Ezetimibe And Simvastatin

Coronary heart disease, prophylaxis of cardiovascular event, Diabetes + 11 more
Treatment
13 FDA approvals
20 Active Studies for Ezetimibe And Simvastatin

What is Ezetimibe And Simvastatin

SimvastatinThe Generic name of this drug
Treatment SummarySimvastatin, also known as Zocor, is a medication used to lower cholesterol levels and reduce the risk of cardiovascular disease. It belongs to a class of drugs called statins, which work by blocking a particular enzyme in the liver that is involved in cholesterol production. Statins are recommended for people with moderate to high risk of developing cardiovascular disease, like those with type 2 diabetes. Simvastatin is one of the most commonly prescribed statin drugs, along with atorvastatin, pravastatin, rosuvastatin, fluvastatin, and lovastatin. Studies have shown that stat
Zocoris the brand name
image of different drug pills on a surface
Ezetimibe And Simvastatin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zocor
Simvastatin
1991
620

Approved as Treatment by the FDA

Simvastatin, otherwise called Zocor, is approved by the FDA for 13 uses like Lipid-Lowering Therapy and Homozygous Familial Hypercholesterolemia .
Lipid-Lowering Therapy
Used to treat Lipid-Lowering Therapy in combination with Ezetimibe
Homozygous Familial Hypercholesterolemia
Used to treat Homozygous Familial Hypercholesterolaemia (HoFH) in combination with Ezetimibe
prophylaxis of cardiovascular event
Diabetes
cholesterol
Helps manage High Cholesterol
Hypercholesterolemia
Used to treat Heterozygous Familial Hypercholesterolemia (HeFH) in combination with Ezetimibe
Coronary heart disease
Peripheral Vascular Disease
Cerebrovascular Disorders
Diet
Used to treat Diet in combination with Ezetimibe
Physical Activity
Used to treat Exercise in combination with Ezetimibe
Mixed Hyperlipidemia
Used to treat Mixed Hyperlipidemia in combination with Ezetimibe
Cardiovascular Events

Effectiveness

How Ezetimibe And Simvastatin Affects PatientsSimvastatin is a medicine used to lower levels of total cholesterol, "bad" low-density lipoprotein (LDL) cholesterol, non-high density lipoprotein (non-HDL) cholesterol, triglycerides (TG), and apolipoprotein B (apoB) in the blood. High levels of these things are linked to a higher risk of heart disease and stroke. It also increases levels of "good" high-density lipoprotein (HDL) cholesterol, which is linked to a lower risk of cardiovascular disease. Taking Simvastatin has been shown to reduce the risk of cardiovascular disease and
How Ezetimibe And Simvastatin works in the bodySimvastatin works by blocking an enzyme in the liver that helps create cholesterol. When this enzyme is blocked, the liver takes up less cholesterol from the blood and makes less of it. Simvastatin also has additional benefits, including helping stabilize and protect blood vessels, reducing oxidative stress and inflammation, and preventing clot formation. Additionally, Simvastatin binds to a protein that helps regulate the movement of white blood cells and helps prevent them from getting too active.

When to interrupt dosage

The measure of Ezetimibe And Simvastatin is reliant upon the diagnosed condition, including Hypercholesterolemia, Diet and Type 2 Diabetes. The extent of dosage varies as per the administration technique outlined in the table beneath.
Condition
Dosage
Administration
Homozygous Familial Hypercholesterolemia
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Coronary heart disease
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
prophylaxis of cardiovascular event
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Diabetes
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Cardiovascular Events
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Lipid-Lowering Therapy
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Physical Activity
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Type 2 Diabetes
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
cholesterol
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Mixed Hyperlipidemia
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Diet
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Hypercholesterolemia
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Peripheral Vascular Disease
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Cerebrovascular Disorders
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular

Warnings

Ezetimibe And Simvastatin Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
active liver disease
Do Not Combine
There are 20 known major drug interactions with Ezetimibe And Simvastatin.
Common Ezetimibe And Simvastatin Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Simvastatin.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Simvastatin.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Simvastatin.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Simvastatin.
Axitinib
Major
The serum concentration of Axitinib can be increased when it is combined with Simvastatin.
image of a doctor in a lab doing drug, clinical research

Ezetimibe And Simvastatin Novel Uses: Which Conditions Have a Clinical Trial Featuring Ezetimibe And Simvastatin?

