What is Chlordiazepoxide Hydrochloride
ChlordiazepoxideThe Generic name of this drug
Treatment SummaryChlordiazepoxide is a medication used to treat anxiety and symptoms associated with alcohol withdrawal. It is a type of benzodiazepine that also has sedative, anticonvulsant, and amnesic properties.
Libraxis the brand name
Chlordiazepoxide Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Librax
Chlordiazepoxide
1966
112
Approved as Treatment by the FDA
Chlordiazepoxide, otherwise known as Librax, is approved by the FDA for 6 uses like Irritable Bowel Syndrome (IBS) and moderate to severe symptoms .Irritable Bowel Syndrome (IBS)
Used to treat Irritable Bowel Syndrome (IBS) in combination with Clidinium
moderate to severe symptoms
Used to treat moderate to severe symptoms in combination with Amitriptyline
Enterocolitis
Used to treat acute Enterocolitis in combination with Clidinium
Peptic Ulcer Disease
Used to treat Peptic Ulcer Disease in combination with Clidinium
Depression
Used to treat Depression in combination with Amitriptyline
Anxiety
Used to treat moderate to severe anxiety in combination with Amitriptyline
Effectiveness
How Chlordiazepoxide Hydrochloride Affects PatientsChlordiazepoxide is a drug used to reduce anxiety, induce sedation, and act as a mild pain reliever. It works by blocking electrical signals in the brain stem that cause arousal. Studies have shown that it can also have an effect on the brain's limbic system, which is responsible for emotions. It has been seen to make hostile monkeys tame, and to reduce fear and aggression in rats with brain lesions. It can be effective at low doses that don't cause sedation.
How Chlordiazepoxide Hydrochloride works in the bodyChlordiazepoxide works by increasing the binding of the neurotransmitter GABA to the GABA receptor in the brain. This increases the inhibitory effects of GABA, leading to sedation, relaxation, and a reduction in anxiety.
When to interrupt dosage
The proposed measure of Chlordiazepoxide Hydrochloride is contingent upon the determined affliction, including Syndrome, moderate to extreme indications and Depression. The quantity of dosage varies, depending on the technique of delivery outlined in the table beneath.Condition
Dosage
Administration
Syndrome
5.0 mg, , 25.0 mg, 10.0 mg, 12.5 mg
, Capsule - Oral, Capsule, gelatin coated - Oral, Tablet, film coated - Oral, Oral, Capsule, Tablet, Tablet - Oral, Capsule, gelatin coated, Tablet, film coated
moderate to severe symptoms
5.0 mg, , 25.0 mg, 10.0 mg, 12.5 mg
, Capsule - Oral, Capsule, gelatin coated - Oral, Tablet, film coated - Oral, Oral, Capsule, Tablet, Tablet - Oral, Capsule, gelatin coated, Tablet, film coated
Depression
5.0 mg, , 25.0 mg, 10.0 mg, 12.5 mg
, Capsule - Oral, Capsule, gelatin coated - Oral, Tablet, film coated - Oral, Oral, Capsule, Tablet, Tablet - Oral, Capsule, gelatin coated, Tablet, film coated
Anxiety
5.0 mg, , 25.0 mg, 10.0 mg, 12.5 mg
, Capsule - Oral, Capsule, gelatin coated - Oral, Tablet, film coated - Oral, Oral, Capsule, Tablet, Tablet - Oral, Capsule, gelatin coated, Tablet, film coated
Enterocolitis
5.0 mg, , 25.0 mg, 10.0 mg, 12.5 mg
, Capsule - Oral, Capsule, gelatin coated - Oral, Tablet, film coated - Oral, Oral, Capsule, Tablet, Tablet - Oral, Capsule, gelatin coated, Tablet, film coated
Peptic Ulcer Disease
5.0 mg, , 25.0 mg, 10.0 mg, 12.5 mg
, Capsule - Oral, Capsule, gelatin coated - Oral, Tablet, film coated - Oral, Oral, Capsule, Tablet, Tablet - Oral, Capsule, gelatin coated, Tablet, film coated
Irritable Bowel Syndrome (IBS)
5.0 mg, , 25.0 mg, 10.0 mg, 12.5 mg
, Capsule - Oral, Capsule, gelatin coated - Oral, Tablet, film coated - Oral, Oral, Capsule, Tablet, Tablet - Oral, Capsule, gelatin coated, Tablet, film coated
Anxiety
5.0 mg, , 25.0 mg, 10.0 mg, 12.5 mg
, Capsule - Oral, Capsule, gelatin coated - Oral, Tablet, film coated - Oral, Oral, Capsule, Tablet, Tablet - Oral, Capsule, gelatin coated, Tablet, film coated
Anxiety Disorders
5.0 mg, , 25.0 mg, 10.0 mg, 12.5 mg
, Capsule - Oral, Capsule, gelatin coated - Oral, Tablet, film coated - Oral, Oral, Capsule, Tablet, Tablet - Oral, Capsule, gelatin coated, Tablet, film coated
Warnings
There are 20 known major drug interactions with Chlordiazepoxide Hydrochloride.Common Chlordiazepoxide Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Deutetrabenazine
Major
The risk or severity of sedation and somnolence can be increased when Chlordiazepoxide is combined with Deutetrabenazine.
