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What is Juluca
RilpivirineThe Generic name of this drug
Treatment SummaryDolutegravir is a medication used to treat HIV-1. It works by blocking the virus from integrating into the host cell, which can prevent further replication of the virus. It is well-tolerated and has minimal side effects, making it a popular treatment option. It was approved by the FDA in 2013 and, in 2017, was combined with rilpivirine to create the first two-drug treatment regimen for HIV-1, called Juluca.
Edurantis the brand name
Juluca Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Edurant
Rilpivirine
2011
12
Approved as Treatment by the FDA
Rilpivirine, also known as Edurant, is approved by the FDA for 4 uses including weight at least 35 kg and HIV .weight at least 35 kg
Used to treat weight at least 35 kg in combination with null
HIV
Used to treat Human Immunodeficiency Virus Type 1 (HIV-1) Infection in combination with null
Treatment Naive
Used to treat Treatment Naive in combination with null
HIV-1 RNA Less Than or Equal to 100,000 copies/mL
Used to treat HIV-1 RNA Less Than or Equal to 100,000 copies/mL in combination with null
Effectiveness
How Juluca Affects PatientsDolutegravir is an antiviral drug for HIV-1 that has been shown to reduce the amount of virus in the body quickly and effectively. Studies have found that it has a strong binding to the virus and that the effects last for several days after the last dose. When combined with the drug ripivirine, it has been found to be just as effective as a three-drug therapy without any mutations or resistance.
How Juluca works in the bodyDolutegravir is a medicine used to treat HIV-1 infections. It blocks the virus from replicating by attaching itself to the active site of the virus and preventing it from adding its genetic material to the cells it invades. This process disrupts the virus' replication cycle and reduces its activity. Dolutegravir is very effective, with an mean EC50 value of 0.5 nanometers (0.21 nanograms per milliliter) to 2.1 nanometers (0.85 nanograms per milliliter) in blood cells and MT-4 cells.
When to interrupt dosage
The recommended dose of Juluca is contingent upon the established condition. The quantity of dosage differs as per the manner of delivery (e.g. Tablet, film coated or Tablet) featured in the table beneath.Condition
Dosage
Administration
HIV
, 25.0 mg, 300.0 mg/mL, 600.0 mg, 900.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intramuscular, Kit; Suspension, extended release, Kit; Suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
treatment failure
, 25.0 mg, 300.0 mg/mL, 600.0 mg, 900.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intramuscular, Kit; Suspension, extended release, Kit; Suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Viral Resistance
, 25.0 mg, 300.0 mg/mL, 600.0 mg, 900.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intramuscular, Kit; Suspension, extended release, Kit; Suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Human Immunodeficiency Virus Type 1 (HIV-1)
, 25.0 mg, 300.0 mg/mL, 600.0 mg, 900.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intramuscular, Kit; Suspension, extended release, Kit; Suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
HIV-1 RNA Less Than or Equal to 100,000 copies/mL
, 25.0 mg, 300.0 mg/mL, 600.0 mg, 900.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intramuscular, Kit; Suspension, extended release, Kit; Suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
virologically-suppressed
, 25.0 mg, 300.0 mg/mL, 600.0 mg, 900.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intramuscular, Kit; Suspension, extended release, Kit; Suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Treatment Naive
, 25.0 mg, 300.0 mg/mL, 600.0 mg, 900.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intramuscular, Kit; Suspension, extended release, Kit; Suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
weight at least 35 kg
, 25.0 mg, 300.0 mg/mL, 600.0 mg, 900.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intramuscular, Kit; Suspension, extended release, Kit; Suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Warnings
Juluca has two known contraindications and must not be taken concurrently with the conditions stated in the table below.Juluca ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
dexamethasone
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Rilpivirine may interact with Pulse Frequency
Common Juluca Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Rilpivirine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Rilpivirine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Rilpivirine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Rilpivirine.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Rilpivirine.
