Your session is about to expire
What is Clozaril
ClozapineThe Generic name of this drug
Treatment SummaryClozapine is a medication used to treat certain mental health disorders. It works by blocking serotonin and dopamine receptors in the brain, reducing the symptoms of psychosis. Clozapine is classified as an atypical antipsychotic agent and is known to cause a rare side effect called agranulocytosis. It is important to monitor blood levels while taking Clozapine to ensure it is taken safely.
Clozarilis the brand name
Clozaril Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Clozaril
Clozapine
1989
97
Approved as Treatment by the FDA
Clozapine, also called Clozaril, is approved by the FDA for 7 uses which include Severe Mental Illness and inadequate response to conventional therapy .Severe Mental Illness
Helps manage Severe Mental Illness
inadequate response to conventional therapy
Helps manage inadequate response to conventional therapy
High Risk
Helps manage High Risk
Schizophrenia
Helps manage Schizophrenia
Suicide
Helps manage Suicidal Behaviour
Schizoaffective Disorder
Helps manage Schizoaffective Disorders
Schizophrenia, Treatment-Resistant
Helps manage Treatment Resistant Schizophrenia
Effectiveness
How Clozaril Affects PatientsClozapine is a medication used to treat schizophrenia, and works by targeting serotonin, dopamine, adrenaline, and histamine receptors in the brain. It can cause side effects such as drowsiness, low blood pressure, and dry mouth. It also carries a risk of serious reactions, such as agranulocytosis (low white blood cell count) or myocarditis (inflammation of the heart muscle). Your doctor will monitor your white blood cell count and other lab values closely while taking this medication, and will also check for signs of myocarditis. If you experience any of these reactions, you should stop taking cl
How Clozaril works in the bodyClozapine works to treat psychosis by blocking certain receptors in the brain. It blocks dopamine receptors to reduce positive symptoms, and serotonin receptors to reduce negative symptoms.
When to interrupt dosage
The advised dosage of Clozaril is contingent upon the specified condition, including High Risk, Severe Mental Illness and Schizoaffective Disorder. The quantity of dosage fluctuates depending on the technique of administration as detailed in the table hereunder.Condition
Dosage
Administration
High Risk
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Schizophrenia, Treatment-Resistant
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Advance Directives
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Schizophrenia
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Schizoaffective Disorder
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Suicide
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Parkinsonian Syndromes
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
inadequate response to conventional therapy
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Severe Mental Illness
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Warnings
There are 20 known major drug interactions with Clozaril.Common Clozaril Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Clozapine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Clozapine.
Acepromazine
Major
Clozapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Clozapine is combined with Aclidinium.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Clozapine.
Clozaril Toxicity & Overdose RiskClozapine has a serious warning due to its potential to cause a severe decrease in white blood cells.
Clozaril Novel Uses: Which Conditions Have a Clinical Trial Featuring Clozaril?
230 active clinical trials are currently in progress to analyze the therapeutic potential of Clozaril in High Risk, Parkinsonian Syndromes and Suicide prevention.Condition
Clinical Trials
Trial Phases
Severe Mental Illness
0 Actively Recruiting
inadequate response to conventional therapy
0 Actively Recruiting
Schizoaffective Disorder
52 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 1, Early Phase 1, Phase 3
Schizophrenia, Treatment-Resistant
5 Actively Recruiting
Not Applicable, Phase 4
Schizophrenia
174 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Advance Directives
0 Actively Recruiting
Suicide
3 Actively Recruiting
Not Applicable
Parkinsonian Syndromes
0 Actively Recruiting
High Risk
1 Actively Recruiting
Phase 1
Clozaril Reviews: What are patients saying about Clozaril?
5Patient Review
4/9/2012 Clozaril has been a life-saver for me. I've tried many other drugs with varying degrees of success, but the side effects were always too severe. With Clozaril, I finally found a medication that is effective without being overly debilitating.
