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What is Exelon
RivastigmineThe Generic name of this drug
Treatment SummaryRivastigmine is a medication used to treat mild to moderate Alzheimer's dementia. It belongs to a class of drugs called cholinesterase inhibitors, which work by increasing the amount of the neurotransmitter acetylcholine in the brain. Rivastigmine works by blocking the enzymes that break down acetylcholine, allowing it to remain active for longer periods of time.
Rivastigmine Tartrateis the brand name
Exelon Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rivastigmine Tartrate
Rivastigmine
2000
128
Approved as Treatment by the FDA
Rivastigmine, also known as Rivastigmine Tartrate, is approved by the FDA for 4 uses including Parkinson Disease and Alzheimer's Disease .Parkinson Disease
Helps manage mild Dementia due to Parkinson's disease
Alzheimer's Disease
Helps manage moderate Alzheimer's Type Dementia
Parkinson Disease
Helps manage moderate Dementia due to Parkinson's disease
mild Dementia of the Alzheimer's Type
Helps manage mild Dementia of the Alzheimer's Type
Effectiveness
How Exelon Affects PatientsRivastigmine is used to treat Alzheimer's disease. It works by increasing the amount of a chemical in the brain called acetylcholine, which helps improve memory and thinking. The exact way it does this is unknown, but it is thought to work by blocking the breakdown of acetylcholine. Over time, as Alzheimer's disease gets worse, there may be fewer healthy neurons in the brain, which could mean that rivastigmine's effects may decrease.
How Exelon works in the bodyRivastigmine works by restoring the balance of a chemical in the brain called acetylcholine. It does this by blocking an enzyme that breaks down acetylcholine, leading to an increase in acetylcholine in the brain. Acetylcholine helps with memory, thinking and behavior, so increasing its levels can help with the symptoms of Alzheimer's disease. Rivastigmine is specifically targeted at acetylcholine in the brain, rather than in other parts of the body.
When to interrupt dosage
The proposed dosage of Exelon is contingent upon the distinguished disorder, for instance, Parkinson Disease, Parkinson Disease and Alzheimer's Disease. The measure of dosage fluctuates, in accordance with the delivery approach (e.g. Patch, extended release - Transdermal or Capsule - Oral) featured in the table beneath.Condition
Dosage
Administration
Parkinson Disease
1.5 mg, , 3.0 mg, 4.5 mg, 6.0 mg, 0.46 mg/hour, 1.33 mg/hour, 0.95 mg/hour, 0.46 mg/[USP'U], 4.6 mg, 9.5 mg, 13.3 mg, 0.95 mg/[USP'U], 2.0 mg/mL, 9.0 mg/cm2, 1.8 mg/cm2
, Oral, Capsule, Capsule - Oral, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Solution, Solution - Oral, Patch - Transdermal, Patch, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
mild Dementia of the Alzheimer's Type
1.5 mg, , 3.0 mg, 4.5 mg, 6.0 mg, 0.46 mg/hour, 1.33 mg/hour, 0.95 mg/hour, 0.46 mg/[USP'U], 4.6 mg, 9.5 mg, 13.3 mg, 0.95 mg/[USP'U], 2.0 mg/mL, 9.0 mg/cm2, 1.8 mg/cm2
, Oral, Capsule, Capsule - Oral, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Solution, Solution - Oral, Patch - Transdermal, Patch, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Parkinson Disease
1.5 mg, , 3.0 mg, 4.5 mg, 6.0 mg, 0.46 mg/hour, 1.33 mg/hour, 0.95 mg/hour, 0.46 mg/[USP'U], 4.6 mg, 9.5 mg, 13.3 mg, 0.95 mg/[USP'U], 2.0 mg/mL, 9.0 mg/cm2, 1.8 mg/cm2
, Oral, Capsule, Capsule - Oral, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Solution, Solution - Oral, Patch - Transdermal, Patch, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Dementia
1.5 mg, , 3.0 mg, 4.5 mg, 6.0 mg, 0.46 mg/hour, 1.33 mg/hour, 0.95 mg/hour, 0.46 mg/[USP'U], 4.6 mg, 9.5 mg, 13.3 mg, 0.95 mg/[USP'U], 2.0 mg/mL, 9.0 mg/cm2, 1.8 mg/cm2
, Oral, Capsule, Capsule - Oral, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Solution, Solution - Oral, Patch - Transdermal, Patch, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Alzheimer's Disease
1.5 mg, , 3.0 mg, 4.5 mg, 6.0 mg, 0.46 mg/hour, 1.33 mg/hour, 0.95 mg/hour, 0.46 mg/[USP'U], 4.6 mg, 9.5 mg, 13.3 mg, 0.95 mg/[USP'U], 2.0 mg/mL, 9.0 mg/cm2, 1.8 mg/cm2
, Oral, Capsule, Capsule - Oral, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Solution, Solution - Oral, Patch - Transdermal, Patch, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Warnings
Exelon ContraindicationsCondition
Risk Level
Notes
Anniversary Reaction
Do Not Combine
Common Exelon Drug Interactions
Drug Name
Risk Level
Description
Metoclopramide
Major
The risk or severity of adverse effects can be increased when Rivastigmine is combined with Metoclopramide.
Acetylcholine
Minor
The risk or severity of adverse effects can be increased when Rivastigmine is combined with Acetylcholine.
Agmatine
Minor
The therapeutic efficacy of Agmatine can be decreased when used in combination with Rivastigmine.
Alcuronium
Minor
The therapeutic efficacy of Alcuronium can be decreased when used in combination with Rivastigmine.
Amantadine
Minor
The therapeutic efficacy of Amantadine can be decreased when used in combination with Rivastigmine.
