Delestrogen

Low Testosterone, hypoestrogenism, Fracture + 25 more

Treatment

3 FDA approvals

20 Active Studies for Delestrogen

What is Delestrogen

Estradiol valerate

The Generic name of this drug

Treatment Summary

Estradiol Valerate (also known as E2V) is a medication that increases the amount of estrogen in the body. Estrogen is a hormone found naturally in the body and is the main female sex hormone. Estradiol Valerate is used to treat symptoms of menopause, such as hot flashes, vaginal dryness, mood changes, irregular menstrual cycles, chills, and sleeping problems. It is also used to treat hypoestrogenism due to hypogonadism, castration, or primary ovarian failure, and advanced androgen-dependent prostate cancer. Estradiol Valerate is available

Delestrogen

is the brand name

image of different drug pills on a surface

Delestrogen Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Delestrogen

Estradiol valerate

1954

22

Approved as Treatment by the FDA

Estradiol valerate, also called Delestrogen, is approved by the FDA for 3 uses like Heavy Menstrual Bleeding and Oral Contraceptives .

Heavy Menstrual Bleeding

Used to treat Heavy Menstrual Bleeding in combination with Dienogest

Oral Contraceptives

Used to treat Oral Contraceptives in combination with Dienogest

Menorrhagia

Used to treat Heavy Menstrual Bleeding in combination with Dienogest

Effectiveness

How Delestrogen Affects Patients

Estrogen has many effects throughout the body, and works by binding to two types of receptors: Estrogen Receptor Alpha (ERα) and Estrogen Receptor Beta (ERβ). It also binds to a G Protein-coupled Estrogen Receptor (GPER), which is important in the quick action of estrogen. Estrogen is found in many areas of the body, such as the breasts, uterus, ovaries, skin, prostate, bone, fat, and brain.

How Delestrogen works in the body

Estradiol is a hormone found in the body, especially in women. When it enters cells, it binds to a receptor and enters the nucleus. It then interacts with genes and forms molecules that affect the cell. It can also increase the production of certain proteins in the body and lower levels of another hormone. All of this helps to reduce the symptoms of menopause, which are caused by a lack of estradiol.

When to interrupt dosage

The prescribed dosage of Delestrogen is contingent upon the diagnosed issue, including extreme menopausal vulvovaginal atrophy, Menopausal Symptoms and Menorrhagia. The amount of dosage fluctuates, in accordance with the administration procedure highlighted in the table below.

Condition

Dosage

Administration

Menopausal Symptoms

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Low Testosterone

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Fracture

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

severe menopausal vulvovaginal atrophy

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Ovarian Resection

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Irregular Menstruation

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Oral Contraceptives

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Uterus

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Pharmaceutical Preparations

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Malignant neoplasm of prostate

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

moderate menopausal vulvovaginal atrophy

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Primary Ovarian Insufficiency

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Primary Amenorrhoea

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Hot flashes

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

hypoestrogenism

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

moderate Menopausal Vasomotor Symptoms

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Hormone Replacement Therapy

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Premature Menopause

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Menstruation Disturbances

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Osteoporosis, Postmenopausal

10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL

, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Warnings

Delestrogen has eleven contraindications and should not be taken when encountering any of the circumstances indicated in the table below.

Delestrogen Contraindications

Condition

Risk Level

Notes

Thromboembolism

Do Not Combine

Venous Thrombosis

Do Not Combine

estrogen-dependent neoplasia

Do Not Combine

Pulmonary Embolism

Do Not Combine

Pulmonary Embolism

Do Not Combine

Thromboembolism

Do Not Combine

Metrorrhagia

Do Not Combine

Breast Cancer

Do Not Combine

Breast

Do Not Combine

Deep Vein Thrombosis

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Estradiol Valerate may interact with Pulse Frequency

There are 20 known major drug interactions with Delestrogen.

Common Delestrogen Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Estradiol valerate.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Estradiol valerate.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Estradiol valerate.

Aminophylline

Major

The metabolism of Aminophylline can be increased when combined with Estradiol valerate.

Anagrelide

Major

The metabolism of Anagrelide can be decreased when combined with Estradiol valerate.

image of a doctor in a lab doing drug, clinical research

Delestrogen Novel Uses: Which Conditions Have a Clinical Trial Featuring Delestrogen?

27 active trials are being conducted to investigate the potential of Delestrogen to address Irregular Menstruation, diminished reproductive organ function and female castration.

