Entecavir

Chronic Hepatitis B Infection, Viral Replication, Transaminases
Treatment
8 Active Studies for Entecavir

What is Entecavir

EntecavirThe Generic name of this drug
Treatment SummaryEntecavir, sold under the brand name Baraclude, is a medication used to treat hepatitis B infection. It works by blocking the three stages of viral replication. Entecavir is more effective than other medications used to treat hepatitis B, such as lamivudine and adefovir. It was approved by the FDA in 2005.
Baracludeis the brand name
image of different drug pills on a surface
Entecavir Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Baraclude
Entecavir
2005
53

Effectiveness

How Entecavir Affects PatientsEntecavir is a drug specifically designed to fight the hepatitis B virus. It is more effective than an earlier hepatitis B drug called lamivudine, as it blocks all three steps of the virus’s replication process.
How Entecavir works in the bodyEntecavir works by blocking the activity of the HBV polymerase, an enzyme that helps the virus reproduce. It does this by competing with a natural molecule in the body, deoxyguanosine triphosphate, which the virus needs to make copies of itself. When entecavir is activated by kinases, it can be incorporated into the virus' DNA, stopping it from replicating.

When to interrupt dosage

The prescribed dosage of Entecavir is reliant upon the determined condition, like Chronic Hepatitis B, Viral Replication and Transaminases. The extent of dosage fluctuates as per the administration approach enumerated in the table beneath.
Condition
Dosage
Administration
Transaminases
, 0.5 mg, 1.0 mg, 0.05 mg/mL
, Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral
Chronic Hepatitis B Infection
, 0.5 mg, 1.0 mg, 0.05 mg/mL
, Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral
Viral Replication
, 0.5 mg, 1.0 mg, 0.05 mg/mL
, Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

There are 20 known major drug interactions with Entecavir.
Common Entecavir Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Moderate
The metabolism of (R)-warfarin can be decreased when combined with Entecavir.
6-O-benzylguanine
Moderate
The metabolism of 6-O-benzylguanine can be decreased when combined with Entecavir.
8-azaguanine
Moderate
The metabolism of 8-azaguanine can be decreased when combined with Entecavir.
8-chlorotheophylline
Moderate
The metabolism of 8-chlorotheophylline can be decreased when combined with Entecavir.
9-Deazaguanine
Moderate
The metabolism of 9-Deazaguanine can be decreased when combined with Entecavir.
Entecavir Toxicity & Overdose RiskHealthy individuals who have taken a single dose of up to 40 mg of entecavir or multiple doses up to 20 mg/day for a maximum of 14 days have not reported any adverse reactions. If a person overdoses on entecavir, they must be monitored for signs of toxicity and given the necessary supportive care.
image of a doctor in a lab doing drug, clinical research

Entecavir Novel Uses: Which Conditions Have a Clinical Trial Featuring Entecavir?

Three active clinical trials are investigating the potential of Entecavir to inhibit Viral Replication, reduce Chronic Hepatitis B symptoms and lower Transaminase concentrations.
Condition
Clinical Trials
Trial Phases
Viral Replication
0 Actively Recruiting
Transaminases
0 Actively Recruiting
Chronic Hepatitis B Infection
8 Actively Recruiting
Phase 3, Phase 2, Phase 1

Entecavir Reviews: What are patients saying about Entecavir?

5Patient Review
9/27/2012
Entecavir for Chronic Hepatitis B
I gained weight very quickly after starting this treatment. Otherwise, I didn't experience any other unusual side effects.
5Patient Review
11/9/2015
Entecavir for Chronic Hepatitis B
I've been taking Viread for five to ten years now and it's been great.
5Patient Review
7/26/2008
Entecavir for Chronic Hepatitis B
I've seen a significant improvement in my liver function since starting this treatment.
4.7Patient Review
1/24/2013
Entecavir for Chronic Hepatitis B
I experienced no negative side effects from this treatment, and it really seemed to help my liver function better.
4Patient Review
7/31/2017
Entecavir for Chronic Hepatitis B
So far, I've had no issues with this medication. I take it at night and sometimes feel tired; however, I wake up feeling rested each morning.
4Patient Review
1/15/2008
Entecavir for Lamivudine-Refractory Chronic Hepatitis B
3.7Patient Review
12/27/2009
Entecavir for Chronic Hepatitis B
The drug worked well for me at first, but after taking it for seven months I started to experience some side effects like dizziness and headaches.
3.3Patient Review
7/18/2013
Entecavir for Chronic Hepatitis B
I've been on this medication for two years now, and I'm not sure if the fatigue, itchiness, and enlarged varicose veins in my lower legs are from this drug or from the other medications I'm taking.
3Patient Review
12/13/2009
Entecavir for Chronic Hepatitis B
Not too many side effects, which is great.
1.7Patient Review
4/2/2022
Entecavir for Chronic Hepatitis B
I've been taking Entecavir for five years now, and I have yet to see any benefits. In fact, the virus is still active. I'm done with this expensive medication that doesn't work; instead, I'm going to try juicing as a natural alternative.
1Patient Review
3/3/2021
Entecavir for Chronic Hepatitis B
While this treatment may provide some relief in the short term, the long term side effects are not worth it. This medication has been linked to irregular heartbeats and even death.
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Patient Q&A Section about entecavir

