Budesonide

Proteinuria, Asthma, Itching + 16 more

Treatment

20 Active Studies for Budesonide

Treatment for

Proteinuria

What is Budesonide

Budesonide

The Generic name of this drug

Treatment Summary

Budesonide is a steroid medication used to reduce inflammation in the lungs and intestines. It is used to treat asthma, COPD, Crohn's disease, and ulcerative colitis. It was approved by the FDA in 1994 and is available as both an inhaler and a pill.

Rhinocort

is the brand name

image of different drug pills on a surface

Budesonide Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Rhinocort

Budesonide

1994

134

Effectiveness

How Budesonide Affects Patients

Budesonide is used to treat a variety of respiratory and digestive conditions by reducing inflammation. The amount of the drug varies from person to person, making it a safe drug. However, it is important to be aware of the potential risk of over-stimulating the body's hormones and causing suppression of the adrenal axis.

How Budesonide works in the body

Corticosteroids are drugs that help reduce inflammation. They work by binding to a receptor in cells and altering gene expression, which leads to several changes in the body. These include stopping white blood cells from travelling to sites of inflammation, reducing the production of molecules that cause inflammation, and promoting molecules that reduce it. Depending on the dose, corticosteroids can either reduce inflammation or suppress the immune system. Long-term use of high-doses can also lead to higher sodium levels and lower potassium levels.

When to interrupt dosage

The recommended amount of Budesonide is contingent upon the diagnosed disorder, like Vasomotor Rhinitis, Crohn's Disease and Chronic Obstructive Pulmonary Disease (COPD). Dosage can be found in the table underneath, contingent upon the mode of administration (e.g. Enema; Kit; Tablet - Rectal or Respiratory (inhalation)).

Condition

Dosage

Administration

Proteinuria

, 0.25 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 0.09 mg, 0.032 mg, 3.0 mg, 0.18 mg, 0.2 mg, 0.5 mg, 9.0 mg, 28.0 mg, 2.3 mg, 0.08 mg, 0.16 mg, 0.00008 mg/hour, 0.32 mg, 1.0 mg, 6.0 mg, 0.125 mg/mL, 4.0 mg, 0.064 mg/pump actuation, 0.4 mg/pump actuation, 0.1 mg/pump actuation, 2.0 mg/pump actuation, 0.2 mg/pump actuation, 0.182 mg/pump actuation

Respiratory (inhalation), Inhalant, , Inhalant - Respiratory (inhalation), Suspension, Suspension - Respiratory (inhalation), Aerosol, powder - Respiratory (inhalation), Aerosol, powder, Nasal, Spray, metered, Capsule, Oral, Spray, metered - Nasal, Capsule - Oral, Powder - Respiratory (inhalation), Powder, Aerosol, metered, Aerosol, metered - Nasal, Tablet, extended release, Tablet, extended release - Oral, Rectal, Aerosol, foam - Rectal, Aerosol, foam, Capsule, delayed release pellets - Oral, Capsule, delayed release pellets, Enema; Kit; Tablet, Enema; Kit; Tablet - Rectal, Capsule, extended release - Oral, Capsule, extended release, Capsule, coated pellets - Oral, Capsule, coated pellets, Powder - Nasal; Respiratory (inhalation), Nasal; Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation), Capsule, gelatin coated, Capsule, gelatin coated - Oral, Inhalant - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Powder, metered, Powder, metered - Respiratory (inhalation), Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Cutaneous, Kit, Kit - Rectal, Aerosol, metered - Respiratory (inhalation), Capsule, delayed release - Oral, Capsule, delayed release, Patch - Cutaneous, Patch

Itching

Rhinitis, Vasomotor

Nasal Polyps

Eosinophilic Esophagitis

Crohn Disease

Asthma

Skin Diseases

maintenance therapy

Chronic Obstructive Pulmonary Disease

Acute Coryza

Ulcerative Colitis

Colitis, Collagenous

Crohn's Disease

Nasal Congestion

Hypersensitivity

IGA Glomerulonephritis

Sinusitis

Crohn Disease

Warnings

Budesonide Contraindications

Condition

Risk Level

Notes

Asthma

Do Not Combine

Severe Hepatic Impairment

Do Not Combine

Status Asthmaticus

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Budesonide may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Budesonide may interact with Pulse Frequency

There are 20 known major drug interactions with Budesonide.

Common Budesonide Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Budesonide is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Budesonide is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abatacept

Major

The risk or severity of adverse effects can be increased when Budesonide is combined with Abatacept.

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Budesonide.

Abetimus

Major

The risk or severity of adverse effects can be increased when Budesonide is combined with Abetimus.

