Gelnique

Nocturia, Urinary Bladder, Overactive, Neurological Disorders + 8 more

Treatment

20 Active Studies for Gelnique

What is Gelnique

Oxybutynin

The Generic name of this drug

Treatment Summary

Oxybutynin, also known as Ditropan XL, is a medication used to treat the symptoms of overactive bladder (OAB), such as frequent urination, urgency, and nocturia. It was approved by the FDA in 1975 and is often the first line of therapy for OAB. Oxybutynin helps to relieve the uncomfortable and embarrassing symptoms associated with OAB and can improve a patient’s quality of life.

Ditropan

is the brand name

image of different drug pills on a surface

Gelnique Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Ditropan

Oxybutynin

1975

256

Effectiveness

How Gelnique Affects Patients

Oxybutynin helps to reduce the uncomfortable symptoms of overactive bladder, like feeling a strong urge to go to the bathroom and going to the bathroom often. It does this by blocking certain receptors in the bladder. However, it can also cause serious side effects like angioedema and anticholinergic effects like hallucinations, confusion, agitation, and drowsiness. If you experience any of these symptoms, stop taking oxybutynin and get medical help right away. It is also recommended to avoid operating heavy machinery until your response to oxybutynin has been monitored. Your doctor may need to adjust your dosage.

How Gelnique works in the body

Oxybutynin relaxes the bladder muscle by blocking the effects of acetylcholine. This leads to an increased capacity for urine in the bladder and a decrease in the frequency and urgency of urination. The active form of oxybutynin is metabolized into N-desethyloxybutynin, which targets muscarinic receptors in the bladder and helps to achieve these effects.

When to interrupt dosage

The endorsed dose of Gelnique is contingent upon the observed condition, including Neurological Disorders, Foley Catheterization and Nocturia. The measure of dosage deviates, as per the technique of delivery (e.g. Tablet, extended release or Patch) mentioned in the table beneath.

Condition

Dosage

Administration

Spinal Dysraphism

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Urinary Bladder, Overactive

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Neurological Disorders

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

increased frequency of urination

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Foley Catheterization

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Longterm Indwelling Ureteral Stent

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Nocturia

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Bladder Spasms

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Urinary Urgency

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Urinary Incontinence, Urge

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Overactive Bladder Syndrome

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Warnings

Gelnique has four contraindications and should be avoided with the circumstances listed in the following table.

Gelnique Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Oxybutynin may interact with Pulse Frequency

Urinary Retention

Do Not Combine

uncontrolled narrow-angle glaucoma

Do Not Combine

Gastric Retention

Do Not Combine

There are 20 known major drug interactions with Gelnique.

Common Gelnique Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Oxybutynin.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Oxybutynin.

Aclidinium

Major

The risk or severity of adverse effects can be increased when Oxybutynin is combined with Aclidinium.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Oxybutynin.

Alpelisib

Major

The metabolism of Alpelisib can be decreased when combined with Oxybutynin.

Gelnique Toxicity & Overdose Risk

The toxic dose of oxybutynin in rats is 460 mg/kg. Signs of an overdose may include confusion, fever, heart palpitations, abnormal heart rhythms, difficulty urinating, trouble breathing, and coma. If someone overdoses on oxybutynin, they should receive supportive care right away and be given activated charcoal and a laxative. Two people have overdosed on a 100mg dose of oxybutynin while also drinking alcohol; they both recovered with supportive treatment.

image of a doctor in a lab doing drug, clinical research

Gelnique Novel Uses: Which Conditions Have a Clinical Trial Featuring Gelnique?

The efficacy of Gelnique is being explored in 79 active trials for the treatment of Overactive Bladder Syndrome, Foley Catheterization and Neurological Disorders.

Condition

Clinical Trials

Trial Phases

Nocturia

4 Actively Recruiting

Not Applicable, Phase 4

Bladder Spasms

1 Actively Recruiting

Phase 2

Spinal Dysraphism

0 Actively Recruiting

Urinary Incontinence, Urge

5 Actively Recruiting

Not Applicable, Phase 4

Foley Catheterization

0 Actively Recruiting

Urinary Urgency

2 Actively Recruiting

Not Applicable

Urinary Bladder, Overactive

0 Actively Recruiting

Overactive Bladder Syndrome

26 Actively Recruiting

Not Applicable, Phase 4, Phase 1, Phase 2, Phase 3

Longterm Indwelling Ureteral Stent

0 Actively Recruiting

Neurological Disorders

7 Actively Recruiting

Not Applicable, Phase 2

increased frequency of urination

3 Actively Recruiting

Not Applicable

Gelnique Reviews: What are patients saying about Gelnique?