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is entecavir used for?

"This medication is used to treat a liver infection caused by the hepatitis b virus. It is part of a class of drugs called antivirals, which are used to treat infections caused by viruses. This drug will not cure hepatitis B, but it will prevent the virus from reproducing and causing further liver damage."

Answered by AI

What class of drug is entecavir?

"Entecavir is a type of nucleoside analog medication. It works by reducing the amount of hepatitis b virus (HBV) in the body."

Answered by AI

How long can you stay on entecavir?

"In one patient, entecavir resistance emerged after 5 years. However, the safety profile of entecavir was still consistent with previous reports. In conclusion, extended therapy with entecavir for 5 years maintained or increased rates of HBV DNA suppression and ALT normalization."

Answered by AI

What is the action of entecavir?

"This medication works by decreasing the amount of hepatitis b virus in the body. It is not known if it lowers the risk of developing liver cancer or liver damage. Entecavir is an antiviral that belongs to a class of drugs known as hepatitis B virus nucleoside reverse transcriptase inhibitors."

Answered by AI

Clinical Trials for Entecavir

Image of National Institutes of Health Clinical Center in Bethesda, United States.

VIR-2218 + Peginterferon Alfa-2a for Chronic Hepatitis B

18 - 65
All Sexes
Bethesda, MD
Background: Chronic hepatitis B virus (HBV) infection affects 292 million people worldwide; 887,000 die each year from cirrhosis, liver cancer, and related issues. Treatment options are limited. Objective: To test 2 drugs (VIR-2218 and peginterferon) in people with mild or inactive HBV infection. Eligibility: People aged 18 to 65 years with mild or inactive HBV infection. Design: Participants will be screened. They will have blood tests and an eye exam. They will have imaging scans of the liver to check the health of the liver. Participants will be in the study for over 2 years. VIR-2218 is an injection given under the skin of the stomach, upper arm, or thigh. Participants will come to the clinic to receive this injection once a month for 6 months. Peginterferon is also injected under the skin. Participants will have this shot once a week for 6 months. They may either inject themselves at home or come to the clinic to get the injections. Participants will get just the VIR-2218 for 3 months, then both shots for 3 months, then just the peginterferon for 3 months. Participants will have two 3-day stays in the hospital. Tests will include: Liver biopsy. A sample of tissue will be taken from their liver. After the procedure, participants will lie on their right side for 2 hours and then on their back for 4 hours. Fine needle aspiration. A small needle will be used to collect cells from the liver. After the last injection of peginterferon, follow-up visits will continue in the outpatient clinic every 4 to 12 weeks.
Phase 2
Recruiting
National Institutes of Health Clinical CenterMarc G Ghany, M.D.
Have you considered Entecavir clinical trials? We made a collection of clinical trials featuring Entecavir, we think they might fit your search criteria.Go to Trials
Image of Institute of Human Virology, University of Maryland School of Medicine in Baltimore, United States.

HEPLISAV-B Vaccine for Chronic Hepatitis B

18+
All Sexes
Baltimore, MD
The goal of this clinical trial is to learn if HEPLISAV-B, a vaccine that is approved to prevent hepatitis B infection in people that are not already infected, is safe in people already chronically infected with hepatitis B. The main quiestions it aims to answer are: 1. Is HEPLISAV-B safe in people with chronic hepatitis B? 2. What side effects, if any, could HEPLISAV-B cause in people with chronic hepatitis B? 3. How does HEPLISAV-B affect the cells that fight chronic hepatitis B? Participants will: * Receive HEPLISAV-B as an injection in the muscle, one injection every 4 weeks, for a total of 2 injections. * Visit the clinic a total of 5 times, and have 3 phone follow ups over 14 months. * Be asked if they are having any side effects from HEPLISAV-B. * Have blood samples collected.
Phase 1
Recruiting
Institute of Human Virology, University of Maryland School of Medicine (+1 Sites)Lydia Tang, MBChB