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What is Evista
RaloxifeneThe Generic name of this drug
Treatment SummaryRaloxifene is a medication used to treat postmenopausal women who are at risk of osteoporosis and breast cancer. It belongs to a class of drugs called selective estrogen receptor modulators or SERMs, which have both anti-estrogenic and estrogenic effects on certain body tissues. Raloxifene helps preserve bone density, reduce the risk of breast cancer, and does not cause endometrial proliferation. However, it may increase the risk of venous thromboembolism and fatal stroke in postmenopausal women with a history of stroke, transient ischemic attack, atrial fibr
Evistais the brand name
Evista Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Evista
Raloxifene
1998
50
Approved as Treatment by the FDA
Raloxifene, otherwise known as Evista, is approved by the FDA for 3 uses which include Osteoporosis and Postmenopausal Osteoporosis .Osteoporosis
Postmenopausal Osteoporosis
Malignant Neoplasms
Effectiveness
How Evista Affects PatientsRaloxifene is a drug that acts like estrogen in some parts of the body, like bones and lipids, while blocking it in other parts, like the uterus and breasts. It helps to increase bone mineral density and reduce the risk of fractures in postmenopausal women, and also helps to lower cholesterol levels. In trials, it was found to reduce the risk of breast cancer in postmenopausal women by 76%. It does not produce the same kind of stimulating effects on the endometrium as hormone replacement therapy, nor does it cause any significant changes to HDL cholesterol or triglyceride levels. It is unclear if these small effects
How Evista works in the bodyRaloxifene is a medication that works like estrogen in some parts of the body and blocks it in others. It binds to the same places that estrogen does in the body, like the estrogen receptor. When it binds, it causes a change in the receptor's shape that helps it move into the nucleus. This movement then helps control gene expression, which affects the way cells work. In bones, raloxifene helps maintain strength by inhibiting the cytokines that recruit osteoclasts, which break down bone. It also increases production of proteins that help build bone. In the breast, it works as an antagonist against estrogen
When to interrupt dosage
The proposed dosage of Evista is contingent on the identified condition, such as Osteoporosis, Osteoporosis caused by glucocorticoid and Postmenopausal Osteoporosis. The measure of dosage shifts, in accordance with the method of delivery described in the following table.Condition
Dosage
Administration
Osteoporosis
60.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Osteoporosis caused by glucocorticoid
60.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Postmenopausal Osteoporosis
60.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Malignant Neoplasms
60.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Breast
60.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Evista has two contraindications; therefore, it should not be administered while experiencing any of the situations mentioned in the following table.Evista ContraindicationsCondition
Risk Level
Notes
Pulmonary Embolism
Do Not Combine
potential for pregnancy
Do Not Combine
Common Evista Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Raloxifene.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Raloxifene.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Raloxifene.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Raloxifene.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Raloxifene.
Evista Toxicity & Overdose RiskThe toxic dose of raloxifene in rats is greater than 5000mg/kg, which is more than 810 times the human dose. Monkeys did not experience any deaths after taking a single oral dose of 1000mg/kg. There have been few reports of overdoses, but one case of a person taking 1.5g experienced common side effects like leg cramps, hot flashes, and dizziness. More serious side effects, such as blood clotting, have been reported when people take more than 180mg. Two 18-month-old children accidentally took 180mg and experienced symptoms like unsteadiness, vomiting, rash
Evista Novel Uses: Which Conditions Have a Clinical Trial Featuring Evista?
71 active trials are currently investigating the potential of Evista to address Postmenopausal Osteoporosis, Osteoporosis induced by glucocorticoids, and Breast Cancer.Condition
Clinical Trials
Trial Phases
Postmenopausal Osteoporosis
3 Actively Recruiting
Not Applicable, Phase 4
Breast
1 Actively Recruiting
Not Applicable
Malignant Neoplasms
22 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1, Phase 1
Osteoporosis
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 3
Osteoporosis caused by glucocorticoid
0 Actively Recruiting
Evista Reviews: What are patients saying about Evista?
5Patient Review
2/11/2019 I am 83 years old and have been taking Evista for about 18 years. I believe that it has kept my bones strong, as I have taken a few falls with no broken bones. My bone density test in 2015 showed me to be excellent and in the top 5% of my age group.
