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What is Glucovance
GlyburideThe Generic name of this drug
Treatment SummaryMetformin is a medication used to treat type 2 diabetes. It helps lower blood sugar levels without causing hypoglycemia. Metformin also helps reduce insulin resistance and fasting insulin levels, which can lead to modest weight loss. It was first approved in Canada in 1972 and in the US in 1995 and is available in regular and extended-release forms. It is now used by over 120 million people worldwide and is the drug of choice for obese type II diabetes patients.
Micronaseis the brand name
Glucovance Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Micronase
Glyburide
1984
341
Approved as Treatment by the FDA
Glyburide, also known as Micronase, is approved by the FDA for 3 uses which include Type 2 Diabetes Mellitus and Type 2 Diabetes .Type 2 Diabetes Mellitus
Helps manage Type 2 Diabetes Mellitus
Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Glycemic Control
Used to treat Glycemic Control in combination with Metformin
Effectiveness
How Glucovance Affects PatientsInsulin is a hormone that helps keep blood sugar levels in check for those with type 2 diabetes. When the pancreas can no longer keep up with this, the body becomes resistant to insulin, leading to high levels of sugar in the blood. Metformin works by reducing the amount of sugar the liver produces, cutting down on how much sugar is absorbed from food, and increasing the body's sensitivity to insulin. Unlike other drugs used to treat diabetes, Metformin does not cause high levels of insulin in the body. In a study of 29 weeks, Metformin was found to reduce fasting blood sugar levels by an average of
How Glucovance works in the bodyMetformin works in various ways to reduce blood sugar levels in people with Type 2 diabetes. It decreases the amount of sugar made in the liver, stops sugar from being absorbed in the intestines, and increases the body's sensitivity to insulin. Metformin is taken up by cells and mitochondria due to its positive charge. This helps it inhibit mitochondrial complex I activity which leads to an increase in cell ADP and AMP levels. This then activates an enzyme called AMP-activated protein kinase (AMPK) which helps regulate glucose metabolism. AMPK also inhibits the enzyme fructose-1,6-bisphosphatase
When to interrupt dosage
The suggested dosage of Glucovance is dependent upon the diagnosed affliction, for example, Diet, inadequate answer to metformin and Diabetic Ketoacidosis. The amount of dosage fluctuates depending on the method of delivery (e.g. Oral or Tablet - Oral) as detailed in the following table.Condition
Dosage
Administration
Type 2 Diabetes
, 1.25 mg, 2.5 mg, 1.5 mg, 3.0 mg, 6.0 mg, 5.0 mg, 6.0 mg/mL, 0.6 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Gestational Diabetes Mellitus
, 1.25 mg, 2.5 mg, 1.5 mg, 3.0 mg, 6.0 mg, 5.0 mg, 6.0 mg/mL, 0.6 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Glycemic Control
, 1.25 mg, 2.5 mg, 1.5 mg, 3.0 mg, 6.0 mg, 5.0 mg, 6.0 mg/mL, 0.6 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Warnings
Glucovance ContraindicationsCondition
Risk Level
Notes
Type 1 Diabetes
Do Not Combine
Acidosis
Do Not Combine
Comatose
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Glyburide may interact with Pulse Frequency
Common Glucovance Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Glyburide.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Glyburide.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Glyburide.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Glyburide.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Glyburide.
Glucovance Toxicity & Overdose RiskMetformin has an oral LD50 of 1g/kg in rats, 500mg/kg when given intraperitoneally, and 300mg/kg when given subcutaneously. In mice, the oral LD50 is 1450mg/kg, the intraperitoneal LD50 is 420mg/kg, and the subcutaneous LD50 is 225mg/kg. Taking too much metformin may lead to lactic acidosis, which is characterized by high levels of lactate in the blood, acidosis, and a high lactate to pyruvate ratio. Risk factors for lactic acidosis include
Glucovance Novel Uses: Which Conditions Have a Clinical Trial Featuring Glucovance?
346 active clinical trials are currently examining the potential of Glucovance to mitigate Type 2 Diabetes, Type 1 Diabetes and suboptimal response to metformin therapy.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
175 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Gestational Diabetes Mellitus
33 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 3, Early Phase 1
Glycemic Control
2 Actively Recruiting
Not Applicable
Glucovance Reviews: What are patients saying about Glucovance?
5Patient Review
9/16/2010 I appreciate that I only have to take one medication instead of two. It's easy to remember the 12 hour interval, and I find that it really works well for me.
5Patient Review
5/23/2015 I've been taking this medication for a while now, and it has effectively lowered my blood sugar levels. Before starting the medication, my blood sugar was over 300. Now, it hovers around 125.
5Patient Review
11/23/2008 Metformin has been a godsend for me. It helps me so much in keeping my blood sugar levels under control, and I know that I can always rely on it if I have an occasional slip-up.
5Patient Review
12/13/2010 This treatment has helped me regulate my blood sugar levels with no adverse effects.
5Patient Review
8/18/2008Patient Q&A Section about glucovance
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Glucovance used for?
"It helps your pancreas produce more insulin. Metformin belongs to the class of drugs known as biguanides. It helps to control blood sugar by decreasing sugar production and increasing sugar uptake by cells.
This combination medication, which includes glyburide and metformin, is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. This product may also be used with other diabetes medications."
Answered by AI
When should Glucovance be taken?
"You should take Glucovance before you eat, to lower the odds of getting an upset stomach or experiencing hypoglycemia. Try to take your medication at the same time each day for the best results."
Answered by AI
What is the generic for Glucovance?
"Glucomance is a medication used to improve blood sugar in adults with type 2 diabetes."
Answered by AI
What is the difference between metformin and Glucovance?
"Brand names for Glucovance include Glyset and Micronase.
The medications Metformin and Glucovance (glyburide/metformin) are used to treat type 2 diabetes in adults and children. Glucovance contains metoformin along with another medication, glyburide. The brand names for Metformin include Glucophage, Glucophage XR, Glumetza, Fortamet, and Riomet. The brand names for Glucovance include Glyset and Micronase."
Answered by AI
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