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What is Celebrex
CelecoxibThe Generic name of this drug
Treatment SummaryCelecoxib is a type of non-steroidal anti-inflammatory drug (NSAID) that helps reduce inflammation and is known for causing less gastrointestinal bleeding than other NSAIDS. It is used to manage symptoms of various types of arthritis pain, reduce precancerous polyps in the colon, and has been studied as a potential cancer treatment. Celecoxib has been sold under the brand name Celebrex since 1998.
Celebrexis the brand name
Celebrex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Celebrex
Celecoxib
1998
379
Approved as Treatment by the FDA
Celecoxib, otherwise called Celebrex, is approved by the FDA for 6 uses which include Ankylosing Spondylitis and Rheumatoid Arthritis, Juvenile .Ankylosing Spondylitis
Helps manage Ankylosing Spondylitis (AS)
Rheumatoid Arthritis, Juvenile
Helps manage Rheumatoid Arthritis, Juvenile
Acute Pain
Helps manage Pain, Acute
Rheumatoid Arthritis
Helps manage Rheumatoid Arthritis
Primary Dysmenorrhoea
Helps manage Primary Dysmenorrhoea
Osteoarthritis (OA)
Helps manage Osteoarthritis (OA)
Effectiveness
How Celebrex Affects PatientsCelecoxib is a pain and inflammation-reducing drug that works by blocking the COX-2 enzyme. Although this drug carries a lower risk of bleeding than other NSAIDs, it still has the potential to cause bleeding, especially in those at high risk for gastrointestinal bleeding. In the early 2000s, concerns arose over the potential cardiovascular risks of taking COX-2 inhibitors, such as Vioxx (or rofecoxib). After evaluating data from large clinical trials, the FDA determined that the benefits of taking celecoxib outweighed the risks. A post-marketing trial (PREC
How Celebrex works in the bodyCelecoxib is an anti-inflammatory medication that works differently than other NSAIDs. It only inhibits the COX-2 enzyme, which helps reduce the production of inflammation-causing molecules like prostaglandins. This means it may cause less damage to the stomach lining than other NSAIDs. Celecoxib can also help fight cancer by binding to proteins involved in tumor growth and blocking a signaling pathway. It also inhibits certain carbonic anhydrase enzymes, which can help stop cancer cells from growing. However, celecoxib can increase the risk of thrombotic events as it stops the production of prostacycl
When to interrupt dosage
The proposed dosage of Celebrex is contingent upon the diagnosed condition, including Ankylosing Spondylitis, Primary Dysmenorrhoea and Rheumatoid Arthritis. The measure can be found in the table beneath, based on the method of delivery (e.g. Tablet - Oral or Oral).Condition
Dosage
Administration
Osteoarthritis (OA)
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Pain
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Rheumatoid Arthritis
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Acute Pain
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Rheumatoid Arthritis, Juvenile
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Ankylosing Spondylitis
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Therapeutic procedure
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Primary Dysmenorrhoea
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Warnings
Celebrex ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
Common Celebrex Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Celecoxib.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Celecoxib.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Celecoxib is combined with Cyclopentamine.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Celecoxib.
Fosphenytoin
Major
The metabolism of Fosphenytoin can be decreased when combined with Celecoxib.
Celebrex Toxicity & Overdose RiskCelecoxib's lowest toxic dose in humans is 5.71 mg/kg. It is not recommended for those with kidney or liver problems, as it may lead to higher concentrations and cause toxicity. Symptoms of overdose include difficulty breathing, being unresponsive, bleeding in the stomach, high blood pressure, kidney failure, nausea, sluggishness, stomach pain, and vomiting. Even if there are no symptoms, patients should be monitored for signs of stomach bleeding. If the patient is seen within 4 hours of taking the drug, vomiting or activated charcoal should be used as a treatment. Diuresis, altering urine pH, dialysis, and hem
Celebrex Novel Uses: Which Conditions Have a Clinical Trial Featuring Celebrex?
102 active clinical trials are presently being conducted to investigate the possibility of Celebrex in providing relief for Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis and Primary Dysmenorrhoea.Condition
Clinical Trials
Trial Phases
Therapeutic procedure
0 Actively Recruiting
Osteoarthritis (OA)
0 Actively Recruiting
Ankylosing Spondylitis
2 Actively Recruiting
Phase 3, Not Applicable
Pain
0 Actively Recruiting
Acute Pain
21 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4, Phase 2, Phase 1
Rheumatoid Arthritis
61 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Primary Dysmenorrhoea
2 Actively Recruiting
Phase 4, Not Applicable
Rheumatoid Arthritis, Juvenile
4 Actively Recruiting
Not Applicable, Phase 3
Celebrex Reviews: What are patients saying about Celebrex?