Condition

Clinical Trials

Trial Phases

Low Testosterone

6 Actively Recruiting

Phase 4, Phase 2, Phase 1

Menopausal Symptoms

1 Actively Recruiting

Not Applicable

hypoestrogenism

1 Actively Recruiting

Phase 4

Hormone Replacement Therapy

0 Actively Recruiting

Fracture

0 Actively Recruiting

Primary Ovarian Insufficiency

0 Actively Recruiting

Osteoporosis, Postmenopausal

0 Actively Recruiting

Menorrhagia

0 Actively Recruiting

Irregular Menstruation

0 Actively Recruiting

Primary Amenorrhoea

0 Actively Recruiting

Ovarian Resection

0 Actively Recruiting

Menopause

0 Actively Recruiting

severe menopausal vulvovaginal atrophy

0 Actively Recruiting

Pharmaceutical Preparations

0 Actively Recruiting

female castration

0 Actively Recruiting

Uterus

0 Actively Recruiting

Malignant neoplasm of prostate

0 Actively Recruiting

Hot flashes

19 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 3

Menstruation Disturbances

1 Actively Recruiting

Not Applicable

Amenorrhea

0 Actively Recruiting

Delestrogen Reviews: What are patients saying about Delestrogen?

5

Patient Review

7/30/2009

Delestrogen for Low Estrogen After Operation to Remove Ovaries

I've been using this medication for three months now and I really like it. It's easy to use, which is great for me because I have trouble remembering to take pills. I'm just waiting for my breasts to stop hurting and swelling. Does anyone know how long that will take?

5

Patient Review

7/20/2011

Delestrogen for Low Estrogen After Operation to Remove Ovaries

Even though I get a bit of a rash after each injection, this treatment helps to supplement the hormones my body is lacking.

5

Patient Review

4/9/2009

Delestrogen for Low Estrogen After Operation to Remove Ovaries

I'm intersex, and this medication does a lot for me.

5

Patient Review

1/4/2009

Delestrogen for Low Estrogen After Operation to Remove Ovaries

I've been using this form of estrogen for two and a half months due to ovarian failure, and I definitely prefer it to taking pills or wearing a patch.

5

Patient Review

11/13/2008

Delestrogen for Primary Ovarian Failure

This medication has completely alleviated my symptoms of hot flashes and dryness. Additionally, it's given me back my sexual desires after a total hysterectomy.

5

Patient Review

11/13/2007

Delestrogen for Low Estrogen After Operation to Remove Ovaries

5

Patient Review

3/5/2008

Delestrogen for Low Estrogen After Operation to Remove Ovaries

5

Patient Review

3/27/2015

Delestrogen for Low Estrogen After Operation to Remove Ovaries

I had to have a full Hysterectomy when I was 31yrs old. Doctors tried me on Premarin pills but they gave me terrible Migraine headaches every day. The Doctor then switched me to the Delestrogen shots once a month. I have been on them for over 30yrs with no side effects. Now the Pharmacist in my town says you can't buy it anymore! What are you suppose to do when nothing else works. Why fix something that isn't broken??? I swear by this medicine..

1.7

Patient Review

4/27/2011

Delestrogen for Low Estrogen After Operation to Remove Ovaries

The delestrogen I have been taking has made me happy in all ways.I have been very satisfied. I am a transgender while taken this I have seen my breasts enlarge along with the nipples and tenderness while using this drug. I would recommend it to all transgender people. I feel so much better about myself.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about delestrogen

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Delestrogen used for in men?

"Delestrogen is a medication used to treat a lack of estrogen. This can be caused by ovarian failure or a condition called hypogonadism. Some forms of estradiol injection are used in fertility treatment for women or men to treat the symptoms of prostate cancer."

Answered by AI

What is Delestrogen used for?

"This medication is a female hormone known as estrogen. It is used to help reduce symptoms of menopause such as hot flashes and vaginal dryness, which are caused by the body producing less estrogen."

Answered by AI

How does Delestrogen make you feel?

"Delestrogen may cause common side effects such as headaches, vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding, thinning scalp hair, or nausea, vomiting, bloating, stomach cramps."

Answered by AI

Clinical Trials for Delestrogen

Image of VA Greater Los Angeles Healthcare System, West Los Angeles, CA in West Los Angeles, United States.

EBQI Strategies for Women's Health

Any Age
All Sexes
West Los Angeles, CA

Women Veterans are the fastest growing segment of VA users, with most users in midlife. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that they will want and be able to use those services. Furthermore, few VA improvement efforts have focused on women Veterans' health and health care in midlife. The EMPOWER QUERI 3.0 Program is a cluster randomized type 3 hybrid implementation-effectiveness trial testing two strategies designed to support implementation and sustainment of evidence-based practices for women Veterans in at least 18 VA facilities from 4 regions.

Waitlist Available
Has No Placebo

VA Greater Los Angeles Healthcare System, West Los Angeles, CA

Erin P Finley, PhD MPH

Image of Goldring Center for High Performance Sport in Toronto, Canada.

