Carisoprodol

Musculoskeletal Diseases, Acute Pain, Acute Coryza

Treatment

5 FDA approvals

4 Active Studies for Carisoprodol

Treatment for

Musculoskeletal Diseases

What is Carisoprodol

CarisoprodolThe Generic name of this drug

Treatment SummaryCarisoprodol is a muscle relaxant prescribed to relieve pain in muscles and bones. It is usually taken as a pill, but can also be combined with aspirin or codeine. In 2012, it was classified as a Schedule IV drug in some US states because it was being abused at high rates, even though it has a low potential for abuse and dependence.

Somais the brand name

image of different drug pills on a surface

Carisoprodol Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Soma

Carisoprodol

1959

193

Approved as Treatment by the FDA

Carisoprodol, also called Soma, is approved by the FDA for 5 uses which include Musculoskeletal Disorders and Pain, Acute .

Musculoskeletal Disorders

Helps manage Musculoskeletal Disorders

Pain, Acute

Helps manage Pain, Acute

Musculoskeletal Diseases

Helps manage Musculoskeletal Disorders

Acute Coryza

Used to treat acute Discomfort in combination with Acetylsalicylic acid

Acute Pain

Helps manage Pain, Acute

Effectiveness

How Carisoprodol Affects PatientsCarisoprodol is a muscle relaxant that works by targeting the central nervous system (CNS). It helps to relieve the pain caused by muscle spasms. A breakdown product of carisoprodol, meprobamate, has calming and sleep-inducing effects. Clinical studies have shown that this drug can impair how a person performs on mental and physical tests.

How Carisoprodol works in the bodyThe exact way carisoprodol works to reduce muscle pain is not known. Animal studies suggest that it changes the activity between neurons in the spinal cord and the brain. It is also thought to have potential for abuse because it can change the way a certain type of brain receptor works. This alters the flow of neurotransmitters and can have a calming effect.

When to interrupt dosage

The recommended measure of Carisoprodol is based on the diagnosed state, including Acute Pain, Acute Coryza and Musculoskeletal Diseases. The quantity of dosage is contingent upon the method of delivery (e.g. Tablet, film coated - Oral or Oral) stated in the table below.

Condition

Dosage

Administration

Acute Coryza

, 350.0 mg, 250.0 mg, 200.0 mg

, Oral, Tablet - Oral, Tablet, Kit, Tablet, film coated, Tablet, film coated - Oral

Musculoskeletal Diseases

, 350.0 mg, 250.0 mg, 200.0 mg

, Oral, Tablet - Oral, Tablet, Kit, Tablet, film coated, Tablet, film coated - Oral

Acute Pain

, 350.0 mg, 250.0 mg, 200.0 mg

, Oral, Tablet - Oral, Tablet, Kit, Tablet, film coated, Tablet, film coated - Oral

Warnings

Carisoprodol Contraindications

Condition

Risk Level

Notes

Acute Coryza

Do Not Combine

Disorders of Porphyrin Metabolism

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Carisoprodol may interact with Pulse Frequency

There are 20 known major drug interactions with Carisoprodol.

Common Carisoprodol Drug Interactions

Drug Name

Risk Level

Description

Azelastine

Major

Carisoprodol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Ethanol

Major

Carisoprodol may increase the central nervous system depressant (CNS depressant) activities of Ethanol.

Oliceridine

Major

The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Carisoprodol is combined with Oliceridine.

Thalidomide

Major

Carisoprodol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.

(R)-warfarin

Moderate

The metabolism of (R)-warfarin can be decreased when combined with Carisoprodol.

Carisoprodol Toxicity & Overdose RiskThe toxic dose of carisoprodol for rats when given intravenously or intraperitoneally is 450 mg/kg and 1,320 mg/kg when taken orally. In mice, these numbers are 165 mg/kg, 980 mg/kg, and 2,340 mg/kg respectively. Overdosing on carisoprodol can lead to a coma, shock, breathing problems, seizures, and death in extreme cases. Other symptoms may include dizziness, blurred vision, fast heartbeat, low blood pressure, confusion, hallucinations, and muscle stiffness. Alcohol or other drugs that depress the central nervous system can increase the effects

image of a doctor in a lab doing drug, clinical research

Carisoprodol Novel Uses: Which Conditions Have a Clinical Trial Featuring Carisoprodol?

23 active clinical trials are investigating the potential of Carisoprodol in providing relief from Acute Pain, Acute Coryza and Musculoskeletal Diseases.

Condition

Clinical Trials

Trial Phases

Musculoskeletal Diseases

2 Actively Recruiting

Not Applicable

Acute Coryza

0 Actively Recruiting

Acute Pain

2 Actively Recruiting

Early Phase 1, Not Applicable

Carisoprodol Reviews: What are patients saying about Carisoprodol?

5Patient Review

11/20/2015

Carisoprodol for Muscle Spasm

I've used this medication for about two decades to manage my MS-induced muscle spasms, and it's been incredibly effective. I have tried other muscle relaxants in the past, but none of them compare to this one. That said, it is difficult to wean yourself off of this medication after long-term use; you have to do it gradually.

5Patient Review

12/28/2015

Carisoprodol for Muscle Spasm

I've been taking this medication for a decade and it's really helped me. I have severe lower back and neck pain, and after multiple surgeries (both fused spine segments and plates/pins), this is the only muscle relaxer that offers me consistent relief.

5Patient Review

11/27/2015

Carisoprodol for Muscle Spasm

Carisoprodol was much more effective than Diazapam at relieving my muscle spasms without making me feel loopy.

5Patient Review

8/31/2016

Carisoprodol for Muscle Spasm

I've been taking Soma for chronic pain that I've had for 16 years now. It's the only thing that helps.

5Patient Review

5/7/2016

Carisoprodol for Muscle Spasm

This muscle relaxant is the only one that has helped me with my severe spasms. It's getting harder to find a physician who will prescribe it though, which is concerning.

View All Reviews

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Patient Q&A Section about carisoprodol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is carisoprodol a narcotic?

"Carisoprodol is not an opioid.

No, Soma (carisoprodol) is not a narcotic. People often use the word "narcotic" to describe all controlled substances, but a narcotic is actually a specific type of opioid pain reliever. Carisoprodol is not an opioid."

Answered by AI

Is carisoprodol a painkiller?

"6 days ago"

Answered by AI

Does carisoprodol 350 mg make you sleepy?

"Carisoprodol can make you feel drowsy and lightheaded. Do not drive or operate heavy machinery until you know how this medication affects you. Carisoprodol can be addictive and may lead to dependence."

Answered by AI

What is carisoprodol used for?

"This medicine is used to relax muscles and relieve discomfort caused by acute, painful muscle or bone conditions. However, it is not a replacement for rest, exercise, physical therapy, or other treatments that your doctor may recommend for your medical condition."

Answered by AI