5Patient Review
4/13/2022 Delaying my knee surgery due to COVID was really frustrating, and the painkillers I was taking just weren't cutting it anymore. Celebrex has been a total game changer for me- it's reduced my pain and swelling significantly, and I don't have nearly as much trouble sleeping or digesting now.
5Patient Review
12/11/2021 Celebrex has been a godsend for me. Fifty years ago, I was in a terrible accident that left my feet crushed and both legs broken. Today, extended periods of standing still cause me significant pain--but Celebrex really helps to reduce it.
5Patient Review
10/15/2021 This medication has been a miracle for my leg and thigh pain. I only feel it when I'm doing physical therapy now, and there have been no side effects.
5Patient Review
7/10/2022 This nsaid is much better than most opiate medications. I have herniated discs and it has helped me be able to get around without as much pain.
5Patient Review
2/24/2022 Celebrex has been a life saver for me. I have arthritis all over my body, and this medication really helps to reduce the swelling in my joints so that I can still move around.
5Patient Review
12/3/2021 I was in a lot of pain and could barely walk due to loss of cartilage in both knees. Celebrex has worked wonders for me! I forgot how it feel to walk w/o pain! It's amazing.
5Patient Review
9/19/2022 This completely alleviated my pain.
5Patient Review
3/13/2022 Celebrex was a godsend. I was diagnosed with osteoarthritis and osteonecrosis in both hips, which made everyday activities quite difficult. But after starting this medication, I found myself pain-free within a week. Not to mention, there were no side effects that I experienced. This drug has truly allowed me to put off getting a hip replacement surgery, and for that I am very thankful.
4.7Patient Review
3/25/2022 For years, I worked on concrete floors in industrial plants and it really did a number on my legs. Sometimes, the pain was so bad that I could barely walk. Ibuprofen didn't help at all. But Celebrex? It's been a total game-changer. I can finally move around without being in agony and feeling like my old self again. Sure, there are some downsides--like loose stools and insomnia every now and then--but overall, I'm incredibly grateful for this medication.
4Patient Review
5/1/2022 This medication has been a godsend for my chronic pain. I highly recommend it to anyone suffering from similar issues.
4Patient Review
5/25/2022 I was in a lot of pain before starting this treatment, to the point where I couldn't stand up straight by the end of the day. It took a couple weeks to see real results, but after one month I was feeling much better. Some side effects like loose stool and gas are improving, and even though I'm gaining weight, it's worth it for the decrease in pain.
3.7Patient Review
7/22/2022 Celebrex alleviated my pain and inflammation well, as per my surgeon's orders. I was only supposed to be on it temporarily until I could get a knee replacement. However, after just one month of use I started having lots of side effects like kidney problems--which I've never had before. So please, stop taking this medication.
3Patient Review
7/14/2022 I found that the 200mg capsules were too hard on my stomach, so I tried the 100mg. They worked better and caused less stomach upset. I also found that they worked better when taken with panadol or panadol osteo. Always take them after food or with a glass of milk. A smaller dose taken twice a day is always better than a high dose once a day which can cause stomach ulcers.
2Patient Review
3/25/2022 I was really disappointed with this treatment. Not only did it not help with my lower back pain, but it also gave me a lot of stomach problems.
1Patient Review
9/24/2022 I developed plantar facitis after spraining my ankle five months ago. I received a steroid injection and was put on Celebrex, but the first dose made me feel hot and gave me stomach cramps, so I stopped taking it.
Patient Q&A Section about celebrex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Celebrex a painkiller or anti-inflammatory?
"This medication works by preventing the production of a substance that causes pain and inflammation."
Answered by AI
Is Celebrex stronger than ibuprofen?
"Both ibuprofen and Celebrex have been studied extensively for specific types of pain relief. The results of these studies have been mixed, with Celebrex being more effective for pain relief from an ankle sprain, while ibuprofen was more effective for dental pain. Both medications were equally effective for pain relief from knee osteoarthritis."
Answered by AI
What are the dangers of taking Celebrex?
""
The use of NSAIDs, including Celebrex, comes with an increased risk of serious gastrointestinal adverse events, such as bleeding, ulceration, and perforation of the stomach or intestines. These events can occur at any time during use and without warning symptoms."
Answered by AI