Celebrex

Rheumatoid Arthritis, Arthritis, Juvenile, Osteoarthritis + 5 more
Treatment
10 FDA approvals
20 Active Studies for Celebrex

What is Celebrex

CelecoxibThe Generic name of this drug
Treatment SummaryCelecoxib is a type of non-steroidal anti-inflammatory drug (NSAID) that helps reduce inflammation and is known for causing less gastrointestinal bleeding than other NSAIDS. It is used to manage symptoms of various types of arthritis pain, reduce precancerous polyps in the colon, and has been studied as a potential cancer treatment. Celecoxib has been sold under the brand name Celebrex since 1998.
Celebrexis the brand name
image of different drug pills on a surface
Celebrex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Celebrex
Celecoxib
1998
379

Approved as Treatment by the FDA

Celecoxib, otherwise called Celebrex, is approved by the FDA for 10 uses which include Arthritis, Juvenile and Acute Pain .
Arthritis, Juvenile
Helps manage Rheumatoid Arthritis, Juvenile
Acute Pain
Helps manage Pain, Acute
Pain, Acute
Helps manage Pain, Acute
Osteoarthritis (OA)
Helps manage Osteoarthritis (OA)
Rheumatoid Arthritis, Juvenile
Helps manage Rheumatoid Arthritis, Juvenile
Ankylosing Spondylitis (AS)
Helps manage Ankylosing Spondylitis (AS)
Ankylosing Spondylitis
Helps manage Ankylosing Spondylitis (AS)
Rheumatoid Arthritis
Helps manage Rheumatoid Arthritis
Primary Dysmenorrhoea
Helps manage Primary Dysmenorrhoea
Osteoarthritis
Helps manage Osteoarthritis (OA)

Effectiveness

How Celebrex Affects PatientsCelecoxib is a pain and inflammation-reducing drug that works by blocking the COX-2 enzyme. Although this drug carries a lower risk of bleeding than other NSAIDs, it still has the potential to cause bleeding, especially in those at high risk for gastrointestinal bleeding. In the early 2000s, concerns arose over the potential cardiovascular risks of taking COX-2 inhibitors, such as Vioxx (or rofecoxib). After evaluating data from large clinical trials, the FDA determined that the benefits of taking celecoxib outweighed the risks. A post-marketing trial (PREC
How Celebrex works in the bodyCelecoxib is an anti-inflammatory medication that works differently than other NSAIDs. It only inhibits the COX-2 enzyme, which helps reduce the production of inflammation-causing molecules like prostaglandins. This means it may cause less damage to the stomach lining than other NSAIDs. Celecoxib can also help fight cancer by binding to proteins involved in tumor growth and blocking a signaling pathway. It also inhibits certain carbonic anhydrase enzymes, which can help stop cancer cells from growing. However, celecoxib can increase the risk of thrombotic events as it stops the production of prostacycl

When to interrupt dosage

The proposed dosage of Celebrex is contingent upon the diagnosed condition, including Ankylosing Spondylitis, Primary Dysmenorrhoea and Rheumatoid Arthritis. The measure can be found in the table beneath, based on the method of delivery (e.g. Tablet - Oral or Oral).
Condition
Dosage
Administration
Rheumatoid Arthritis
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Arthritis, Juvenile
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Osteoarthritis
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Ankylosing Spondylitis
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Acute Pain
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Primary Dysmenorrhoea
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Therapeutic procedure
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Pain
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid

Warnings

Celebrex Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
There are 20 known major drug interactions with Celebrex.
Common Celebrex Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Celecoxib.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Celecoxib.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Celecoxib is combined with Cyclopentamine.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Celecoxib.
Fosphenytoin
Major
The metabolism of Fosphenytoin can be decreased when combined with Celecoxib.
Celebrex Toxicity & Overdose RiskCelecoxib's lowest toxic dose in humans is 5.71 mg/kg. It is not recommended for those with kidney or liver problems, as it may lead to higher concentrations and cause toxicity. Symptoms of overdose include difficulty breathing, being unresponsive, bleeding in the stomach, high blood pressure, kidney failure, nausea, sluggishness, stomach pain, and vomiting. Even if there are no symptoms, patients should be monitored for signs of stomach bleeding. If the patient is seen within 4 hours of taking the drug, vomiting or activated charcoal should be used as a treatment. Diuresis, altering urine pH, dialysis, and hem
image of a doctor in a lab doing drug, clinical research