Budesonide Toxicity & Overdose Risk

Overdosing on corticosteroids is not common, but taking them for long periods of time can lead to an excess amount of the hormone in the body (hypercorticism) and can stop the adrenal glands from functioning properly. If an overdose occurs, the dosage of corticosteroids should be reduced temporarily. In mice, it has been found that 200mg orally is lethal to female mice while 400mg orally is lethal to male mice.

image of a doctor in a lab doing drug, clinical research

Budesonide Novel Uses: Which Conditions Have a Clinical Trial Featuring Budesonide?

516 clinical trials are presently assessing the efficacy of Budesonide in treating Chronic Obstructive Pulmonary Disease (COPD), Ulcerative Colitis and Allergic Inflammation.

Condition

Clinical Trials

Trial Phases

Asthma

84 Actively Recruiting

Phase 1, Phase 4, Early Phase 1, Not Applicable, Phase 2, Phase 3

Itching

3 Actively Recruiting

Phase 3, Not Applicable

Chronic Obstructive Pulmonary Disease

70 Actively Recruiting

Phase 3, Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4

Proteinuria

5 Actively Recruiting

Phase 2, Phase 3, Phase 4, Phase 1

IGA Glomerulonephritis

0 Actively Recruiting

Ulcerative Colitis

17 Actively Recruiting

Phase 3, Phase 2, Phase 1, Not Applicable, Phase 4

Sinusitis

0 Actively Recruiting

Crohn's Disease

52 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1

Hypersensitivity

1 Actively Recruiting

Phase 4

Colitis, Collagenous

0 Actively Recruiting

Skin Diseases

0 Actively Recruiting

maintenance therapy

0 Actively Recruiting

Rhinitis, Vasomotor

1 Actively Recruiting

Not Applicable

Eosinophilic Esophagitis

0 Actively Recruiting

Acute Coryza

0 Actively Recruiting

Crohn Disease

0 Actively Recruiting

Nasal Polyps

0 Actively Recruiting

Crohn Disease

0 Actively Recruiting

Nasal Congestion

0 Actively Recruiting

Budesonide Reviews: What are patients saying about Budesonide?

Patient Review

1/29/2017

Budesonide for Ulcerated Colon

I've been taking this medication for a while, but it has caused some serious side effects like skin thinning and vision problems. I might have to switch back to pentasa.

Patient Review

4/29/2022

Budesonide for Collagenous Colitis

Worked great for my lympathic colitis, but unfortunately the diahrea came back a few weeks after I finished the regimen. Waiting to hear from my doctor about what to do next.

Patient Review

11/20/2017

Budesonide for Crohn's Disease Maintenance of Remission

I've been on this drug for six years and it's worked great, but recently I've been feeling fatigue and a lack of energy for over twelve months now. Going to see if the doctor thinks it might be due to long-term use of this medication.

Patient Review

8/19/2017

Budesonide for Ulcerated Colon

This is the only medication I've found that provides relief from my ulcerative colitis.

Patient Review

5/3/2019

Budesonide for Ulcerated Colon

I've been on this medication for about 10 months now for my ulcerative colitis. I feel much better, especially in the last two months.

4.7

Patient Review

4/29/2016

Budesonide for Ulcerated Colon

It's effective, but you should know that it's possible to gain weight while taking this medication and doing exercise regularly. It's also quite expensive.

Patient Review

11/21/2016

Budesonide for Crohn's Disease Maintenance of Remission

I always feel great after taking this drug, but it is a bit of an inconvenience to have to take three large pills in the morning.

Patient Review

3/17/2022

Budesonide for Ulcerated Colon

This medicine finally stopped my diarrhea after other treatments failed. However, I've been having some difficulty breathing and panic attacks since starting this medication.

Patient Review

7/12/2022

Budesonide for Collagenous Colitis

I've only been taking this for two weeks, but it's already done wonders for my healing process. I had a polyp removal and hemorrhoidectomy recently, and the diarrhea was out of control. This medication really helped me get things back under control within just a couple days. I am a bit more tired now, but it's worth it to me since the alternative is so much worse.

3.7

Patient Review

12/21/2018

Budesonide for Crohn's Disease

I've only been taking this medication for a short while, but I'm already wondering how long it will take to see results. Has anyone else out there achieved remission and how long did it take?

1.7

Patient Review

1/20/2017

Budesonide for Crohn's Disease

Unfortunately, I couldn't tolerate this medication well. I experienced shortness of breath, an irregular heartbeat, excessive fatigue, and vision and balance problems.

1.7

Patient Review

3/29/2022

Budesonide for Crohn's Disease

I've been on this medication for Crohn's disease for a little while now, and it unfortunately has not worked at all. If anything, it seems to be making the symptoms worse rather than better.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about budesonide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What budesonide is used for?

"Budesonide is an inhalation medication used to prevent the symptoms of asthma. Inhaled budesonide is taken regularly every day to decrease the number and severity of asthma attacks."

Answered by AI

What are the side effects to budesonide?

"Body aches and pains, congestion, dryness or soreness of the throat, headache, muscle aches and pains, shortness of breath or troubled breathing, sore throat, tender, swollen glands in the neck."

