Glucovance

Glycemic Control, Type 2 Diabetes, Gestational Diabetes Mellitus
Treatment
3 FDA approvals
20 Active Studies for Glucovance

What is Glucovance

GlyburideThe Generic name of this drug
Treatment SummaryMetformin is a medication used to treat type 2 diabetes. It helps lower blood sugar levels without causing hypoglycemia. Metformin also helps reduce insulin resistance and fasting insulin levels, which can lead to modest weight loss. It was first approved in Canada in 1972 and in the US in 1995 and is available in regular and extended-release forms. It is now used by over 120 million people worldwide and is the drug of choice for obese type II diabetes patients.
Micronaseis the brand name
image of different drug pills on a surface
Glucovance Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Micronase
Glyburide
1984
341

Approved as Treatment by the FDA

Glyburide, also known as Micronase, is approved by the FDA for 3 uses which include Type 2 Diabetes Mellitus and Type 2 Diabetes .
Type 2 Diabetes Mellitus
Helps manage Type 2 Diabetes Mellitus
Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Glycemic Control
Used to treat Glycemic Control in combination with Metformin

Effectiveness

How Glucovance Affects PatientsInsulin is a hormone that helps keep blood sugar levels in check for those with type 2 diabetes. When the pancreas can no longer keep up with this, the body becomes resistant to insulin, leading to high levels of sugar in the blood. Metformin works by reducing the amount of sugar the liver produces, cutting down on how much sugar is absorbed from food, and increasing the body's sensitivity to insulin. Unlike other drugs used to treat diabetes, Metformin does not cause high levels of insulin in the body. In a study of 29 weeks, Metformin was found to reduce fasting blood sugar levels by an average of
How Glucovance works in the bodyMetformin works in various ways to reduce blood sugar levels in people with Type 2 diabetes. It decreases the amount of sugar made in the liver, stops sugar from being absorbed in the intestines, and increases the body's sensitivity to insulin. Metformin is taken up by cells and mitochondria due to its positive charge. This helps it inhibit mitochondrial complex I activity which leads to an increase in cell ADP and AMP levels. This then activates an enzyme called AMP-activated protein kinase (AMPK) which helps regulate glucose metabolism. AMPK also inhibits the enzyme fructose-1,6-bisphosphatase

When to interrupt dosage

The suggested dosage of Glucovance is dependent upon the diagnosed affliction, for example, Diet, inadequate answer to metformin and Diabetic Ketoacidosis. The amount of dosage fluctuates depending on the method of delivery (e.g. Oral or Tablet - Oral) as detailed in the following table.
Condition
Dosage
Administration
Type 2 Diabetes
, 1.25 mg, 2.5 mg, 1.5 mg, 3.0 mg, 6.0 mg, 5.0 mg, 6.0 mg/mL, 0.6 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Gestational Diabetes Mellitus
, 1.25 mg, 2.5 mg, 1.5 mg, 3.0 mg, 6.0 mg, 5.0 mg, 6.0 mg/mL, 0.6 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral
Glycemic Control
, 1.25 mg, 2.5 mg, 1.5 mg, 3.0 mg, 6.0 mg, 5.0 mg, 6.0 mg/mL, 0.6 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral

Warnings

Glucovance Contraindications
Condition
Risk Level
Notes
Type 1 Diabetes
Do Not Combine
Acidosis
Do Not Combine
Comatose
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Glyburide may interact with Pulse Frequency
There are 20 known major drug interactions with Glucovance.
Common Glucovance Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Glyburide.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Glyburide.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Glyburide.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Glyburide.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Glyburide.
Glucovance Toxicity & Overdose RiskMetformin has an oral LD50 of 1g/kg in rats, 500mg/kg when given intraperitoneally, and 300mg/kg when given subcutaneously. In mice, the oral LD50 is 1450mg/kg, the intraperitoneal LD50 is 420mg/kg, and the subcutaneous LD50 is 225mg/kg. Taking too much metformin may lead to lactic acidosis, which is characterized by high levels of lactate in the blood, acidosis, and a high lactate to pyruvate ratio. Risk factors for lactic acidosis include
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Glucovance Novel Uses: Which Conditions Have a Clinical Trial Featuring Glucovance?

