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What is Hectorol
DoxercalciferolThe Generic name of this drug
Treatment SummaryDoxercalciferol is a form of vitamin D2 that is activated in the body to become 1α,25-(OH)2D2, a form of vitamin D that occurs naturally. It is used to treat an overactive parathyroid gland in patients with chronic kidney disease on dialysis, as well as Stage 3 and 4 chronic kidney disease. It is sold under the brand name Hectoral and is made by Genzyme Corporation and Catalent Pharma Solutions, Inc.
Hectorolis the brand name
Hectorol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Hectorol
Doxercalciferol
2006
47
Effectiveness
How Hectorol works in the bodyCalcitriol and 1α,25-(OH)2D2 help regulate the amount of calcium in the blood, to support normal body functions. They control how much calcium is absorbed from food and how much is reabsorbed by the kidneys, as well as how much calcium is released from the bones. These vitamin D metabolites work by attaching to special receptor proteins in different parts of the body. People with chronic kidney disease can't produce enough of these metabolites, which leads to an excess of parathyroid hormone and causes metabolic bone disease.
When to interrupt dosage
The measure of Hectorol is contingent upon the diagnosed affliction, including Chronic Kidney Disease, Stage 3 (Moderate), Hemodialysis and Stage 4 Chronic Kidney Disease. The amount likewise varies as per the process of delivery featured in the table beneath.Condition
Dosage
Administration
Chronic Kidney Disease, Stage 3 (Moderate)
0.002 mg/mL, , 0.0005 mg, 0.0025 mg, 0.001 mg, 0.004 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, Capsule - Oral, Injection, solution, Injection, solution - Intravenous
Stage 4 Chronic Kidney Disease
0.002 mg/mL, , 0.0005 mg, 0.0025 mg, 0.001 mg, 0.004 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, Capsule - Oral, Injection, solution, Injection, solution - Intravenous
Hyperparathyroidism, Secondary
0.002 mg/mL, , 0.0005 mg, 0.0025 mg, 0.001 mg, 0.004 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, Capsule - Oral, Injection, solution, Injection, solution - Intravenous
Warnings
Hectorol ContraindicationsCondition
Risk Level
Notes
Hypercalcemia
Do Not Combine
vitamin D intoxication
Do Not Combine
Common Hectorol Drug Interactions
Drug Name
Risk Level
Description
Sucralfate
Major
The serum concentration of Sucralfate can be increased when it is combined with Doxercalciferol.
1alpha-Hydroxyvitamin D5
Moderate
The risk or severity of adverse effects can be increased when Doxercalciferol is combined with 1alpha-Hydroxyvitamin D5.
Acetyldigitoxin
Moderate
The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Doxercalciferol is combined with Acetyldigitoxin.
Acetyldigoxin
Moderate
The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Doxercalciferol is combined with Acetyldigoxin.
Aluminum hydroxide
Moderate
The serum concentration of Aluminum hydroxide can be increased when it is combined with Doxercalciferol.
Hectorol Novel Uses: Which Conditions Have a Clinical Trial Featuring Hectorol?
Fifteen active studies are currently in progress to assess the potential of Hectorol to mitigate the effects of Hemodialysis, Hyperparathyroidism, Secondary and Stage 4 Chronic Kidney Disease.Condition
Clinical Trials
Trial Phases
Hyperparathyroidism, Secondary
5 Actively Recruiting
Phase 3
Stage 4 Chronic Kidney Disease
5 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2, Phase 3
Chronic Kidney Disease, Stage 3 (Moderate)
5 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Hectorol Reviews: What are patients saying about Hectorol?
5Patient Review
4/10/2010 I feel better taking this medication. It is small and easy to swallow, which is great for me since I have polycystic kidneys and they aren't working very well (only at seven percent). The downside is that it's quite expensive.
5Patient Review
3/30/2009 Hectorol was easy to take and affordable, and it did its job well. I'm now doing great thanks to my new kidney, and so my doctors have taken me off the medication.
4.7Patient Review
9/23/20073Patient Review
4/21/2010 Didn't see any significant results.
2.3Patient Review
10/19/2009 I found that this drug caused me to feel dizzy.
1Patient Review
5/14/2010 I took one caplet and felt very sick afterwards. I would not recommend this medication.
Patient Q&A Section about hectorol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Hectorol used for?
"Hectorol is a prescription vitamin d hormone that is a treatment for SHPT in adult patients with CKD."
Answered by AI
Does Hectorol raise calcium?
"PTH stands for parathyroid hormone. This medication works by decreasing PTH levels and increasing calcium and phosphorus levels in the body."
Answered by AI
Why is Hectorol given on dialysis?
"The active ingredient in this medicine works by decreasing the amount of PTH made by your parathyroid glands.
This medication is used to treat people who have serious kidney disease and are on dialysis. These people have high levels of a substance called parathyroid hormone (PTH). PTH levels affect the balance of minerals in your body, such as calcium and phosphorus. This can cause weak bones. The active ingredient in this medicine decreases the amount of PTH made by your parathyroid glands."
Answered by AI
Is Hectorol active vitamin D?
"The chemical structure of doxercalciferol is similar to that of vitamin D2.
Doxercalciferol is a synthetic form of vitamin D2 that is biologically active. It is structurally similar to vitamin D2."
Answered by AI