Estropipate

Low Testosterone, hypoestrogenism, moderate Vulvovaginal atrophy + 7 more
Treatment
10 FDA approvals
20 Active Studies for Estropipate

What is Estropipate

Estrone sulfateThe Generic name of this drug
Treatment SummaryEstrone sulfate (also known as estropipate) is a form of estrogen used to treat a variety of conditions, including menopause symptoms, infertility, underdeveloped female sexual characteristics, vaginal dryness, some types of breast cancer (particularly in men and postmenopausal women), prostate cancer, and osteoporosis.
Ogenis the brand name
image of different drug pills on a surface
Estropipate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ogen
Estrone sulfate
1977
21

Approved as Treatment by the FDA

Estrone sulfate, also known as Ogen, is approved by the FDA for 10 uses including female castration and Menopause .
female castration
Menopause
Postmenopausal Osteoporosis
Premature Menopause
moderate Vulvovaginal atrophy
Hot flashes
moderate Menopausal Vasomotor Symptoms
Low Testosterone
hypoestrogenism
severe menopausal vulvovaginal atrophy

Effectiveness

How Estropipate Affects PatientsEstropipate is a type of estrogen, which is a hormone naturally produced by the body. Estrogens work by attaching to receptors in the body's cells. Estrogens also control the amount of two other hormones in the body, LH and FSH, which can be too high in postmenopausal women. Estropipate helps to reduce these high levels and bring them back to normal.
How Estropipate works in the bodyEstradiol is a hormone that affects many parts of the body. It enters target cells and binds to a receptor, allowing it to enter the nucleus of the cell. The estradiol then causes genes to produce messenger RNA, which then creates proteins that bring about physical changes. Estradiol also stimulates the production of certain proteins in the liver, and reduces the amount of follicle-stimulating hormone in the pituitary gland.

When to interrupt dosage

The suggested dosage of Estropipate depends on the diagnosed condition, such as Menopause, Menopause and hypoestrogenism. The amount of dosage is contingent upon the type of delivery (e.g. Oral or Tablet, coated) specified in the table beneath.
Condition
Dosage
Administration
Menopause
0.75 mg, , 1.5 mg, 3.0 mg, 0.625 mg, 1.25 mg, 1.5 mg/mL, 0.0015 mg/mg, 6.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Vaginal, Cream, Cream - Vaginal, Tablet, coated, Tablet, coated - Oral
moderate Vulvovaginal atrophy
0.75 mg, , 1.5 mg, 3.0 mg, 0.625 mg, 1.25 mg, 1.5 mg/mL, 0.0015 mg/mg, 6.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Vaginal, Cream, Cream - Vaginal, Tablet, coated, Tablet, coated - Oral
severe menopausal vulvovaginal atrophy
0.75 mg, , 1.5 mg, 3.0 mg, 0.625 mg, 1.25 mg, 1.5 mg/mL, 0.0015 mg/mg, 6.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Vaginal, Cream, Cream - Vaginal, Tablet, coated, Tablet, coated - Oral
Hot flashes
0.75 mg, , 1.5 mg, 3.0 mg, 0.625 mg, 1.25 mg, 1.5 mg/mL, 0.0015 mg/mg, 6.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Vaginal, Cream, Cream - Vaginal, Tablet, coated, Tablet, coated - Oral
Low Testosterone
0.75 mg, , 1.5 mg, 3.0 mg, 0.625 mg, 1.25 mg, 1.5 mg/mL, 0.0015 mg/mg, 6.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Vaginal, Cream, Cream - Vaginal, Tablet, coated, Tablet, coated - Oral
moderate Menopausal Vasomotor Symptoms
0.75 mg, , 1.5 mg, 3.0 mg, 0.625 mg, 1.25 mg, 1.5 mg/mL, 0.0015 mg/mg, 6.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Vaginal, Cream, Cream - Vaginal, Tablet, coated, Tablet, coated - Oral
hypoestrogenism
0.75 mg, , 1.5 mg, 3.0 mg, 0.625 mg, 1.25 mg, 1.5 mg/mL, 0.0015 mg/mg, 6.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Vaginal, Cream, Cream - Vaginal, Tablet, coated, Tablet, coated - Oral
female castration
0.75 mg, , 1.5 mg, 3.0 mg, 0.625 mg, 1.25 mg, 1.5 mg/mL, 0.0015 mg/mg, 6.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Vaginal, Cream, Cream - Vaginal, Tablet, coated, Tablet, coated - Oral
Premature Menopause
0.75 mg, , 1.5 mg, 3.0 mg, 0.625 mg, 1.25 mg, 1.5 mg/mL, 0.0015 mg/mg, 6.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Vaginal, Cream, Cream - Vaginal, Tablet, coated, Tablet, coated - Oral
Postmenopausal Osteoporosis
0.75 mg, , 1.5 mg, 3.0 mg, 0.625 mg, 1.25 mg, 1.5 mg/mL, 0.0015 mg/mg, 6.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Vaginal, Cream, Cream - Vaginal, Tablet, coated, Tablet, coated - Oral

