Pentosan Polysulphate Sodium for Osteoarthritis, Knee

Genetic and neurological predisposition are the strongest risk factors for developing osteoarthritis. On average, women live one year less than men of the same age.

Osteoarthritis is a degenerative disease of articular cartilage and bone. It usually begins with moderate symptoms and includes stiffness, pain at the joints, and occasional locking or locking pain. Knee swelling is a key feature of osteoarthritis. Symptoms of osteoarthritis in many cases can be reduced or prevented through modification of risk factors and prevention of osteoarthritis. Some early osteoarthritis signs include early onset of osteoarthritis following an injury, persistent pain and swelling, and decreased range of motion. Late osteoarthritis signs include pain in the joints, which usually increases with activity.

OA of the knee is commonly treated with analgesics, NSAIDs, exercise and tibial nerve stimulation at the Mayo Clinic in Rochester and other clinics in the United States. Patients are encouraged to seek independent evaluation of their condition from their clinician. In addition, the disease may be treated effectively in those wishing to avoid medication as part of their treatment plan.

Osteoarthritis, knee is a knee disorder, affecting people of all ages. Symptoms commonly include stiffness, pain, weakness or loss of mobility. There are several causes and several diagnostic options. Treatment depends on the degree of symptoms people are suffering from.

Approximately 24% of all adults have knee osteoarthritis at some point during their lives. The rates of knee osteoarthritis vary by race, sex, and education level.

While the evidence is limited, it is generally supportive of the principle of evidence-based medicine, which suggests that no cure exists for [knee osteoarthritis](https://www.withpower.com/clinical-trials/knee-osteoarthritis) and a cure for osteoarthritis is unlikely to be found.

The most recent research findings for osteoarthritis are encouraging, and there is some evidence that there is some benefit for a subset of patients. It will take time before we can come to a consensus regarding the benefits and risks of these treatments. The most recent systematic review of complementary and alternative treatments concluded that there is only minimal evidence supporting their effectiveness. Other reviews will be published in the future.

Recent findings of this study suggest that PPS is safe and effective in reducing pain and improving function with less side effects. PPS has been licensed for this indication since October 2017.

The knee was the most prevalent site of OA and seemed to be the site of origin of disease. Recent findings support our hypothesis of the knee being the location of OA disease.

The efficacy of PPS may be enhanced when PPS solution is diluted 100-fold into the standard PVS. It was found that this dilution can be safely added and maintained in the circulation for at least 3 months.

The frequency of use of PPBS as a single treatment was less than 10%; however, the prescription of PPBS in the presence of other medical therapies, especially those that affect blood pressure, was not uncommon. This suggests that PPBS is typically used in combination with other treatments known to affect blood pressure. Although not as popular, PPBS may be more effective as a monotherapy. The use of PPBS should be reconsidered, based on these findings.