Emsam

Depression, Parkinson's Disease, Attention Deficit Hyperactivity Disorder
Treatment
2 FDA approvals
20 Active Studies for Emsam

What is Emsam

SelegilineThe Generic name of this drug
Treatment SummaryDeprenyl is a medication used to treat symptoms of Parkinson’s disease. It is an inhibitor of Type B monoamine oxidase and works by slowing the progression of the clinical disease and delaying the need for levodopa therapy. Deprenyl may also be prescribed in combination with levodopa when the symptoms of Parkinson’s disease become more severe.
Eldeprylis the brand name
image of different drug pills on a surface
Emsam Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Eldepryl
Selegiline
1989
29

Approved as Treatment by the FDA

Selegiline, commonly known as Eldepryl, is approved by the FDA for 2 uses like Parkinson's Disease (PD) and Parkinson's Disease .
Parkinson's Disease (PD)
Used in combination with other therapies
Parkinson's Disease
Used in combination with other therapies

Effectiveness

How Emsam Affects PatientsDopamine is an important chemical found in various parts of the body. People with Parkinson's disease have too little dopamine because it breaks down too quickly. Selegiline helps to prevent the breakdown of dopamine by blocking an enzyme called monoamine oxidase (MAO). It can also help keep more dopamine between nerve cells and make it easier for dopamine to be released from those cells.
How Emsam works in the bodySelegiline works by blocking an enzyme called monoamine oxidase type B (MAO-B). This enzyme breaks down dopamine, which is important for controlling movement. By blocking MAO-B, selegiline helps increase the amount of dopamine in the brain, which can improve movement problems in people with Parkinson's disease. At higher doses, selegiline can also block monoamine oxidase type A (MAO-A), which is helpful for treating depression.

When to interrupt dosage

The advocated dosage of Emsam is contingent upon the determined disorder, including Attention Deficit Hyperactivity Disorder, Depression and Parkinson's Disease. The amount of dosage can be seen in the table below, relative to the mode of administration (e.g. Patch or Oral).
Condition
Dosage
Administration
Attention Deficit Hyperactivity Disorder
, 5.0 mg, 1.25 mg, 0.6 mg/hour, 0.9 mg/hour, 1.2 mg/hour
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Patch, Patch - Transdermal, Transdermal
Depression
, 5.0 mg, 1.25 mg, 0.6 mg/hour, 0.9 mg/hour, 1.2 mg/hour
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Patch, Patch - Transdermal, Transdermal
Parkinson's Disease
, 5.0 mg, 1.25 mg, 0.6 mg/hour, 0.9 mg/hour, 1.2 mg/hour
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Patch, Patch - Transdermal, Transdermal

Warnings

Emsam Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
contraindicated drugs
Do Not Combine
Pulse Frequency
Do Not Combine
Pheochromocytoma
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Emsam.
Common Emsam Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
Selegiline may increase the hypertensive activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Selegiline.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of adverse effects can be increased when Selegiline is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Alaproclate
Major
Selegiline may increase the serotonergic activities of Alaproclate.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Selegiline.
Emsam Toxicity & Overdose RiskThe lethal dose of this drug for rats when administered intravenously is 63mg/kg.
image of a doctor in a lab doing drug, clinical research

Emsam Novel Uses: Which Conditions Have a Clinical Trial Featuring Emsam?

308 active clinical trials are being conducted to assess the potential of Emsam in providing relief from Depression, Parkinson's Disease and Attention Deficit Hyperactivity Disorder.
Condition
Clinical Trials
Trial Phases
Attention Deficit Hyperactivity Disorder
66 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1, Early Phase 1
Depression
195 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Parkinson's Disease
39 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Phase 3, Early Phase 1

Emsam Reviews: What are patients saying about Emsam?

5Patient Review
10/18/2013
Emsam for Major Depressive Disorder
The 12mg dosage has worked for me; however, I am now being checked out for a fluid retention side effect. My legs have swollen from below my knees to the top of my feet.
5Patient Review
7/23/2020
Emsam for Major Depressive Disorder
This patch has been an incredible help for my short bowel syndrome. I was struggling for over three years before finally trying this, and it's made such a difference in my quality of life.
5Patient Review
6/11/2014
Emsam for Major Depressive Disorder
After trying a 6mg dosage and seeing no results, I upped it to 9mg. This completely changed my life for the better and saved me from suicidal thoughts.
5Patient Review
5/16/2019
Emsam for Major Depressive Disorder
Emsam has been an amazing medication for me. I feel like myself again, full of energy and social confidence. This is the first SSRI that has ever worked for me, and at such a low dose too!
4.7Patient Review
11/10/2017
Emsam for Major Depressive Disorder
This treatment has been extremely effective for me and has overall improved my quality of life. The only downsides are that it's caused insomnia and a low sex drive, but I'm still very satisfied with it.
View All Reviews
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Patient Q&A Section about emsam

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Emsam good for anxiety?

"However, it did take some getting used to, and when I first started using it I had to keep an eye on my skin to be sure it did not get too dry. Overall, it was a great help and I would recommend it to others.”

EMSAM was a great help for my depression and anxiety. I had to get used to it a bit, and when I first started using it I kept an eye on my skin to make sure it didn't get too dry. Overall it was a big help, and I would recommend it to others."

Answered by AI

What is Emsam used to treat?

"Emsam (selegiline) is a patch that is applied to the skin once daily. It is used to treat depression in adults and is a good option for people who can't or don't want to take medications by mouth."

Answered by AI

Is Emsam still available?

"There is no version of Emsam currently available in the United States that is therapeutically equivalent. Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Emsam. These medications may be counterfeit and potentially unsafe."

Answered by AI

Clinical Trials for Emsam

Have you considered Emsam clinical trials? We made a collection of clinical trials featuring Emsam, we think they might fit your search criteria.
Have you considered Emsam clinical trials? We made a collection of clinical trials featuring Emsam, we think they might fit your search criteria.
Have you considered Emsam clinical trials? We made a collection of clinical trials featuring Emsam, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
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