5

Patient Review

8/4/2011

Gelnique for Urine Leakage When there is a Strong Desire to Void

Though this drug was highly effective in treating OAB, the "dry mouth" side effect became increasingly intolerable over time. Eventually, I stopped producing saliva entirely. This made me realize just how important saliva is! I'm now exploring other options with my doctor.

5

Patient Review

2/7/2013

Gelnique for Overactive Bladder

I'm satisfied with this product, but it does unfortunately exacerbate my chronic dry eye. I'm currently using the 10% packets, but I might switch to the 3% to see if that still has the same effectiveness without as much drying.

5

Patient Review

10/15/2011

Gelnique for Overactive Bladder

I experienced some dizziness and drowsiness, as well as constipation. However, I was able to manage these side effects by drinking plenty of water and eating lots of fruit.

5

Patient Review

7/20/2014

Gelnique for Overactive Bladder

Even though it's expensive, this is a great treatment.

4.7

Patient Review

11/6/2011

Gelnique for Urine Leakage When there is a Strong Desire to Void

Gelnique made my bladder feel a bit uncomfortable, but it did decrease the amount of times I had to go. I might try it again and see if there's any difference. It can be quite messy, though.

4.7

Patient Review

7/8/2011

Gelnique for Frequent Urination

4.3

Patient Review

12/27/2012

Gelnique for Overactive Bladder

I love the effects of this drug/delivery system, but develop a rash on all of the treatment areas, despite the fact that I rotate them daily to try and lessen the effect. The rash is small itchy bumps. Insurance doesn't cover the $200/mo cost, so I can't use it every month.

4.3

Patient Review

7/31/2011

Gelnique for Overactive Bladder

I've been using this medication for two months now and it's really helped. I originally took it every day, but found that it was more effective and comfortable to take it every three days. After one month of use, my symptoms were alleviated by 90%!

4

Patient Review

3/27/2014

Gelnique for Overactive Bladder

Gelnique was by far the most effective OAB medication I've tried, RX or OTC. The only downside was that it caused extreme dry mouth for me, to the point where I had to buy Biotene products. On occasion, it also made it hard for me to fall asleep at bedtime. However, due to being a newer drug, my out of pocket cost was $100/month. Being on Medicare and a fixed income, I had to stop taking it as couldn't afford it. Now, I'm looking into injections for OAB treatment options since they may be more affordable..

3.7

Patient Review

5/16/2012

Gelnique for Needing to Urinate Immediately

I used this medication a few years ago and it worked great with no noticeable side effects. I started taking it again a couple months ago and my symptoms improved, but then I started feeling dizzy and nauseous to the point where I couldn't function. I stopped taking the medication 10 days ago and I'm back to normal now.

3.7

Patient Review

7/23/2011

Gelnique for Overactive Bladder

3.7

Patient Review

10/17/2011

Gelnique for Urine Leakage When there is a Strong Desire to Void

I tried this treatment but unfortunately it caused more problems with constipation so I had to stop.

3.3

Patient Review

9/5/2016

Gelnique for A Condition of Bladder Dysfunction from Nerve Disorder

The lower concentration pump gel worked great for me, but it was discontinued. The 10% packets are not nearly as effective; they don't absorb well and don't seem to work at all. I've only been using them for a week, so there's a chance they might improve, but I doubt it. The out-of-pocket expense is also quite high for such an ineffective product.

2.7

Patient Review

8/15/2014

Gelnique for Needing to Urinate Immediately

I've been using Gelnique for over two months now, and while it did help a little bit, my doctor added Sanctura. I'm now back to feeling like I'm not using anything at all. After trying everything else, my only options now are the implant, Botox, or acupuncture.

2.7

Patient Review

6/18/2012

Gelnique for Needing to Urinate Immediately

At first, I was convinced this would help me. And it did—for a little while. It became less effective the more I used it, though, so my doctor switched me to Enablex. I've tried a lot of different treatments and medications, but none of them seem to work in the long run.

2

Patient Review

5/17/2015

Gelnique for Overactive Bladder

This didn't quite work for me the way I wanted it to. It was also pretty messy and annoying to apply.

1.7

Patient Review

11/3/2011

Gelnique for Frequent Urination

I find that the gel is not nearly as effective now as it was when I first started using it. Blurred vision and headaches are common side effects for me, and my mouth has been incredibly dry since starting this treatment.

1.3

Patient Review

9/4/2011

Gelnique for Needing to Urinate Immediately

The dry mouth is a big problem for me..........I hope I can find a way to overcome it.