Celebrex Novel Uses: Which Conditions Have a Clinical Trial Featuring Celebrex?

102 active clinical trials are presently being conducted to investigate the possibility of Celebrex in providing relief for Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis and Primary Dysmenorrhoea.
Condition
Clinical Trials
Trial Phases
Acute Pain
1 Actively Recruiting
Not Applicable
Ankylosing Spondylitis
3 Actively Recruiting
Phase 3, Not Applicable
Pain
0 Actively Recruiting
Osteoarthritis
0 Actively Recruiting
Rheumatoid Arthritis
58 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Arthritis, Juvenile
1 Actively Recruiting
Not Applicable
Primary Dysmenorrhoea
2 Actively Recruiting
Not Applicable
Therapeutic procedure
0 Actively Recruiting

Celebrex Reviews: What are patients saying about Celebrex?

5Patient Review
4/13/2022
Celebrex for Joint Damage causing Pain and Loss of Function
Delaying my knee surgery due to COVID was really frustrating, and the painkillers I was taking just weren't cutting it anymore. Celebrex has been a total game changer for me- it's reduced my pain and swelling significantly, and I don't have nearly as much trouble sleeping or digesting now.
5Patient Review
12/11/2021
Celebrex for Joint Damage causing Pain and Loss of Function
Celebrex has been a godsend for me. Fifty years ago, I was in a terrible accident that left my feet crushed and both legs broken. Today, extended periods of standing still cause me significant pain--but Celebrex really helps to reduce it.
5Patient Review
10/15/2021
Celebrex for Painful Periods
This medication has been a miracle for my leg and thigh pain. I only feel it when I'm doing physical therapy now, and there have been no side effects.
5Patient Review
7/10/2022
Celebrex for Pain
This nsaid is much better than most opiate medications. I have herniated discs and it has helped me be able to get around without as much pain.
5Patient Review
2/24/2022
Celebrex for Joint Inflammatory Disease in Children and Young Adults
Celebrex has been a life saver for me. I have arthritis all over my body, and this medication really helps to reduce the swelling in my joints so that I can still move around.
5Patient Review
12/3/2021
Celebrex for Joint Damage causing Pain and Loss of Function
I was in a lot of pain and could barely walk due to loss of cartilage in both knees. Celebrex has worked wonders for me! I forgot how it feel to walk w/o pain! It's amazing.
5Patient Review
9/19/2022
Celebrex for Rheumatoid Arthritis
This completely alleviated my pain.
5Patient Review
3/13/2022
Celebrex for Joint Damage causing Pain and Loss of Function
Celebrex was a godsend. I was diagnosed with osteoarthritis and osteonecrosis in both hips, which made everyday activities quite difficult. But after starting this medication, I found myself pain-free within a week. Not to mention, there were no side effects that I experienced. This drug has truly allowed me to put off getting a hip replacement surgery, and for that I am very thankful.
4.7Patient Review
3/25/2022
Celebrex for Joint Damage causing Pain and Loss of Function
For years, I worked on concrete floors in industrial plants and it really did a number on my legs. Sometimes, the pain was so bad that I could barely walk. Ibuprofen didn't help at all. But Celebrex? It's been a total game-changer. I can finally move around without being in agony and feeling like my old self again. Sure, there are some downsides--like loose stools and insomnia every now and then--but overall, I'm incredibly grateful for this medication.
4Patient Review
5/1/2022
Celebrex for Non-Radiographic Axial Spondyloarthritis
This medication has been a godsend for my chronic pain. I highly recommend it to anyone suffering from similar issues.
4Patient Review
5/25/2022
Celebrex for Pain
I was in a lot of pain before starting this treatment, to the point where I couldn't stand up straight by the end of the day. It took a couple weeks to see real results, but after one month I was feeling much better. Some side effects like loose stool and gas are improving, and even though I'm gaining weight, it's worth it for the decrease in pain.
3.7Patient Review
7/22/2022
Celebrex for Joint Damage causing Pain and Loss of Function
Celebrex alleviated my pain and inflammation well, as per my surgeon's orders. I was only supposed to be on it temporarily until I could get a knee replacement. However, after just one month of use I started having lots of side effects like kidney problems--which I've never had before. So please, stop taking this medication.
3Patient Review
7/14/2022
Celebrex for Joint Damage causing Pain and Loss of Function
I found that the 200mg capsules were too hard on my stomach, so I tried the 100mg. They worked better and caused less stomach upset. I also found that they worked better when taken with panadol or panadol osteo. Always take them after food or with a glass of milk. A smaller dose taken twice a day is always better than a high dose once a day which can cause stomach ulcers.
2Patient Review
3/25/2022
Celebrex for Non-Radiographic Axial Spondyloarthritis
I was really disappointed with this treatment. Not only did it not help with my lower back pain, but it also gave me a lot of stomach problems.
1Patient Review
9/24/2022
Celebrex for Pain
I developed plantar facitis after spraining my ankle five months ago. I received a steroid injection and was put on Celebrex, but the first dose made me feel hot and gave me stomach cramps, so I stopped taking it.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about celebrex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Celebrex a painkiller or anti-inflammatory?

