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What is Kariva
EthinylestradiolThe Generic name of this drug
Treatment SummaryDesogestrel is a type of steroid hormone used in combination with estrogen to prevent pregnancy. It was first developed in 1972 by Organon USA Inc and approved by the FDA in 1992. Desogestrel is derived from naturally occurring plant steroids and works by inhibiting ovulation and thickening cervical mucus to prevent sperm from entering the uterus.
LOESTRIN Fe 1.5/30is the brand name
Kariva Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
LOESTRIN Fe 1.5/30
Ethinylestradiol
1973
679
Approved as Treatment by the FDA
Ethinylestradiol, also known as LOESTRIN Fe 1.5/30, is approved by the FDA for 1 uses including Birth Control .Birth Control
Used to treat Contraception in combination with Levonorgestrel
Effectiveness
How Kariva Affects PatientsDesogestrel works by preventing ovulation in 97% of cycles and has a Pearl failure rate of 0.17 per 100 women-years. It can also change the endometrium and affect other hormones. However, taking desogestrel can increase the risk of venous thromboembolism due to increased blood coagulation factors. Luckily, it does not significantly raise the level of total cholesterol, usually staying within 10%.
How Kariva works in the bodyDesogestrel prevents pregnancy by entering the cell and binding to the progesterone receptor. This binding triggers a chain of events that stops an egg from being released. Its active metabolite, etonogestrel, has a high progestational activity with minimal androgenicity.
When to interrupt dosage
The accepted dosage of Kariva is contingent upon the diagnosed condition, for example Birth Control, Nursing Women and Hormonal Contraception. The amount of dosage also depends on the mode of delivery (e.g. Kit or Kit; Tablet - Oral) outlined in the table beneath.Condition
Dosage
Administration
Birth Control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Mild to Moderate Acne
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Menopausal Osteoporosis
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Patient desires oral contraception for birth control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Acne Vulgaris
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Folate supplementation therapy
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Hormonal Contraception
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Menopause
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Warnings
Kariva has twenty-five contraindications, hence it should not be combined with the conditions in the following table.Kariva ContraindicationsCondition
Risk Level
Notes
Heavy Smoking
Do Not Combine
Metrorrhagia
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Thrombophlebitis
Do Not Combine
high risk of venous thrombotic disease
Do Not Combine
history of deep venous thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
Breast
Do Not Combine
Coronary Artery Disease
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Thromboembolism
Do Not Combine
Coronary Artery Disease (CAD)
Do Not Combine
Hypersensitivity
Do Not Combine
Pulse Frequency
Do Not Combine
Adrenal Insufficiency
Do Not Combine
major surgery with prolonged immobilization
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypertension
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Breast Cancer
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Decompensated Cirrhosis
Do Not Combine
Breast
Do Not Combine
Impaired Renal Function
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ethinylestradiol may interact with Pulse Frequency
Common Kariva Drug Interactions
Drug Name
Risk Level
Description
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Ethinylestradiol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Ethinylestradiol.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Ethinylestradiol.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Ethinylestradiol.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Ethinylestradiol.
Kariva Toxicity & Overdose RiskLarge amounts of desogestrel have been known to have strong hormonal effects, but cause no long-term harm. The reported toxic dose in rats is higher than 2000mg/kg. An overdose of desogestrel may cause nausea and withdrawal bleeding, but there are no serious side effects. Reports have not linked desogestrel to an increased risk of breast cancer, but there may be an increased risk of cervical intra-epithelial neoplasia. However, these results are not conclusive.
Kariva Novel Uses: Which Conditions Have a Clinical Trial Featuring Kariva?
38 active clinical trials are being conducted to assess the potential of Kariva to aid Nursing Women, facilitate Birth Control and support Hormonal Contraception.Condition
Clinical Trials
Trial Phases
Birth Control
31 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Patient desires oral contraception for birth control
0 Actively Recruiting
Folate supplementation therapy
0 Actively Recruiting
Hormonal Contraception
0 Actively Recruiting
Mild to Moderate Acne
0 Actively Recruiting
Menopausal Osteoporosis
0 Actively Recruiting
Menopause
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Kariva Reviews: What are patients saying about Kariva?
5Patient Review
6/28/2016 I was really pleased with how this pill worked. My skin cleared up almost entirely, and I experienced no side effects whatsoever.
