What is Lisinopril And Hydrochlorothiazide
LisinoprilThe Generic name of this drug
Treatment SummaryLisinopril is a medication used to treat high blood pressure, heart failure, and heart attack. It belongs to a type of drugs called ACE inhibitors, which work by blocking the enzyme angiotensin converting enzyme and affecting the renin-angiotensin-aldosterone system. ACE inhibitors are often used as the first line of treatment for people with high blood pressure, along with thiazide diuretics or beta blockers. Lisinopril was approved by the FDA in 1987.
Prinivilis the brand name
Lisinopril And Hydrochlorothiazide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prinivil
Lisinopril
1987
1216
Approved as Treatment by the FDA
Lisinopril, commonly known as Prinivil, is approved by the FDA for 3 uses which include Congestive Heart Failure and Hypertensive disease .Congestive Heart Failure
Used in combination with other therapies
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Heart Attack
Helps manage Acute Myocardial Infarction (AMI)
Effectiveness
How Lisinopril And Hydrochlorothiazide Affects PatientsLisinopril is a medication used to treat high blood pressure, heart failure, and heart attack. It works by blocking the enzyme and hormone system that controls blood pressure. It has been found to be a safe drug with lasting effects when taken at the proper dose (10-80mg) daily.
How Lisinopril And Hydrochlorothiazide works in the bodyLisinopril works by blocking the conversion of angiotensin I to angiotensin II. Normally, angiotensin II would cause narrowing of the coronary blood vessels and an increase in muscle size and cell growth. Lisinopril stops this from happening, and also increases levels of bradykinin, which helps relax the blood vessels for improved blood flow.
When to interrupt dosage
The ration of Lisinopril And Hydrochlorothiazide relies upon the determined condition, including Migraine, Congestive Heart Failure and prophylaxis of cardiovascular event. The measure of dosage fluctuates as per the approach of delivery (e.g. Tablet - Oral or Tablet) specified in the table beneath.Condition
Dosage
Administration
Migraine
10.0 mg, , 40.0 mg, 2.5 mg, 1.0 mg/mL, 20.0 mg, 30.0 mg, 5.0 mg, 0.1 mg
Tablet - Oral, Tablet, Kit, , Solution - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Solution
Congestive Heart Failure
10.0 mg, , 40.0 mg, 2.5 mg, 1.0 mg/mL, 20.0 mg, 30.0 mg, 5.0 mg, 0.1 mg
Tablet - Oral, Tablet, Kit, , Solution - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Solution
prophylaxis of cardiovascular event
10.0 mg, , 40.0 mg, 2.5 mg, 1.0 mg/mL, 20.0 mg, 30.0 mg, 5.0 mg, 0.1 mg
Tablet - Oral, Tablet, Kit, , Solution - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Solution
Hypertensive disease
10.0 mg, , 40.0 mg, 2.5 mg, 1.0 mg/mL, 20.0 mg, 30.0 mg, 5.0 mg, 0.1 mg
Tablet - Oral, Tablet, Kit, , Solution - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Solution
Diabetic Nephropathy
10.0 mg, , 40.0 mg, 2.5 mg, 1.0 mg/mL, 20.0 mg, 30.0 mg, 5.0 mg, 0.1 mg
Tablet - Oral, Tablet, Kit, , Solution - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Solution
Cardiovascular Events
10.0 mg, , 40.0 mg, 2.5 mg, 1.0 mg/mL, 20.0 mg, 30.0 mg, 5.0 mg, 0.1 mg
Tablet - Oral, Tablet, Kit, , Solution - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Solution
prophylaxis of migraine headaches
10.0 mg, , 40.0 mg, 2.5 mg, 1.0 mg/mL, 20.0 mg, 30.0 mg, 5.0 mg, 0.1 mg
Tablet - Oral, Tablet, Kit, , Solution - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Solution
Heart Attack
10.0 mg, , 40.0 mg, 2.5 mg, 1.0 mg/mL, 20.0 mg, 30.0 mg, 5.0 mg, 0.1 mg
Tablet - Oral, Tablet, Kit, , Solution - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Solution
Diabetes
10.0 mg, , 40.0 mg, 2.5 mg, 1.0 mg/mL, 20.0 mg, 30.0 mg, 5.0 mg, 0.1 mg
Tablet - Oral, Tablet, Kit, , Solution - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Solution
Warnings
Lisinopril And Hydrochlorothiazide has five contraindications, thus it should not be used when experiencing any of the conditions in the following table.Lisinopril And Hydrochlorothiazide ContraindicationsCondition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
Toxoplasma Infections
Do Not Combine
Angioedema
Do Not Combine
Angioedemas, Hereditary
Do Not Combine
Toxoplasma Infections
Do Not Combine
Common Lisinopril And Hydrochlorothiazide Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Lisinopril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Lisinopril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Lisinopril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Lisinopril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Lisinopril.
Lisinopril And Hydrochlorothiazide Toxicity & Overdose RiskThe lowest toxic dose of lisinopril in rats has been found to be greater than 8500mg/kg in rats and greater than 9100mg/kg in mice. Those who overdose on lisinopril may experience low blood pressure, which can be reversed by administering saline intravenously. Since lisinopril does not bind to protein, dialysis can be used to remove the drug from the bloodstream.
Lisinopril And Hydrochlorothiazide Novel Uses: Which Conditions Have a Clinical Trial Featuring Lisinopril And Hydrochlorothiazide?
