Ketamine Hydrochloride

General Anesthesia, Induction and Maintenance of General Anesthesia
Treatment
2 FDA approvals
3 Active Studies for Ketamine Hydrochloride

What is Ketamine Hydrochloride

KetamineThe Generic name of this drug
Treatment SummaryKetamine is a medication used as an anesthetic for minor surgeries, particularly those performed on children. It was developed in 1963 as an alternative to phencyclidine (PCP). Ketamine has been proven to produce fewer hallucinogenic and psychotomimetic effects than PCP, and was approved by the FDA in 1970. It is largely used in veterinary medicine, but is also used for human anesthetic purposes.
Ketalaris the brand name
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Ketamine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ketalar
Ketamine
1970
39

Approved as Treatment by the FDA

Ketamine, also called Ketalar, is approved by the FDA for 2 uses including Induction and Maintenance of General Anesthesia and General Anesthesia .
Induction and Maintenance of General Anesthesia
General Anesthesia

Effectiveness

How Ketamine Hydrochloride Affects PatientsKetamine is a fast-acting anesthetic that is used to produce a state of deep pain relief, normal muscle tone, and stimulation of the cardiovascular and respiratory systems. It is sometimes referred to as “dissociative anesthesia” because it appears to interrupt the pathways of the brain that are involved in sensation, while still keeping the more primitive parts of the brain active. Ketamine can also act as an antidepressive by stimulating serotonin pathways, and it can reduce pain by preventing central sensitization in the spinal cord and by inhibiting nitric oxide production. However, it can cause some changes to the cardiovascular system and
How Ketamine Hydrochloride works in the bodyKetamine interacts with a variety of receptors in the body, including those for opioids, certain neurotransmitters, and calcium ions. It does not affect the GABA receptors like other anesthetics do.

When to interrupt dosage

The measure of Ketamine Hydrochloride is contingent upon the identified disorder. The dosage likewise shifts regarding the method of delivery featured in the table beneath.
Condition
Dosage
Administration
General Anesthesia
, 50.0 mg/mL, 100.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 25.0 mg
Injection, solution, concentrate, , Intramuscular; Intravenous, Injection, solution, concentrate - Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Topical, Cream, Cream - Topical, Troche - Sublingual, Sublingual, Troche
Induction and Maintenance of General Anesthesia
, 50.0 mg/mL, 100.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 25.0 mg
Injection, solution, concentrate, , Intramuscular; Intravenous, Injection, solution, concentrate - Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Topical, Cream, Cream - Topical, Troche - Sublingual, Sublingual, Troche

Warnings

Ketamine Hydrochloride Contraindications
Condition
Risk Level
Notes
Vascular Diseases
Do Not Combine
Hypertensive disease
Do Not Combine
Stroke
Do Not Combine
Arteriovenous Malformations
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ketamine may interact with Pulse Frequency
There are 20 known major drug interactions with Ketamine Hydrochloride.
Common Ketamine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Ketamine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Ketamine.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Ketamine.
Capmatinib
Major
The serum concentration of Capmatinib can be decreased when it is combined with Ketamine.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Ketamine.
Ketamine Hydrochloride Toxicity & Overdose RiskTaking ketamine for more than 3 hours may cause cognitive problems due to the drug blocking NMDA receptors and causing cell death in the brain. There have been no studies to examine its effects on cancer or fertility, but it has been found to be a cause of genetic abnormalities and to not have an effect on fertility.
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Ketamine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Ketamine Hydrochloride?

Four investigations are underway to assess the potential of Ketamine Hydrochloride in providing Induction and Maintenance of General Anesthesia.
Condition
Clinical Trials
Trial Phases
General Anesthesia
3 Actively Recruiting
Not Applicable, Phase 3
Induction and Maintenance of General Anesthesia
0 Actively Recruiting

Ketamine Hydrochloride Reviews: What are patients saying about Ketamine Hydrochloride?

5Patient Review
8/26/2012
Ketamine Hydrochloride for Additional Local Anesthesia
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Patient Q&A Section about ketamine hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Ketamine Hydrochloride