Menstrual Cycle vs. Birth Control Pills for Protein Metabolism

18 - 40
Female
Toronto, Canada

The muscles of the body are constantly breaking down old proteins and building new ones. These two processes, protein breakdown and protein synthesis, together are known as protein turnover. Protein turnover is essential for maintaining healthy muscle. Despite its importance, females have historically been underrepresented in protein metabolism research. A long-standing assumption has been that fluctuations in female sex hormones such as estrogen and progesterone, whether across the natural menstrual cycle or in individuals using oral contraceptives (OCs), make metabolism and training responses too variable to study. Because of this, many researchers have excluded female participants for logistical reasons. Resistance exercise, such as weightlifting, is the most effective way to increase muscle size and strength. Each resistance-training session triggers muscle protein synthesis (MPS), the process by which new muscle proteins are built. Consuming dietary protein or individual amino acids further increases the rate at which new proteins are formed. Over time, higher rates of protein synthesis support muscle growth and the maintenance of other lean tissues in the body. The purpose of this study is to examine how menstrual cycle phases and OC use influence the synthesis of proteins in both muscle tissue and the rest of the body. Improving scientific understanding in this area will support more effective, evidence-based training and nutrition recommendations for females.

Recruiting
Has No Placebo

Goldring Center for High Performance Sport

Image of Erevna Innovations Inc. in Montreal, Canada.

Sculptra + Restylane for Post-Menopausal Skin Concerns

40 - 65
Female
Montreal, Canada

The post-menopausal state is marked by a sharp decline in estrogen, leading to significant structural and functional changes in the skin, including collagen loss, dryness, thinning, and reduced elasticity. To address these concerns, aesthetic injectables products such as Sculptra® Aesthetic (poly-L-lactic-acid \[PLLA- SCA\]) and Restylane Skinboosters®\[HASBV\] (small-particle hyaluronic acid - SP-HA) can be used. PLLA-SCA stimulates collagen production via cellular activation (biostimulator), gradually improving dermal structure. HASBV enhances hydration, elasticity, and skin texture when injected under the skin. Considering that hydration and laxity represent the primary aesthetic concerns in this patient population. Targeted treatment with SP-HA (HASBV) to improve hydration and PLLA-SCA to address laxity have been shown to produce significant clinical outcomes by directly addressing these key dermal deficiencies. This approach forms the basis of the current study.

Phase 4
Recruiting

Erevna Innovations Inc.

Andreas Nikolis, MD, PhD

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We made a collection of clinical trials featuring Delestrogen, we think they might fit your search criteria.
Go to Trials

Have you considered Delestrogen clinical trials?

We made a collection of clinical trials featuring Delestrogen, we think they might fit your search criteria.
Go to Trials
Image of Rehabilitation R&D Service, Baltimore, MD in Baltimore, United States.

Cognitive Behavioral Therapy for Menopause

18+
Female
Baltimore, MD

Women are the fastest-growing group of U.S. Veterans. Over half of those using VA care are 45 or older, with more age-related health concerns than civilian women. The VA urgently needs gender-informed strategies to ensure women Veterans receive tailored care that addresses their intersecting mental, physical, and age related health concerns, as well as gender-linked stressors. One prominent example is menopause, a health transition period that, for many women, can be associated with negative physical and mental health concerns that can worsen their functioning and quality of life. This project will: (1) integrate stakeholder feedback to tailor Cognitive Behavioral Therapy for Menopause (CBT-Meno) for women Veterans with menopause concerns; and (2) refine and evaluate tailored CBT-Meno as a treatment to address these intersecting needs in a clinical trial.

Waitlist Available
Has No Placebo

Rehabilitation R&D Service, Baltimore, MD (+2 Sites)

Haley Miles-McLean, PhD

Image of Student Health and Wellness Building - Department of Kinesiology in Charlottesville, United States.

Nitrate Supplementation and Exercise for Menopause

45 - 75
Female
Charlottesville, VA

Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal females. Oral nitrate supplementation enhances exercise performance and CVD risk profile in several clinical conditions. The investigators recently reported that 3-days of nitrate supplementation in postmenopausal females enhances acute post-exercise vascular function, in an intensity dependent manner. The effects of nitrate supplementation and exercise training over a longer training program remains unexplored. This investigation will examine the impact of exercise training intensity with and without inorganic nitrate supplementation, on CVD and fitness outcomes. Postmenopausal females will be tested for maximal oxygen uptake and lactate threshold before randomization to one of four groups: that inorganic nitrate-rich beetroot juice, or beetroot juice with nitrate extracted; and assigned to one-month of calorie matched high-intensity or moderate-intensity exercise training. Vascular function and fitness will be evaluated before and after training.

Recruiting
Paid Trial

Student Health and Wellness Building - Department of Kinesiology

Jason Allen, PhD

Have you considered Delestrogen clinical trials?

We made a collection of clinical trials featuring Delestrogen, we think they might fit your search criteria.
Go to Trials