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What is Lisinopril And Hydrochlorothiazide
HydrochlorothiazideThe Generic name of this drug
Treatment SummaryLisinopril is a medication used to treat high blood pressure, heart failure, and heart attack. It belongs to a type of drugs called ACE inhibitors, which work by blocking the enzyme angiotensin converting enzyme and affecting the renin-angiotensin-aldosterone system. ACE inhibitors are often used as the first line of treatment for people with high blood pressure, along with thiazide diuretics or beta blockers. Lisinopril was approved by the FDA in 1987.
Esidrixis the brand name
Lisinopril And Hydrochlorothiazide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esidrix
Hydrochlorothiazide
1959
2181
Approved as Treatment by the FDA
Hydrochlorothiazide, also called Esidrix, is approved by the FDA for 22 uses including Stroke and calcium channel blockers .Stroke
Used to treat Cerebrovascular Accident in combination with Losartan
calcium channel blockers
Used to treat calcium channel blockers in combination with Eprosartan
inadequate response to other therapeutic measures
Used to treat inadequate response to other therapeutic measures in combination with Spironolactone
inadequate control of blood pressure with monotherapy
Used to treat inadequate control of blood pressure with monotherapy in combination with Aliskiren
Antepartum magnesium sulfate prophylaxis
Helps manage prophylaxis of preeclampsia
Congestive Heart Failure
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Antihypertensive Treatment
Used to treat Antihypertensive Treatment in combination with Eprosartan
hypokalemia with solo treatment
Used to treat hypokalemia with solo treatment in combination with Triamterene
Bedrest
Used to treat Bedrest in combination with Spironolactone
Cirrhosis
Used to treat Cirrhosis of the Liver in combination with Spironolactone
Diuretics
Used to treat Hypokalemia caused by diuretics in combination with Amiloride
restriction of fluid and sodium
Used to treat restriction of fluid and sodium in combination with Spironolactone
Edema
Helps manage Premenstrual tension with edema
Hypertensive disease
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
blood pressure inadequately controlled with monotherapy
Used to treat blood pressure inadequately controlled with monotherapy in combination with Irbesartan
Sodium retention
Used to treat Sodium retention in combination with Spironolactone
Swollen feet or ankles
Used to treat Edema in combination with Triamterene
Ascites
Used to treat Ascites in combination with Spironolactone
Nephrotic Syndrome
Used to treat Nephrotic Syndrome in combination with Spironolactone
Therapeutic procedure
Used to treat inadequate response to treatment in combination with Spironolactone
Left Ventricular Hypertrophy
Used to treat Left Ventricular Hypertrophy in combination with Losartan
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Losartan
Effectiveness
How Lisinopril And Hydrochlorothiazide Affects PatientsLisinopril is a medication used to treat high blood pressure, heart failure, and heart attack. It works by blocking the enzyme and hormone system that controls blood pressure. It has been found to be a safe drug with lasting effects when taken at the proper dose (10-80mg) daily.
How Lisinopril And Hydrochlorothiazide works in the bodyLisinopril works by blocking the conversion of angiotensin I to angiotensin II. Normally, angiotensin II would cause narrowing of the coronary blood vessels and an increase in muscle size and cell growth. Lisinopril stops this from happening, and also increases levels of bradykinin, which helps relax the blood vessels for improved blood flow.
When to interrupt dosage
The ration of Lisinopril And Hydrochlorothiazide relies upon the determined condition, including Migraine, Congestive Heart Failure and prophylaxis of cardiovascular event. The measure of dosage fluctuates as per the approach of delivery (e.g. Tablet - Oral or Tablet) specified in the table beneath.Condition
Dosage
Administration
inadequate control of blood pressure with monotherapy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrotic Syndrome
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
prophylaxis of calcium nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antepartum magnesium sulfate prophylaxis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
calcium channel blockers
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diabetes Insipidus
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Congestive Heart Failure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
inadequate response to other therapeutic measures
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Bedrest
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Cirrhosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Renal tubular acidosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
restriction of fluid and sodium
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Therapeutic procedure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diuretics
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
blood pressure inadequately controlled with monotherapy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antihypertensive Treatment
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Edema
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Left Ventricular Hypertrophy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Ascites
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Lisinopril And Hydrochlorothiazide has five contraindications, thus it should not be used when experiencing any of the conditions in the following table.Lisinopril And Hydrochlorothiazide ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Common Lisinopril And Hydrochlorothiazide Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Fenofibrate
Major
The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxyzine.
Lisinopril And Hydrochlorothiazide Toxicity & Overdose RiskThe lowest toxic dose of lisinopril in rats has been found to be greater than 8500mg/kg in rats and greater than 9100mg/kg in mice. Those who overdose on lisinopril may experience low blood pressure, which can be reversed by administering saline intravenously. Since lisinopril does not bind to protein, dialysis can be used to remove the drug from the bloodstream.
Lisinopril And Hydrochlorothiazide Novel Uses: Which Conditions Have a Clinical Trial Featuring Lisinopril And Hydrochlorothiazide?