"This medication works by preventing the production of a substance that causes pain and inflammation."

Answered by AI

What is Celebrex usually prescribed for?

"Celecoxib is a drug used to relieve symptoms of arthritis, such as inflammation, swelling, stiffness, and joint pain. It is sold under the brand name Celebrex."

Answered by AI

Is Celebrex stronger than ibuprofen?

"Both ibuprofen and Celebrex have been studied extensively for specific types of pain relief. The results of these studies have been mixed, with Celebrex being more effective for pain relief from an ankle sprain, while ibuprofen was more effective for dental pain. Both medications were equally effective for pain relief from knee osteoarthritis."

Answered by AI

What are the dangers of taking Celebrex?

""

The use of NSAIDs, including Celebrex, comes with an increased risk of serious gastrointestinal adverse events, such as bleeding, ulceration, and perforation of the stomach or intestines. These events can occur at any time during use and without warning symptoms."

Answered by AI

Clinical Trials for Celebrex

Image of Sunnybrook Health Sciences Centre in Toronto, Canada.

Steroids for Rheumatoid Arthritis

18+
All Sexes
Toronto, Canada
People living with rheumatoid arthritis (RA) often experience flares-periods where their symptoms suddenly get worse. These flares can cause significant pain, make it harder to move and do daily activities, and lower overall quality of life. Doctors often treat flares with medications called glucocorticoids (GCs), which reduce inflammation. These medications can be taken by mouth (oral/PO) or given as a single injection into the muscle (intramuscular/IM). However, it's not clear which option works better from the patient's point of view-especially when it comes to relief of symptoms, improvements in function, and satisfaction with treatment. Most research so far has focused on how well the drugs control the disease, rather than how they impact the patient's overall experience. Our Research Questions: 1. Does a single GC injection work just as well as taking pills over a few weeks in improving symptoms reported by patients? 2. How do the two treatments compare in terms of symptom relief, ability to function, and patient satisfaction? 3. What do patients think and feel about using GCs to treat RA flares? What We Think: We believe that a one-time GC injection is just as good as taking pills for a few weeks when it comes to managing RA flares. In fact, the injection might even be safer and preferred by patients. What We're Doing: We will study 220 adults with RA who are currently having a flare (with at least 3 swollen and tender joints). These patients will be recruited from rheumatology clinics at the University of Toronto and must not have used GCs in the past month. They will be randomly assigned to receive either: A single injection (Methylprednisolone 120 mg), or Oral pills (Prednisone starting at 15 mg daily and tapering down over 3 weeks). The main thing we'll look at is how much better patients feel after 6 weeks, based on a questionnaire designed to measure RA flares. We'll also look at how well they function, how satisfied they are with the treatment, and whether they had any side effects. In addition, 20 patients (10 from each group) will be interviewed to understand their experiences and opinions about flare treatment in more detail. Why This Is Possible: We've already surveyed University of Toronto rheumatologists who support the idea and provided input on study design. We've also partnered with experts in research methods, national arthritis organizations, and patient groups to make sure the study is relevant and meaningful. Ethics approval has been obtained. Why It Matters: RA flares can have a major impact on people's lives. While current treatments help control inflammation, we need to better understand how these treatments affect people from their own perspective. This study will shift the focus to what matters most to patients, helping doctors and patients choose the best treatment based not only on medical results but also on the patient's experience. This could lead to more effective and personalized care for people living with RA.
