Juvisync

Coronary heart disease, prophylaxis of cardiovascular event, Diabetes + 11 more
Treatment
13 FDA approvals
20 Active Studies for Juvisync

What is Juvisync

SimvastatinThe Generic name of this drug
Treatment SummarySimvastatin, which is also known as Zocor, is a medication used to lower the risk of cardiovascular disease. It belongs to a class of drugs called statins, which are used to reduce cholesterol levels in the body by blocking an enzyme that helps produce cholesterol in the liver. Simvastatin and other statin drugs are commonly prescribed following any cardiovascular events and for people with a moderate to high risk for developing CVD. Studies have shown that statins can reduce the risk of heart attack, stroke, and other cardiovascular events by 20-22%, and they have few side effects or long-term risks. There are
Zocoris the brand name
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Juvisync Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zocor
Simvastatin
1991
620

Approved as Treatment by the FDA

Simvastatin, otherwise called Zocor, is approved by the FDA for 13 uses like Homozygous Familial Hypercholesterolemia and Coronary heart disease .
Homozygous Familial Hypercholesterolemia
Used to treat Homozygous Familial Hypercholesterolaemia (HoFH) in combination with Ezetimibe
Coronary heart disease
Lipid-Lowering Therapy
Used to treat Lipid-Lowering Therapy in combination with Ezetimibe
Diabetes
Peripheral Vascular Disease
cholesterol
Helps manage High Cholesterol
Cerebrovascular Disorders
prophylaxis of cardiovascular event
Hypercholesterolemia
Used to treat Heterozygous Familial Hypercholesterolemia (HeFH) in combination with Ezetimibe
Diet
Used to treat Diet in combination with Ezetimibe
Physical Activity
Used to treat Exercise in combination with Ezetimibe
Mixed Hyperlipidemia
Used to treat Mixed Hyperlipidemia in combination with Ezetimibe
Cardiovascular Events

Effectiveness

How Juvisync Affects PatientsSimvastatin is a drug taken to lower cholesterol levels. It reduces LDL cholesterol, apolipoprotein B, non-HDL cholesterol and triglyceride concentrations, while increasing HDL cholesterol levels. High LDL cholesterol, low HDL cholesterol, and high triglycerides are linked to an increased risk of heart disease. Studies have shown that taking simvastatin can reduce the risk of developing heart disease or having a fatal or non-fatal cardiovascular event, even for those with a low risk for such events. However, it can cause muscle pain, tenderness or weakness, as well as occasional liver enzyme abnormalities. It can also
How Juvisync works in the bodySimvastatin is a medication used to help reduce cholesterol. It works by blocking an enzyme in the liver that is responsible for producing cholesterol. This forces the liver to increase its production of LDL and VLDL receptors, which increases the amount of cholesterol absorbed by the liver. Simvastatin also has some other beneficial effects on the body, such as improving endothelial function and reducing inflammation and oxidative stress. It has also been found to bind to a protein that helps regulate T-cell activation in the body.

When to interrupt dosage

The prescribed dosage of Juvisync is dependent on the diagnosed affliction, including Hypercholesterolemia, Diet and Type 2 Diabetes. The magnitude of dosage can be found in the table below, contingent upon the approach of administration.
Condition
Dosage
Administration
Homozygous Familial Hypercholesterolemia
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Coronary heart disease
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
prophylaxis of cardiovascular event
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Diabetes
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Cardiovascular Events
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Lipid-Lowering Therapy
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Physical Activity
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Type 2 Diabetes
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
cholesterol
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Mixed Hyperlipidemia
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Diet
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Hypercholesterolemia
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Peripheral Vascular Disease
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Cerebrovascular Disorders
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular

Warnings

Juvisync Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
active liver disease
Do Not Combine
There are 20 known major drug interactions with Juvisync.
Common Juvisync Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Simvastatin.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Simvastatin.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Simvastatin.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Simvastatin.
Axitinib
Major
The serum concentration of Axitinib can be increased when it is combined with Simvastatin.
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Juvisync Novel Uses: Which Conditions Have a Clinical Trial Featuring Juvisync?

Currently, 756 active trials are assessing the efficacy of Juvisync in improving Cerebrovascular Disorders, as well as Type 2 Diabetes and Physical Activity levels.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
193 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
cholesterol
6 Actively Recruiting
Phase 3, Not Applicable
Hypercholesterolemia
2 Actively Recruiting
Phase 3, Not Applicable
Mixed Hyperlipidemia
0 Actively Recruiting
Cerebrovascular Disorders
0 Actively Recruiting
Physical Activity
39 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Diet
5 Actively Recruiting
Not Applicable
Coronary heart disease
0 Actively Recruiting
Lipid-Lowering Therapy
0 Actively Recruiting
prophylaxis of cardiovascular event
0 Actively Recruiting
Diabetes
542 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4, Early Phase 1
Cardiovascular Events
3 Actively Recruiting
Not Applicable
Homozygous Familial Hypercholesterolemia
4 Actively Recruiting
Phase 3, Phase 2
Peripheral Vascular Disease
8 Actively Recruiting
Phase 1, Not Applicable, Phase 3

Patient Q&A Section about juvisync

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Clinical Trials for Juvisync

Have you considered Juvisync clinical trials? We made a collection of clinical trials featuring Juvisync, we think they might fit your search criteria.
Have you considered Juvisync clinical trials? We made a collection of clinical trials featuring Juvisync, we think they might fit your search criteria.
Have you considered Juvisync clinical trials? We made a collection of clinical trials featuring Juvisync, we think they might fit your search criteria.