Answered by AI

Is prednisone and budesonide the same?

"Brand names of budesonide include Pulmicort, Rhinocort, and Entocort.

Prednisone and budesonide are both types of corticosteroids. Prednisone is available under the brand names Deltasone, Rayos, and Prednisone Intensol. Budesonide is available under the brand names Pulmicort, Rhinocort, and Entocort."

Answered by AI

Is budesonide a strong steroid?

"Although the use of corticosteroids in active Crohn's disease often becomes limited by side effects, Budesonide is a potent corticosteroid that is not extensively metabolized by the liver, and thus has low systemic bioavailability."

Answered by AI

Clinical Trials for Budesonide

Have you considered Budesonide clinical trials?

We made a collection of clinical trials featuring Budesonide, we think they might fit your search criteria.

Have you considered Budesonide clinical trials?

We made a collection of clinical trials featuring Budesonide, we think they might fit your search criteria.

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MoblO2 for Chronic Lung Diseases

18+

All Sexes

Stanford, CA

Many patients with chronic lung disease (e.g., chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD)) require supplemental oxygen (O2) at some point during their disease course. Practitioners prescribe O2 to patients with chronic lung disease in hopes of the following: 1) that it will limit desaturation events and combat breathlessness, thus preventing the frustratingly slow pace and numerous rest breaks patients are forced to adopt while doing even simple tasks; 2) that it will allow patients to be more active physically (perhaps increase their ability to exercise) and socially (perhaps leave the home more often); 3) that it will stave off putative complications of hypoxemia (e.g., cognitive dysfunction, pulmonary hypertension) and 4) that it will improve health-related quality of life (HRQL). However, despite the rationale for O2, and prescribers' good intentions, patients generally view O2 with frustration and fear - it threatens their HRQL, which is already impaired by having a condition that imposes itself on every aspect of their lives. Nasal cannulas and delivery devices call unwanted attention to patients when they are out in public. O2 users feel stigmatized and are often viewed as "smokers who get what they deserve, even if they never smoked a day in their lives" - or as disabled, sick or even infectious. O2 steals patients' independence, forcing them to plan their lives around it. The anxiety that patients and their caregivers experience around running out of oxygen, or not getting enough, immobilizes them and restricts participation in activities outside of the home. O2 disrupts the home environment, adding stress, and creating a burden for patients' caregiver-loved-ones who are often saddled with the responsibility of ensuring adequate equipment and supply of O2, and O2 is a constant reminder to patients they are living with a condition that could shorten their lives. O2 delivery equipment is typically heavy, unwieldy and intimidating. Different recommendations (e.g., insurance companies use 88% as a cut-off for SpO2, while many practitioners focus on 90%) make it confusing for patients, which almost certainly affects adherence. O2-requiringpatients are starving for things that can make their lives easier. An auto-adjusting O2 delivery device - one that automatically delivers the correct amount of O2 to maintain blood oxygen at desired, pre-set levels - would alleviate the need for patients to constantly (incessantly for many) monitor their peripheral oxygen saturation (SpO2) and adjust O2flow to meet the demands as exertion levels vary . The MoblO2 device is a battery-operated, light-weight, closed-loop O2 delivery device that houses a regulator (which attaches to compressed gas O2 tanks) and adjusts O2 flow to meet a pre-set blood oxygen level. A pulse oximeter is worn on the ear and transmits via Bluetooth to the device, which adjusts an internal valve to control flow on a second-to-second basis. The user sets the dial to the highest flow of O2 needed to meet the demands of activities they might perform (up to 15 liters per minute), and the device adjusts flow, up to the pre-set level to maintain SpO2 at a preset level (e.g., \> 90%). To conserve O2 supply in the tank - and to avoid over-oxygenation (which could be problematic for a small percentage of patients with the most severe COPD) - the MoblO2 begins to limit O2 flow at a SpO2 of 93%. The device can be manually over-ridden by the user, and should the battery run out - or the device fail for some unforeseen reason - the default position is valve open, so the users receive whatever flow of oxygen has been set on the dial. Given the substantial burdens of O2 on patients and their families, the hassles patients describe with having to monitor their SpO2 and repeatedly adjust the flow of O2 to meet their needs, patients and experts around the world have called for improvements in O2 delivery equipment. The MoblO2 is just such a remarkable improvement and a giant step forward in helping to ease the burdens of O2 on patients who require it. The purpose of this study is to investigate the effects of the MoblO2 O2 delivery device on a range of outcomes, including physical activity, amount (liters) O2 use; maintenance of adequate SpO2 levels; patient reported outcomes including symptoms, HRQL and satisfaction with the MoblO2 O2 device.

Waitlist Available

Has No Placebo

Stanford University

Jeff Swigris, DO, MS

Minnesota Health Solutions