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What is Clobex
Clobetasol propionateThe Generic name of this drug
Treatment SummaryClobetasol Propionate is a corticosteroid medication used to reduce inflammation in skin conditions. It is more powerful than other corticosteroid medications and was first developed in 1974. Clobetasol propionate was approved by the FDA in 1985.
Temovate Scalp Applicationis the brand name
Clobex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Temovate Scalp Application
Clobetasol propionate
1990
245
Effectiveness
How Clobex Affects PatientsCorticosteroids attach to the hormone receptor that controls inflammation, reducing inflammation and increasing anti-inflammatory signals. Clobetasol propionate is usually applied twice per day, and its effects last for an extended period. The recommended dose for this drug is often higher than what the body naturally produces. It is important to note that taking corticosteroids can suppress the hormone system that controls stress and increase a person's risk of getting infections.
How Clobex works in the bodyCorticosteroids reduce swelling caused by inflammation. This is done by changing the way some genes work and by stopping certain chemicals from forming. Corticosteroids also prevent white blood cells from going to the site of inflamation. Lower doses of corticosteroids can reduce inflamation, while higher doses weaken your immune system. Prolonged use of high doses can also increase the amount of sodium in your body and decrease the amount of potassium.
When to interrupt dosage
The proposed dosage of Clobex is contingent upon the determined affliction, including Psoriasis, corticosteroid responsive, Inflammatory Dermatosis and Pruritus. The measure of dosage is subject to the technique of delivery (e.g. Topical or Ointment) stated in the table below.Condition
Dosage
Administration
corticosteroid responsive, Inflammatory Dermatosis
0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg
, Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Lotion, Lotion - Topical, Spray, Spray - Topical, Aerosol, foam - Topical, Aerosol, foam, Kit, Emulsion - Topical, Emulsion, Liquid, Liquid - Topical, Kit - Topical
Severe Plaque psoriasis
0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg
, Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Lotion, Lotion - Topical, Spray, Spray - Topical, Aerosol, foam - Topical, Aerosol, foam, Kit, Emulsion - Topical, Emulsion, Liquid, Liquid - Topical, Kit - Topical
Psoriasis
0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg
, Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Lotion, Lotion - Topical, Spray, Spray - Topical, Aerosol, foam - Topical, Aerosol, foam, Kit, Emulsion - Topical, Emulsion, Liquid, Liquid - Topical, Kit - Topical
Alopecia
0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg
, Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Lotion, Lotion - Topical, Spray, Spray - Topical, Aerosol, foam - Topical, Aerosol, foam, Kit, Emulsion - Topical, Emulsion, Liquid, Liquid - Topical, Kit - Topical
Psoriasis
0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg
, Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Lotion, Lotion - Topical, Spray, Spray - Topical, Aerosol, foam - Topical, Aerosol, foam, Kit, Emulsion - Topical, Emulsion, Liquid, Liquid - Topical, Kit - Topical
Psoriasis
0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg
, Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Lotion, Lotion - Topical, Spray, Spray - Topical, Aerosol, foam - Topical, Aerosol, foam, Kit, Emulsion - Topical, Emulsion, Liquid, Liquid - Topical, Kit - Topical
Pruritus
0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg
, Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Lotion, Lotion - Topical, Spray, Spray - Topical, Aerosol, foam - Topical, Aerosol, foam, Kit, Emulsion - Topical, Emulsion, Liquid, Liquid - Topical, Kit - Topical
Warnings
There are 20 known major drug interactions with Clobex.Common Clobex Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Abatacept.
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Clobetasol propionate.
Abetimus
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Abetimus.
Clobex Toxicity & Overdose RiskTaking too much of a glucocorticoid, such as clobetasol propionate, can lead to decreased activity of the adrenal glands and an inability to respond to stress. Long-term use of high doses of glucocorticoids can cause or worsen eye problems, high blood pressure, fluid retention, high cholesterol, ulcers, inflammation of the pancreas, muscle weakness, mental changes, skin irritation, allergies, acne, increased hair growth, weakened immune system, diabetes, calcium deficiency, phosphorus deficiency, and acidosis. Treatment for an overdose of glucocorticoids may involve adjusting the dose
Clobex Novel Uses: Which Conditions Have a Clinical Trial Featuring Clobex?
