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What is Glyburide
GlyburideThe Generic name of this drug
Treatment SummaryGlyburide is an oral medication used to treat type 2 diabetes in patients who are unable to manage their condition with metformin. It works by stimulating the release of insulin through the closing of ATP-sensitive potassium channels, increasing the concentration of potassium and calcium ions inside cells. Glyburide was approved by the FDA in 1984, and a combination drug with metformin was approved in 2000.
Micronaseis the brand name
Glyburide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Micronase
Glyburide
1984
341
Approved as Treatment by the FDA
Glyburide, also known as Micronase, is approved by the FDA for 2 uses which include Type 2 Diabetes and Glycemic Control .Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Glycemic Control
Used to treat Glycemic Control in combination with Metformin
Effectiveness
How Glyburide Affects PatientsGlyburide is a type of medication used to increase insulin in the body. It is usually taken once per day and doses can range from 0.75mg to 10mg or more. Glyburide has been shown to increase the risk of cardiovascular mortality, similar to another type of sulfonylurea called tolbutamide.
How Glyburide works in the bodyGlyburide helps the body make more insulin. It belongs to a group of drugs called sulfonylureas. These drugs work by blocking a type of potassium channel found on pancreatic beta cells. When these channels are blocked, the cells' membrane potential increases, which triggers the release of insulin granules. This helps the body make more insulin, allowing it to better regulate blood sugar levels.
When to interrupt dosage
The measure of Glyburide is contingent upon the diagnosed condition, including Glycemic Control, Type 2 Diabetes and Gestational Diabetes. The amount likewise fluctuates as per the method of delivery (e.g. Oral or Tablet) depicted in the table beneath.Condition
Dosage
Administration
Glycemic Control
, 1.25 mg, 2.5 mg, 1.5 mg, 3.0 mg, 6.0 mg, 5.0 mg, 6.0 mg/mL, 0.6 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Type 2 Diabetes
, 1.25 mg, 2.5 mg, 1.5 mg, 3.0 mg, 6.0 mg, 5.0 mg, 6.0 mg/mL, 0.6 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Gestational Diabetes Mellitus
, 1.25 mg, 2.5 mg, 1.5 mg, 3.0 mg, 6.0 mg, 5.0 mg, 6.0 mg/mL, 0.6 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Warnings
Glyburide has six recognized contraindications which means it should be avoided if any of the conditions named in the table below are present.Glyburide ContraindicationsCondition
Risk Level
Notes
Type 1 Diabetes
Do Not Combine
Metabolic Acidosis
Do Not Combine
Comatose
Do Not Combine
Diabetic ketoacidosis with coma
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Glyburide may interact with Pulse Frequency
Common Glyburide Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Glyburide.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Glyburide.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Glyburide.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Glyburide.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Glyburide.
Glyburide Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats has been found to be greater than 3200mg/kg, in mice is greater than 1500mg/kg, in rabbits is greater than 10,000mg/kg, and in guinea pigs is greater than 1500mg/kg. Those who overdose may develop low blood sugar levels. Mild cases can be treated with oral glucose and changes to drug doses or meal schedules. Severe hypoglycemia can cause coma, seizure, or other neurological issues and requires immediate hospital treatment with intravenous glucose and monitoring for 24-48 hours.
Glyburide Novel Uses: Which Conditions Have a Clinical Trial Featuring Glyburide?
At present, there are 196 active studies exploring the potential of Glyburide to ameliorate Gestational Diabetes, Glycemic Control and Type 2 Diabetes.Condition
Clinical Trials
Trial Phases
Gestational Diabetes Mellitus
37 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2, Early Phase 1
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Glycemic Control
3 Actively Recruiting
Not Applicable
Glyburide Reviews: What are patients saying about Glyburide?
5Patient Review
12/22/2012 I only used this treatment for a short time, but it worked better than the other medication I was taking (glipizide).
5Patient Review
10/16/2013 Gly-Buride in combination with Metformin ER has been much more effective for me in lowering my blood sugar than just Metformin ER alone.
5Patient Review
2/28/2014 This medication is excellent at regulating my blood sugar levels.
5Patient Review
3/13/2014 I've only been using this treatment for two days, but my sugar levels have already lowered by 70 points. So far, so good!
4.3Patient Review
9/12/2012 Sometimes I have issues with hypoglycemia.
4.3Patient Review
12/25/2013 This drug was really effective in controlling my Type II diabetes. I was taking it alongside Metformin and Januvia, and it made a big difference.
4.3Patient Review
6/8/2017 I was on this treatment for 30 years before my doctor took me off and put me on metform. It had an effect on me, but I'm not sure what that effect was.
4.3Patient Review
6/21/2013 I've been on this drug for a few years now. Recently, my doctor's nurse advised me to take it 20 minutes before eating, rather than during or after. This allows the drug to start working before sugar from the meal hits my system. I had no apparent results taking it at other times, but changing when I take it has lowered my blood sugars into the acceptable range.
4.3Patient Review
8/13/20124.3Patient Review
2/10/2013 I sometimes experience lightheadedness and increased appetite after taking this medication.
4Patient Review
5/19/2015 My doctor said that this drug isn't recommended for those over 65 because it can have negative effects on the liver and kidneys. Even so, I found it effective. Now he's put me on Glimepiride 2mg instead though.
3.7Patient Review
9/20/2020 After taking this medication for two days, my blood sugar levels have dropped to dangerously low levels. I feel shaky and weak, and have had to resort to drinking soda just to get my levels up. I won't be taking this medication any longer; it's not worth the risk.
3.3Patient Review
2/23/2014 I've been taking this drug for fifteen years and my micro albumin levels have gone up to 1200+. Is there a connection between this and the glyburide? I'm 68 now and my sugar is usually controlled between 90-145. My blood pressure is also controlled between 85/129 to 85/140. So why is my microalbumin so high?
3Patient Review
1/12/2013 This medication really helps to keep my blood sugar levels stable.
2.7Patient Review
8/24/2016 The first dose of this medication caused my blood sugar to drop to 36. I experienced a lot of symptoms like sweating, dizziness, sleepiness, shaking, etc. I had to take four glucose tabs and eat a small trail mix just to be able to function again. The next day, I tried half a tablet and still had the same result with my blood sugar only going up to 78.
2.7Patient Review
3/2/2015 I'm curious if this medication has any connection to nerve damage, specifically in the spine.
2.3Patient Review
11/2/2014 I found it very difficult to manage my weight while on this medication, and actually lost nearly 20 pounds once I stopped taking it. Additionally, it was only effective in the short term and often resulted in low blood sugar levels.
2.3Patient Review
8/11/20122Patient Review
3/5/2014 I took this medication for two years and in July 2006 my AIC was 7. In September 2006, while playing tennis, I had a problem. It was found that my LAD artery was 99% blocked. Many doctors won't prescribe it because they say it decreases circulation in the heart - a potassium channel blocker. Some published studies on dogs show that it decreases blood flow through the LAD artery by about 50%! I should never have taken it!
Patient Q&A Section about glyburide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of glyburide?
"diarrhea, dizziness, headache, heartburn, nausea, gas, weight gain"
Answered by AI
What is glyburide used for?
"Glyburide is used to treat high blood sugar levels caused by type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream."
Answered by AI
Is glyburide the same as metformin?
"Glyburide helps your pancreas release more insulin into the bloodstream. Metformin reduces the amount of sugar absorbed from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better. This medicine is available only with a doctor's prescription."
Answered by AI
What type of drug is glyburide?
"Glyburide is a type of drug called a sulfonylurea. It lowers blood sugar by causing the release of insulin from your body."
Answered by AI