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What is Didronel
Etidronic acidThe Generic name of this drug
Treatment SummaryEtidronic acid is a type of medication used to regulate calcium levels in the body. It was the first drug of its kind when it was approved by the FDA in 1977, but has since been replaced by newer drugs, known as nitrogen-containing bisphosphonates. Etidronic acid is still used, but not as widely as the newer drugs.
Didronelis the brand name
Didronel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Didronel
Etidronic acid
1977
9
Approved as Treatment by the FDA
Etidronic acid, commonly known as Didronel, is approved by the FDA for 4 uses such as Paget's Disease of Bone and Heterotopic Ossification .Paget's Disease of Bone
Heterotopic Ossification
Spinal Cord Injury
Total Hip Replacements
Effectiveness
How Didronel Affects PatientsEtidronic acid is a medication that stops bone from breaking down. It is considered to be very safe, even when taken in large doses, and its effects can last a long time. However, it can cause issues in the upper digestive tract, so patients should be aware of this before taking it.
How Didronel works in the bodyBisphosphonates are taken into the bones, where they bind to a mineral called hydroxyapatite. Bone resorption by osteoclasts creates an acidic environment that forces the bisphosphonates out of their binding site and into the osteoclast. Once in the osteoclast, the bisphosphonates interfere with the osteoclast's ability to break down the bones. This prevents the resorption of bones by the osteoclast. Early generation bisphosphonates mimic a molecule called pyrophosphate, which cannot be broken down, and thus stops all energy-dependent functions of
When to interrupt dosage
The advocated dosage of Didronel is contingent upon the identified condition, including Total Hip Replacements, Paget's Disease of Bone and Heterotopic Ossification. The magnitude of dosage varies, as per the delivery strategy outlined in the table beneath.Condition
Dosage
Administration
Paget's Disease of Bone
200.0 mg, , 400.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Kit; Tablet, Kit; Tablet - Oral, Intravenous, Solution - Intravenous, Solution
Heterotopic Ossification
200.0 mg, , 400.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Kit; Tablet, Kit; Tablet - Oral, Intravenous, Solution - Intravenous, Solution
Total Hip Replacements
200.0 mg, , 400.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Kit; Tablet, Kit; Tablet - Oral, Intravenous, Solution - Intravenous, Solution
Spinal Cord Injury
200.0 mg, , 400.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Kit; Tablet, Kit; Tablet - Oral, Intravenous, Solution - Intravenous, Solution
Warnings
Didronel ContraindicationsCondition
Risk Level
Notes
Achalasia, Esophageal
Do Not Combine
delayed esophageal emptying
Do Not Combine
Esophageal Strictures
Do Not Combine
Esophagus
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Etidronic Acid may interact with Pulse Frequency
Common Didronel Drug Interactions
Drug Name
Risk Level
Description
Incadronic acid
Minor
The risk or severity of adverse effects can be increased when Etidronic acid is combined with Incadronic acid.
Tiludronic acid
Minor
The risk or severity of adverse effects can be increased when Etidronic acid is combined with Tiludronic acid.
Deferasirox
Moderate
The risk or severity of gastrointestinal bleeding and gastrointestinal ulceration can be increased when Etidronic acid is combined with Deferasirox.
Parathyroid hormone
Moderate
The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Etidronic acid.
Technetium Tc-99m oxidronate
Moderate
The risk or severity of hypocalcemia can be increased when Etidronic acid is combined with Technetium Tc-99m oxidronate.
Didronel Toxicity & Overdose RiskAn overdose of calcium gluconate can cause symptoms such as low calcium levels, vomiting, tingling sensations, and diarrhea. Treatment may involve managing electrolyte levels and administering intravenous calcium gluconate.
Didronel Novel Uses: Which Conditions Have a Clinical Trial Featuring Didronel?
48 active clinical trials are presently examining the potential of Didronel to alleviate Heterotopic Ossification, Paget's Disease of Bone and Spinal Cord Injury.Condition
Clinical Trials
Trial Phases
Paget's Disease of Bone
0 Actively Recruiting
Heterotopic Ossification
1 Actively Recruiting
Not Applicable
Total Hip Replacements
1 Actively Recruiting
Not Applicable
Spinal Cord Injury
44 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Early Phase 1, Phase 3
Didronel Reviews: What are patients saying about Didronel?
3.7Patient Review
12/24/2013 This treatment has been effective for me over the long term. It can be difficult to find, but it's worth seeking out.
3Patient Review
9/13/2010Patient Q&A Section about didronel
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is etidronate a bisphosphonate?
"Etidronate falls into a category of drugs known as bisphosphonates. Its mode of action is to slow the deterioration of existing bone and the formation of new bone."
Answered by AI
Is Didronel a bisphosphonate?
"Didronel is a medicine that affects how bones are formed and broken down in the body. This can slow down the loss of bone mass, and may help to prevent fractures. Didronel is used to treat a condition called Paget's disease, which affects the bones."
Answered by AI
Is etidronate discontinued?
"This drug is not available in the U.S. The recommended dose was 7.5 mg/kg IV infusion once daily, administered for 3 consecutive days. Etidronate was designated an orphan drug by the FDA for this indication; however, etidronate therapy has been replaced with more potent bisphosphonates for this condition."
Answered by AI
What is Didronel used for?
"Etidronate isused topersona certain type of bone disease called Paget's disease. This disease weakens and deforms bones. Etidronatereduce works by slowing bone loss, helping to keep your bones strong and less likely to break. It also helps reduce bone pain from this disease."
Answered by AI