Haloperidol

Delirium, Schizophrenia, Schizophrenia + 9 more
Treatment
2 FDA approvals
20 Active Studies for Haloperidol

What is Haloperidol

HaloperidolThe Generic name of this drug
Treatment SummaryHaloperidol is a medication used to reduce symptoms of psychotic disorders, such as schizophrenia. It blocks the dopamine receptors in the brain, particularly in the mesolimbic and mesocortical systems, which helps to reduce psychotic symptoms. Haloperidol is also used off-label to treat Huntington’s disease and intractable hiccups. It has been found to be effective in reducing hallucinations, aggression/hostility, disorganized speech, psychomotor agitation and other psychotic symptoms. However, it can cause movement disorders, sedation, weight gain, and prolactin changes. Haloperidol may
Haldolis the brand name
image of different drug pills on a surface
Haloperidol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Haldol
Haloperidol
1971
300

Approved as Treatment by the FDA

Haloperidol, otherwise known as Haldol, is approved by the FDA for 2 uses which include Gilles de la Tourette's Syndrome and Tourette Syndrome .
Gilles de la Tourette's Syndrome
Helps manage Gilles de la Tourette's Syndrome
Tourette Syndrome
Helps manage Gilles de la Tourette's Syndrome

Effectiveness

How Haloperidol Affects PatientsHaloperidol is an antipsychotic drug that is effective in managing the positive symptoms of schizophrenia, such as hallucinations, hearing voices, and agitated behavior. However, it can cause movement problems, tiredness, weight gain, and other side effects.Haloperidol is generally better at causing fewer side effects than the lower potency first-generation antipsychotics, but it is more likely to cause movement problems. Taking too much haloperidol can cause an irregular heartbeat and even sudden death. In some cases, a serious condition called Neuroleptic Malignant Syndrome (NMS) can also occur. Symptoms of NMS include
How Haloperidol works in the bodyHaloperidol works by blocking dopamine receptors in the brain, which can help reduce the symptoms of psychosis. It mainly blocks D2 dopamine receptors, but also has some effect on other receptors. It's believed that this blocking stops the overproduction of dopamine, which is thought to cause schizophrenia. Haloperidol also blocks receptors in the brainstem, which makes it an effective antiemetic. However, it has a strong binding to the D2 receptor, which can lead to unpleasant and long-lasting side effects known as extrapyramidal symptoms. For this reason, newer antipsychotic medications have been developed which have a lower

When to interrupt dosage

The recommended measure of Haloperidol is contingent upon the diagnosed situation, including Palliative Care, violent response and phencyclidine. The amount of dosage is delineated in the accompanying table, depending on the method of administration.
Condition
Dosage
Administration
phencyclidine
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Obsessive-Compulsive Disorder
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Schizophrenia
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Palliative Treatment
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Severe Disruptive Behaviour Disorders
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Tourette Syndrome
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Aggression
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Nausea
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Huntington Disease
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Delirium
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
severe Hyperactivity
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular
Schizophrenia
5.0 mg/mL, , 2.0 mg/mL, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 0.5 mg, 20.0 mg, 50.0 mg/mL, 100.0 mg/mL, 1.5 mg, 500.0 mg/mL, 70.52 mg/mL, 141.04 mg/mL
, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Oral, Solution, concentrate, Solution, concentrate - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Injection, Liquid - Intramuscular, Liquid, Solution - Intramuscular

Warnings

Haloperidol has six contraindications and should not be combined with the ailment listed in the table below.Haloperidol Contraindications
Condition
Risk Level
Notes
Coma
Do Not Combine
Asthma
Do Not Combine
Parkinson's Disease
Do Not Combine
Mental Depression
Do Not Combine
Basal Ganglia Lesions
Do Not Combine
Mental Depression
Do Not Combine
There are 20 known major drug interactions with Haloperidol.
Common Haloperidol Drug Interactions
Drug Name
Risk Level
Description
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Haloperidol.
Amisulpride
Major
Haloperidol may increase the antipsychotic activities of Amisulpride.
Azelastine
Major
Haloperidol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Cariprazine
Major
The metabolism of Cariprazine can be decreased when combined with Haloperidol.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Haloperidol.
Haloperidol Toxicity & Overdose RiskThe average toxic dose of this drug in rats when taken orally is 71mg/kg.
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Haloperidol Novel Uses: Which Conditions Have a Clinical Trial Featuring Haloperidol?

285 active clinical trials are currently in progress to assess the potential of Haloperidol in providing relief from Obsessive-Compulsive Disorder, Palliative Care and Phencyclidine intoxication.
Condition
Clinical Trials
Trial Phases
Schizophrenia
107 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 2, Phase 1
Obsessive-Compulsive Disorder
16 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 1
Schizophrenia
33 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4
Huntington Disease
5 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Aggression
0 Actively Recruiting
Nausea
0 Actively Recruiting
Severe Disruptive Behaviour Disorders
0 Actively Recruiting
Tourette Syndrome
0 Actively Recruiting
Palliative Treatment
1 Actively Recruiting
Not Applicable
Delirium
30 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1
phencyclidine
0 Actively Recruiting
severe Hyperactivity
0 Actively Recruiting

Haloperidol Reviews: What are patients saying about Haloperidol?

5Patient Review
12/5/2012
Haloperidol for Schizophrenia
The generic didn't work for me, haloperidol is the right one.
4.7Patient Review
3/17/2012
Haloperidol for Mental Disorder with Loss of Normal Personality & Reality
Haldol was great for my severe mania four years ago. It helped me a lot, but I experienced some drooling, the "Haldol shuffle," and my legs would jerk when I woke up. This time around, though, I haven't had any EPS side effects at all!
4.7Patient Review
6/24/2011
Haloperidol for Nausea and Vomiting caused by Cancer Drugs
4.3Patient Review
11/1/2014
Haloperidol for Schizophrenia
Haldol worked well for me, but I experienced some side effects like restless and pain in my legs. It's unclear if the drug was the cause of these problems.
4.3Patient Review
9/28/2013
Haloperidol for Schizophrenia
This medication works well for me, with the only notable side effect being akithisia.
View All Reviews
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Patient Q&A Section about haloperidol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What class of drug is haloperidol?

"Haloperidol is a type of medication known as a conventional antipsychotic. It works by decreasing abnormal excitement in the brain."

Answered by AI

What are some side effects of haloperidol?

"The effects listed above may occur when taking this medication. If they persist or worsen, notify your doctor or pharmacist. Dizziness and lightheadedness may cause falls."

Answered by AI

What is haloperidol drug used for?

"Haloperidol is a medication used to treat psychotic disorders, conditions that cause difficulty distinguishing between reality and what is not real."

Answered by AI

How does haloperidol make you feel?

"This medicine may cause some people to feel dizzy, drowsy, or have trouble thinking or controlling their body movements, which could lead to falls, fractures, or other injuries. You may feel drowsy or less alert when you wake up, even if you took haloperidol at bedtime."

Answered by AI

Clinical Trials for Haloperidol

Have you considered Haloperidol clinical trials? We made a collection of clinical trials featuring Haloperidol, we think they might fit your search criteria.
Have you considered Haloperidol clinical trials? We made a collection of clinical trials featuring Haloperidol, we think they might fit your search criteria.
Have you considered Haloperidol clinical trials? We made a collection of clinical trials featuring Haloperidol, we think they might fit your search criteria.
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