What is Isentress
RaltegravirThe Generic name of this drug
Treatment SummaryRaltegravir is a medication used to treat HIV infections. It was first approved by the FDA in 2007 and is the first drug of its kind, known as an integrase inhibitor. It is produced by Merck & Co. and is used to help control HIV infections.
Isentressis the brand name
Isentress Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Isentress
Raltegravir
2007
20
Approved as Treatment by the FDA
Raltegravir, commonly known as Isentress, is approved by the FDA for 1 uses like HIV .HIV
Used to treat Human Immunodeficiency Virus Type 1 (HIV-1) Infection in combination with null
Effectiveness
How Isentress works in the bodyRaltegravir stops HIV from copying its genetic material into human cells. It is broken down in the body by glucuronidation.
When to interrupt dosage
The advised dosage of Isentress is contingent upon the identified affliction. The sum additionally depends on the technique of delivery specified in the table beneath.Condition
Dosage
Administration
post-exposure prophylaxis for occupational exposure to HIV therapy
, 300.0 mg, 600.0 mg, 100.0 mg, 400.0 mg, 25.0 mg
, Tablet, Oral, Tablet - Oral, Granule, for suspension - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, chewable - Oral, Tablet, chewable, Granule - Oral, Granule, Granule, for suspension
HIV
, 300.0 mg, 600.0 mg, 100.0 mg, 400.0 mg, 25.0 mg
, Tablet, Oral, Tablet - Oral, Granule, for suspension - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, chewable - Oral, Tablet, chewable, Granule - Oral, Granule, Granule, for suspension
Warnings
Isentress ContraindicationsCondition
Risk Level
Notes
Toxoplasma Infections
Do Not Combine
Common Isentress Drug Interactions
Drug Name
Risk Level
Description
Atorvastatin
Minor
The risk or severity of myopathy and rhabdomyolysis can be increased when Raltegravir is combined with Atorvastatin.
Cerivastatin
Minor
The risk or severity of myopathy and rhabdomyolysis can be increased when Raltegravir is combined with Cerivastatin.
Fluvastatin
Minor
The risk or severity of myopathy and rhabdomyolysis can be increased when Raltegravir is combined with Fluvastatin.
Lovastatin
Minor
The risk or severity of myopathy and rhabdomyolysis can be increased when Raltegravir is combined with Lovastatin.
Mevastatin
Minor
The risk or severity of myopathy and rhabdomyolysis can be increased when Raltegravir is combined with Mevastatin.
Isentress Novel Uses: Which Conditions Have a Clinical Trial Featuring Isentress?
43 active trials are examining the potential of Isentress to provide treatment for HIV (Human Immunodeficiency Virus).Condition
Clinical Trials
Trial Phases
HIV
45 Actively Recruiting
Phase 2, Phase 3, Early Phase 1, Phase 1, Phase 4, Not Applicable
post-exposure prophylaxis for occupational exposure to HIV therapy
0 Actively Recruiting
Isentress Reviews: What are patients saying about Isentress?
5Patient Review
10/1/2011 I've been on this treatment for two years and it has done a great job of keeping my virus undetectable. My CD4 count is slowly rising, which is encouraging. I do still have some trouble sleeping, but that's manageable.
5Patient Review
7/21/2013 So far, I've had zero side effects from taking Truvada and Isentress. This is my first experience with HIV medication, so I'm cautiously optimistic. I'll update this review when I have more information.
5Patient Review
10/6/2010 I began to experience some adverse effects after a couple of months on this medication. They included difficulty sleeping, dizziness, and severe joint pain in my knees which also radiated to my lower back.
5Patient Review
6/16/2011 I was feeling really weak and depressed before I started this treatment, but it's helped me a lot. I'm not as annoyed with everything, either.
5Patient Review
7/2/2013 So far the medication has been effective and the virus is no longer detectable.
5Patient Review
2/13/2014 I've been taking this medication for a while now, and it's been great. It's kept my viral load undetectable.
4.7Patient Review
7/28/2011 Since starting this medication, I have felt incredibly exhausted. This has made it difficult to stick to my normal exercise routine. Additionally, I've been taking naps almost every day, which is something I never did before. The dreams I have been having are also very strange and vivid. Lastly, I am constantly feeling down and on edge. Luckily, my next doctor's appointment isn't too far away so that we can explore other options as this just hasn't been working well for me.
4.7Patient Review
9/14/2014 I've been taking this medication since October 2009 and it's been great. I haven't had any detectable levels of the virus in my system since then and I haven't experienced any negative side effects. However, I'm looking to switch to Triumeq now that there is an equivalent once-a-day medication available.
4.7Patient Review
1/24/2013 Comparing this medication to others, it definitely is one of the better ones. I was having HORRIBLE insomnia prior to taking this drug and now Tylenol PM helps about 80%. However, I'm going to request a stronger sleeping aid from my ID doctor because sleep is far too crucial for me. Additionally, I've found that if I take the drug at dinner time or early evening around 5 or 6pm, I sleep better.
4Patient Review
8/15/2013 I started taking Isentress and Truvada about three months ago, and I haven't experienced any negative side effects. Recently, I saw my HIV specialist and my bloodwork came back with no detection of the virus. My cd4 count also increased from just over 11 to 263.
3.7Patient Review
10/20/2010 I was extremely sick and the doctors said I wouldn't make it. But my GP put me on this medication, and even though I'd become resistant to other treatments, this one worked. My CD4 count went from 7 to 463 - the highest it's ever been!
3Patient Review
10/5/20102.7Patient Review
8/29/2012 I've been very lucky in that I haven't had any negative side effects from the drugs I've taken. Sustiva caused me to have disruptive, strange dreams, but that was manageable. I switched to Kaletra/Viread/Combivir and took that for 9 years before adding Isentress into the mix. So far so good!
2.3Patient Review
4/9/2014 Though this drug was helpful in reducing my viral load, I couldn't handle the side effects. In particular, I suffered from terrible hyper-acidity and acid reflux.
1Patient Review
7/2/2012 I have been on Isentress with no side effects and I feel great! I have energy to do my daily tasks, I sleep very well and awake refreshed. The fact that I take it twice a day and if I miss my am dose I can double it with the pm makes this a God send for me.
Patient Q&A Section about isentress
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Isentress used for?
"This text is discussing ISENTRESS, a prescription medication used to treat HIV-1 infection in both adults and children. The medication is taken with other antiretroviral medicines, and is safe for children weighing at least 4.4 pounds."
Answered by AI
What type of drug is Isentress?
"Isentress is a medication used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). It belongs to a group of antiretroviral drugs that prevent the virus from multiplying in your body. Raltegravir is not a cure for HIV or AIDS."
Answered by AI
How long do you take Isentress for?
"You should take Isentress for 28 days if you are taking it as part of your PEP regimen. If you are taking Isentress as part of your HIV regimen, you should continue taking it until your healthcare provider tells you to stop."
Answered by AI
Do you have to take Truvada and Isentress together?
"It's important to take Isentress at the same time every day. You can take it with or without food. If you're also taking Truvada, you can take them at the same time."
Answered by AI