Duavee

Hot flashes, Osteoporosis, Postmenopausal, Menopause + 1 more
Treatment
5 FDA approvals
17 Active Studies for Duavee

What is Duavee

BazedoxifeneThe Generic name of this drug
Treatment SummaryBazedoxifene is a medication that helps to prevent postmenopausal osteoporosis by acting on estrogen receptors in the body. It is sold as part of the combination drug DUAVEE and is approved for use in the European Union, Japan, and the United States. Bazedoxifene is used to treat moderate to severe vasomotor symptoms caused by menopause, as well as to prevent postmenopausal osteoporosis in women.
Duaveeis the brand name
image of different drug pills on a surface
Duavee Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Duavee
Bazedoxifene
2013
3

Approved as Treatment by the FDA

Bazedoxifene, also known as Duavee, is approved by the FDA for 5 uses including Postmenopausal Osteoporosis and moderate Menopausal Vasomotor Symptoms .
Postmenopausal Osteoporosis
Used to treat Postmenopausal Osteoporosis in combination with Conjugated estrogens
moderate Menopausal Vasomotor Symptoms
Used to treat moderate Menopausal Vasomotor Symptoms in combination with Conjugated estrogens
Osteoporosis, Postmenopausal
Used to treat Postmenopausal Osteoporosis in combination with Conjugated estrogens
Menopause
Used to treat severe Vasomotor Symptoms Associated With Menopause in combination with Conjugated estrogens
Hot flashes
Used to treat Menopause in combination with Conjugated estrogens

Effectiveness

How Duavee works in the bodyBazedoxifene is a type of drug that changes how the body responds to estrogen. By doing this, it reduces bone loss and increases bone density. This helps protect against fractures. In some tissues, like the uterus and breast, bazedoxifene acts as a blocker of estrogen's effects.

When to interrupt dosage

The suggested amount of Duavee is contingent upon the identified condition, including moderate Menopausal Vasomotor Symptoms, Menopause and Postmenopausal Osteoporosis. The dosage fluctuates as per the technique of delivery (e.g. Oral or Tablet, film coated) outlined in the table beneath.
Condition
Dosage
Administration
Hot flashes
20.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release
Osteoporosis, Postmenopausal
20.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release
Menopause
20.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release
moderate Menopausal Vasomotor Symptoms
20.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release

Warnings

Duavee has fourteen contraindications, so it should not be taken while one is encountering the conditions in the table below.Duavee Contraindications
Condition
Risk Level
Notes
Pulmonary Embolism
Do Not Combine
Protein C Deficiency
Do Not Combine
Breast Cancer
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Thromboembolism
Do Not Combine
Pulmonary Embolism
Do Not Combine
Venous Thrombosis
Do Not Combine
Venous Thrombosis
Do Not Combine
Protein Deficiency
Do Not Combine
Thromboembolism
Do Not Combine
Metrorrhagia
Do Not Combine
Thrombophilia
Do Not Combine
Liver Disease
Do Not Combine
Antithrombin III Deficiency
Do Not Combine
There are 2 known major drug interactions with Duavee.
Common Duavee Drug Interactions
Drug Name
Risk Level
Description
Ospemifene
Major
The risk or severity of adverse effects can be increased when Bazedoxifene is combined with Ospemifene.
Fluoroestradiol F-18
Moderate
Bazedoxifene may decrease effectiveness of Fluoroestradiol F-18 as a diagnostic agent.

Duavee Novel Uses: Which Conditions Have a Clinical Trial Featuring Duavee?

Currently, 20 active trials are analyzing the effectiveness of Duavee in alleviating moderate Menopausal Vasomotor Symptoms, Postmenopausal Osteoporosis and Menopausal related conditions.
Condition
Clinical Trials
Trial Phases
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Osteoporosis, Postmenopausal
0 Actively Recruiting
Hot flashes
17 Actively Recruiting
Phase 1, Phase 4, Not Applicable, Early Phase 1, Phase 2, Phase 3
Menopause
0 Actively Recruiting

Duavee Reviews: What are patients saying about Duavee?

5Patient Review
11/1/2016
Duavee for "Change of Life" Signs
I started feeling dizzy not long after taking this drug as directed by my doctor. How long will these side effects last?
5Patient Review
1/7/2017
Duavee for "Change of Life" Signs
This medication quickly and effectively relieved my hot flashes and mood swings with no negative side effects.
4Patient Review
1/17/2018
Duavee for "Change of Life" Signs
I've been taking this medication for three months to combat hot flashes. At first, it seemed to make them worse, but after the first week they decreased noticeably and have all but stopped now. I also experienced some acne during weeks two and three, but that's gone away as well. The only other symptom has been occasional leg cramping at night, which I hope doesn't get worse.
4Patient Review
3/14/2018
Duavee for "Change of Life" Signs
I was on Duavee for almost three years and it worked well for me. I stopped taking it last week because my insurance stopped covering it, and I've gained 25 pounds since starting the medication. My eyesight has also gotten worse quickly, though I'm not sure if that's a side effect of the drug or just a result of getting older. I'm hoping my body can adjust to not taking the medication and that I'll be able to lose the weight gain.
3.7Patient Review
12/8/2017
Duavee for "Change of Life" Signs
I've been using Duavee for four days now to mitigate hot flashes, night sweats, moodiness and low libido. So far I'm seeing great results with all of those issues; however, today I am feeling very nauseous, have a stomach ache, and a horrible headache. I'm wondering if anybody else has experienced these side effects from the drug? If so, did you have to go off the medication because of them?
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about duavee

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic name for Duavee?

"Duavee is a medication that contains a female hormone called estrogen, as well as an agonist/antagonist that is used to treat symptoms associated with menopause and to prevent postmenopausal osteoporosis."

Answered by AI

What is the difference between PremPro and Duavee?

"This medication can be used by women who still have their uterus. Most other estrogen medications increase the risk of breast cancer when used by themselves, but this one does not."

Answered by AI

Why is Duavee no longer available?

"Unfortunately, during the trial, Duavee became no longer available due to an issue with packaging and dissolution of the active agents."

Answered by AI

Is Duavee available now?

"DUAVEE is unavailable at the moment. Please check with your healthcare provider about treatment options until DUAVEE becomes available again."

Answered by AI

Clinical Trials for Duavee

Have you considered Duavee clinical trials? We made a collection of clinical trials featuring Duavee, we think they might fit your search criteria.
Have you considered Duavee clinical trials? We made a collection of clinical trials featuring Duavee, we think they might fit your search criteria.
Image of University of Colorado Anschutz Medical Center, Clinical Translational Research Center and Exercise Research Laboratory in Aurora, United States.

MitoQ + Exercise for Menopause-Related Vascular Health

50 - 120
Female
Aurora, CO
This trial tests whether combining moderate aerobic exercise with the antioxidant MitoQ can improve blood vessel function in postmenopausal women who lack estrogen. MitoQ aims to reduce oxidative stress and enhance blood flow by improving mitochondrial function. The study will compare the effects of exercise with MitoQ, exercise alone, and MitoQ alone. MitoQ is a mitochondria-targeted antioxidant that has been studied for its potential to enhance exercise-induced muscle adaptations and improve peak power in untrained middle-aged men.
Phase < 1
Waitlist Available
Paid Trial
University of Colorado Anschutz Medical Center, Clinical Translational Research Center and Exercise Research LaboratoryKerrie L Moreau, PhD
Have you considered Duavee clinical trials? We made a collection of clinical trials featuring Duavee, we think they might fit your search criteria.
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