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What is Loryna
DrospirenoneThe Generic name of this drug
Treatment SummaryDrospirenone is a synthetic hormone used in combination with Ethinyl estradiol and Estetrol for birth control pills. It can also be used to treat acne and premenstrual dysphoric disorder (PMDD). There have been concerns about an increased risk of venous thromboembolism associated with its use, but the FDA concluded that the risk remains unclear as studies have been conflicting. However, the risk is still lower than the risk of this condition during pregnancy or after childbirth.
Yasminis the brand name
Loryna Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Yasmin
Drospirenone
2001
64
Effectiveness
How Loryna Affects PatientsDrospirenone is a contraceptive medication used to prevent pregnancy. It works by blocking the ovulation process, and can also help improve acne and hirsutism. Taking drospirenone with ethinyl estradiol has been shown to be beneficial to the plasma lipid profile. It is similar to natural progesterone, and may cause fewer side effects such as breast tenderness and mood swings. However, taking drospirenone increases the risk of venous thromboembolism and cardiovascular events, especially in smokers and women aged 35 or older. It also increases the risk of hyperkalemia, so patients at
How Loryna works in the bodyDrospirenone and ethinyl estradiol work together to prevent pregnancy. They stop the release of hormones that cause ovulation and make changes to the cervical mucus, making it harder for sperm to travel. Drospirenone also has anti-mineralocorticoid activity, blocking aldosterone receptors and increasing sodium and water excretion. It also has anti-androgenic activity, blocking the binding of DHT to its receptor and preventing androgen synthesis in the ovaries, which helps treat acne and hirsutism. Finally, drospirenone may decrease the level of edema in sebaceous
When to interrupt dosage
The quantity of Loryna is contingent upon the diagnosed condition, such as moderate to severe symptoms, Menopause and Post-Menarche. The quantity of dosage is contingent upon the method of administration (e.g. Tablet, film coated - Oral or Oral) shown in the table below.Condition
Dosage
Administration
Atrophic
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Atrophy of vulva
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Hormonal Contraception
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
N-Cadherins
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
moderate to severe symptoms
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Birth Control
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Acne Vulgaris
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Folate supplementation therapy
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Post-Menarche
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Hot flashes
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Vasomotor System
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Adherence to Oral Contraceptive Therapy
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Warnings
Loryna has 26 contraindications, so it should not be employed when managing the conditions mentioned in the following table.Loryna ContraindicationsCondition
Risk Level
Notes
Chronic Kidney Disease
Do Not Combine
high risk of venous thrombotic disease
Do Not Combine
Neoplasms, Hormone-Dependent
Do Not Combine
Migraine, Classic
Do Not Combine
Porphyria
Do Not Combine
Breast
Do Not Combine
suspected pregnancy
Do Not Combine
Breast Milk Production
Do Not Combine
Metrorrhagia
Do Not Combine
Hypersensitivity
Do Not Combine
acute liver disease
Do Not Combine
Renal Insufficiency, Acute
Do Not Combine
Deep Vein Thrombosis (DVT)
Do Not Combine
Vision Loss
Do Not Combine
untreated endometrial hyperplasia
Do Not Combine
Tobacco Use
Do Not Combine
Liver Function Tests
Do Not Combine
Thrombophilia
Do Not Combine
Thromboembolism
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
Adrenal Insufficiency
Do Not Combine
recent thromboembolic event
Do Not Combine
Breast
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Common Loryna Drug Interactions
Drug Name
Risk Level
Description
Tranexamic acid
Major
Drospirenone may increase the thrombogenic activities of Tranexamic acid.
Acetohexamide
Minor
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Drospirenone.
Agmatine
Minor
The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Agmatine.
Aliskiren
Minor
The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Aliskiren.
Anisodamine
Minor
The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Anisodamine.
Loryna Toxicity & Overdose RiskThe lowest toxic dose of drospirenone in rats has been found to be greater than 2000mg/kg. Overdosing on drospirenone may cause nausea or bleeding, and can also lead to changes in sodium and potassium levels. In cases of overdose, it is important to monitor levels of acid and potassium in addition to sodium levels.
Loryna Novel Uses: Which Conditions Have a Clinical Trial Featuring Loryna?