5Patient Review
6/2/2009 Weight gain was a bit extreme, but this drug really helped with my insomnia. I have to go for monthly bloodwork and appointments with the doctor, but it's worth it. The pain in my joints and muscles wasn't severe.
5Patient Review
10/19/2016 My brother has been on Clozaril for 12 years plus. He has been in and out of hospitals his whole life and this drug has enabled him to lead somewhat of a normal life. Now, we are unable to find a doctor who takes Medicare and will prescribe this medication. It has been devastating for our family.
5Patient Review
4/28/2017 This drug has helped my son immensely. He's been taking it for around a year to manage his schizophrenia and bipolarity, and we've seen vast improvements. His other medications have since been discontinued or decreased in dosage because of this drug, and he's doing great!
5Patient Review
1/14/2013 This medication has helped me deal with the voices. I would recommend it to those individuals seeking relief from auditory hallucinations.
5Patient Review
4/23/2012 At first, the weekly blood work was tough to handle. Now I only have to go monthly. This medication has been a true wonder drug for me and I haven't had to stay in the hospital for over two years now.
4.7Patient Review
4/10/2011 So far, clozaril has been working great for me. I've only been taking it for a week, but I feel like I'm able to cope better already. I've tried other drugs in the past, but this one seems to be the best fit for me.
4.3Patient Review
9/3/2009 Clozaril was a godsend for my son. He was very ill and we had tried every treatment available with little success. After starting Clozaril, he is now doing great in college with only a fraction of his previous symptoms.
3.7Patient Review
10/19/2010 Clozaril has made a world of difference for my son. He was taking a lot of other drugs that didn't really help, and some even made things worse. But this medication has helped him to act more like himself again.
3.7Patient Review
6/16/2015 I've been using this medication for over two decades, but recently stopped and then restarted. I'm not seeing the same results as before and am now experiencing depression where I didn't before.
3.7Patient Review
1/13/2009 My son has been on this medication for a week to help with his bi-polar disorder and psycho-affective disorder. So far, he is still very sleepy and delusional.
3.3Patient Review
3/20/2009 I've been using this medication for a while now and it's starting to impact my memory. It's becoming difficult to keep a job or maintain relationships when I can't remember things. That said, it's still been helpful overall.
3.3Patient Review
4/23/2013 I've been on clozapine since 1995 and it's been effective for me. The weight gain is an issue, but I'm able to keep a full-time job because of the medication. I have been told that there may be a slight heart issue that is not caused by clozapine, but I would try everything else before starting this medication again.
1Patient Review
9/7/2013 After my diagnosis last year, I was hospitalized for four months. I was put on Cloazaril after trying three other atypical antipsychotics, and it has been a total game-changer. Within three months, I was back to work and happy again. The downside is that it can make you sleepy, and you have to get your blood drawn and weigh yourself every week.
1Patient Review
5/4/2010 I was on Clozaril for a number of years, but then I started having major issues with things like memory and weight gain. Thankfully, my doctor was able to switch me to a different medication.
Patient Q&A Section about clozaril
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the main side effects of Clozaril?
"Side effects that are commonly seen include feeling sleepy, dizzy, having a headache, trembling, a fast heart rate, low blood pressure, passing out, drooling, sweating, a dry mouth, visual issues, constipation, feeling nauseous, and having a fever."
Answered by AI
What type of drug is Clozaril?
"Clozapine is a medication that belongs to a class of antipsychotics called atypical antipsychotics. This medication works by changing the activity of natural substances in the brain."
Answered by AI
What is the drug Clozaril used for?
"Clozapine is a medication that works in the brain to treat schizophrenia by rebalancing dopamine and serotonin. It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic."
Answered by AI
What is the most serious side effect of clozapine?
"The following text contains information about the possible side effects of Clozapine. Clozapine may cause drowsiness, blurred vision, convulsions (seizures), or difficulties with thinking or controlling body movements, which may lead to falls, fractures or other injuries."
Answered by AI