Presently, there are 756 active studies investigating the potential of Ezetimibe and Simvastatin to ameliorate Cerebrovascular Disorders, Type 2 Diabetes and Physical Activity.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
190 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
cholesterol
5 Actively Recruiting
Phase 3
Hypercholesterolemia
2 Actively Recruiting
Phase 3, Not Applicable
Mixed Hyperlipidemia
0 Actively Recruiting
Cerebrovascular Disorders
0 Actively Recruiting
Physical Activity
38 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Diet
3 Actively Recruiting
Not Applicable
Coronary heart disease
0 Actively Recruiting
Lipid-Lowering Therapy
0 Actively Recruiting
prophylaxis of cardiovascular event
0 Actively Recruiting
Diabetes
539 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4, Early Phase 1
Cardiovascular Events
3 Actively Recruiting
Not Applicable
Homozygous Familial Hypercholesterolemia
4 Actively Recruiting
Phase 3, Phase 2
Peripheral Vascular Disease
8 Actively Recruiting
Not Applicable, Phase 3

Ezetimibe And Simvastatin Reviews: What are patients saying about Ezetimibe And Simvastatin?

5Patient Review
11/8/2009
Ezetimibe And Simvastatin for High Cholesterol
I've been on cholesterol medication for 35 years now, and this is by far the best one I've tried. My readings are great - around 115 - and my LDL and HDL are well within the healthy range.
5Patient Review
9/27/2021
Ezetimibe And Simvastatin for High Cholesterol
I've been taking Vytorin for ten years now and it's the only statin that doesn't give me muscle pains. My levels stay well below average, and I haven't experienced any side effects that I know of. Although, sometimes it's hard to fall asleep at night, but I'm not sure if that has anything to do with the medication or not.
2.7Patient Review
3/28/2011
Ezetimibe And Simvastatin for Combined High Blood Cholesterol and Triglyceride Level
I'm finding it hard to sleep, does anyone else have this problem?
2.3Patient Review
11/12/2008
Ezetimibe And Simvastatin for High Cholesterol
I developed pain across both of my shoulders after starting to take this medication. The pain developed within two weeks.
2.3Patient Review
4/1/2008
Ezetimibe And Simvastatin for High Cholesterol
I was experiencing extreme muscle pain in my chest, right arm and back.
2Patient Review
9/29/2016
Ezetimibe And Simvastatin for High Cholesterol
I experienced a lot of stomach pain and gas while taking this pill, only after 12 days.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ezetimibe and simvastatin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can you take ezetimibe and simvastatin together?

"You may be at an increased risk for muscle injury and kidney problems if you take these medications with ezetimibe and simvastatin."

Answered by AI

What class of drug is ezetimibe and simvastatin?

"Ezetimibe is a cholesterol-lowering medication that can be used alone or in combination with a statin."

Answered by AI

What is the best time to take ezetimibe simvastatin?

"There is no time of day that is better to take ezetimibe, as it works the same whether taken in the morning, afternoon, or evening. Ezetimibe is taken once a day at the same time each day and can be taken with or without food."

Answered by AI

Why is simvastatin combined with ezetimibe?

"This medicine is a combination of two drugs, Ezetimibe and Simvastatin, which are used together with a proper diet to treat high cholesterol and triglyceride levels in the blood. This medicine may help prevent heart attacks and strokes by keeping blood vessels clear."

Answered by AI

Clinical Trials for Ezetimibe And Simvastatin

Have you considered Ezetimibe And Simvastatin clinical trials? We made a collection of clinical trials featuring Ezetimibe And Simvastatin, we think they might fit your search criteria.
Have you considered Ezetimibe And Simvastatin clinical trials? We made a collection of clinical trials featuring Ezetimibe And Simvastatin, we think they might fit your search criteria.
Have you considered Ezetimibe And Simvastatin clinical trials? We made a collection of clinical trials featuring Ezetimibe And Simvastatin, we think they might fit your search criteria.