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What is Januvia
SitagliptinThe Generic name of this drug
Treatment SummarySitagliptin is a medication used to help manage blood sugar levels in people with type 2 diabetes. It belongs to a class of drugs called DPP-4 inhibitors and works by increasing insulin production and decreasing the amount of glucagon in the body, both of which help to regulate blood sugar. Sitagliptin was approved by the FDA in 2006.
Januviais the brand name
Januvia Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Januvia
Sitagliptin
2006
52
Effectiveness
How Januvia Affects PatientsSitagliptin works by blocking an enzyme (DPP-4) which leads to increased levels of hormones that help control blood sugar levels (GLP-1 and GIP), and reduces levels of another hormone (glucagon). It also helps the body respond better to glucose.
How Januvia works in the bodySitagliptin helps the body manage blood sugar levels. It does this by blocking an enzyme called DPP-4, which prevents certain hormones (known as incretins) from working properly. When these hormones work correctly, they help the body control the release of insulin and glucagon, which in turn helps balance blood sugar levels. This is shown by lower levels of sugar in the blood, as measured by a decrease in glycosylated hemoglobin (HbA1c).
When to interrupt dosage
The advised measure of Januvia is contingent upon the diagnosed condition. The dosage may differ, depending on the method of delivery listed in the table beneath.Condition
Dosage
Administration
Type 2 Diabetes
, 100.0 mg, 50.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Diet
, 100.0 mg, 50.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Physical Activity
, 100.0 mg, 50.0 mg, 25.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Warnings
Januvia has a single contraindication and must not be employed when dealing with the conditions stated in the following table.Januvia ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Sitagliptin may interact with Pulse Frequency
Common Januvia Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Sitagliptin.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Sitagliptin.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Sitagliptin.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Sitagliptin.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Sitagliptin.
Januvia Toxicity & Overdose RiskAnimal studies have not shown any negative effects on mothers or babies at normal doses. However, higher doses of Sitagliptin have been linked to increased rib deformities in animals. It is currently not known if Sitagliptin is found in human breast milk. The safety and effectiveness of Sitagliptin in children has not been studied, and elderly patients may be more likely to develop reduced kidney function from taking the drug. Taking Sitagliptin has also been linked to a 34% higher risk of infection. No differences in safety or effectiveness were found when considering factors such as sex, age, race, ethnicity, and BMI.
Januvia Novel Uses: Which Conditions Have a Clinical Trial Featuring Januvia?
162 active trials are presently investigating the potential of Januvia in managing Type 2 Diabetes.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Physical Activity
39 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Diet
5 Actively Recruiting
Not Applicable
Januvia Reviews: What are patients saying about Januvia?
5Patient Review
8/27/2021 This medication has helped to regulate my blood sugar levels and I haven't had any negative spikes or dips since starting it.
4Patient Review
3/30/2019 This medication has been really effective in managing my blood sugar levels. After just three months of taking it, my a1c went from 9.6 to 6.1. And after cutting back to half a pill for the next three months, it went down even further to 5.1. I haven't experienced any side effects so far, which is great. I walk 1.25 miles every day and try to keep my carb intake at 60 or less per day. Having had sepsis shock a few years ago, I have to be careful with my kidneys since I lost 50% function in them. But so far
4Patient Review
6/15/2022 I've been on this medication for almost a year now, and it seems to work well. My blood sugar levels have mostly stayed in range, although there are the occasional high readings. I need to be mindful of my diet and make sure to include protein and limit carbohydrates.
3.3Patient Review
9/1/2019 I took this drug for one month and saw my forgetfulness and reasoning skills decline sharply. By the fourth week, I was experiencing symptoms similar to a stroke. Thankfully, my husband took me to the ER where I was quickly admitted and taken off the medication. All of my symptoms resolved within a few days.
3.3Patient Review
12/14/20173Patient Review
9/29/2019 The only drawback I've experienced is constipation, which has gotten so bad that I may have to stop taking the medication.
1.7Patient Review
4/14/2019 I haven't experienced any negative side effects from this medication yet.
1Patient Review
4/22/2018 This drug was extremely dangerous and caused me a great deal of suffering. I'm lucky that I didn't experience any permanent damage.
1Patient Review
10/23/2022 I wrote a review already but I couldn't find it so I'm writing again.This is such a terrible medicine. It's supposed to treat the disease but it made my diabetes worse and I had severe side effects within days of taking it.
1Patient Review
11/1/20171Patient Review
10/20/2022 I really didn't enjoy taking this medication. It caused my blood sugar to spike and I felt nauseous most of the time.
Patient Q&A Section about januvia
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is metformin and Januvia the same?
"In a 24-week clinical trial, it was found that Januvia and metformin led to similar improvements in A1c levels in patients with type 2 diabetes. Although both treatments were generally well-tolerated, the incidence of gastrointestinal-related side effects was significantly lower with Januvia than with metformin."
Answered by AI
What type of drug is Januvia?
"The drug Januvia is a type of DPP-4 inhibitor, which helps to regulate insulin levels and decrease the amount of glucose that the body produces. Januvia is taken in tablet form."
Answered by AI
Is it better to take Januvia in the morning or at night?
"Take Januvia at the same time each day for best results. The drug can be taken with or without food. If you forget a dose, take it as soon as you remember."
Answered by AI
What is the drug Januvia used for?
"You should take JANUVIA if you have type 2 diabetes and want to lower your blood sugar levels through diet and exercise. JANUVIA should not be taken if you have type 1 diabetes or diabetic ketoacidosis."
Answered by AI
What are the side effects of taking Januvia?
"Common side effects of JANUVIA include upper respiratory infection, stuffy or runny nose and sore throat, and headache. JANUVIA may also cause stomach upset and diarrhea, swelling of the hands or legs when used with metformin and rosiglitazone (Avandia®)."
Answered by AI