5Patient Review
4/3/2019 I've been taking Evista/Raloxifene for over 15 years and it's been great. No negative side effects that I've experienced.
5Patient Review
12/6/2021 I was originally hesitant to try this medication because of possible side effects, but it has really helped me. I experienced GERD and leg cramps when first starting to take it, but switching to taking it during the day eliminated those problems. My DEXA score also improved after 6 months, so I would say it is definitely worth the risk.
5Patient Review
7/19/2021 The Evista is giving me rashes inbetween my legs, as well as headaches and body aches. Some days are worse than others. I originally started taking it for osteoporosis prevention and breast cancer, but the side effects from both the cancer medication and the Evista were terrible, so I had to stop taking them both.
5Patient Review
5/26/2021 I've been using Evista for several years now with great results. I had a bone scan done recently and was pleased to see that there has been no deterioration in my condition over the past five years.
4Patient Review
8/2/2016 I've been on Evista for ten months now and I can say that it's helped me a lot. I no longer have the spine/hip pain that I used to have; in fact, I rarely feel any pain at all. I haven't had a DEXA scan since starting treatment because it's only been ten months, but I'm optimistic about the future.
3.3Patient Review
10/7/2017 I've been on Evista for a little while now, but my doctor wants me to switch to biphosphonates. I would rather try more natural methods to increase bone mass before resorting to medication, so I'm going to give that a shot. From what I can tell thus far, Evista hasn't really been all that effective.
2.7Patient Review
9/10/2019 I'm really hesitant to take this after reading about the possible side effects and all of the restrictions. Is it worth it?
2.3Patient Review
5/13/2018 I took Evista for approximately five years. However, I recently had to see an oral surgeon who informed me that Evista was the cause of my teeth decaying and breaking off. This led me to question what else this medication might be doing to my body, so I have decided to stop taking it.
2.3Patient Review
1/12/2020 I was on Evista for three years and developed severe migraines. Once I discontinued the medication, my headaches went away--and they haven't come back since.
2.3Patient Review
1/25/2021 I personally experienced zero results with this drug in terms of bone density improvement. I would not recommend it to others seeking the same treatment, as I believe it to be a waste of both time and money.
2.3Patient Review
3/10/2021 I unfortunately saw no benefits to my bone loss after taking Evista for an entire year. I did not experience any side effects, but I did develop a vaginal polyp while on the medication.
2Patient Review
1/28/2020 I was prescribed this drug as a preventative measure for breast cancer. However, after three years of enduring daily leg and hand cramps (which often left my muscles sore for days), terrible insomnia, and extreme irritability, I finally decided to stop taking the medication. Within 24 hours of my last dose, the cramps subsided and I've been able to sleep soundly and feel much more even-keeled ever since.
1.3Patient Review
8/8/2016 My osteoporosis actually got worse after switching from estradiol to Evista. I had hoped this would help with my hot flashes, but unfortunately it didn't.
1Patient Review
7/10/2017 I took Raloxifene for almost two years and all it gave me were problems. My legs swelled up and I was in constant pain, hot flashes, blurred vision, weight gain...I stopped taking it as soon as I could.
Patient Q&A Section about evista
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long should you take Evista for osteoporosis?
"In these trials, patients were evaluated for up to eight years. The available information supports EVISTA use for more than three years, but the optimum duration of EVISTA therapy is not known."
Answered by AI
What are the benefits of taking Evista?
"Evista is a type of medication known as a selective estrogen receptor modulator (SERM). This means that it binds to certain estrogen receptors in the body, which can have different effects in different tissues. In bones, Evista binds to estrogen receptors and this decreases bone breakdown and increases bone mineral density. This is why it is used to treat and reduce the risk of osteoporosis."
Answered by AI
What is the difference between Evista and Fosamax?
"Although Fosamax is the first-line treatment for osteoporosis, it can be difficult to take. It prevents bone loss and lowers your risk of invasive breast cancer. Evista can also help reduce bone loss and lower the risk of breast cancer in post-menopausal women, but it may cause blood clots."
Answered by AI