Warnings

There are 20 known major drug interactions with Estropipate.
Common Estropipate Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Estrone sulfate.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Estrone sulfate.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Estrone sulfate.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Estrone sulfate.
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Estrone sulfate.
image of a doctor in a lab doing drug, clinical research

Estropipate Novel Uses: Which Conditions Have a Clinical Trial Featuring Estropipate?

39 active clinical trials are evaluating the potential of Estropipate to treat Low Testosterone, Hypoestrogenism and Moderate Menopausal Vasomotor Symptoms.
Condition
Clinical Trials
Trial Phases
Low Testosterone
15 Actively Recruiting
Phase 1, Phase 4, Phase 2, Not Applicable
moderate Vulvovaginal atrophy
0 Actively Recruiting
Menopause
0 Actively Recruiting
hypoestrogenism
2 Actively Recruiting
Phase 4
female castration
0 Actively Recruiting
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Premature Menopause
1 Actively Recruiting
Phase 2
severe menopausal vulvovaginal atrophy
0 Actively Recruiting
Postmenopausal Osteoporosis
3 Actively Recruiting
Not Applicable, Phase 4
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1

Estropipate Reviews: What are patients saying about Estropipate?

5Patient Review
11/29/2007
Estropipate for Low Estrogen After Operation to Remove Ovaries
Enjuvia has been a total game-changer for me and my hot flashes. I was really struggling before I found this medication, but it's unfortunately become too expensive since I moved back to my hometown.
5Patient Review
8/26/2014
Estropipate for Low Estrogen After Operation to Remove Ovaries
This treatment was very effective for me in terms of reducing hot flashes. I experienced no negative side effects and have been using it successfully for five years now.
5Patient Review
3/16/2009
Estropipate for "Change of Life" Signs
Just as good as the more expensive options, but much cheaper.
4.7Patient Review
2/21/2011
Estropipate for Defective Internal Secretion of Ovaries
This medicine has been very helpful in reducing the side effect of a lack of estrogen in my system.
3Patient Review
4/17/2011
Estropipate for Low Estrogen After Operation to Remove Ovaries
I'm feeling really weird since I started taking this medication. It's the only change in my routine, and now my insides feel all crawl-y. I'm going to speak with my doctor soon to see if this is a common side effect or not.
2Patient Review
11/26/2015
Estropipate for "Change of Life" Signs
This medicine made me feel nauseous, tender in the chest, and lethargic. I didn't like the way it impacted my daily life.
1.7Patient Review
9/10/2011
Estropipate for "Change of Life" Signs
I have to use the restroom at least two or three times an hour when I take this medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about estropipate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is estropipate still available?

"The drug estropipate is no longer available in the United States."

Answered by AI

Is estradiol the same as estropipate?

"Activella can help to relieve menopausal symptoms, lower your risk of developing osteoporosis and also help with any low estrogen levels. Ogen can also help to relieve symptoms associated with menopause as well as help to prevent any bone loss."

Answered by AI

What is estropipate tablets used for?

"Estropipate can help relieve moderate to severe symptoms of menopause such as hot flashes and night sweats."

Answered by AI

What is estropipate 1.5 mg used for?

"Estropipate is a medication used to treat menopause symptoms, prevent osteoporosis, and replace estrogen in women who don't produce enough of it naturally."

Answered by AI

Clinical Trials for Estropipate

Have you considered Estropipate clinical trials? We made a collection of clinical trials featuring Estropipate, we think they might fit your search criteria.
Have you considered Estropipate clinical trials? We made a collection of clinical trials featuring Estropipate, we think they might fit your search criteria.
Have you considered Estropipate clinical trials? We made a collection of clinical trials featuring Estropipate, we think they might fit your search criteria.
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