Levonorgestrel And Ethinyl Estradiol

Endometrial Hyperplasia, Endometriosis, Hot flashes + 6 more
Treatment
7 FDA approvals
20 Active Studies for Levonorgestrel And Ethinyl Estradiol

What is Levonorgestrel And Ethinyl Estradiol

LevonorgestrelThe Generic name of this drug
Treatment SummaryLevonorgestrel (LNG) is a hormone used in contraception and hormone therapy. It is commonly known as Plan B and is used as an emergency contraceptive pill and in IUDs like Jaydess, Kyleena and Mirena. Levonorgestrel can also be implanted under the skin to slowly release the hormone over time. It is the most widely used emergency contraceptive and was approved by the FDA in 1982. It works more effectively and has fewer side effects than older emergency contraceptives due to its lack of estrogen.
Triphasil-21is the brand name
image of different drug pills on a surface
Levonorgestrel And Ethinyl Estradiol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Triphasil-21
Levonorgestrel
1984
243

Approved as Treatment by the FDA

Levonorgestrel, also known as Triphasil-21, is approved by the FDA for 7 uses including Osteoporosis, Postmenopausal and Has had at least 1 child .
Osteoporosis, Postmenopausal
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
Has had at least 1 child
Postmenopausal Osteoporosis
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
Menopause
Used to treat severe Vasomotor Symptoms Associated With Menopause in combination with Estradiol
moderate Menopausal Vasomotor Symptoms
Used to treat moderate Menopausal Vasomotor Symptoms in combination with Estradiol
Emergency Contraception
Hot flashes
Used to treat Menopause in combination with Estradiol

Effectiveness

How Levonorgestrel And Ethinyl Estradiol Affects PatientsLevonorgestrel is a medication that can prevent pregnancy by preventing ovulation, fertilization, and implantation. It is most effective when taken within 72 hours after intercourse, giving it an 89% success rate. When used in combination with the intrauterine or implantable devices, it is more than 99% effective. Levonorgestrel can also be used as part of hormonal therapy to help prevent endometrial cancer caused by estrogen.
How Levonorgestrel And Ethinyl Estradiol works in the bodyLevonorgestrel works in a few ways to prevent pregnancy. It reduces the release of hormones from the hypothalamus that control ovulation, which stops eggs from being released from the ovaries. It also thickens cervical mucus, making it harder for sperm to enter the uterus and fertilize an egg. Levonorgestrel may also make it harder for eggs to attach to the uterus, making implantation less likely. When taken with estrogen, levonorgestrel helps reduce the risk of endometrial cancer.

When to interrupt dosage

The prescribed dosage of Levonorgestrel And Ethinyl Estradiol is contingent upon the ascertained condition, including Endometrial Hyperplasia, Emergency Contraception and Hypermenorrhea. The amount of dosage may differ as per the technique of delivery featured in the table below.
Condition
Dosage
Administration
Hot flashes
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Osteoporosis, Postmenopausal
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
moderate Menopausal Vasomotor Symptoms
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Endometrial Hyperplasia
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Endometriosis
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Emergency Contraception
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Menorrhagia
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Has had at least 1 child
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Menopause
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral

Warnings

Levonorgestrel And Ethinyl Estradiol has forty-three contraindications, thus it should not be taken in combination with any of the conditions listed in the table below.Levonorgestrel And Ethinyl Estradiol Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Levonorgestrel may interact with Pulse Frequency
Abortion, Septic
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Abortion, Spontaneous
Do Not Combine
HCG elevated
Do Not Combine
Pelvic Infection
Do Not Combine
Vaginitis
Do Not Combine
Acute Coryza
Do Not Combine
Breast Neoplasms
Do Not Combine
Uterine Cervicitis
Do Not Combine
Communicable Diseases
Do Not Combine
Gonorrhea
Do Not Combine
Breast Cancer
Do Not Combine
Intrauterine Devices
Do Not Combine
Liver Neoplasms
Do Not Combine
congenital or aquired uterine abnormality
Do Not Combine
Chlamydia Infections
Do Not Combine
Hypersensitivity
Do Not Combine
Emergency Contraception
Do Not Combine
Endocarditis, Bacterial
Do Not Combine
Vaginosis, Bacterial
Do Not Combine
suspected pregnancy
Do Not Combine
Uterine Cervicitis
Do Not Combine
Uterine Neoplasms
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
Breast Neoplasms
Do Not Combine
Uterine Cervical Neoplasms
Do Not Combine
Fibroid Tumor
Do Not Combine
Endometritis
Do Not Combine
chlamydial cervical infection
Do Not Combine
PAP Test Abnormalities
Do Not Combine
Liver Failure, Acute
Do Not Combine
Uterine anomaly distorting uterine cavity
Do Not Combine
Breast Cancer
Do Not Combine
Cervical Dysplasia
Do Not Combine
Thromboembolism
Do Not Combine
Bacterial Vaginosis
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
Breast
Do Not Combine
Vaginal Bleeding
Do Not Combine
Bacterial Vaginosis
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
Gonorrhea
Do Not Combine
There are 20 known major drug interactions with Levonorgestrel And Ethinyl Estradiol.
Common Levonorgestrel And Ethinyl Estradiol Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Levonorgestrel.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Levonorgestrel.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Levonorgestrel.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Levonorgestrel.
Crizotinib
Major
The metabolism of Crizotinib can be decreased when combined with Levonorgestrel.
Levonorgestrel And Ethinyl Estradiol Toxicity & Overdose RiskThe lowest toxic dose of levonorgestrel in rats has been found to be greater than 5000mg/kg. Symptoms of an overdose on this drug may include nausea and bleeding. If someone experiences an overdose, they should seek treatment for their symptoms and contact their local poison control center. There is no specific antidote for a levonorgestrel overdose.
image of a doctor in a lab doing drug, clinical research