Phase 4
Waitlist Available
Sunnybrook Health Sciences Centre (+4 Sites)
Image of California Clinical Trials Medical Group in Glendale, United States.

NTR-1011 for Lupus and Rheumatoid Arthritis

18 - 75
All Sexes
Glendale, CA
This phase 1a and 1b study is designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary efficacy of NTR-1011 in healthy adults and in adult patients with systemic lupus erythematosus and rheumatoid arthritis. The main goals of this study are to determine the safety profile of NTR-1011 across subcutaneous and intravenous dose levels, understand how the drug behaves in the body, characterize its biological activity through relevant pharmacodynamic markers, assess the potential for immune responses to treatment, and explore early signals of clinical benefit in autoimmune disease settings. This is a randomized, double blind, placebo controlled study that begins with a single ascending dose evaluation in healthy volunteers followed by a multiple dose assessment in patients. The design is intended to define the highest safe and well tolerated dose, establish a robust PK and PD baseline, and generate initial patient level evidence to support dose selection and advancement into subsequent clinical development.
Phase 1
Recruiting
California Clinical Trials Medical GroupHakop Gevorkyan, MDNeutrolis
Image of Weill Cornell Medical College in New York, United States.

Health Coaching for Rheumatoid Arthritis

18+
All Sexes
New York, NY
The goal of this clinical trial is to learn if peer coaching works to reduce levels of anxiety and/or depression in adults diagnosed with Rheumatoid Arthritis (RA). The main questions it aims to answer are: Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months from baseline? Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months compared to those in the control arm? Researchers will compare the peer coaching intervention to an active-control arm (where people without RA coach participants on general health and nutrition topics) to see if peer coaching works to reduce anxiety and/or depression. Participants will meet with a coach every week for 9 weeks and complete several surveys before, during and after the intervention
Recruiting
Has No Placebo
Weill Cornell Medical CollegeIris Y Navarro-Millán, MDBristol-Myers Squibb
Image of Humana Healthcare Research, Inc. in Louisville, United States.

Academic Detailing for Rheumatoid Arthritis

Any Age
All Sexes
Louisville, KY
The goal of this trial is to learn if an interactive evidence-based educational outreach visits to clinicians who prescribe biologics change prescribing of biosimilar medications. The main questions it aims to answer are: 1. Do educational outreach visits lead to a higher number of prescriptions for biosimilar versions of adalimumab? 2. Do in-person or virtual visits work better? Researchers will compare clinicians offered the educational outreach visit to those who are not offered the visit to see if there is a difference in prescribing of biosimilar versions of adalimumab instead of the original brand-name version. Participants will be offered the chance to meet with a trained clinician who will provide educational information tailored to their knowledge and attitudes on the topic. They will also be provided an educational brochure and patient educational materials.
Waitlist Available
Has No Placebo
Humana Healthcare Research, Inc. (+1 Sites)
Have you considered Celebrex clinical trials? We made a collection of clinical trials featuring Celebrex, we think they might fit your search criteria.Go to Trials
Image of University of Minnesota Medical School, Division of Rheumatic and Autoimmune Diseases in Minneapolis, United States.

