions
Drug Name
Risk Level
Description
Cinoxacin
Major
The therapeutic efficacy of Cinoxacin can be decreased when used in combination with Nitrofurantoin.
Ciprofloxacin
Major
The therapeutic efficacy of Ciprofloxacin can be decreased when used in combination with Nitrofurantoin.
Delafloxacin
Major
The therapeutic efficacy of Delafloxacin can be decreased when used in combination with Nitrofurantoin.
Difloxacin
Major
The therapeutic efficacy of Difloxacin can be decreased when used in combination with Nitrofurantoin.
Enoxacin
Major
The therapeutic efficacy of Enoxacin can be decreased when used in combination with Nitrofurantoin.
Macrobid Toxicity & Overdose RiskSome of the symptoms of an overdose of nitrofurantoin include vomiting. To treat an overdose, you should induce vomiting if it has not already occurred and drink more fluids to help flush the drug out of your system. In serious cases, nitrofurantoin can be removed from the bloodstream with dialysis.
image of a doctor in a lab doing drug, clinical research

Macrobid Novel Uses: Which Conditions Have a Clinical Trial Featuring Macrobid?

10 active trials are currently assessing the potential of Macrobid to alleviate symptoms of Urinary Tract Infection.
Condition
Clinical Trials
Trial Phases
Cystitis
0 Actively Recruiting
Urinary Tract Infections
7 Actively Recruiting
Not Applicable, Phase 4

Macrobid Reviews: What are patients saying about Macrobid?

5Patient Review
6/3/2022
Macrobid for Bacterial Urinary Tract Infection
I'm grateful that I haven't had any side effects from this medication. The UTI was so painful that I went to the ER early Wednesday morning. By Wednesday evening, the symptoms had subsided almost completely. Thursday midday, I felt back to normal (besides my sleep schedule being totally screwed up).
3Patient Review
6/30/2022
Macrobid for Bacterial Urinary Tract Infection
Though this drug was effective in treating my burning, I experienced some very intense side effects a few hours later. Thankfully, they didn't last too long and I woke up feeling better the next day.
3Patient Review
9/18/2022
Macrobid for Bacterial Urinary Tract Infection
I had a really terrible experience with this medication. The first dose gave me a headache, and the second made me feel like I was dying. I went to the ER, but they couldn't find anything wrong with me. I'm having awful nightmares now and I'm not even sure if I can finish the full course of treatment.
2.7Patient Review
9/24/2022
Macrobid for Bacterial Urinary Tract Infection
Almost immediately after taking this drug, I started experiencing a range of concerning symptoms like joint pain, sweating, fever, chills, exhaustion, vision problems, dizziness, nausea, and shortness of breath. Thankfully, I didn't wind up going to the ER--but only because the side effects abated a few days later.
2Patient Review
5/26/2022
Macrobid for Urinary Tract Infection due to E. Coli Bacteria
I was prescribed this antibiotics twice for the last 2 UTI's that I had. The first time, my only side effects were headaches and fatigue. Now, the second time I was prescribed this, I felt awful - nothing like the first time. Migraines, nausea/vomiting, and overall body weakness. I wasn't able to go to work or get out of the bed. I am currently on day 3 of 7 and I still feel discomfort in my pelvic area. Please inform yourself of this before you take it..
2Patient Review
9/8/2022
Macrobid for Urinary Tract Infection due to E. Coli Bacteria
I took Macrobid twice for a mild UTI. The second time I didn't remember which antibiotic I had. Both times I had fever, chills, body aches. There are other antibiotics that also treat UTIs effectively and with fewer side effects. This was a terrible experience and I will never take this medication again.
1.7Patient Review
11/10/2022
Macrobid for Infection of the Urinary Tract caused by Enterococcus
I had a UTI with no symptoms and discovered it through a routine urine test. I took one macrobid 100mg and now feel awful--body aches, headaches (but no fever), my skin hurts to the touch, dizzy and chilly. This is by far the worst antibiotic I've ever taken.
1.3Patient Review
7/15/2022
Macrobid for Bacterial Urinary Tract Infection
After taking this medication for just three days, I started experiencing intense leg pain and neuropathy. This was despite the fact that I'm retired from a medical field where I treated patients with urinary tract infections! Needless to say, I stopped taking the pills and will never use them again.
1Patient Review
7/25/2022
Macrobid for Bacterial Urinary Tract Infection
I would rather suffer from a UTI than take this medication again. I had terrible chills, body aches, and a headache. This antibiotic is poison and should not be on the market.
1Patient Review
8/27/2022
Macrobid for Bacterial Urinary Tract Infection
I was really sick after taking just two doses of this medication. I had a raging headache, body aches, and joint pain. I thought I was coming down with the flu but it turns out that these are all side effects of the medication!
1Patient Review
11/5/2022
Macrobid for Bacterial Urinary Tract Infection
I was really sick after taking this medication. It gave me a severe headache, chills, made me sleepy and dizzy, and caused serious nausea.
1Patient Review
6/24/2022
Macrobid for Bacterial Urinary Tract Infection
I had a terrible experience with this medicine. I felt like I had a severe kidney infection after only taking it for 2.5 days. If you don't feel right while taking this medication, definitely talk to your doctor. I was told that I could be on the verge of a stroke when I spoke with the prescriber.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about macrobid

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Macrobid a penicillin?

