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What is Clobex
Clobetasol propionateThe Generic name of this drug
Treatment SummaryClobetasol Propionate is a corticosteroid medication used to reduce inflammation in skin conditions. It is more powerful than other corticosteroid medications and was first developed in 1974. Clobetasol propionate was approved by the FDA in 1985.
Temovate Scalp Applicationis the brand name
Clobex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Temovate Scalp Application
Clobetasol propionate
1990
245
Effectiveness
How Clobex Affects PatientsCorticosteroids attach to the hormone receptor that controls inflammation, reducing inflammation and increasing anti-inflammatory signals. Clobetasol propionate is usually applied twice per day, and its effects last for an extended period. The recommended dose for this drug is often higher than what the body naturally produces. It is important to note that taking corticosteroids can suppress the hormone system that controls stress and increase a person's risk of getting infections.
How Clobex works in the bodyCorticosteroids reduce swelling caused by inflammation. This is done by changing the way some genes work and by stopping certain chemicals from forming. Corticosteroids also prevent white blood cells from going to the site of inflamation. Lower doses of corticosteroids can reduce inflamation, while higher doses weaken your immune system. Prolonged use of high doses can also increase the amount of sodium in your body and decrease the amount of potassium.
When to interrupt dosage
The proposed dosage of Clobex is contingent upon the determined affliction, including Psoriasis, corticosteroid responsive, Inflammatory Dermatosis and Pruritus. The measure of dosage is subject to the technique of delivery (e.g. Topical or Ointment) stated in the table below.Condition
Dosage
Administration
Psoriasis
0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg
, Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Lotion, Lotion - Topical, Spray, Spray - Topical, Aerosol, foam - Topical, Aerosol, foam, Kit, Emulsion - Topical, Emulsion, Liquid, Liquid - Topical, Kit - Topical
Pruritus
0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg
, Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Lotion, Lotion - Topical, Spray, Spray - Topical, Aerosol, foam - Topical, Aerosol, foam, Kit, Emulsion - Topical, Emulsion, Liquid, Liquid - Topical, Kit - Topical
Alopecia
0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg
, Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Lotion, Lotion - Topical, Spray, Spray - Topical, Aerosol, foam - Topical, Aerosol, foam, Kit, Emulsion - Topical, Emulsion, Liquid, Liquid - Topical, Kit - Topical
Psoriasis
0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg
, Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Lotion, Lotion - Topical, Spray, Spray - Topical, Aerosol, foam - Topical, Aerosol, foam, Kit, Emulsion - Topical, Emulsion, Liquid, Liquid - Topical, Kit - Topical
Psoriasis
0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg
, Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Lotion, Lotion - Topical, Spray, Spray - Topical, Aerosol, foam - Topical, Aerosol, foam, Kit, Emulsion - Topical, Emulsion, Liquid, Liquid - Topical, Kit - Topical
Severe Plaque psoriasis
0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg
, Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Lotion, Lotion - Topical, Spray, Spray - Topical, Aerosol, foam - Topical, Aerosol, foam, Kit, Emulsion - Topical, Emulsion, Liquid, Liquid - Topical, Kit - Topical
corticosteroid responsive, Inflammatory Dermatosis
0.4625 mg/mL, , 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.462 mg/mL, 0.0005 mL/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL, 0.00025 mg/mg, 0.5 mg/mg, 0.00015 mg/mg
, Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Lotion, Lotion - Topical, Spray, Spray - Topical, Aerosol, foam - Topical, Aerosol, foam, Kit, Emulsion - Topical, Emulsion, Liquid, Liquid - Topical, Kit - Topical
Warnings
There are 20 known major drug interactions with Clobex.Common Clobex Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Abatacept.
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Clobetasol propionate.
Abetimus
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Abetimus.
Clobex Toxicity & Overdose RiskTaking too much of a glucocorticoid, such as clobetasol propionate, can lead to decreased activity of the adrenal glands and an inability to respond to stress. Long-term use of high doses of glucocorticoids can cause or worsen eye problems, high blood pressure, fluid retention, high cholesterol, ulcers, inflammation of the pancreas, muscle weakness, mental changes, skin irritation, allergies, acne, increased hair growth, weakened immune system, diabetes, calcium deficiency, phosphorus deficiency, and acidosis. Treatment for an overdose of glucocorticoids may involve adjusting the dose
Clobex Novel Uses: Which Conditions Have a Clinical Trial Featuring Clobex?
47 active clinical trials are currently underway to determine the potential of Clobex in providing corticosteroid responsive treatment measures for Inflammatory Dermatosis, Psoriasis and Alopecia.Condition
Clinical Trials
Trial Phases
Alopecia
15 Actively Recruiting
Early Phase 1, Not Applicable, Phase 3, Phase 2, Phase 1
Severe Plaque psoriasis
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Pruritus
0 Actively Recruiting
corticosteroid responsive, Inflammatory Dermatosis
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Clobex Reviews: What are patients saying about Clobex?
5Patient Review
9/16/2010 I used this originally for small dermatitis breakouts on my body, which it worked great for. However, I then started using it on my face for a tiny spot of what I thought was dermatitis. Big mistake. Six months later and I'm now dealing with PERI-ORAL DERMATITIS because of overusing this product (especially around the delicate skin on my face). If only I had read the directions better or listened to my dermatologist's advice not to use it on my face in the first place!
5Patient Review
4/25/2011 This treatment has helped me immensely. I had huge, unsightly plaques on my scalp that made it difficult to wash my hair regularly. After just two weeks of using Clobex, they were all gone. Now I only have to use it once a day, one week out of the month.
5Patient Review
12/29/2011 My doctor diagnosed a rash on my wrist as eczema and prescribed Clobex. I had tried other creams with no success, but this lotion cleared up the eczema in just a few days.
5Patient Review
6/21/20105Patient Review
8/10/2012 Clobex spray is incredible. I could see it working within hours, and it was well worth the price.
Patient Q&A Section about clobex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Do you need a prescription for Clobex?
"Clobex is a brand-name prescription drug that treats certain skin conditions that have been approved by the FDA. It comes in the form of a shampoo, lotion, or spray. Depending on the form of Clobex that is prescribed, this drug can be used to treat moderate to severe psoriasis."
Answered by AI
What is Clobex used to treat?
"A super-high-potency corticosteroid, Clobetasol is used by adults to treat moderate to severe plaque psoriasis, reducing the swelling, itching and redness that can occur with this condition."
Answered by AI
Does Clobex cause hair loss?
"The following may occur when this medication is first applied to the scalp: burning, stinging, itching, irritation, redness, discoloration, dry skin, hair loss, headache, or acne. However, this should only be temporary as your body adjusts to the medication."
Answered by AI
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