Glyburide

Glycemic Control, Type 2 Diabetes, Gestational Diabetes Mellitus
Treatment
3 FDA approvals
20 Active Studies for Glyburide

What is Glyburide

GlyburideThe Generic name of this drug
Treatment SummaryGlyburide is an oral medication used to treat type 2 diabetes in patients who are unable to manage their condition with metformin. It works by stimulating the release of insulin through the closing of ATP-sensitive potassium channels, increasing the concentration of potassium and calcium ions inside cells. Glyburide was approved by the FDA in 1984, and a combination drug with metformin was approved in 2000.
Micronaseis the brand name
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Glyburide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Micronase
Glyburide
1984
341

Approved as Treatment by the FDA

Glyburide, also known as Micronase, is approved by the FDA for 3 uses which include Type 2 Diabetes Mellitus and Type 2 Diabetes .
Type 2 Diabetes Mellitus
Helps manage Type 2 Diabetes Mellitus
Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Glycemic Control
Used to treat Glycemic Control in combination with Metformin

Effectiveness

How Glyburide Affects PatientsGlyburide is a type of medication used to increase insulin in the body. It is usually taken once per day and doses can range from 0.75mg to 10mg or more. Glyburide has been shown to increase the risk of cardiovascular mortality, similar to another type of sulfonylurea called tolbutamide.
How Glyburide works in the bodyGlyburide helps the body make more insulin. It belongs to a group of drugs called sulfonylureas. These drugs work by blocking a type of potassium channel found on pancreatic beta cells. When these channels are blocked, the cells' membrane potential increases, which triggers the release of insulin granules. This helps the body make more insulin, allowing it to better regulate blood sugar levels.

When to interrupt dosage

The measure of Glyburide is contingent upon the diagnosed condition, including Glycemic Control, Type 2 Diabetes and Gestational Diabetes. The amount likewise fluctuates as per the method of delivery (e.g. Oral or Tablet) depicted in the table beneath.
Condition
Dosage
Administration
Type 2 Diabetes
, 1.25 mg, 2.5 mg, 1.5 mg, 3.0 mg, 6.0 mg, 5.0 mg, 6.0 mg/mL, 0.6 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Gestational Diabetes Mellitus
, 1.25 mg, 2.5 mg, 1.5 mg, 3.0 mg, 6.0 mg, 5.0 mg, 6.0 mg/mL, 0.6 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Glycemic Control
, 1.25 mg, 2.5 mg, 1.5 mg, 3.0 mg, 6.0 mg, 5.0 mg, 6.0 mg/mL, 0.6 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral

Warnings

Glyburide has six recognized contraindications which means it should be avoided if any of the conditions named in the table below are present.Glyburide Contraindications
Condition
Risk Level
Notes
Type 1 Diabetes
Do Not Combine
Acidosis
Do Not Combine
Comatose
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Glyburide may interact with Pulse Frequency
There are 20 known major drug interactions with Glyburide.
Common Glyburide Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Glyburide.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Glyburide.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Glyburide.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Glyburide.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Glyburide.
Glyburide Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats has been found to be greater than 3200mg/kg, in mice is greater than 1500mg/kg, in rabbits is greater than 10,000mg/kg, and in guinea pigs is greater than 1500mg/kg. Those who overdose may develop low blood sugar levels. Mild cases can be treated with oral glucose and changes to drug doses or meal schedules. Severe hypoglycemia can cause coma, seizure, or other neurological issues and requires immediate hospital treatment with intravenous glucose and monitoring for 24-48 hours.
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Glyburide Novel Uses: Which Conditions Have a Clinical Trial Featuring Glyburide?

At present, there are 196 active studies exploring the potential of Glyburide to ameliorate Gestational Diabetes, Glycemic Control and Type 2 Diabetes.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
177 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Gestational Diabetes Mellitus
33 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 3, Early Phase 1
Glycemic Control
2 Actively Recruiting
Not Applicable

Glyburide Reviews: What are patients saying about Glyburide?

5Patient Review
12/22/2012
Glyburide for Type 2 Diabetes Mellitus
I only used this treatment for a short time, but it worked better than the other medication I was taking (glipizide).
5Patient Review
10/16/2013
Glyburide for Type 2 Diabetes Mellitus
Gly-Buride in combination with Metformin ER has been much more effective for me in lowering my blood sugar than just Metformin ER alone.
5Patient Review
2/28/2014
Glyburide for Type 2 Diabetes Mellitus
This medication is excellent at regulating my blood sugar levels.
5Patient Review
3/13/2014
Glyburide for Type 2 Diabetes Mellitus
I've only been using this treatment for two days, but my sugar levels have already lowered by 70 points. So far, so good!
4.3Patient Review
9/12/2012
Glyburide for Type 2 Diabetes Mellitus
Sometimes I have issues with hypoglycemia.
View All Reviews
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Patient Q&A Section about glyburide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of glyburide?

"diarrhea, dizziness, headache, heartburn, nausea, gas, weight gain"

Answered by AI

What is glyburide used for?

"Glyburide is used to treat high blood sugar levels caused by type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream."

Answered by AI

Is glyburide the same as metformin?

"Glyburide helps your pancreas release more insulin into the bloodstream. Metformin reduces the amount of sugar absorbed from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better. This medicine is available only with a doctor's prescription."

Answered by AI

What type of drug is glyburide?

"Glyburide is a type of drug called a sulfonylurea. It lowers blood sugar by causing the release of insulin from your body."

Answered by AI

Clinical Trials for Glyburide

Have you considered Glyburide clinical trials? We made a collection of clinical trials featuring Glyburide, we think they might fit your search criteria.
Have you considered Glyburide clinical trials? We made a collection of clinical trials featuring Glyburide, we think they might fit your search criteria.
Have you considered Glyburide clinical trials? We made a collection of clinical trials featuring Glyburide, we think they might fit your search criteria.
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