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What is Entecavir
EntecavirThe Generic name of this drug
Treatment SummaryEntecavir, sold under the brand name Baraclude, is a medication used to treat hepatitis B infection. It works by blocking the three stages of viral replication. Entecavir is more effective than other medications used to treat hepatitis B, such as lamivudine and adefovir. It was approved by the FDA in 2005.
Baracludeis the brand name
Entecavir Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Baraclude
Entecavir
2005
53
Effectiveness
How Entecavir Affects PatientsEntecavir is a drug specifically designed to fight the hepatitis B virus. It is more effective than an earlier hepatitis B drug called lamivudine, as it blocks all three steps of the virus’s replication process.
How Entecavir works in the bodyEntecavir works by blocking the activity of the HBV polymerase, an enzyme that helps the virus reproduce. It does this by competing with a natural molecule in the body, deoxyguanosine triphosphate, which the virus needs to make copies of itself. When entecavir is activated by kinases, it can be incorporated into the virus' DNA, stopping it from replicating.
When to interrupt dosage
The prescribed dosage of Entecavir is reliant upon the determined condition, like Chronic Hepatitis B, Viral Replication and Transaminases. The extent of dosage fluctuates as per the administration approach enumerated in the table beneath.Condition
Dosage
Administration
Transaminases
, 0.5 mg, 1.0 mg, 0.05 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral
Chronic Hepatitis B Infection
, 0.5 mg, 1.0 mg, 0.05 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral
Viral Replication
, 0.5 mg, 1.0 mg, 0.05 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
There are 20 known major drug interactions with Entecavir.Common Entecavir Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Moderate
The metabolism of (R)-warfarin can be decreased when combined with Entecavir.
6-O-benzylguanine
Moderate
The metabolism of 6-O-benzylguanine can be decreased when combined with Entecavir.
8-azaguanine
Moderate
The metabolism of 8-azaguanine can be decreased when combined with Entecavir.
8-chlorotheophylline
Moderate
The metabolism of 8-chlorotheophylline can be decreased when combined with Entecavir.
9-Deazaguanine
Moderate
The metabolism of 9-Deazaguanine can be decreased when combined with Entecavir.
Entecavir Toxicity & Overdose RiskHealthy individuals who have taken a single dose of up to 40 mg of entecavir or multiple doses up to 20 mg/day for a maximum of 14 days have not reported any adverse reactions. If a person overdoses on entecavir, they must be monitored for signs of toxicity and given the necessary supportive care.
Entecavir Novel Uses: Which Conditions Have a Clinical Trial Featuring Entecavir?
Three active clinical trials are investigating the potential of Entecavir to inhibit Viral Replication, reduce Chronic Hepatitis B symptoms and lower Transaminase concentrations.Condition
Clinical Trials
Trial Phases
Viral Replication
0 Actively Recruiting
Transaminases
0 Actively Recruiting
Chronic Hepatitis B Infection
6 Actively Recruiting
Phase 3, Phase 2
Entecavir Reviews: What are patients saying about Entecavir?
5Patient Review
9/27/2012 I gained weight very quickly after starting this treatment. Otherwise, I didn't experience any other unusual side effects.
5Patient Review
11/9/2015 I've been taking Viread for five to ten years now and it's been great.
5Patient Review
7/26/2008 I've seen a significant improvement in my liver function since starting this treatment.
4.7Patient Review
1/24/2013 I experienced no negative side effects from this treatment, and it really seemed to help my liver function better.
4Patient Review
7/31/2017 So far, I've had no issues with this medication. I take it at night and sometimes feel tired; however, I wake up feeling rested each morning.
Patient Q&A Section about entecavir
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is entecavir used for?
"This medication is used to treat a liver infection caused by the hepatitis b virus. It is part of a class of drugs called antivirals, which are used to treat infections caused by viruses. This drug will not cure hepatitis B, but it will prevent the virus from reproducing and causing further liver damage."
Answered by AI
What class of drug is entecavir?
"Entecavir is a type of nucleoside analog medication. It works by reducing the amount of hepatitis b virus (HBV) in the body."
Answered by AI
How long can you stay on entecavir?
"In one patient, entecavir resistance emerged after 5 years. However, the safety profile of entecavir was still consistent with previous reports. In conclusion, extended therapy with entecavir for 5 years maintained or increased rates of HBV DNA suppression and ALT normalization."
Answered by AI
What is the action of entecavir?
"This medication works by decreasing the amount of hepatitis b virus in the body. It is not known if it lowers the risk of developing liver cancer or liver damage. Entecavir is an antiviral that belongs to a class of drugs known as hepatitis B virus nucleoside reverse transcriptase inhibitors."
Answered by AI
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