Ultrasound Therapy for Rheumatoid Arthritis

18+
All Sexes
Minneapolis, MN
The At-Home ULTRA Study will evaluate performance of the MINI system as indicated for the treatment of adults with active, moderate to severe rheumatoid arthritis who are inadequate responders or are intolerant to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), biologic DMARDs (bDMARDs), or targeted synthetic DMARDs (tsDMARDs). The non-invasive study device delivers ultrasound stimulation to the spleen to reduce inflammation. The study will enroll at least 60 participants at up to 8 sites. There will be three arms consisting of two active stimulation groups (treatment) and one non-active stimulation group (sham-control). After completing the double-blinded primary endpoint assessment period at Week 12, there will be a one-way crossover of control participants to active stimulation and an additional 12 week follow-up with all participants to evaluate long-term outcomes.
Recruiting
Drug
University of Minnesota Medical School, Division of Rheumatic and Autoimmune DiseasesHubert LimSecondWave Systems Inc.
Have you considered Celebrex clinical trials? We made a collection of clinical trials featuring Celebrex, we think they might fit your search criteria.Go to Trials
Image of Pender Community Health Centre in Vancouver, Canada.

Personalized Outreach for Rheumatic Diseases

18+
All Sexes
Vancouver, Canada
The primary goal of this study is to determine whether providing patient honoraria and/or outreach services can improve the attendance rate of appointments at an inner city rheumatology clinic in Vancouver, British Columbia. The main question it aims to answer are: * Does providing a financial honorarium ($20 for each follow-up appointment with completed bloodwork) improve attendance rate at an inner city rheumatology clinic? * Does providing a personalized outreach service for rheumatic diseases improve attendance rate at an inner city rheumatology clinic? The researchers will compare providing patient honoraria to providing both honoraria and outreach services, and compare each of these to the regular appointment schedule without honoraria or outreach. Participants will: * Undergo randomization to receive honoraria or honoraria and outreach services together * Complete surveys about their health and understanding of their rheumatic disease at baseline, 3-month, and 6-month intervals * Visit the clinic every month for check-ups and monitoring bloodwork if they are started on immunosuppressants for their condition
Waitlist Available
Has No Placebo
Pender Community Health CentreBrent R Ohata, MD
Image of Clinical Research Of West Florida - Phase I Unit /ID# 272428 in Clearwater, United States.

Targeted Therapies for Rheumatoid Arthritis

18+
All Sexes
Clearwater, FL
Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will evaluate the efficacy and safety of targeted therapies through a series of substudies for the treatment of moderately to severely active Rheumatoid Arthritis (RA). This study currently includes 3 substudies evaluating different treatments in participants with RA. Substudy 1 will evaluate lutikizumab monotherapy (treatment given alone) compared to placebo (looks like the study treatment but contains no medicine). Substudy 2 will evaluate ravagalimab monotherapy compared to placebo and Substudy 3 will evaluate lutikizumab and ravagalimab combination therapy (treatments given together) compared to placebo. Approximately 180 participants who have failed 1 or 2 biologic/targeted synthetic disease-modifying antirheumatic drug (tsDMARD) therapies will be enrolled in the study at approximately 65 sites worldwide. There may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Phase 2
Recruiting
Clinical Research Of West Florida - Phase I Unit /ID# 272428 (+31 Sites)ABBVIE INC.AbbVie
Have you considered Celebrex clinical trials? We made a collection of clinical trials featuring Celebrex, we think they might fit your search criteria.Go to Trials
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Terms of Service·Privacy Policy·Cookies·Security