Levaquin

Plague, Yersinia pestis, inhaled anthrax caused by Bacillus anthracis + 21 more
Treatment
1 FDA approval
12 Active Studies for Levaquin

What is Levaquin

LevofloxacinThe Generic name of this drug
Treatment SummaryLevofloxacin is an antibiotic that is 8 to 128 times more effective against both gram-positive and gram-negative bacteria than the other isomer of racemic ofloxacin. It is part of the third generation of fluoroquinolones, commonly referred to as the “respiratory quinolones” due to its effectiveness against bacteria associated with respiratory infections. Levofloxacin was first approved by the FDA in 1996, and was quickly approved in many other countries after.
Levaquinis the brand name
image of different drug pills on a surface
Levaquin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Levaquin
Levofloxacin
1996
421

Approved as Treatment by the FDA

Levofloxacin, also known as Levaquin, is approved by the FDA for 1 uses like Pseudomonas Infections .
Pseudomonas Infections
Used to treat Nosocomial Pneumonia caused by Pseudomonas Infections in combination with Piperacillin

Effectiveness

How Levaquin Affects PatientsLevofloxacin is an antibiotic that works by stopping bacteria from reproducing. It usually only needs to be taken once or twice per day and can be effective against certain types of bacteria, like Chlamydia and Legionella. However, some bacteria can become resistant to levofloxacin due to changes in their DNA. Cross-resistance between levofloxacin and other antibiotics is unlikely because they work differently. Different areas have different bacteria, so it is important to check local antibiotic resistance patterns before taking levofloxacin.
How Levaquin works in the bodyLevofloxacin is an antibiotic that works by blocking two key enzymes in bacteria: DNA gyrase and topoisomerase IV. DNA gyrase helps with DNA replication and topoisomerase IV helps with cell division. Levofloxacin binds to the enzymes and stops them from working, which prevents DNA replication and cell division and ultimately kills the bacteria.

When to interrupt dosage

The advised quantity of Levaquin is contingent upon the diagnosed condition, including Pseudomonas Infections, Abscess and Therapeutic procedure. The dosage also relies on the approach of delivery, as outlined in the table below.
Condition
Dosage
Administration
Yersinia pestis
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Cystic Fibrosis
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Pseudomonas Infections
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Impetigo
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Wound Infection
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Community Acquired Pneumonia (CAP) caused by susceptible bacteria
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
furuncle
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Pyoderma
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Hospital acquired pneumonia
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Communicable Diseases
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Cellulitis
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Abscess
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Prostatitis
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Pseudomonas Infections
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Communicable Diseases
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Sinusitis
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Urinary tract infection
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Bacterial conjunctivitis
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Therapeutic procedure
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)
Plague
250.0 mg, 500.0 mg, 750.0 mg, , 5.0 mg/mL, 25.0 mg/mL, 15.0 mg/mL, 7.5 mg/mL, 50.0 mg/mL, 75.0 mg/mL, 240.0 mg, 240.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Intravenous, Injection, solution - Intravenous, Injection, solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Oral, Injection, Injection - Intravenous, Solution - Ophthalmic, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Topical, Solution / drops - Topical, Respiratory (inhalation), Solution - Respiratory (inhalation)

Warnings

Levaquin Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Levofloxacin may interact with Pulse Frequency
There are 20 known major drug interactions with Levaquin.
Common Levaquin Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Levofloxacin.
Amiodarone
Major
The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Amiodarone.
Amitriptyline
Major
Levofloxacin may increase the QTc-prolonging activities of Amitriptyline.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Arsenic trioxide.
Levaquin Toxicity & Overdose RiskLevofloxacin has a low risk of acute toxicity. In tests, high doses of levofloxacin caused symptoms such as unsteadiness, drooping eyelids, reduced movement, difficulty breathing, shaking, and seizures. If someone overdoses on levofloxacin, they should have their stomach emptied and receive general supportive care. It is also recommended to monitor the patient's heart rhythm to make sure it is within a normal range. Dialysis is not very effective in removing levofloxacin from the body in cases of overdose.
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Levaquin Novel Uses: Which Conditions Have a Clinical Trial Featuring Levaquin?

