Butrans

Pain, Opioid-Related Disorders, Pain
Treatment
2 FDA approvals
0 Active Studies for Butrans

What is Butrans

BuprenorphineThe Generic name of this drug
Treatment SummaryBuprenorphine is a medication used to treat severe pain and opioid addiction. It is sold under the brand name Suboxone, in combination with naloxone, a drug that helps reduce the risk of abuse. Buprenorphine binds to opioid receptors in the body and has a long-lasting effect, providing relief from pain and withdrawal symptoms for up to 36 hours. It has fewer side effects and a lower risk of overdose than other potent opioids. Buprenorphine is used in opioid agonist treatment (OAT) or opioid substitution therapy (OST), which is used to reduce cravings and drug-
Buprenexis the brand name
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Butrans Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Buprenex
Buprenorphine
1985
261

Approved as Treatment by the FDA

Buprenorphine, commonly known as Buprenex, is approved by the FDA for 2 uses which include Opioid Dependence and Opioid-Related Disorders .
Opioid Dependence
Used to treat Opioid Dependence in combination with Naloxone
Opioid-Related Disorders
Used to treat Opioid Dependence in combination with Naloxone

Effectiveness

How Butrans Affects PatientsBuprenorphine interacts with the opioid mu-receptor in the brain, spinal cord, and other tissues, causing pain relief, sedation, and changes in mood. It can also slow down the respiratory system and cause constipation. Taking this drug for a long time can affect the hormones in the body, leading to lower sex drive or fertility issues. Buprenorphine can cause withdrawal symptoms if stopped too quickly. It can also lead to adrenal insufficiency, hepatitis, low blood pressure, and increased pressure in the brain or bile duct. Patients should be aware of potential side effects such as constipation,
How Butrans works in the bodyBuprenorphine is a drug that binds to the mu-opioid receptor in the brain. It has a strong binding affinity, which means it sticks to the receptor well, but it has low activity which means it doesn't activate it very much. This reduces the risk of overdose and other side effects like sedation and euphoria, and also helps to reduce the reinforcing effects of opioids that can lead to drug-seeking behaviors. When taken by someone who is already dependent on opioids, buprenorphine can cause a rapid and intense onset of withdrawal symptoms, known as "precipitated withdrawal". To prevent this

When to interrupt dosage

The recommended dosage of Butrans is contingent upon the diagnosed disorder, including Pain, Pain and Opioid Dependence. The magnitude of dosage relies on the method of delivery (e.g. Tablet - Oral or Sublingual) outlined in the table beneath.
Condition
Dosage
Administration
Pain
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Opioid-Related Disorders
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Pain
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous

Warnings

Butrans Contraindications
Condition
Risk Level
Notes
Alcohol Withdrawal Delirium
Do Not Combine
Asthma
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
suspected gastrointestinal obstruction
Do Not Combine
Pulse Frequency
Do Not Combine
Asthma
Do Not Combine
Gastrointestinal obstruction
Do Not Combine
Head
Do Not Combine
ethanol
Do Not Combine
Stomatitis
Do Not Combine
Abdomen
Do Not Combine
severe CNS depression
Do Not Combine
opioid naive
Do Not Combine
Myasthenia Gravis
Do Not Combine
Epilepsy
Do Not Combine
Hypocalcemia
Do Not Combine
Hypokalemia
Do Not Combine
Hypomagnesemia
Do Not Combine
Mental Depression
Do Not Combine
Cerebrospinal Fluid
Do Not Combine
Long QT Syndrome
Do Not Combine
There are 20 known major drug interactions with Butrans.
Common Butrans Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Buprenorphine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Buprenorphine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Buprenorphine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Buprenorphine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Buprenorphine.
Butrans Toxicity & Overdose RiskSigns of an overdose on opioids include very small pupils, excessive sleepiness, low blood pressure, difficulty breathing, and in extreme cases, death.
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Butrans Novel Uses: Which Conditions Have a Clinical Trial Featuring Butrans?

21 active clinical trials are currently in progress to determine the potential of Butrans for managing Opioid Dependence, Pain and related Ailments.
Condition
Clinical Trials
Trial Phases
Pain
0 Actively Recruiting
Pain
0 Actively Recruiting
Opioid-Related Disorders
0 Actively Recruiting

Butrans Reviews: What are patients saying about Butrans?

5Patient Review
2/25/2021
Butrans for severe chronic pain requiring long-term opioid treatment
I was taking Morphine for 6 years and couldn't get my levels below 7. I am on the Butrans 10mcg now and my pain levels have been the lowest they have been in years. My pain management doctor told me I do need to increase the dosage because it isn't being effective for the full 7 days, but that's better than before. Overall, I am pleased with it. The side effects I have are weight loss, chills and headaches.
5Patient Review
7/28/2022
Butrans for severe chronic pain with opioid tolerance
This treatment, combining medication and nerve blocks, has drastically improved my quality of life. I was taking large doses of painkillers for over 10 years, but they stopped being effective. Now I'm on a much lower dose of morphine and it's helped me lose 45lbs and walk 2km - things I could never do before.
5Patient Review
7/18/2022
Butrans for severe chronic pain with opioid tolerance
This is the only patch that has worked for me. I've tried morphine and Percocet in the past, but this is by far the most effective treatment. It does make me a little sleepy, but it's worth it for the pain relief.
5Patient Review
6/28/2022
Butrans for severe chronic pain requiring long-term opioid treatment
This medication completely removed my pain without making me feel drugged.
4.7Patient Review
6/29/2020
Butrans for Chronic Pain
Tramadol didn't help me much, even at high doses. Butrans, however, has been a game changer. I saw relief after just a few days and my pain is now manageable.
View All Reviews
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Patient Q&A Section about butrans

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Butrans the same as Suboxone?

"Both Buprenorphine (Butrans) and Suboxone contain the same active ingredient, buprenorphine. Buprenorphine (Butrans) is a patch that is used to treat pain, while Suboxone is a medication that is placed under the tongue to treat opioid dependence."

Answered by AI

Is Butrans the same as tramadol?

"The medication Ultram (tramadol) is effective for treating pain. Although it is not as strong as some other opioids, it can still be habit-forming. The medication Butrans (buprenorphine) comes in a patch that only needs to be replaced once a week. Butrans (buprenorphine) provides around-the-clock relief from pain."

Answered by AI

How does Butrans make you feel?

"Buprenorphine is a partial agonist of mu opioid receptors, so it can produce similar effects to full mu-agonists, like sedation, euphoria, and respiratory depression. However, this is more likely to happen at higher doses of buprenorphine, like those delivered by Butrans."

Answered by AI

What is Butrans prescribed for?

"The BuTrans patch contains the active ingredient buprenorphine, which is a strong analgesic. These patches have been prescribed by your doctor to relieve moderate, long-lasting pain."

Answered by AI
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