Your session is about to expire
What is Gelnique
OxybutyninThe Generic name of this drug
Treatment SummaryOxybutynin, also known as Ditropan XL, is a medication used to treat the symptoms of overactive bladder (OAB), such as frequent urination, urgency, and nocturia. It was approved by the FDA in 1975 and is often the first line of therapy for OAB. Oxybutynin helps to relieve the uncomfortable and embarrassing symptoms associated with OAB and can improve a patient’s quality of life.
Ditropanis the brand name
Gelnique Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ditropan
Oxybutynin
1975
256
Effectiveness
How Gelnique Affects PatientsOxybutynin helps to reduce the uncomfortable symptoms of overactive bladder, like feeling a strong urge to go to the bathroom and going to the bathroom often. It does this by blocking certain receptors in the bladder. However, it can also cause serious side effects like angioedema and anticholinergic effects like hallucinations, confusion, agitation, and drowsiness. If you experience any of these symptoms, stop taking oxybutynin and get medical help right away. It is also recommended to avoid operating heavy machinery until your response to oxybutynin has been monitored. Your doctor may need to adjust your dosage.
How Gelnique works in the bodyOxybutynin relaxes the bladder muscle by blocking the effects of acetylcholine. This leads to an increased capacity for urine in the bladder and a decrease in the frequency and urgency of urination. The active form of oxybutynin is metabolized into N-desethyloxybutynin, which targets muscarinic receptors in the bladder and helps to achieve these effects.
When to interrupt dosage
The endorsed dose of Gelnique is contingent upon the observed condition, including Neurological Disorders, Foley Catheterization and Nocturia. The measure of dosage deviates, as per the technique of delivery (e.g. Tablet, extended release or Patch) mentioned in the table beneath.Condition
Dosage
Administration
Nocturia
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Longterm Indwelling Ureteral Stent
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Overactive Bladder Syndrome
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Spina Bifida
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Urinary Urgency
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Urinary Urge Incontinence
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Detrusor Hyperreflexia
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Bladder Spasms
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Neurological Disorders
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
increased frequency of urination
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Foley Catheterization
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Warnings
Gelnique has four contraindications and should be avoided with the circumstances listed in the following table.Gelnique ContraindicationsCondition
Risk Level
Notes
Urinary Retention
Do Not Combine
uncontrolled narrow-angle glaucoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Oxybutynin may interact with Pulse Frequency
Gastric Retention
Do Not Combine
Common Gelnique Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Oxybutynin.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Oxybutynin.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Oxybutynin is combined with Aclidinium.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Oxybutynin.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Oxybutynin.
Gelnique Toxicity & Overdose RiskThe toxic dose of oxybutynin in rats is 460 mg/kg. Signs of an overdose may include confusion, fever, heart palpitations, abnormal heart rhythms, difficulty urinating, trouble breathing, and coma. If someone overdoses on oxybutynin, they should receive supportive care right away and be given activated charcoal and a laxative. Two people have overdosed on a 100mg dose of oxybutynin while also drinking alcohol; they both recovered with supportive treatment.
Gelnique Novel Uses: Which Conditions Have a Clinical Trial Featuring Gelnique?
The efficacy of Gelnique is being explored in 79 active trials for the treatment of Overactive Bladder Syndrome, Foley Catheterization and Neurological Disorders.Condition
Clinical Trials
Trial Phases
Nocturia
6 Actively Recruiting
Phase 4, Not Applicable
Spina Bifida
15 Actively Recruiting
Not Applicable
Overactive Bladder Syndrome
32 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2
increased frequency of urination
2 Actively Recruiting
Phase 4, Not Applicable
Longterm Indwelling Ureteral Stent
0 Actively Recruiting
Urinary Urge Incontinence
15 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Urinary Urgency
3 Actively Recruiting
Phase 4, Phase 1, Not Applicable
Detrusor Hyperreflexia
0 Actively Recruiting
Foley Catheterization
0 Actively Recruiting
Bladder Spasms
1 Actively Recruiting
Phase 1
Neurological Disorders
6 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Gelnique Reviews: What are patients saying about Gelnique?
5Patient Review
8/4/2011 Though this drug was highly effective in treating OAB, the "dry mouth" side effect became increasingly intolerable over time. Eventually, I stopped producing saliva entirely. This made me realize just how important saliva is! I'm now exploring other options with my doctor.
