Kanamycin Sulfate

Bacterial Infection caused by Klebsiella Pneumoniae, Bacterial Infections, Acinetobacter Infections + 3 more

Treatment

0 Active Studies for Kanamycin Sulfate

Treatment for

Bacterial Infection caused by Klebsiella Pneumoniae

What is Kanamycin Sulfate

Kanamycin

The Generic name of this drug

Treatment Summary

Kanamycin (also known as kanamycin A) is an antibiotic medicine used to treat bacterial infections. It is derived from the Streptomyces kanamyceticus bacterium and is available in oral, intravenous, and intramuscular forms. Kanamycin sulfate is the most commonly administered form of the drug.

Kanamycin

is the brand name

image of different drug pills on a surface

Kanamycin Sulfate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Kanamycin

2003

Effectiveness

How Kanamycin Sulfate Affects Patients

Kanamycin is an antibiotic that stops bacteria from creating proteins needed to survive and grow. It is typically used to treat infections caused by certain types of bacteria, including those in the Pseudomonas, Acinetobacter, and Enterobacter families. It can also be used to treat some mycobacteria, including those that cause tuberculosis. Sometimes it is used together with other antibiotics to treat streptococcal infections. It is not effective against anaerobic bacteria, fungi, and viruses.

How Kanamycin Sulfate works in the body

Kanamycin is an aminoglycoside, a type of drug that works by binding to proteins and RNA in cells. It attaches to four specific parts of the ribosome, which is the part of the cell responsible for creating proteins. This disrupts the ribosome's ability to read mRNA, resulting in incorrect proteins being produced. This causes the cell to break down, or become toxic and nonfunctional.

When to interrupt dosage

The advocated dosage of Kanamycin Sulfate is contingent upon the perceived condition, including Bacterial Infections, Bacterial Infection provoked by Klebsiella Pneumoniae and Bacterial Infections. The extent of dosage fluctuates, in light of the method of delivery (e.g. Injection, solution or Intramuscular; Intravenous) featured in the table beneath.

Condition

Dosage

Administration

Bacterial Infection caused by Klebsiella Pneumoniae

, 333.0 mg/mL, 1000.0 mg/mL

, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intramuscular; Intraperitoneal; Intravenous; Irrigation; Respiratory (inhalation), Injection, solution - Intramuscular; Intraperitoneal; Intravenous; Irrigation; Respiratory (inhalation)

Bacterial Infections

, 333.0 mg/mL, 1000.0 mg/mL

Acinetobacter Infections

, 333.0 mg/mL, 1000.0 mg/mL

Bacterial Infections

, 333.0 mg/mL, 1000.0 mg/mL

Bacterial Infections

, 333.0 mg/mL, 1000.0 mg/mL

Bacterial Infection caused by Enterobacter aerogenes

, 333.0 mg/mL, 1000.0 mg/mL

Warnings

Kanamycin Sulfate has a single contraindication; therefore, it should be avoided when experiencing the conditions in the following table.

Kanamycin Sulfate Contraindications

Condition

Risk Level

Notes

long term therapy

Do Not Combine

There are 20 known major drug interactions with Kanamycin Sulfate.

Common Kanamycin Sulfate Drug Interactions

Drug Name

Risk Level

Description

Neomycin

Major

The risk or severity of nephrotoxicity can be increased when Kanamycin is combined with Neomycin.

Tenofovir

Major

Kanamycin may increase the nephrotoxic activities of Tenofovir.

Tenofovir alafenamide

Major

Kanamycin may increase the nephrotoxic activities of Tenofovir alafenamide.

Tenofovir disoproxil

Major

Kanamycin may increase the nephrotoxic activities of Tenofovir disoproxil.

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Kanamycin.

Kanamycin Sulfate Toxicity & Overdose Risk

Amikacin can cause mild and reversible kidney damage in up to 25% of patients. It can also cause permanent hearing loss and damage to the inner ear, which is related to the amount of drug taken over time. High-pitched sounds are usually lost first, followed by lower-pitched sounds. This can be accompanied by dizziness, vertigo, nausea, and vomiting. The lowest toxic dose in mice is 17500 mg/kg, over 4 g/kg in rats, and over 3 g/kg in rabbits.

image of a doctor in a lab doing drug, clinical research

Kanamycin Sulfate Novel Uses: Which Conditions Have a Clinical Trial Featuring Kanamycin Sulfate?

No active clinical trials are currently examining the potential of Kanamycin Sulfate to treat Bacterial Infections caused by Acinetobacter species, Enterobacter aerogenes and other bacterial infections.

Condition

Clinical Trials

Trial Phases

Acinetobacter Infections

0 Actively Recruiting

Bacterial Infections

0 Actively Recruiting

Bacterial Infection caused by Enterobacter aerogenes

0 Actively Recruiting

Bacterial Infections

0 Actively Recruiting

Bacterial Infections

0 Actively Recruiting

Bacterial Infection caused by Klebsiella Pneumoniae

0 Actively Recruiting

Kanamycin Sulfate Reviews: What are patients saying about Kanamycin Sulfate?

4.7

Patient Review

12/17/2016

Kanamycin Sulfate for Bacterial Urinary Tract Infection

I was treated with kanamycin and found it to be very effective. I was cured within a week, and experienced no pain when urinating.

4.7

Patient Review

12/17/2016

Kanamycin Sulfate for Bacterial Urinary Tract Infection

Kanamycin worked well for me and I was cured within a week. The only downside was that it caused pain when urinating.

Patient Q&A Section about kanamycin sulfate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the mechanism of action of kanamycin?

"Kanamycin works by binding to the 30S subunit of the bacterial ribosome, which results in incorrect alignment with mRNA and eventually causes the wrong amino acid to be placed into the peptide."

Answered by AI

Is kanamycin sulfate the same as kanamycin?

"Kanamycin is an antibiotic that kills bacteria. It is available in different forms that can be taken by mouth, intravenously, or as a shot. It is used to treat infections that affect different parts of the body. Kanamycin sulfate is the most commonly used form of the antibiotic."

Answered by AI

What is the generic name of kanamycin?

"Kantrex is an antibiotic that is used to treat infections that are caused by bacteria. It is in the aminoglycoside class of antibiotics."

Answered by AI

What is kanamycin sulfate used for?

"This medicine is called KANAMYCIN and it is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections."

Answered by AI