Juluca Toxicity & Overdose RiskTaking dolutegravir during conception or early in pregnancy may increase the risk of neural tube defects in the unborn baby. Adolescents and adults of childbearing potential should discuss the risks and benefits of taking dolutegravir with their doctor, as an alternative treatment may be needed. Animal studies have not found any evidence of adverse developmental outcomes at exposures lower than those seen in humans. If an overdose occurs, supportive treatment should be given, though it is unlikely that the drug will be removed by dialysis due to its high protein binding.
Juluca Novel Uses: Which Conditions Have a Clinical Trial Featuring Juluca?
43 active clinical trials are presently assessing the potential of Juluca to combat HIV (Human Immunodeficiency Virus).Condition
Clinical Trials
Trial Phases
treatment failure
0 Actively Recruiting
Treatment Naive
0 Actively Recruiting
virologically-suppressed
0 Actively Recruiting
Viral Resistance
0 Actively Recruiting
HIV-1 RNA Less Than or Equal to 100,000 copies/mL
0 Actively Recruiting
Human Immunodeficiency Virus Type 1 (HIV-1)
6 Actively Recruiting
Phase 3, Phase 2, Phase 1, Early Phase 1
HIV
42 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
weight at least 35 kg
0 Actively Recruiting
Juluca Reviews: What are patients saying about Juluca?
5Patient Review
2/7/2019 After being diagnosed with HIV and trying two different medications that didn't work well for me, I finally found Juluca. This medication is easy to take and has very few side effects. My CD4 levels are stable and my viral load is undetectable. The only downside is that I sometimes feel tired, but overall this drug has been a lifesaver.
5Patient Review
9/23/2018 I'm a little apprehensive about taking this new medication, but I'll update you all soon.
4.3Patient Review
7/15/2022 I've been taking Juluca for 21 years and it's really helped me. I was able to reduce my pill intake from 3 pills to 1, and I haven't experienced any negative side effects.
4Patient Review
2/15/2020 After using Biktarvy and Triumeq for a year and being very sick with puking and weakness, I now take Juluca and feel much better. No puking. Walking erect and without a cane again. I still deal with depression though.
3Patient Review
2/29/2020 I had been living with HIV for 25 years when I switched to Biktarvy in August 2019 due to resistance. However, I got off the medication in January 2020 because I experienced muscle pain and fatigue, even though my lab results were good. Now I'm on Juluca and while I don't have muscle pain anymore, I do still have fatigue and sometimes feel faintheaded. Before switching to Biktarvy, I felt great. I'm feeling a little better now and will follow up with my doctor.
2.3Patient Review
3/1/2019 Juluca was helpful at first, but I am now experiencing muscle pain and weakness in my hands. This feeling is getting worse over time, and I have also gained a lot of weight and my face and body are swollen.
1.7Patient Review
4/26/2019 My viral load increased from 49 to 67 after six months. Can somebody explain this to me? I'm very confused and upset.
Patient Q&A Section about juluca
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What class of drug is Juluca?
"Dolutegravir is an HIV integrase inhibitor while rilpivirine is a non-nucleoside reverse transcriptase inhibitor. Both drugs work against HIV in different ways."
Answered by AI
What is Juluca used for?
"JULUCA is a prescription medicine used to treat Human Immunodeficiency Virus-1 (HIV-1) infection in adults, without the use of other antiretroviral medicines. This medicine is only to be taken when healthcare providers determine that the patient meets certain requirements."
Answered by AI
Is Juluca brand or generic?
"These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy.
Although there is no generic version of Juluca currently available in the United States, it is possible that someone might try to sell a counterfeit version of the drug illegally. If you are considering buying Juluca online, be sure to only purchase it from a reputable and valid online pharmacy to avoid potentially dangerous counterfeit drugs."
Answered by AI
When is the best time to take Juluca?
"You should take JULUCA every day at mealtimes, as your doctor advises. It is important to take JULUCA with a meal, as this ensures that your body receives the correct dose of medicine. A protein drink is not a suitable substitute for a meal. You should take JULUCA at approximately the same time each day (or night)."
Answered by AI