5Patient Review
1/10/2018 I've used this for 20 years with no problems, and then got pregnant the month after I stopped.
5Patient Review
2/19/2021 I've been on Kariva for 8 months and love it. I am also on Accutane and needed to get on BC, but I haven't experienced any bad side effects. I take the pill at the same time everyday and it works great. My period comes at the same time every month and only lasts around 4 days. I think it also helped with lightening my flow. I plan to stay on the drug even after I am off of Accutane.
4.7Patient Review
3/26/2015 I've been taking Kariva for a little over a year now. I experienced some bloating early on, but it quickly subsided. Additionally, I have not noticed any negative changes in my mood or sex drive. However, there is one spider vein that has become more prominent recently. This concerns me as it may be indicative of deeper issues.
4.7Patient Review
5/4/2015 This has been a really great medication for me with few negative side effects. I also appreciate that it is still effective even when I am not able to take it at the exact same time each day.
4.3Patient Review
2/24/2016 I was on Kariva for nine years and it was totally effective for me. I didn't always take it at the same time every day, but when I started dating someone who noticed, I began to be more consistent with taking it.
3.7Patient Review
9/10/2019 The first three months were okay, but after that I started getting migraines, horrible sleep, and tons of breast cysts. The cysts got so bad that I'm now constantly running between doctors trying to figure out if any of them are cancerous lumps. This medicine has ruined my summer and my life in general. CVS switched me to this after I was on Azurette without issues for 2 years. I've completely stopped taking it and I'm already seeing improvement.
3.7Patient Review
3/23/2019 I tried this pill in order to help with my irregular periods and acne, but it unfortunately just made my skin worse. On top of that, it gave me anxiety and paranoia which then bled into other aspects of my life. I'll be discontinuing use of this birth control as soon as possible.
3.7Patient Review
3/31/2015 I was switched to Kariva by my doctor because of the increased risk of blood clots with Beyaz (which I never had and don't smoke). I took it for 3 months and experienced decreased libido, BAD acne, headaches and constant hunger - causing me to gain more weight. I am changing to another pill; this one just doesn't work well for me. With Beyaz, I only experienced mood swings...I wish they would've just left me on that!!
3.7Patient Review
8/3/2022 I started having negative experiences with this medication after about three months. I was always hungry, tired, and sleeping so much that I would sometimes miss my pill the next morning. My libido decreased to the point where I didn't even want my boyfriend of 1 1/2 years to kiss me. I gained 5-10lbs. I'm definitely going to look into getting this switched.
3Patient Review
6/11/2015 My grand daughter used this for about one year and developed five deep vein thrombosis in her leg and pulmonary embolism. It was life threatening. The doctors ruled out any other cause.
2.7Patient Review
3/15/2022 There are some definite pros to this treatment - my skin looked amazing after using it for a few months. However, there were also some significant cons that led me to stop taking the medication. These included weight gain, loss of sex drive, vaginal dryness, constant fatigue, anxiety, and nonstop spotting. I stopped taking Kariva a few days ago and have already noticed an improvement in my energy level and weight.
2Patient Review
9/28/2021 I had awful side effects while taking this birth control. I would get depressed, have hot flashes, and put on weight. Even though it was effective in preventing pregnancy, I would never take it again because of how terrible I felt.
Patient Q&A Section about kariva
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Kariva a good birth control?
"It seemed to work well for a few months, but I gained about 10 pounds. The side effects weren’t really worth it, so I switched to another pill.”
While some reviewers found Kariva to be an effective treatment for Birth control, others found the side effects not worth the trouble, reporting weight gain and negative experiences."
Answered by AI
What is the generic name for Kariva?
"Kariva is a birth control pill that contains two female hormones, a progestin and an estrogen. It is a generic version of the brand-name birth control pill, Mircette."
Answered by AI
What is Kariva used for?
"This medication is a combination of two hormones, desogestrel and ethinyl estradiol, which are used to prevent pregnancy."
Answered by AI
What kind of birth control pill is Kariva?
"- Feb 20, 2022
Kariva is a combination birth control pill that uses female hormones to prevent ovulation. It also causes changes in cervical mucus and the uterine lining, making it harder for sperm to reach the uterus and for a fertilized egg to attach to it."
Answered by AI