647 ongoing investigations are assessing the potential of Lisinopril And Hydrochlorothiazide to ameliorate Type 2 Diabetes, Diabetic Nephropathy and Hypertensive Disease.Condition
Clinical Trials
Trial Phases
Migraine
61 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Phase 3
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4
Diabetes
553 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4, Early Phase 1
prophylaxis of migraine headaches
0 Actively Recruiting
Cardiovascular Events
4 Actively Recruiting
Not Applicable
Heart Attack
7 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Congestive Heart Failure
22 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
prophylaxis of cardiovascular event
0 Actively Recruiting
Lisinopril And Hydrochlorothiazide Reviews: What are patients saying about Lisinopril And Hydrochlorothiazide?
5Patient Review
5/12/2019 I've been using this to treat my high blood pressure for 3 months now, and I haven't had any negative side effects. Additionally, it has lowered my blood pressure significantly.
5Patient Review
11/19/2017 This treatment really helped me with my dry cough and headaches. I was dehydrated, and once I started drinking more water, the symptoms went away.
4.3Patient Review
4/10/2019 One week after starting this medication, my blood pressure has lowered from 191/132 to 132/75. I have found that it is effective at lowering blood pressure; however, I experience a dry cough at night and extreme fatigue during the day. If this fatigue continues, I will talk to my doctor about lowering the dose.
4Patient Review
10/18/2017 I've been taking this medication for a little over two weeks now, and my blood pressure has never been lower. This is by far the best treatment I've tried in years.
3.3Patient Review
10/16/2020 I developed a persistent cough not long after starting to take Lisinopril.
3Patient Review
9/19/2017 Lisinopril was not working well for me. I had been coughing for five months straight with no other allergies or illness, and it caused weight gain and low energy levels. My doctor took me off the medication today and put me on losartan.
3Patient Review
4/16/2018 I had some serious swelling after taking just a single pill. It lasted for a couple of days and was really uncomfortable.
3Patient Review
10/13/2017 I've been on this medication for almost a decade now, and I can't say that the pros outweigh the cons. For example, I can't go out in the sun without breaking out in itchy water blisters; and if those pop, they leave scars. Additionally, I haven't had a good night's sleep in years and experience hair loss and blurry vision. All things considered, I think it's time to ask my doctor for something else.
2.7Patient Review
2/8/2019 I had used Lisinopril for years without any issues, but then it just stopped working. I was given Lisinopril HCTZ and experienced some problems. Eventually, I got dizzy spells every day and just didn't feel good. So, I stopped taking the Lisinopril and switched to another medication. Thankfully, things are getting better now.
2.3Patient Review
4/18/2018 I developed a debilitating dry cough that's plagued me for over a month now. It's so bad it interrupts my sleep, and I often wake up feeling exhausted. Additionally, I've had persistent headaches and some dizziness.
2.3Patient Review
4/25/2018 I had awful stomach pain and diarrhea on the first day, which only got worse the second day. My blood pressure also dropped to a very dangerous level, and I was constantly cold. This medication is not worth it.
2.3Patient Review
10/4/2021 After doing some research, I found that Lisinopril HCTZ may not work for everyone. Be sure to do your own homework and speak with your doctor about the best options for you.
1.7Patient Review
1/27/2019 I had terrible insomnia when I took this medication at night. And during the day, I was constantly tired. Definitely going to switch to something else. Though I will say that it did lower my blood pressure as advertised.
1.7Patient Review
12/10/2019 I was seeing moderate results from amlodipine, so my doctor added hydrochlorothiazide-lisinopril. Within a week, I developed a dry cough and severe pain in both my elbows that made it difficult to extend them fully. My BP wasn't reduced. After one month, the doctor took me off hydrochlorothiazide-lisinopril and the elbow pain went away. He put me on lisinopril 20mg and amlodipine 10mg. It's too early to tell if there are any side effects yet.
1.3Patient Review
7/5/2018 I had some really unpleasant side effects while taking this medication, including headaches, sleeplessness, and a fast heart rate. I told my doctor and she told me to stop taking it. Ever since then, I've been having problems with my heart.
1Patient Review
7/15/2017 Don't bother with this drug; it ruined my life. I was on it for 1.5 years and had to deal with ringing in my ears and numbness in my feet. Once I stopped taking it, though, I felt so much better!
1Patient Review
10/20/2018 My face was covered in blisters after using this treatment
Patient Q&A Section about lisinopril and hydrochlorothiazide
When is the best time to take lisinopril hydrochlorothiazide?
"This medicine is typically taken once a day in the morning, with or without food. If it makes you urinate more often, it's best to take it at least 4 hours before bedtime, so you don't have to get up to go during the night." - Anonymous Online Contributor
Unverified Answer
Can hydrochlorothiazide be used with lisinopril?
"Lisinopril and hydrochlorothiazide is a combination drug that is used to treat high blood pressure. This drug combination works by reducing the workload on the heart and arteries. If this drug is taken for a long period of time, it can improve the function of the heart and arteries." - Anonymous Online Contributor
Unverified Answer
Why are lisinopril and hydrochlorothiazide taken together?
"The combination of lisinopril and hydrochlorothiazide is used to treat high blood pressure. Lisinopril belongs to a class of medications called angiotensin-converting enzyme (ACE) inhibitors. This drug works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly." - Anonymous Online Contributor
Unverified Answer
Does lisinopril with hydrochlorothiazide affect your kidneys?
"Taking certain pain drugs while also taking lisinopril/hydrochlorothiazide may decrease your kidney function, which can cause swelling in your legs or problems urinating." - Anonymous Online Contributor
Unverified Answer