Ethanol
Major
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methadone
Major
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Chlordiazepoxide is combined with Oliceridine.
Chlordiazepoxide Hydrochloride Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats has been found to be 537mg/kg when taken orally. Overdosing on this drug can cause slowed breathing, muscle weakness, and drowsiness.
Chlordiazepoxide Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Chlordiazepoxide Hydrochloride?
Currently, 794 active trials are investigating the effectiveness of Chlordiazepoxide Hydrochloride in ameliorating Anxiety Disorders, moderate to severe associated symptoms and Syndrome.Condition
Clinical Trials
Trial Phases
Syndrome
4 Actively Recruiting
Not Applicable, Phase 1, Phase 2
moderate to severe symptoms
0 Actively Recruiting
Anxiety Disorders
191 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
Anxiety
3 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Peptic Ulcer Disease
0 Actively Recruiting
Anxiety
0 Actively Recruiting
Enterocolitis
0 Actively Recruiting
Depression
641 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4
Irritable Bowel Syndrome (IBS)
8 Actively Recruiting
Not Applicable
Chlordiazepoxide Hydrochloride Reviews: What are patients saying about Chlordiazepoxide Hydrochloride?
5Patient Review
1/12/2014 I felt great while taking this medication, but unfortunately my old anxieties came back with a vengeance after I tapered off. I'm told that the drug can't be taken for long periods of time.
5Patient Review
5/28/2016 This treatment is really effective in helping you through the tough initial withdrawals. The only downside I experienced was feeling very tired and fuzzy-headed while on it; although, I will say that I slept like a baby.
5Patient Review
11/28/2012 I felt noticeably better after taking this medication. I was able to get through my day with more energy and less anxiety.
4.7Patient Review
6/8/2015 I started using this to help me drink less alcohol.
4.7Patient Review
2/22/2010 The only downside I experienced was some dizziness and dry mouth.
4.3Patient Review
6/3/2014 The medication was very effective in helping me detox. I think a higher dosage for a longer period of time would have been beneficial, but it is essential that someone commits to abstaining from the drug they are detoxing from.
3.3Patient Review
12/18/20093.3Patient Review
4/14/2011 I'm still drinking.
1.7Patient Review
1/31/2010Patient Q&A Section about chlordiazepoxide hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is chlordiazepoxide an antidepressant?
"Chlordiazepoxide belongs to a class of medications called benzodiazepines/anticonvulsants.
This product contains two medicines, amitriptyline and chlordiazepoxide, which are used to treat mental and mood disorders, such as depression with anxiety symptoms. Amitriptyline is a tricyclic antidepressant, while chlordiazepoxide is a benzodiazepine/anticonvulsant."
Answered by AI
Is chlordiazepoxide used for sleep?
"Librium is thegeneric name for Chlordiazepoxide, a sedative-hypnotic Benzodiazepine. The effects of Librium are similar to the effects of Xanax, Valium, and Ativan. A proper dose of Librium will relieve a person's anxiety and help them sleep through the night."
Answered by AI
What is chlordiazepoxide hydrochloride used for?
"Chlordiazepoxide is a medication used to relieve symptoms of anxiety or nervousness before surgery, as well as symptoms of alcohol withdrawal. It is a benzodiazepine."
Answered by AI
How does chlordiazepoxide make you feel?
"Chlordiazepoxide affects the way neurotransmitters pass messages to your brain cells, creating a calming effect. This can be helpful for people with anxiety, for whom the drug is sometimes prescribed."
Answered by AI