Levonorgestrel And Ethinyl Estradiol Novel Uses: Which Conditions Have a Clinical Trial Featuring Levonorgestrel And Ethinyl Estradiol?

99 active clinical trials are currently assessing the potential of Levonorgestrel And Ethinyl Estradiol in providing relief from Postmenopausal Osteoporosis, Postpartum Status and Endometrial Hyperplasia.
Condition
Clinical Trials
Trial Phases
Hot flashes
17 Actively Recruiting
Phase 1, Phase 4, Not Applicable, Early Phase 1, Phase 2, Phase 3
Endometriosis
29 Actively Recruiting
Early Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4
Has had at least 1 child
0 Actively Recruiting
Menorrhagia
0 Actively Recruiting
Endometrial Hyperplasia
4 Actively Recruiting
Not Applicable, Phase 2, Phase 3
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Menopause
0 Actively Recruiting
Osteoporosis, Postmenopausal
0 Actively Recruiting
Emergency Contraception
1 Actively Recruiting
Phase 4

Levonorgestrel And Ethinyl Estradiol Reviews: What are patients saying about Levonorgestrel And Ethinyl Estradiol?

5Patient Review
2/18/2021
Levonorgestrel And Ethinyl Estradiol for Birth Control
I've been on this pill for 3/4 years, and it's been a revelation. I used to get the depo shot, which was fine for a while, but after my first child I started having really bad mood swings around my cycle. The pill has helped regulate that so that now I only have a light bleed every 13 weeks or so.
5Patient Review
7/9/2021
Levonorgestrel And Ethinyl Estradiol for Abnormally Long or Heavy Periods
I've been on a lot of different pills, and this is by far the best one. It's shortened my periods from 9 days to just 5-6, and I haven't had any negative mood changes or side effects like cystic acne.
5Patient Review
12/15/2021
Levonorgestrel And Ethinyl Estradiol for Painful Periods
This birth control completely stopped my monthly period cramps.
5Patient Review
5/31/2021
Levonorgestrel And Ethinyl Estradiol for Birth Control
This drug has been a life saver for me. It not only helped with my period, but it also got rid of the infection I had. And on top of that, it's also great for birth control.
4.7Patient Review
7/19/2022
Levonorgestrel And Ethinyl Estradiol for Abnormally Long or Heavy Periods
My doctor prescribed this to me for peri-menopause and I've been taking it without issue. It's been more effective than other birth control pills I've tried in the past, with no negative mood changes or breakthrough bleeding. The only downside is that it hasn't helped clear my hormonal acne, but the alternative pill my doctor suggested has terrible side effects.
View All Reviews

Patient Q&A Section about levonorgestrel and ethinyl estradiol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does it take for levonorgestrel and ethinyl estradiol tablets to work?

"You will need to use a second form of birth control for the first week you take this medication, as it takes your body that long to adjust to the medicine. Be sure to take the medication at the same time each day."

Answered by AI

Do you get your period on levonorgestrel and ethinyl estradiol?

"The expected result of taking levonorgestrel and ethinyl estradiol tablets and ethinyl estradiol tablets is to have four scheduled periods per year. Each period is likely to last about two to three days."

Answered by AI

What are the side effect to levonorgestrel and ethinyl estradiol?

"The following side effects may occur while taking this medication: nausea, vomiting, headache, abdominal cramps/bloating, breast tenderness, swelling of the ankles/feet (retaining fluid), or weight change. If you experience any of these side effects, speak to your doctor or pharmacist. It is common for women to not have regular periods while taking this medication."

Answered by AI

Does levonorgestrel cause weight gain?

"A few other possible side effects from using the levonorgestrel system have been weight gain, depression, acne, and some people have also anecdotally reported losing a lot of hair from using it."

Answered by AI

Clinical Trials for Levonorgestrel And Ethinyl Estradiol

Have you considered Levonorgestrel And Ethinyl Estradiol clinical trials? We made a collection of clinical trials featuring Levonorgestrel And Ethinyl Estradiol, we think they might fit your search criteria.
Have you considered Levonorgestrel And Ethinyl Estradiol clinical trials? We made a collection of clinical trials featuring Levonorgestrel And Ethinyl Estradiol, we think they might fit your search criteria.
Have you considered Levonorgestrel And Ethinyl Estradiol clinical trials? We made a collection of clinical trials featuring Levonorgestrel And Ethinyl Estradiol, we think they might fit your search criteria.
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