An active clinical trial is currently investigating the potential of Levaquin in the treatment of Urinary tract infection, Pyoderma and Yersinia pestis.
Condition
Clinical Trials
Trial Phases
Bronchitis
0 Actively Recruiting
Wound Infection
0 Actively Recruiting
inhaled anthrax caused by Bacillus anthracis
0 Actively Recruiting
Prostatitis
4 Actively Recruiting
Not Applicable, Phase 4
Cellulitis
0 Actively Recruiting
Pseudomonas Infections
0 Actively Recruiting
Pseudomonas Infections
0 Actively Recruiting
Communicable Diseases
0 Actively Recruiting
Urinary tract infection
0 Actively Recruiting
Hospital acquired pneumonia
0 Actively Recruiting
Sinusitis
0 Actively Recruiting
Yersinia pestis
0 Actively Recruiting
Plague
0 Actively Recruiting
Communicable Diseases
0 Actively Recruiting
Pyoderma
8 Actively Recruiting
Phase 2, Phase 4, Early Phase 1, Phase 3, Not Applicable
Impetigo
0 Actively Recruiting
furuncle
0 Actively Recruiting
Community Acquired Pneumonia (CAP) caused by susceptible bacteria
0 Actively Recruiting
Urinary tract infection
0 Actively Recruiting
Communicable Diseases
0 Actively Recruiting

Levaquin Reviews: What are patients saying about Levaquin?

3.3Patient Review
8/31/2018
Levaquin for Pneumonia caused by Bacteria
I was given this medication for pleurisy and it took care of the infection. However, I was left with incredibly painful joints- to the point where I could barely walk or take stairs. I've been tested for arthritis and other conditions, but none have come back positive. It's clear to me that this drug has done serious damage, and though I'm getting better, it's a long road ahead. Thank goodness my husband is able to help care for me- otherwise I would be in a nursing home at this point.
2.3Patient Review
3/25/2018
Levaquin for Pneumonia caused by Bacteria
I was prescribed Levofloxacin 750 mg tablets for 7 days for bacterial pneumonia. I started taking the drug on a Friday and it is now Sunday. I haven't slept since I started taking this drug. After reading the reviews on here, Azithromycin seems to be much more tolerated without all the side effects.
2Patient Review
1/9/2022
Levaquin for Bacterial Urinary Tract Infection
I took Levofloxacin for 10 days and developed severe tendonitis a few days in. This eventually went away, but I also started having digestive issues around the same time. This led to Gastroparesis, which is a condition where your stomach can't empty properly. I don't recommend this drug at all and think it should be banned in the United States. If your doctor prescribes it, get a different antibiotic!
1Patient Review
1/18/2019
Levaquin for Bacterial Infection with Bronchitis
I took one dose of this drug and was awake for 72 hours. Itchy, tingly skin, constipated, and knee pain. I hope my message is heard clearly: do not prescribe this medication.
1Patient Review
5/11/2020
Levaquin for Bacterial Infection of Kidney due to E. Coli Organism
I was prescribed 5 doses of 250 mg. Only took 2 doses and i have had massive headaches all over my head, unbearable sinus pressure and tendon pain. I havent taken in 5 days and headaches are not going away.
View All Reviews
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Patient Q&A Section about levaquin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why was Levaquin taken off the market?

"Kelsey Buckholtz, a spokeswoman for Janssen, said that they decided to discontinue Levaquin because there are a lot of other treatment options available and they want to focus on developing new medicines."

Answered by AI

What are side effects of Levaquin?

"You may experience some or all of the following side effects: nausea, vomiting, diarrhea, headache, constipation, difficulty sleeping (insomnia), dizziness, abdominal pain."

Answered by AI

What is Levaquin used to treat?

"It will not work for viral infections (such as common cold, flu).

Levofloxacin is used to treat a variety of bacterial infections. This medication belongs to a class of drugs known as quinolone antibiotics. These drugs work by interfering with the production of essential proteins needed by bacteria to survive. This particular antibiotic is effective against a wide variety of bacteria. However, it is important to remember that this drug will not work against viral infections."

Answered by AI

Is Levaquin and amoxicillin the same?

"Both Levaquin and amoxicillin are antibiotics used to treat infections. Levaquin is a fluoroquinolone and amoxicillin is a penicillin. They are both used to treat infections of the lungs, airways, skin, urinary tract, and ears. The main difference between the two drugs is the conditions they are used to treat."

Answered by AI

Clinical Trials for Levaquin

Have you considered Levaquin clinical trials? We made a collection of clinical trials featuring Levaquin, we think they might fit your search criteria.
Have you considered Levaquin clinical trials? We made a collection of clinical trials featuring Levaquin, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
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