346 active clinical trials are currently examining the potential of Glucovance to mitigate Type 2 Diabetes, Type 1 Diabetes and suboptimal response to metformin therapy.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
165 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Gestational Diabetes Mellitus
27 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Early Phase 1
Glycemic Control
4 Actively Recruiting
Not Applicable

Glucovance Reviews: What are patients saying about Glucovance?

5Patient Review
9/16/2010
Glucovance for Type 2 Diabetes Mellitus
I appreciate that I only have to take one medication instead of two. It's easy to remember the 12 hour interval, and I find that it really works well for me.
5Patient Review
5/23/2015
Glucovance for Type 2 Diabetes Mellitus
I've been taking this medication for a while now, and it has effectively lowered my blood sugar levels. Before starting the medication, my blood sugar was over 300. Now, it hovers around 125.
5Patient Review
11/23/2008
Glucovance for Type 2 Diabetes Mellitus
Metformin has been a godsend for me. It helps me so much in keeping my blood sugar levels under control, and I know that I can always rely on it if I have an occasional slip-up.
5Patient Review
12/13/2010
Glucovance for Type 2 Diabetes Mellitus
This treatment has helped me regulate my blood sugar levels with no adverse effects.
5Patient Review
8/18/2008
Glucovance for Type 2 Diabetes Mellitus
5Patient Review
8/20/2008
Glucovance for Type 2 Diabetes Mellitus
4.7Patient Review
11/4/2008
Glucovance for Type 2 Diabetes Mellitus
4.3Patient Review
2/9/2014
Glucovance for Type 2 Diabetes Mellitus
I found that this treatment improved my control over blood sugar levels.
4.3Patient Review
4/22/2010
Glucovance for Type 2 Diabetes Mellitus
Though this medicine was very effective in controlling my blood sugar levels, the side effects were unfortunately too much for me to handle. Severe pain and bloating made it impossible to continue taking after just a few days.
4Patient Review
6/22/2009
Glucovance for Type 2 Diabetes Mellitus
I've been on this medication for 8 years now, and it's been working great. As long as I take it every 12 hours, my sugar levels stay pretty level. Recently I had to start taking Januvia in the mornings as well, but diet is still the biggest factor by far. I can have the occasional sweet treat, but it's not usually worth the blood sugar spike. And of course, exercise is always important too.
4Patient Review
3/23/2009
Glucovance for Type 2 Diabetes Mellitus
I've been using this stuff twice a day for the past week, and it works pretty well.
3.7Patient Review
1/19/2013
Glucovance for Type 2 Diabetes Mellitus
This has been successful in lowering my blood sugar levels.
3.3Patient Review
4/21/2011
Glucovance for Type 2 Diabetes Mellitus
I've been on this medication for a month now and the gastrointestinal side effects are really bad. I'm constantly dealing with diarrhea, bloating, and gas that feels out of control. Not sure how other people function while taking this medication.
3.3Patient Review
10/28/2008
Glucovance for Type 2 Diabetes Mellitus
3Patient Review
2/24/2012
Glucovance for Type 2 Diabetes Mellitus
This treatment was effective for me for about three years, and then it stopped working.
3Patient Review
2/15/2010
Glucovance for Type 2 Diabetes Mellitus
I had some strange dreams while taking this medication, but they didn't bother me too much.
2.3Patient Review
11/27/2010
Glucovance for Type 2 Diabetes Mellitus
I was disappointed with this treatment, as it didn't do much to relieve the gas build-up in my abdomen.
2.3Patient Review
9/4/2014
Glucovance for Type 2 Diabetes Mellitus
I developed a seriously itchy rash, as well as discoloration and burning of the skin.
1Patient Review
6/23/2010
Glucovance for Type 2 Diabetes Mellitus
I have reduced my medication because of high amounts of exercise. I need to take 1/2 of dosage of 1.25/250 so I cut tablets. However, the brand name is no longer manufactured. I can't take generic - I get wheezing, mucus, nasal swelling and cough from probably the coating or other stuff in pill.
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Patient Q&A Section about glucovance

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Glucovance used for?

"It helps your pancreas produce more insulin. Metformin belongs to the class of drugs known as biguanides. It helps to control blood sugar by decreasing sugar production and increasing sugar uptake by cells.

This combination medication, which includes glyburide and metformin, is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. This product may also be used with other diabetes medications."

Answered by AI

When should Glucovance be taken?