647 ongoing investigations are assessing the potential of Lisinopril And Hydrochlorothiazide to ameliorate Type 2 Diabetes, Diabetic Nephropathy and Hypertensive Disease.Condition
Clinical Trials
Trial Phases
Antihypertensive Treatment
0 Actively Recruiting
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Renal tubular acidosis
0 Actively Recruiting
Antepartum magnesium sulfate prophylaxis
18 Actively Recruiting
Phase 1, Not Applicable, Phase 3, Early Phase 1, Phase 2, Phase 4
Congestive Heart Failure
23 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Cirrhosis
50 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
inadequate control of blood pressure with monotherapy
0 Actively Recruiting
Ascites
10 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
Diabetes Insipidus
1 Actively Recruiting
Phase 1
Stroke
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
calcium channel blockers
0 Actively Recruiting
Nephrolithiasis
0 Actively Recruiting
hypokalemia with solo treatment
0 Actively Recruiting
blood pressure inadequately controlled with monotherapy
0 Actively Recruiting
inadequate response to other therapeutic measures
0 Actively Recruiting
Diuretics
0 Actively Recruiting
Bedrest
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Sodium retention
0 Actively Recruiting
Lisinopril And Hydrochlorothiazide Reviews: What are patients saying about Lisinopril And Hydrochlorothiazide?
5Patient Review
5/12/2019 I've been using this to treat my high blood pressure for 3 months now, and I haven't had any negative side effects. Additionally, it has lowered my blood pressure significantly.
5Patient Review
11/19/2017 This treatment really helped me with my dry cough and headaches. I was dehydrated, and once I started drinking more water, the symptoms went away.
4.3Patient Review
4/10/2019 One week after starting this medication, my blood pressure has lowered from 191/132 to 132/75. I have found that it is effective at lowering blood pressure; however, I experience a dry cough at night and extreme fatigue during the day. If this fatigue continues, I will talk to my doctor about lowering the dose.
4Patient Review
10/18/2017 I've been taking this medication for a little over two weeks now, and my blood pressure has never been lower. This is by far the best treatment I've tried in years.
3.3Patient Review
10/16/2020 I developed a persistent cough not long after starting to take Lisinopril.
3Patient Review
9/19/2017 Lisinopril was not working well for me. I had been coughing for five months straight with no other allergies or illness, and it caused weight gain and low energy levels. My doctor took me off the medication today and put me on losartan.
3Patient Review
4/16/2018 I had some serious swelling after taking just a single pill. It lasted for a couple of days and was really uncomfortable.
3Patient Review
10/13/2017 I've been on this medication for almost a decade now, and I can't say that the pros outweigh the cons. For example, I can't go out in the sun without breaking out in itchy water blisters; and if those pop, they leave scars. Additionally, I haven't had a good night's sleep in years and experience hair loss and blurry vision. All things considered, I think it's time to ask my doctor for something else.
2.7Patient Review
2/8/2019 I had used Lisinopril for years without any issues, but then it just stopped working. I was given Lisinopril HCTZ and experienced some problems. Eventually, I got dizzy spells every day and just didn't feel good. So, I stopped taking the Lisinopril and switched to another medication. Thankfully, things are getting better now.
2.3Patient Review
4/18/2018 I developed a debilitating dry cough that's plagued me for over a month now. It's so bad it interrupts my sleep, and I often wake up feeling exhausted. Additionally, I've had persistent headaches and some dizziness.
2.3Patient Review
4/25/2018 I had awful stomach pain and diarrhea on the first day, which only got worse the second day. My blood pressure also dropped to a very dangerous level, and I was constantly cold. This medication is not worth it.
2.3Patient Review
10/4/2021 After doing some research, I found that Lisinopril HCTZ may not work for everyone. Be sure to do your own homework and speak with your doctor about the best options for you.
1.7Patient Review
1/27/2019 I had terrible insomnia when I took this medication at night. And during the day, I was constantly tired. Definitely going to switch to something else. Though I will say that it did lower my blood pressure as advertised.
1.7Patient Review
12/10/2019 I was seeing moderate results from amlodipine, so my doctor added hydrochlorothiazide-lisinopril. Within a week, I developed a dry cough and severe pain in both my elbows that made it difficult to extend them fully. My BP wasn't reduced. After one month, the doctor took me off hydrochlorothiazide-lisinopril and the elbow pain went away. He put me on lisinopril 20mg and amlodipine 10mg. It's too early to tell if there are any side effects yet.
1.3Patient Review
7/5/2018 I had some really unpleasant side effects while taking this medication, including headaches, sleeplessness, and a fast heart rate. I told my doctor and she told me to stop taking it. Ever since then, I've been having problems with my heart.
1Patient Review
7/15/2017 Don't bother with this drug; it ruined my life. I was on it for 1.5 years and had to deal with ringing in my ears and numbness in my feet. Once I stopped taking it, though, I felt so much better!
1Patient Review
10/20/2018 My face was covered in blisters after using this treatment
Patient Q&A Section about lisinopril and hydrochlorothiazide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.When is the best time to take lisinopril hydrochlorothiazide?
"This medicine is typically taken once a day in the morning, with or without food. If it makes you urinate more often, it's best to take it at least 4 hours before bedtime, so you don't have to get up to go during the night."
Answered by AI
Can hydrochlorothiazide be used with lisinopril?
"Lisinopril and hydrochlorothiazide is a combination drug that is used to treat high blood pressure. This drug combination works by reducing the workload on the heart and arteries. If this drug is taken for a long period of time, it can improve the function of the heart and arteries."
Answered by AI
Why are lisinopril and hydrochlorothiazide taken together?
"The combination of lisinopril and hydrochlorothiazide is used to treat high blood pressure. Lisinopril belongs to a class of medications called angiotensin-converting enzyme (ACE) inhibitors. This drug works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly."
Answered by AI
Does lisinopril with hydrochlorothiazide affect your kidneys?
"Taking certain pain drugs while also taking lisinopril/hydrochlorothiazide may decrease your kidney function, which can cause swelling in your legs or problems urinating."
Answered by AI