Duzallo

Hyperuricemia, Lesch-Nyhan Syndrome, Chemotherapy + 15 more
Treatment
16 FDA approvals
20 Active Studies for Duzallo

What is Duzallo

AllopurinolThe Generic name of this drug
Treatment SummaryGout is an inflammatory condition caused by the accumulation of monosodium urate crystals in the body, especially around joints. It has been known since ancient times and has been documented in medical records and biographies. Allopurinol is a common medication used to reduce urate levels and treat chronic gout. It was approved by the FDA in 1966 and is now made by several different companies.
Zyloprimis the brand name
image of different drug pills on a surface
Duzallo Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zyloprim
Allopurinol
1966
270

Approved as Treatment by the FDA

Allopurinol, also called Zyloprim, is approved by the FDA for 16 uses such as Kidney Calculi and female patients with daily uric acid excretion that exceeds 750 mg/day .
Kidney Calculi
female patients with daily uric acid excretion that exceeds 750 mg/day
Cancer
Hyperuricemia
Leukemias
Malignant Lymphomas
Arthritis, Gouty
Used to treat Gouty Arthritis in combination with Lesinurad
failed previous allopurinol monotherapy
Used to treat failed previous allopurinol monotherapy in combination with Lesinurad
Hyperuricemia
Hyperuricemia
Chemotherapy
Lymphoma, Non-Hodgkin
Leukemia
Symptomatic
Secondary gout
Primary Gout

Effectiveness

How Duzallo Affects PatientsAllopurinol works by reducing the amount of uric acid the body makes. This helps to relieve the symptoms of gout such as painful swelling, joint pain, redness, and difficulty moving.
How Duzallo works in the bodyAllopurinol helps reduce gout symptoms by blocking an enzyme that converts hypoxanthine to xanthine and xanthine to uric acid. This drug also increases the amount of hypoxanthine and xanthine for nucleotide and nucleic acid synthesis. As a result, uric acid levels in the urine and blood drop, which reduces the risk of gout symptoms. Allopurinol also encourages the dissolution of existing gout tophi by lowering the amount of uric acid in the blood below its solubility limit. Although hypoxanthine and xanthine levels increase after allop

When to interrupt dosage

The recommended dosage of Duzallo is contingent upon the diagnosed condition, including Gout Flares, Leukemias and Cancer. The amount of dosage is contingent on the method of delivery (e.g. Injection, powder, lyophilized, for solution - Intravenous or Tablet, film coated - Oral) provided in the following table.
Condition
Dosage
Administration
Symptomatic
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Chemotherapy
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Chronic Kidney Disease (CKD)
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Metabolic Diseases
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Gout Flares
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Eczema
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Leukemia
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Primary Gout
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Hyperuricemia
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Lesch-Nyhan Syndrome
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Arthritis, Gouty
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Kidney Calculi
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
female patients with daily uric acid excretion that exceeds 750 mg/day
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
failed previous allopurinol monotherapy
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Hyperuricemia
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Urinary Bladder Calculi (disorder)
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Lymphoma, Non-Hodgkin
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Secondary gout
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Warnings

There are 20 known major drug interactions with Duzallo.
Common Duzallo Drug Interactions
Drug Name
Risk Level
Description
Didanosine
Major
The serum concentration of Didanosine can be increased when it is combined with Allopurinol.
Oteracil
Major
The therapeutic efficacy of Oteracil can be decreased when used in combination with Allopurinol.
Pegloticase
Major
The risk or severity of adverse effects can be increased when Allopurinol is combined with Pegloticase.
Abacavir
Minor
Allopurinol may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aclidinium
Minor
Allopurinol may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Duzallo Toxicity & Overdose RiskThe lowest toxic dose for rats is 10 mg/kg, while the lowest toxic dose for mice is 78 mg/kg. Reproductive studies on rats and rabbits have not shown any adverse effects, but there have been reports of increased numbers of dead fetuses and malformations in pregnant mice given 50 or 100 mg/kg allopurinol. Nursing women should be cautious while taking allopurinol as it has been found in the milk of a nursing mother. Studies have not found allopurinol to be mutagenic or carcinogenic.
image of a doctor in a lab doing drug, clinical research

Duzallo Novel Uses: Which Conditions Have a Clinical Trial Featuring Duzallo?

560 active clinical trials are investigating the potential of Duzallo to mitigate Kidney Disease, Chemotherapy-related complications and Metabolic Diseases.
Condition
Clinical Trials
Trial Phases
Chronic Kidney Disease (CKD)
26 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1
Secondary gout
0 Actively Recruiting
Lymphoma, Non-Hodgkin
2 Actively Recruiting
Phase 1
Leukemia
0 Actively Recruiting
failed previous allopurinol monotherapy
0 Actively Recruiting
Eczema
10 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 3
Lesch-Nyhan Syndrome
0 Actively Recruiting
Arthritis, Gouty
4 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Hyperuricemia
0 Actively Recruiting
Chemotherapy
3 Actively Recruiting
Phase 1, Phase 3, Not Applicable
female patients with daily uric acid excretion that exceeds 750 mg/day
0 Actively Recruiting
Kidney Calculi
0 Actively Recruiting
Metabolic Diseases
2 Actively Recruiting
Not Applicable
Hyperuricemia
4 Actively Recruiting
Phase 3, Phase 1
Urinary Bladder Calculi (disorder)
0 Actively Recruiting
Primary Gout
0 Actively Recruiting
Gout Flares
0 Actively Recruiting
Symptomatic
0 Actively Recruiting

Duzallo Reviews: What are patients saying about Duzallo?

3.7Patient Review
10/21/2018
Duzallo for Treatment to Prevent Gout
I experienced a lot of side effects with this medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about duzallo

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does allopurinol do?

"This medication is used to lower the level of uric acid in your blood. Uric acid build-up can cause tiny, sharp crystals to form in and around your joints, which is a condition known as gout. Kidney stones can also be caused by too much uric acid. Allopurinol is used to prevent these conditions from occurring or to lessen their symptoms."

Answered by AI

Why was lesinurad discontinued?

"- The FDA has announced the discontinuation of Ironwood Pharmaceuticals' Duzallo (lesinurad/allopurinol) and Zurampic (lesinurad). This is due to business reasons and not because of any safety, efficacy or quality issues."

Answered by AI

What is Duzallo used for?

"Duzallo is a medication used to lower uric acid levels in adults with gout. It is typically given when allopurinol alone has not been effective."

Answered by AI

Clinical Trials for Duzallo

Have you considered Duzallo clinical trials? We made a collection of clinical trials featuring Duzallo, we think they might fit your search criteria.
Have you considered Duzallo clinical trials? We made a collection of clinical trials featuring Duzallo, we think they might fit your search criteria.
Have you considered Duzallo clinical trials? We made a collection of clinical trials featuring Duzallo, we think they might fit your search criteria.
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