"You should take Glucovance before you eat, to lower the odds of getting an upset stomach or experiencing hypoglycemia. Try to take your medication at the same time each day for the best results."

Answered by AI

What is the generic for Glucovance?

"Glucomance is a medication used to improve blood sugar in adults with type 2 diabetes."

Answered by AI

What is the difference between metformin and Glucovance?

"Brand names for Glucovance include Glyset and Micronase.

The medications Metformin and Glucovance (glyburide/metformin) are used to treat type 2 diabetes in adults and children. Glucovance contains metoformin along with another medication, glyburide. The brand names for Metformin include Glucophage, Glucophage XR, Glumetza, Fortamet, and Riomet. The brand names for Glucovance include Glyset and Micronase."

Answered by AI

Clinical Trials for Glucovance

Image of University of California, Los Angeles in Los Angeles, United States.

Tailored DPP for Prediabetes

17 - 25
All Sexes
Los Angeles, CA
The goal of this study is to enhance reach and uptake of diabetes prevention among young adults, with a focus on recruiting underserved and high-need students who face additional challenges, including food and financial insecurity. The specific aims are: Aim 1 - Evaluate the efficacy of an AYA-tailored version of the UC DPP for mitigating type 2 diabetes risk (i.e., weight change) in a pre/post pilot trial. The investigators hypothesize that the AYA-tailored intervention will be effective at producing 5% weight loss from baseline to program completion (at 9-months). Aim 2 - Assess the feasibility and acceptability of an AYA-tailored version of the UC DPP program. The investigators hypothesize that it will be feasible to recruit the desired number of participants given proposed innovative outreach strategies, and that the AYA-tailored intervention will be deemed acceptable to participants both qualitatively and in regards to their retention in the program at rates similar to the larger UC DPP. The investigators will recruit 80 UCLA undergraduate students. Participants will be asked to complete a brief screening online form to assess eligibility and to collect contact information. The PI and/or Research Assistants (RAs) will reach out to eligible participants to obtain informed consent and enroll them in the pilot trial. The investigators will randomize participants to the tailored DPP cohort vs control cohort. Control participants will be offered the opportunity to participate in the tailored DPP in the following academic year. The tailored DPP intervention will be online and asynchronously. Participants will be asked to complete the intervention lessons on their own time. Each lesson typically takes on average 15 minutes to complete. Control group will receive each intervention materials via e-mail for participants to review on their own time and will receive acceptability surveys. The interventions for the control group will be remote. A research assistant will meet with control participants via Zoom to explain the intervention materials. Control group will receive access to a study habits intervention, alcohol use intervention, and financial literacy intervention. At the end of each quarter (Fall, Winter, and Spring), both control and intervention participants will receive an email with a unique link to a brief REDCap survey to ascertain acceptability of sessions/lessons. Furthermore, participants will complete baseline and 9-month follow-up assessments. Participants will complete a 30 minute questionnaire and height/weight measurements will be collected by a RA. Participants will be asked to self-report weight and physical activity at the end of the fall and winter quarter; data will be collected via brief REDCap survey.
Recruiting
Has No Placebo
University of California, Los AngelesLauren E Wisk, PhD
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PATAS for Type 2 Diabetes

18 - 55
All Sexes
Cincinnati, OH
The primary objective of Part 1 of this study is to evaluate safety and tolerability of single subcutaneous (SC) doses of PATAS in healthy subjects. The secondary objective of Part 1 of this study is to determine the pharmacokinetics (PK) of single SC doses of PATAS in healthy subjects. The primary objectives of Part 2 of this study are to evaluate the safety and tolerability of 4 weekly SC doses of PATAS in subjects with T2D; and to determine the PK and pharmacodynamics (PD) of 4 weekly SC doses of PATAS in subjects with T2D. The secondary objectives of Part 2 of this study are to evaluate the potential effect of multiple SC doses of PATAS on markers of glycemic control, as measured by glucose levels, insulin levels, and other metabolomic biomarkers; and to characterize the adverse event (AE) profiles of the various dose levels of PATAS.
Phase 1
Waitlist Available
Medpace Clinical Pharmaology UnitVincent Marion, Ph.D.AdipoPharma LLC
Image of The Worship Center Cristian Church in Birmingham, United States.