Patient Q&A Section about gelnique

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Gelnique used for?

"Gelnique is an over-the-counter gel used to treat overactive bladder. The gel can be transferred to other people through close skin-to-skin contact and can cause irritating skin reactions."

Answered by AI

How do you apply Gelnique?

"Do not apply GELNIQUE to open sores, recently shaved skin, or skin with rashes. Apply to dry intact skin on your stomach (abdomen), upper arms, shoulders, or thighs. Change your application site every day."

Answered by AI

Is oxybutynin used for anxiety?

"Patients with HH who experienced improvements in sweating immediately after treatment with oxybutynin exhibited small, significant improvements in their levels of depression and anxiety, as well as their quality of life."

Answered by AI

How do you use oxybutynin gel?

"Make sure to wash your hands with soap and water before and after applying this gel. Apply it to clean, dry, unbroken skin on the abdomen, upper arms, shoulders, or thighs. Rub the gel gently into the skin until it dries."

Answered by AI

Clinical Trials for Gelnique

Image of Stanford Medicine Department of Obstetrics & Gynecology in Palo Alto, United States.

Detrusor Nerve Radiofrequency Ablation for Overactive Bladder

22 - 80
Female
Palo Alto, CA

The goal of this clinical trial is to learn if a vaginal radiofrequency (RF) device called MORPHEUSV works to treat overactive bladder (OAB) in women. Researchers also want to learn how safe the device is for this indication. This study will include women ages 22 to 80 who have had OAB symptoms for at least 6 months. The main questions it aims to answer are: Does the MORPHEUSV device lower the number of daily episodes of accidental urine leakage caused by urgency? Does it work better than a sham (placebo) treatment? Researchers will compare the MORPHEUSV device to a sham treatment to see how well it reduces symptoms of overactive bladder. Participants will: 1) Receive one session of either the MORPHEUSV or sham treatment. 2) Track their symptoms using a diary and questionnaires 3) Return for three to six follow-up visits over 12 months. This study is being conducted at multiple clinics in the United States.

Waitlist Available
Device

Stanford Medicine Department of Obstetrics & Gynecology (+10 Sites)

Mickey Karram, MD

InMode MD Ltd.

Have you considered Gelnique clinical trials?

We made a collection of clinical trials featuring Gelnique, we think they might fit your search criteria.
Go to Trials

Have you considered Gelnique clinical trials?

We made a collection of clinical trials featuring Gelnique, we think they might fit your search criteria.
Go to Trials
Image of Rossignol Medical Center in Phoenix, United States.

Photobiomodulation for Autism

4 - 12
All Sexes
Phoenix, AZ

For this study, the proposed intervention will be noninvasively delivered near infra-red (NIR) light - transcranial Photobiomodulation (tPBM) - to the brains of autistic children. This will occur, twice a week, for 10 weeks. The NIR light is delivered to specific brain areas by Cognilum, a wearable device developed by Jelikalite. The expected outcome is improved focus, improved eye contact, improved speech, improved behavior, and gains in functional skills. Cognilum may impact the clinical practice of treating autism. At the beginning, at five weeks, and at the end of study, the clinician will complete the CARS-2, SRS, CGI, and a caregiver interview; additionally, questionnaires will be administered to caregivers during one of the 1-hour weekly treatment sessions.

Phase 2
Recruiting

Rossignol Medical Center

Richard E Frye, M.D., Ph.D

Image of Mickey Karram MD in Corona Del Mar, United States.

Nerve Ablation for Overactive Bladder

21 - 80
Female
Corona Del Mar, CA

The goal of this Safety and efficacy of transvaginal Detrusor Nerve Ablation for treatment of overactive bladder symptoms, including refractory overactive bladder The main questions it aims to answer are: •Change from baseline to the end of treatment in a 3-day diary analysis to assess the reduction of urgency incontinence episodes. \[Time Frame: 3 months\] Subjects will undergo one treatment session and be reassessed at 4 weeks post-treatment. If less than a 50% improvement is noted, a second and third treatment session will be performed at 4-week intervals. If more than a 50% improvement is noted, patients will be followed longitudinally to assess the durability of the treatment. Investigators will have the ability to initiate a second and or third treatment on an individual basis. Follow-up will occur at 3- months, 6-months and 12 months after the subject's last treatment.

Waitlist Available
Has No Placebo

Mickey Karram MD (+2 Sites)

Mickey Karram, MD

InMode MD Ltd.

Have you considered Gelnique clinical trials?

We made a collection of clinical trials featuring Gelnique, we think they might fit your search criteria.
Go to Trials