Exelon Novel Uses: Which Conditions Have a Clinical Trial Featuring Exelon?
17 active trials are being conducted to investigate the potential of Exelon in treating Dementia, Alzheimer's Disease and mild Cognitive Impairment of the Alzheimer's Type.Condition
Clinical Trials
Trial Phases
Parkinson Disease
0 Actively Recruiting
Dementia
18 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 2, Early Phase 1
Alzheimer's Disease
2 Actively Recruiting
Phase 3, Phase 2
Parkinson Disease
0 Actively Recruiting
mild Dementia of the Alzheimer's Type
0 Actively Recruiting
Exelon Reviews: What are patients saying about Exelon?
5Patient Review
12/31/2013 My parents both took this patch for years with different dosages. After my father passed away, my mom tried to use up his dosages (9.5 mg), but it made her hallucinate and experience flu symptoms, so she changed back to a lower dosage. The only side effect now is the redness and sometimes itchiness of the skin after removing the patch, but using alcohol wipes have made those problems disappear.
5Patient Review
6/6/2008 My 89 year old grandmother took this medication and it improved her quality of life quite significantly. She became more energetic and interested in things when she was taking the medication, but when she ran out and stopped taking it, she quickly lost that energy and interest.
5Patient Review
12/30/2014 I was having some serious issues with my memory, so my doctor put me on Exelon. After a few months of gradually increasing the dosage, I (and more importantly, my family) started to notice an improvement in my concentration and memory retention. Unfortunately, this stopped after a while and we had to up the dosage again. So far so good, but I have experienced some nausea and insomnia which comes with the territory I suppose.
5Patient Review
4/13/2010 The drug was effective, but the patient experienced a lot of drooling, which was embarrassing.
5Patient Review
10/7/2008 My mother was prescribed this medication, and within two weeks we noticed a scary difference. She began to lose more memory, become more incoherent, and then she started getting weak until the point of falling on the kitchen floor. We took her off immediately.
5Patient Review
3/7/20085Patient Review
7/8/2012 We had to stop my mother from taking this because it started causing her to forget things. We're going to see if there's a different medication that can help with her memory.
4.7Patient Review
9/9/2010 The patient is much happier and more sensible on exalon. While he still experiences delusions, they are not as severe or frightening as with other treatments. He also follows instructions better.
4.7Patient Review
1/2/2010 My husband was diagnosed eight years ago and has been taking 6mg of Exelon twice a day and 10mg Namenda twice a day. Recently, he's been more agitated so his neurologist increased the dosage of Exelon to 9mg twice a day. The doctor said that in Europe this increase has helped many patients. So far, my husband has been much calmer with no side effects noted.
4Patient Review
9/7/2010 Aricept and Namenda didn't do anything for my mother that we could tell, but she's been wearing the Exelon patch for almost two years now and it has improved her life in a number of ways. She can feed herself again and is much more cheerful. Although she can't hold a conversation, she loves to talk and smile. The Exelon has made her caregiving much easier.
3.3Patient Review
3/12/2009 The patch was a godsend. The time release 4.6 mg. patch starter dose worked temporarily, but I seemed to need more in the afternoon. The 9.5 mg. patch worked terrifically for 24 hrs, but I fell asleep too often during the day on it. Both are extremely expensive - and I ended up with the 'priced right' time release 4.5mg pill which got me through the whole day. Godsend medication though. (For Lews Body Dementia)
2.7Patient Review
4/3/2011 I don't understand how this drug can be proactive and also interfere with L DOPA.
2.3Patient Review
6/7/2018 I was concerned that my mom was nearing the end of her life, but after hospice came to visit and she ran out of her Excelon patch script, she's been doing much better. She's more alert and even walking around now. I'm not sure if I would recommend this treatment, though.
2.3Patient Review
4/29/2018 The Exelon patch can be dangerous if you don't carefully check for interactions with other drugs. This is especially true for those with heart problems or who are taking heart medications. Be sure to do your research before starting this medication, as your doctor may not give you all the information you need.
2Patient Review
2/27/2011 I used this treatment for a month, but unfortunately had to discontinue use. The patch caused redness and itchiness that progressively got worse over time.
2Patient Review
1/18/2011 My husband has been taking 6mg of Exelon twice a day for at least 5 years. He also takes 10mg Namenda twice a day. They both have helped him. We tried the Exelon patch and it did not work as well for him.
2Patient Review
10/6/2008 My husband has been using Exelon for over 3 yrs. He is now taking Namenda with it. They are both helping to improve his condition.
Patient Q&A Section about exelon
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What type of company is Exelon?
"A paraphrased version of the text might read:
Exelon is a large energy company with many utility customers, a clean and low-cost power generation fleet, and a large retail customer base. The Exelon family of companies is involved in nearly every stage of the energy business, from generation and power sales to..."
Answered by AI
What companies does Exelon own?
"Exelon is a company that is made up of BGE, ComEd, PECO, Atlantic City Electric, Delmarva Power, and Pepco. Exelon Business Services Company is a unit that is shared by all of these different parts of the company. We are currently in a time period where the energy industry is changing rapidly and we have to adapt."
Answered by AI
What is going on with Exelon?
"Exelon is planning to finish the separation in the first quarter of 2022. The current CEO Chris Crane and management team will stay until the separation is done, which will be when SpinCo is publicly listed."
Answered by AI
Is Exelon a good stock to buy?
"A majority of analysts rate Exelon as a "Buy," with the company's average rating score being 2.54 out of a possible 5. This is based on 7 analysts rating the company as a "Buy," 6 rating it as a "Hold," and no analysts rating it as a "Sell.""
Answered by AI