Black Impact for Heart Health

18+
Male
Birmingham, AL
The goal of this clinical trial is to evaluate the implementation and effectiveness of the Black Impact program-a church-based cardiovascular health (CVH) intervention-in Black men aged 35-70 who are at risk for heart disease, diabetes, obesity, and related conditions. The main questions this study aims to answer are: * Does participation in the Black Impact program improve cardiovascular health metrics (e.g., blood pressure, cholesterol, blood sugar) and health behaviors among Black men at The Worship Center Christian Church (TWC)? * What factors influence the adoption, delivery, and sustainability of the Black Impact program in a faith-based setting? Researchers will compare an immediate-start intervention group and a delayed-start (waitlist control) group to assess both short-term health outcomes and program implementation factors. Participants will: * Attend a 90-minute weekly session for 24 weeks, including 45 minutes of physical activity led by a certified trainer and 45 minutes of health education delivered by trained coaches. * Receive one-on-one support from a community health worker to reduce barriers to care and engage with primary care. * Complete biometric health screenings and surveys at baseline, 12 weeks, and 24 weeks to assess clinical and behavioral outcomes. * Use a smartwatch, blood pressure cuff, and other tools to track progress in real time. * Participate in exit focus groups or interviews to share feedback about the intervention. * A subset of TWC leaders and interventionists (N=15) will also be interviewed to assess implementation, resource needs, and sustainability. This study uses the RE-AIM framework to assess Reach, Effectiveness, Adoption, Implementation, and Maintenance, and aims to inform scalable strategies for improving CVH among Black men in trusted community settings.
Waitlist Available
Has No Placebo
The Worship Center Cristian Church
Have you considered Glucovance clinical trials? We made a collection of clinical trials featuring Glucovance, we think they might fit your search criteria.Go to Trials
Have you considered Glucovance clinical trials? We made a collection of clinical trials featuring Glucovance, we think they might fit your search criteria.Go to Trials
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Continuous vs Finger-stick Glucose Monitoring for Type 2 Diabetes in Pregnancy

18+
Female
Sewell, NJ
The purpose of this study is to compare patient adherence to blood sugar monitoring during pregnancy using two different measurement methods in pregnancies complicated by pregestational type 2 diabetes (T2DM). Pregnant patients with T2DM are at risk of having larger babies, babies with low sugar levels in the first 24 hours of life, higher rates of cesarean delivery, stillbirth (death of baby inside the womb), and hypertensive or high blood pressure disorders of pregnancy, such as preeclampsia. Prior studies have shown that treating high blood sugars in pregnancy with medications can reduce these risks. To determine the amount of medication needed, recording of blood sugar levels is necessary. This trial aims to determine whether continuous blood sugar monitors have improved patient recording of blood sugar levels over finger stick blood sugar measurements. Patients involved in the study will be assigned to either: 1. Fingerstick glucose monitoring (FSG) 2. Continuous glucose monitoring (CGM) Patients will be randomize in a 1:1 ratio. FSG Group: blood sugar is tested four times daily - once fasting and two hours after every meal (post-prandial). Blood will be tested using a glucometer, and values will be recorded in a blood sugar log from the time of enrollment to the time of delivery. CGM Group: A CGM sensor will be placed on the patient's arm for blood sugar collection every 3-5 minutes. This data is sent to a phone application from the time of enrollment to the time of delivery. These sensors will need to be replaced every 14 days. Percent adherence will be recorded from the time you were randomized to a study group until delivery.
Recruiting
Has No Placebo
Jefferson Health New Jersey (+1 Sites)
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Health Coaching for Type 2 Diabetes and Mental Health

18+
All Sexes
Hamilton, Canada
Managing both type 2 diabetes and mental health challenges can be difficult, and many people do not receive care that supports both. This study looks at how virtual health coaching and support from interdisciplinary care teams can help people better manage their health. The purpose of this study is to test the effectiveness of a virtual health coaching program for adults living with type 2 diabetes and mental health challenges compared to usual care. The Technology-Enabled Collaborative Care for type 2 Diabetes and Mental health (TECC-DM) program includes weekly coaching calls, support from an interdisciplinary care team, and online tools to aid self-management. The findings from this study will be used to help improve services for people who have type 2 diabetes and co-occurring mental health symptoms.
Waitlist Available
Has No Placebo
McMaster UniversityCarly Whitmore, RN PhD
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