Blenoxane

Pleural Effusion, Malignant, Teratocarcinoma, Testicular Embryonal Carcinoma + 5 more
Treatment
7 FDA approvals
20 Active Studies for Blenoxane

What is Blenoxane

BleomycinThe Generic name of this drug
Treatment SummaryBleomycin is a type of antibiotic that is made up of two components, Bleomycin A2 and B2. It is derived from the <i>Streptomyces verticillus</i> bacteria and is used to treat certain types of cancer, particularly solid tumors. It works by inhibiting the metabolism of DNA. Bleomycin A2 is used as the primary structure for Bleomycin.
Bleomycinis the brand name
image of different drug pills on a surface
Blenoxane Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Bleomycin
Bleomycin
2000
19

Approved as Treatment by the FDA

Bleomycin, also known as Bleomycin, is approved by the FDA for 7 uses such as Hodgkin's Lymphoma and Testicular Embryonal Carcinoma .
Hodgkin's Lymphoma
Helps manage Lymphoma, Hodgkins
Testicular Embryonal Carcinoma
Helps manage Testicular Embryonal Carcinoma
Teratocarcinoma
Helps manage Teratocarcinoma
Palliative Treatment
Helps manage Palliative Treatment
Non-Hodgkin's Lymphoma
Helps manage Non-Hodgkin's Lymphoma (NHL)
Testicular Choriocarcinoma
Helps manage Testicular Choriocarcinoma
Pleural Effusion, Malignant
Helps manage Pleural Effusion, Malignant

Effectiveness

How Blenoxane Affects PatientsBleomycin is an antibiotic that is used to fight tumors. It works by blocking the cell's ability to make DNA and RNA. Bleomycin has been found to stop the growth of B cells, T cells, and macrophages, which are all types of immune cells. It also affects how these cells present antigens and how they produce certain proteins. Bleomycin is unique among other antitumor drugs because it specifically targets cells during the G2 and M phases of the cell cycle.
How Blenoxane works in the bodyBleomycin works by inhibiting DNA, RNA, and protein synthesis. This process relies on the presence of oxygen and metal ions, which interact with bleomycin to form free radicals that damage DNA. This reaction can lead to cell death and stop cancer growth.

When to interrupt dosage

The suggested measure of Blenoxane is contingent upon the determined condition, for instance Testicular Embryonal Carcinoma, Hodgkin's Lymphoma and Non-Hodgkin's Lymphoma. The amount of dosage depends on the delivery technique (e.g. Intramuscular; Intrapleural; Intravenous; Subcutaneous or Powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous) as featured in the following table.
Condition
Dosage
Administration
Palliative Treatment
15.0 units, , 15.0 [USP'U], 30.0 [USP'U], 15000.0 [iU]
, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, Injection, powder, lyophilized, for solution - Intra-arterial; Intramuscular; Intravenous, Intra-arterial; Intramuscular; Intravenous
Non-Hodgkin's Lymphoma
15.0 units, , 15.0 [USP'U], 30.0 [USP'U], 15000.0 [iU]
, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, Injection, powder, lyophilized, for solution - Intra-arterial; Intramuscular; Intravenous, Intra-arterial; Intramuscular; Intravenous
Squamous Cell Carcinoma
15.0 units, , 15.0 [USP'U], 30.0 [USP'U], 15000.0 [iU]
, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, Injection, powder, lyophilized, for solution - Intra-arterial; Intramuscular; Intravenous, Intra-arterial; Intramuscular; Intravenous
Hodgkin's Lymphoma
15.0 units, , 15.0 [USP'U], 30.0 [USP'U], 15000.0 [iU]
, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, Injection, powder, lyophilized, for solution - Intra-arterial; Intramuscular; Intravenous, Intra-arterial; Intramuscular; Intravenous
Testicular Embryonal Carcinoma
15.0 units, , 15.0 [USP'U], 30.0 [USP'U], 15000.0 [iU]
, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, Injection, powder, lyophilized, for solution - Intra-arterial; Intramuscular; Intravenous, Intra-arterial; Intramuscular; Intravenous
Pleural Effusion, Malignant
15.0 units, , 15.0 [USP'U], 30.0 [USP'U], 15000.0 [iU]
, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, Injection, powder, lyophilized, for solution - Intra-arterial; Intramuscular; Intravenous, Intra-arterial; Intramuscular; Intravenous
Teratocarcinoma
15.0 units, , 15.0 [USP'U], 30.0 [USP'U], 15000.0 [iU]
, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, Injection, powder, lyophilized, for solution - Intra-arterial; Intramuscular; Intravenous, Intra-arterial; Intramuscular; Intravenous
Testicular Choriocarcinoma
15.0 units, , 15.0 [USP'U], 30.0 [USP'U], 15000.0 [iU]
, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Powder, for solution - Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Intra-arterial; Intracavitary; Intramuscular; Intravenous; Subcutaneous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection - Intramuscular; Intrapleural; Intravenous; Subcutaneous, Injection, Injection, powder, lyophilized, for solution - Intra-arterial; Intramuscular; Intravenous, Intra-arterial; Intramuscular; Intravenous

Warnings

There are 20 known major drug interactions with Blenoxane.
Common Blenoxane Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Bleomycin is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Bleomycin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Bleomycin is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Bleomycin is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Bleomycin is combined with Acteoside.
Blenoxane Toxicity & Overdose RiskToo much exposure to bleomycin can result in fever, chills, nausea, vomiting, mental confusion, and difficulty breathing. The drug can also irritate the eyes, skin, and respiratory tract and make the skin darker or thicker. An allergic reaction is also possible.
image of a doctor in a lab doing drug, clinical research

Blenoxane Novel Uses: Which Conditions Have a Clinical Trial Featuring Blenoxane?

296 active trials are being conducted to investigate the potential of Blenoxane to target Teratocarcinoma, Testicular Choriocarcinoma and Malignant Pleural Effusions.
Condition
Clinical Trials
Trial Phases
Non-Hodgkin's Lymphoma
160 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Early Phase 1
Palliative Treatment
0 Actively Recruiting
Pleural Effusion, Malignant
2 Actively Recruiting
Phase 1
Testicular Choriocarcinoma
0 Actively Recruiting
Hodgkin's Lymphoma
74 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable
Teratocarcinoma
0 Actively Recruiting
Squamous Cell Carcinoma
31 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Testicular Embryonal Carcinoma
0 Actively Recruiting

Patient Q&A Section about blenoxane

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is bleomycin used to treat?

"Bleomycin is an antibiotic that is only used in cancer chemotherapy. It slows or stops the growth of cancer cells in your body."

Answered by AI

How is Blenoxane administered?

"BLENOXANE should be injected intramuscularly, intravenously, subcutaneously, or intrapleurally with caution."

Answered by AI

What is the generic name for Blenoxane?

"Bleomycin is the name for the trade name drug Blenoxane. In some cases, health care professionals may use the trade name Blenoxane when referring to the generic drug name. Bleomycin is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug."

Answered by AI

Clinical Trials for Blenoxane

Have you considered Blenoxane clinical trials? We made a collection of clinical trials featuring Blenoxane, we think they might fit your search criteria.
Have you considered Blenoxane clinical trials? We made a collection of clinical trials featuring Blenoxane, we think they might fit your search criteria.
Have you considered Blenoxane clinical trials? We made a collection of clinical trials featuring Blenoxane, we think they might fit your search criteria.
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