"Macrobid is an antibiotic that is part of the nitrofuran class. Augmentin, on the other hand, is a combination of a penicillin-type antibiotic and a beta-lactamase inhibitor."

Answered by AI

What is Macrobid antibiotic good for?

"This medication is an antibiotic used to treat bladder infections (acute cystitis) by stopping the growth of bacteria. It will not work for viral infections (such as common cold, flu)."

Answered by AI

How quickly does Macrobid work for UTI?

"It's sold under the brand names Macrobid, Macrodantin, and Furadantin.

Nitrofurantoin is used to treat urinary tract infections. It should start working within three to five days, although it may take up to a week for symptoms to clear. Be sure to complete the full course of medication."

Answered by AI

Is Macrobid the best antibiotic for UTI?

"Nitrofurantoin is an antibiotic that is only effective in treating UTIs. It works by preventing bacteria from being able to create the DNA and proteins they need to survive."

Answered by AI

Clinical Trials for Macrobid

Image of UPMC Magee-Womens Hospital in Pittsburgh, United States.

Catheterization Methods for Postpartum Urinary Problems

18+
All Sexes
Pittsburgh, PA
At least ten percent of patients have postpartum urinary retention or difficulty urinating after birth, which can cause incontinence and other urinary problems long-term. After getting an epidural placed, patients should be numb in their pelvic region. This numbness makes it difficult to feel the need to urinate, so patients need a urinary catheter placed to empty the bladder. Some patients have one catheter placed throughout their labor and others have a catheter placed to empty the bladder then removed every few hours. The investigators are studying whether placing a catheter once or catheterizing multiple times affects the rate of postpartum urinary problems and infection.
Waitlist Available
Has No Placebo
UPMC Magee-Womens HospitalAnna Binstock, MD
Image of University of California, San Francisco in San Francisco, United States.

Trimethoprim-Sulfamethoxazole for Urinary Tract Infections

13 - 29
All Sexes
San Francisco, CA
The goal of this clinical trial is to learn if a common antibiotic called trimethoprim-sulfamethoxazole (TMP-SMX) can help prevent urinary tract infections (UTIs) in children and young adults who recently had a kidney transplant. Most people take TMP-SMX for about 6 months after getting a kidney transplant. In this study, researchers want to see what happens if people keep taking it for 6 more months. The main questions this study is asking are: * Does TMP-SMX lower the number of UTIs in the first year after transplant? * What side effects or problems do participants have while taking TMP-SMX? Researchers will compare TMP-SMX to a placebo (a look-alike pill that does not contain any medication) to see if TMP-SMX works to prevent UTIs. Participants will: * Take either TMP-SMX or a placebo pill by mouth every day for 6 months * Have three visits to touch base with the study team about any issues * Complete short monthly online surveys about any symptoms or side effects * Share blood and urine test results from their regular transplant clinic visits
Phase 4
Waitlist Available
University of California, San FranciscoAlexandra Bicki, MD
Have you considered Macrobid clinical trials? We made a collection of clinical trials featuring Macrobid, we think they might fit your search criteria.Go to Trials
Image of Vriginia Mason Medical Center in Seattle, United States.

Antibiotic Usage for Overactive Bladder

18+
All Sexes
Seattle, WA
Intradetrusor injection of onabotulinumtoxinA, which is performed through a cystoscopic procedure, has been demonstrated to be efficacious in the treatment of both neurogenic and non-neurogenic overactive bladder (OAB), and is FDA approved as a treatment for overactive bladder. Intradetrusor of onabotulinumtoxinA is currently standard of care of patients with OAB who have persistent OAB symptoms despite behavioral therapies and oral medication treatments for OAB. As one of the main adverse events associated with intradetrusor injection of onabotulinumtoxinA is UTI, and published guidelines for cystoscopic procedures with manipulation recommend the use of prophylactic antibiotics, a single dose of prophylactic antibiotic is administered prior to this procedure. However, these recommendations are primarily based on data from randomized controlled trials (RCTs) involving antimicrobial prophylaxis during transurethral resection of the prostate. A previously published prospective study demonstrated that the rate of post-procedural UTI did not differ amongst patients with neurogenic bladder who did not receive prophylactic antibiotics and were asymptomatic for UTI, regardless of whether they had sterile urine cultures or asymptomatic bacteriuria, suggesting that patients who are not symptomatic for UTI may not require antibiotic prophylaxis prior to intradetrusor onabotulinumtoxinA injection. Studies have reported that up to 50% of antibiotic usage is inappropriate, leading to unnecessary exposure of patients to potential complications of antibiotic therapy, including Clostridium difficile infection which can cause recurrent diarrhea that may progress to sepsis and death, increasing antibiotic resistances, as well as dermal/allergic and gastro-intestinal manifestations. Therefore, in an effort to optimize antibiotic use, the investigators propose a prospective, randomized study to formally evaluate the differences in UTI frequency in subjects who have a negative urinalysis and are not symptomatic for UTI and receive prophylactic antibiotics at the time of intradetrusor onabotulinumtoxinA injection compared to those who do not receive prophylactic antibiotics at the time of injection. The proposed study seeks to evaluate the current practice standard of antibiotic prophylaxis prior to intradetrusor onabotulinumtoxin injection.
Recruiting
Has No Placebo
Vriginia Mason Medical Center (+1 Sites)Justina Tam, MD
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