5Patient Review
2/7/2013 I'm satisfied with this product, but it does unfortunately exacerbate my chronic dry eye. I'm currently using the 10% packets, but I might switch to the 3% to see if that still has the same effectiveness without as much drying.
5Patient Review
10/15/2011 I experienced some dizziness and drowsiness, as well as constipation. However, I was able to manage these side effects by drinking plenty of water and eating lots of fruit.
5Patient Review
7/20/2014 Even though it's expensive, this is a great treatment.
4.7Patient Review
11/6/2011 Gelnique made my bladder feel a bit uncomfortable, but it did decrease the amount of times I had to go. I might try it again and see if there's any difference. It can be quite messy, though.
4.7Patient Review
7/8/20114.3Patient Review
12/27/2012 I love the effects of this drug/delivery system, but develop a rash on all of the treatment areas, despite the fact that I rotate them daily to try and lessen the effect. The rash is small itchy bumps. Insurance doesn't cover the $200/mo cost, so I can't use it every month.
4.3Patient Review
7/31/2011 I've been using this medication for two months now and it's really helped. I originally took it every day, but found that it was more effective and comfortable to take it every three days. After one month of use, my symptoms were alleviated by 90%!
4Patient Review
3/27/2014 Gelnique was by far the most effective OAB medication I've tried, RX or OTC. The only downside was that it caused extreme dry mouth for me, to the point where I had to buy Biotene products. On occasion, it also made it hard for me to fall asleep at bedtime. However, due to being a newer drug, my out of pocket cost was $100/month. Being on Medicare and a fixed income, I had to stop taking it as couldn't afford it. Now, I'm looking into injections for OAB treatment options since they may be more affordable..
3.7Patient Review
5/16/2012 I used this medication a few years ago and it worked great with no noticeable side effects. I started taking it again a couple months ago and my symptoms improved, but then I started feeling dizzy and nauseous to the point where I couldn't function. I stopped taking the medication 10 days ago and I'm back to normal now.
3.7Patient Review
7/23/20113.7Patient Review
10/17/2011 I tried this treatment but unfortunately it caused more problems with constipation so I had to stop.
3.3Patient Review
9/5/2016 The lower concentration pump gel worked great for me, but it was discontinued. The 10% packets are not nearly as effective; they don't absorb well and don't seem to work at all. I've only been using them for a week, so there's a chance they might improve, but I doubt it. The out-of-pocket expense is also quite high for such an ineffective product.
2.7Patient Review
8/15/2014 I've been using Gelnique for over two months now, and while it did help a little bit, my doctor added Sanctura. I'm now back to feeling like I'm not using anything at all. After trying everything else, my only options now are the implant, Botox, or acupuncture.
2.7Patient Review
6/18/2012 At first, I was convinced this would help me. And it did—for a little while. It became less effective the more I used it, though, so my doctor switched me to Enablex. I've tried a lot of different treatments and medications, but none of them seem to work in the long run.
2Patient Review
5/17/2015 This didn't quite work for me the way I wanted it to. It was also pretty messy and annoying to apply.
1.7Patient Review
11/3/2011 I find that the gel is not nearly as effective now as it was when I first started using it. Blurred vision and headaches are common side effects for me, and my mouth has been incredibly dry since starting this treatment.
1.3Patient Review
9/4/2011 The dry mouth is a big problem for me..........I hope I can find a way to overcome it.
Patient Q&A Section about gelnique
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Gelnique used for?
"Gelnique is an over-the-counter gel used to treat overactive bladder. The gel can be transferred to other people through close skin-to-skin contact and can cause irritating skin reactions."
Answered by AI
How do you apply Gelnique?
"Do not apply GELNIQUE to open sores, recently shaved skin, or skin with rashes. Apply to dry intact skin on your stomach (abdomen), upper arms, shoulders, or thighs. Change your application site every day."
Answered by AI
Is oxybutynin used for anxiety?
"Patients with HH who experienced improvements in sweating immediately after treatment with oxybutynin exhibited small, significant improvements in their levels of depression and anxiety, as well as their quality of life."
Answered by AI
How do you use oxybutynin gel?
"Make sure to wash your hands with soap and water before and after applying this gel. Apply it to clean, dry, unbroken skin on the abdomen, upper arms, shoulders, or thighs. Rub the gel gently into the skin until it dries."
Answered by AI