47 active clinical trials are currently underway to determine the potential of Clobex in providing corticosteroid responsive treatment measures for Inflammatory Dermatosis, Psoriasis and Alopecia.Condition
Clinical Trials
Trial Phases
Severe Plaque psoriasis
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
corticosteroid responsive, Inflammatory Dermatosis
0 Actively Recruiting
Pruritus
0 Actively Recruiting
Alopecia
50 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1, Phase 3, Phase 4, Phase 1
Psoriasis
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Clobex Reviews: What are patients saying about Clobex?
5Patient Review
9/16/2010 I used this originally for small dermatitis breakouts on my body, which it worked great for. However, I then started using it on my face for a tiny spot of what I thought was dermatitis. Big mistake. Six months later and I'm now dealing with PERI-ORAL DERMATITIS because of overusing this product (especially around the delicate skin on my face). If only I had read the directions better or listened to my dermatologist's advice not to use it on my face in the first place!
5Patient Review
4/25/2011 This treatment has helped me immensely. I had huge, unsightly plaques on my scalp that made it difficult to wash my hair regularly. After just two weeks of using Clobex, they were all gone. Now I only have to use it once a day, one week out of the month.
5Patient Review
12/29/2011 My doctor diagnosed a rash on my wrist as eczema and prescribed Clobex. I had tried other creams with no success, but this lotion cleared up the eczema in just a few days.
5Patient Review
6/21/20105Patient Review
8/10/2012 Clobex spray is incredible. I could see it working within hours, and it was well worth the price.
4.7Patient Review
11/10/2015 This stuff is amazing for psoriasis--I saw results within just a few days. The only downside is that it burns when you put it on, but thankfully that only lasts for a minute or two.
4.7Patient Review
12/27/2010 I've been using this treatment for years. I find that it works best when used on a weekday schedule, with breaks on weekends. I also use Dovonex during my breaks to help maintain the results. This is by far the best topical treatment I have ever used for psoriasis.
4Patient Review
11/6/2012 I had a large, ugly plaque on my right kneecap that was painful and itchy. I tried multiple treatments over the course of three years with no success. Luckily, I received a sample of this medication from my new dermatologist and it cleared up the plaque within a few weeks. Once I ran out, the plaque still hadn't returned after another three weeks. So far, so good!
3.3Patient Review
7/27/2010 My contact dermatitis was gone within two days of using this lotion, which was great. I didn't experience any negative side effects, and my skin looked healthy and normal afterwards.
3Patient Review
8/9/2010 This treatment is very expensive, and the problem areas always come back within a day of discontinuing use.
2.7Patient Review
11/1/2011 I experienced significant hair loss while using this treatment, to the point where it was noticeable to others. My other symptoms improved, but at what cost?
2.3Patient Review
12/20/2013 I've only just started using this, so I can't speak to its long-term effectiveness yet.
2Patient Review
8/5/2018 I have used Clobex spray for a while now on various areas of my body, but I unfortunately have not seen any results. Furthermore, the spray has caused my skin to lighten in color and become slightly transparent where it has been applied, which is an additional problem that I did not anticipate.
2Patient Review
1/29/2016 Please be aware that when using this medication, you may experience major mood changes. I did, and it was absolutely horrible. It also didn't work for my psoriasis.
1.7Patient Review
12/3/2013 Worked well for a month, then the problem came back twice as bad. I'm going to try UVB light next and see how that goes.
1.7Patient Review
7/28/2010 This has helped to soothe my itchy and red skin.
Patient Q&A Section about clobex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Do you need a prescription for Clobex?
"Clobex is a brand-name prescription drug that treats certain skin conditions that have been approved by the FDA. It comes in the form of a shampoo, lotion, or spray. Depending on the form of Clobex that is prescribed, this drug can be used to treat moderate to severe psoriasis."
Answered by AI
What is Clobex used to treat?
"A super-high-potency corticosteroid, Clobetasol is used by adults to treat moderate to severe plaque psoriasis, reducing the swelling, itching and redness that can occur with this condition."
Answered by AI
Does Clobex cause hair loss?
"The following may occur when this medication is first applied to the scalp: burning, stinging, itching, irritation, redness, discoloration, dry skin, hair loss, headache, or acne. However, this should only be temporary as your body adjusts to the medication."
Answered by AI