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What is Bijuva
ProgesteroneThe Generic name of this drug
Treatment SummaryEstradiol is a hormone produced naturally in female bodies. It is available in various forms as a hormone therapy to treat conditions caused by low estrogen levels, such as hot flashes and vaginal dryness. It can be taken orally as a pill, injected, used as a vaginal ring, patch, spray, gel, or cream. When taken orally or by injection, it is usually combined with a pro-drug ester. Ethinyl estradiol is a synthetic version of estradiol that is commonly used in combination with other hormones in birth control pills. It is more effective than estradiol because it is more bioavailable and
Progesteroneis the brand name
Bijuva Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Progesterone
Progesterone
1978
124
Effectiveness
How Bijuva Affects PatientsEstradiol is used to treat hot flashes, vaginal dryness, and other urogenital symptoms. It can also help increase bone density, improve the levels of certain proteins and hormones in the blood, and reduce the amount of follicle-stimulating hormones. However, it can increase the risk of developing cardiovascular disease, blood clots, and stroke. It also causes a hyper-coagulable state and can lead to increased levels of sodium in the body, which can cause hypertension.
How Bijuva works in the bodyEstrogen is naturally produced in the ovaries of adult women. After menopause, the majority of estrogen is created in the body from androstenedione, a hormone produced by the adrenal cortex. Estrogen works by binding to two types of receptors, ERα and ERβ, as well as GPER, which helps control its rapid effects. Once bound, estrogen enters the cell's nucleus and changes gene expression, which leads to the relief of postmenopausal symptoms like hot flashes, chills, sleep problems, and more.
When to interrupt dosage
The recommended measure of Bijuva is contingent upon the recognized condition, including Premature Menopause, Pharmaceutical Preparations and Postmenopause. The dosage fluctuates in line with the administration method depicted in the table beneath.Condition
Dosage
Administration
Reproductive Technology
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Endometrial Hyperplasia
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Amenorrhea
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
hormonal imbalance
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Postmenopause
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Hysterectomy
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Amenorrhea
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Uterine hemorrhage
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Vasomotor System
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
recurrent spontaneous preterm birth
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Hot flashes
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
prophylaxis of recurrent spontaneous preterm birth
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Warnings
Bijuva ContraindicationsCondition
Risk Level
Notes
Liver Diseases
Do Not Combine
Thromboembolism
Do Not Combine
suspected pregnancy
Do Not Combine
Pulmonary Embolism
Do Not Combine
Stroke
Do Not Combine
Cerebrovascular accident
Do Not Combine
Thrombophlebitis
Do Not Combine
Breast
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Pulmonary Embolism
Do Not Combine
Pulmonary Embolism
Do Not Combine
Breast Cancer
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Breast
Do Not Combine
Breast
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
suspected pregnancy
Do Not Combine
Thromboembolism
Do Not Combine
Malignant Neoplasms
Do Not Combine
Stroke
Do Not Combine
undiagnosed vaginal bleeding
Do Not Combine
Abortion, Spontaneous
Do Not Combine
Venous Thrombosis
Do Not Combine
Thrombophlebitis
Do Not Combine
Stroke
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Progesterone may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Progesterone may interact with Pulse Frequency
Common Bijuva Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Progesterone.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Progesterone.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Progesterone.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Progesterone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Progesterone.
Bijuva Toxicity & Overdose RiskTests have shown that taking a small amount of estradiol every day over a 90 day period has no adverse effects. However, taking too much estradiol can lead to nausea, vomiting, abdominal pain, breast tenderness, blood clots, and vaginal bleeding. If someone has taken too much estradiol, it is recommended to stop taking it and provide supportive care.
Bijuva Novel Uses: Which Conditions Have a Clinical Trial Featuring Bijuva?
Currently, 867 active clinical trials are assessing the potential of Bijuva to address Osteoporosis, Amenorrhea of 6 months or longer duration and Urogenital Atrophy.Condition
Clinical Trials
Trial Phases
Endometrial Hyperplasia
0 Actively Recruiting
Postmenopause
8 Actively Recruiting
Phase 2, Not Applicable, Phase 1
recurrent spontaneous preterm birth
0 Actively Recruiting
Uterine hemorrhage
0 Actively Recruiting
hormonal imbalance
0 Actively Recruiting
Vasomotor System
0 Actively Recruiting
Hot flashes
16 Actively Recruiting
Phase 1, Phase 4, Not Applicable, Early Phase 1, Phase 2
Amenorrhea
0 Actively Recruiting
Reproductive Technology
1 Actively Recruiting
Not Applicable
Amenorrhea
0 Actively Recruiting
prophylaxis of recurrent spontaneous preterm birth
0 Actively Recruiting
Hysterectomy
3 Actively Recruiting
Phase 3, Not Applicable, Phase 4
Bijuva Reviews: What are patients saying about Bijuva?
5Patient Review
9/11/2020 I've been taking Bijuva for just under a year now and it's really helped.
5Patient Review
9/30/2020 I'm really pleased with this medication.
5Patient Review
6/20/2021 I've tried two different treatments and had bad reactions to both of them. I was willing to put up with it because they were working so well, but my doctor suggested Bijuvia and it's been a week with no negative side effects so far.
5Patient Review
7/20/2020 I just started taking Bijuva and it's fantastic.
5Patient Review
1/11/2021 This treatment is really effective. I was amazed at how well it worked and how quickly I felt better.
Patient Q&A Section about bijuva
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Bijuva a bioidentical hormone?
"Bijuva contains estradiol and progesterone that are chemically identical to the hormones that women produce naturally."
Answered by AI
Does Bijuva make you gain weight?
"Since Bijuva contains the hormones estradiol (a form of estrogen) and progesterone, it's possible that you may experience weight gain as a side effect of Bijuva. If you're concerned about weight gain or weight loss while taking Bijuva, talk with your doctor to see if this is a normal side effect or something to be concerned about."
Answered by AI
What are the benefits of taking Bijuva?
"1 capsule of BIJUVA once a day can help with moderate to severe hot flashes by replacing the estrogen your body loses during menopause. A study showed that BIJUVA can reduce the frequency and severity of moderate to severe hot flashes in menopausal women."
Answered by AI
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