At present, 104 active studies are investigating the potential of Loryna to be used in Acne Vulgaris, Post-Menarche and N-Cadherins treatment regimens.Condition
Clinical Trials
Trial Phases
Atrophic
5 Actively Recruiting
Phase 2, Phase 4, Not Applicable
Atrophy of vulva
1 Actively Recruiting
Not Applicable
Birth Control
31 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Folate supplementation therapy
0 Actively Recruiting
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
moderate to severe symptoms
0 Actively Recruiting
N-Cadherins
1 Actively Recruiting
Phase 1
Hormonal Contraception
0 Actively Recruiting
Post-Menarche
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Adherence to Oral Contraceptive Therapy
0 Actively Recruiting
Vasomotor System
0 Actively Recruiting
Loryna Reviews: What are patients saying about Loryna?
5Patient Review
8/3/2019 This drug has some downsides—slight weight gain and decreased interest in sex—but the upsides (tremendous positive impact on my mood, effectiveness in preventing pregnancy, improvement to my skin) outweigh them. I feel so much better since taking this; it's really helped with my PMS, too.
5Patient Review
3/30/2019 I was really nervous about starting this birth control after reading some of the reviews online. I'm so glad I decided to go ahead with it anyway. It's been great for my acne, and I haven't gained any weight. It works just as well as any other birth control pill would.
5Patient Review
1/21/2019 I've been on this medication for four months now, and I'm happy to say that it's cleared up my acne completely. The only downside is some hyperpigmentation, but that's a small price to pay for clear skin.
5Patient Review
12/20/2021 I've been on Loryna for four years now and it's great. My acne cleared up within weeks, and though my sex drive dropped a bit, that was only if I missed a dose. Otherwise, no changes to my mood or body. I was also put on it for weight gain prevention and saw changes in appetite that eventually evened out. Plus, way less cramps than before! All things considered, this is the best birth control I've ever used.
4.7Patient Review
4/23/2018 I was scared to try the pill because of all the horror stories I'd heard about it, but Loryna has been great for me so far. No acne, no weight gain, and my breasts have gotten bigger (which might explain my increased appetite). Overall, very happy with this experience.
4Patient Review
4/12/2020 This medication helped me with cramps, but caused problems with my sex drive and weight. After a couple years on the meds, I realized that it was the actual reason I didn’t have a sex drive or why I was very moody.
2Patient Review
5/17/2018 Disappointed is right. It did help with my cycles and acne, but I gained weight while constantly bloated. My periods were also longer than normal. Beyond that, I felt really out of sorts on this pill; it made me feel irritable and upset all the time.
1Patient Review
5/12/2021 I've only been taking this medication for three days, and it has already caused me a great deal of pain in my chest, nausea, and dizziness. I ended up having to go to the hospital.
Patient Q&A Section about loryna
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What kind of birth control is Loryna?
"Loryna is a pill that contains female hormones which stop ovulation from happening. Loryna also affects the cervical mucus and the lining of the uterus, making it harder for sperm to reach the egg and for a fertilized egg to attach to the uterus."
Answered by AI
Is Loryna same as Yaz?
"As far as usage is concerned, both drugs may be used as birth control pills, but Yaz also has the added benefit of helping to relieve symptoms of PMDD.
The main difference between Yaz and Loryna is the price, with Yaz being more expensive. Yaz also has the added benefit of helping with symptoms of PMDD."
Answered by AI
Does Loryna make u gain weight?
"In fact, some women may even experience temporary weight loss when first taking Loryna.
Is there a chance that Loryna will cause weight gain?
Few women experience weight gain when taking Loryna. The medicine has a diuretic effect, which helps the body get rid of water. Some women may even have temporary weight loss when they start taking Loryna."
Answered by AI
What are side effects of Loryna?
"If you experience any of the following side effects, you should speak with your doctor as they may be a sign of a more serious problem:
You may experience some common side effects when taking this medication, such as nausea, vomiting, headache, bloating, breast tenderness, or fluid retention. Some women also experience spotting between periods or missed/irregular periods, especially during the first few months of use. If you experience any of these side effects, you should speak with your doctor as they may be a sign of a more serious problem."
Answered by AI