Dobutrex

Therapeutic procedure, Coronary Artery Disease (CAD), Heart Attack + 3 more
Treatment
1 FDA approval
20 Active Studies for Dobutrex

What is Dobutrex

DobutamineThe Generic name of this drug
Treatment SummaryDobutamine is a drug used to increase the strength of heart contractions, making it useful for treating heart conditions such as after a heart attack or open heart surgery. It works by stimulating the beta-1 receptors in the heart without causing an increase in heart rate or narrowing of the blood vessels.
Dobutamine Hydrochloride in Dextroseis the brand name
image of different drug pills on a surface
Dobutrex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dobutamine Hydrochloride in Dextrose
Dobutamine
1993
22

Approved as Treatment by the FDA

Dobutamine, otherwise called Dobutamine Hydrochloride in Dextrose, is approved by the FDA for 1 uses like Cardiac Decompensation .
Cardiac Decompensation
Helps manage Cardiac Decompensation

Effectiveness

How Dobutrex Affects PatientsDobutamine is a drug that strengthens the heart and increases its ability to pump blood. It works by activating the beta-1 adrenergic receptors in the heart, but has only small effects on other types of receptors. Unlike dopamine, it does not cause the body to produce more norepinephrine.
How Dobutrex works in the bodyDobutamine helps the heart pump more blood by stimulating the beta-1 receptors in the heart. This increases the amount of blood the heart pumps out, resulting in a greater cardiac output.

When to interrupt dosage

The quantity of Dobutrex is contingent upon the identified disorder, including Heart Attack, Cardiac Surgical Procedures (D006348) and Coronary Artery Disease (CAD). The amount of dosage is contingent upon the technique of delivery (e.g. Intravenous or Liquid - Intravenous) specified in the following table.
Condition
Dosage
Administration
Cardiac Surgical Procedures (D006348)
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Stress Echocardiography (SE)
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Coronary Artery Disease (CAD)
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Therapeutic procedure
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Heart Attack
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Cardiac Decompensation
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous

Warnings

Dobutrex has one contraindication, and should not be utilized if any of the conditions in the following table are present.Dobutrex Contraindications
Condition
Risk Level
Notes
Obstructive Hypertrophic Cardiomyopathy
Do Not Combine
There are 20 known major drug interactions with Dobutrex.
Common Dobutrex Drug Interactions
Drug Name
Risk Level
Description
Iobenguane
Major
Dobutamine can cause a decrease in the absorption of Iobenguane resulting in a reduced serum concentration and potentially a decrease in efficacy.
1-benzylimidazole
Minor
The risk or severity of hypertension can be increased when Dobutamine is combined with 1-benzylimidazole.
2,5-Dimethoxy-4-ethylamphetamine
Minor
The risk or severity of hypertension can be increased when Dobutamine is combined with 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
Minor
The risk or severity of hypertension can be increased when Dobutamine is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
Minor
The risk or severity of hypertension can be increased when Dobutamine is combined with 4-Bromo-2,5-dimethoxyamphetamine.
image of a doctor in a lab doing drug, clinical research

Dobutrex Novel Uses: Which Conditions Have a Clinical Trial Featuring Dobutrex?

63 active studies are presently investigating the potential of Dobutrex to effectuate Therapeutic procedure, Cardiac Decompensation and Myocardial Infarction.
Condition
Clinical Trials
Trial Phases
Cardiac Surgical Procedures (D006348)
0 Actively Recruiting
Cardiac Decompensation
0 Actively Recruiting
Stress Echocardiography (SE)
1 Actively Recruiting
Not Applicable
Therapeutic procedure
0 Actively Recruiting
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
Heart Attack
55 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1

Dobutrex Reviews: What are patients saying about Dobutrex?

2.7Patient Review
3/16/2009
Dobutrex for Failure of the Heart to Maintain Adequate Circulation
1Patient Review
10/5/2010
Dobutrex for Failure of the Heart to Maintain Adequate Circulation
We had to convince the medical staff multiple times to stop giving this medication to our son while he was in the ICU. Every time they administered it, his vitals would drop and everything would go haywire for a couple hours.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about dobutrex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is dobutrex used for?

"Dobutamine is a drug that is used to stimulate the heart muscle and improve blood flow. It is typically used in cases where the heart muscle has weakened and other heart medications have not been successful."

Answered by AI

Does dobutrex increase heart rate?

"Dobutamine primarily increases stroke volume and cardiac output in healthy animals due to its inotropic effects. There is also a small increase in heart rate, which is a minor contribution to the increase in cardiac output."

Answered by AI

Does dobutrex increase blood pressure?

"Dobutamine increases heart rate and blood pressure, especially systolic pressure. In clinical studies, 10% of patients had an increase in heart rate of 30 beats per minute or more, and 7.5% had an increase in systolic pressure of 50 mm Hg or more."

Answered by AI

What type of drug is dobutrex?

"Dobutrex is a synthetic catecholamine that helps improve the heart's pumping ability by strengthening the heart muscle. It also helps improve blood flow and relieve symptoms associated with heart failure."

Answered by AI

Clinical Trials for Dobutrex

Have you considered Dobutrex clinical trials? We made a collection of clinical trials featuring Dobutrex, we think they might fit your search criteria.
Have you considered Dobutrex clinical trials? We made a collection of clinical trials featuring Dobutrex, we think they might fit your search criteria.
Have you considered Dobutrex clinical trials? We made a collection of clinical trials featuring Dobutrex, we think they might fit your search criteria.