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What is Benztropine Mesylate
BenzatropineThe Generic name of this drug
Treatment SummaryBenztropine is a medication used to treat the symptoms of Parkinson's disease. It is made up of a combination of a tropane ring, similar to cocaine, and a diphenyl ether, which is known to inhibit dopamine uptake. Studies have shown that adding a chlorine substituent to one of the phenyl rings increases the potency of the drug while also decreasing its inhibition of serotonin and norepinephrine. Benztropine was developed by USL Pharma and approved by the FDA in 1996.
Cogentinis the brand name
Benztropine Mesylate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cogentin
Benzatropine
1959
200
Effectiveness
How Benztropine Mesylate Affects PatientsBenztropine increases the amount of dopamine in the brain, resulting in a sedative effect that can last up to 24 hours. It also has antihistamine and anticholinergic properties, which are similar to the effects of pyrilamine and atropine. The effects usually start within an hour or two after taking the drug.
How Benztropine Mesylate works in the bodyBenztropine is a drug with anti-muscarinic and antihistaminic effects. It works by blocking the activity of dopamine transporters, as well as histamine and muscarine receptors in the brain. By blocking these receptors, it helps to restore the balance between dopamine and acetylcholine which is often disrupted in Parkinson's patients.
When to interrupt dosage
The prescribed dosage of Benztropine Mesylate relies on the diagnosed condition. The amount of dosage fluctuates congruent with the method of delivery (e.g. Tablet - Oral or Solution - Oral) indicated in the table below.Condition
Dosage
Administration
Parkinsonism
, 1.0 mg/mL, 0.5 mg, 1.0 mg, 2.0 mg, 2.0 mg/mL
, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Parenteral, Injection - Parenteral, Solution, Solution - Oral, Liquid, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous
Warnings
Benztropine Mesylate ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Benzatropine may interact with Pulse Frequency
Common Benztropine Mesylate Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Benzatropine is combined with Aclidinium.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Benzatropine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Benzatropine.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Benzatropine is combined with Cimetropium.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Benzatropine.
Benztropine Mesylate Toxicity & Overdose RiskExperiencing an overdose of benztropine may lead to symptoms such as heart or breathing failure, confusion, shock, unconsciousness, seizures, difficulty walking, lack of sweating, high fever, difficulty swallowing, and decreased bowel sounds. In rats, the lowest toxic dose was found to be 940 mg/kg.
Benztropine Mesylate Novel Uses: Which Conditions Have a Clinical Trial Featuring Benztropine Mesylate?
Two active trials are assessing the utility of Benztropine Mesylate for the alleviation of Parkinsonism.Condition
Clinical Trials
Trial Phases
Parkinsonism
3 Actively Recruiting
Phase 4
Patient Q&A Section about benztropine mesylate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Benztropine used for in mental health?
"Benztropine improves movement by restoring the balance of dopamine and acetylcholine in the brain."
Answered by AI
What does Benztropine do to the brain?
"Benztropine works to restore the balance between the two brain chemicals, acetylcholine and dopamine, which control the action of muscles."
Answered by AI
What is Benztropine mesylate used to treat?
"Benztropine is used to treat the symptoms of Parkinson's disease, muscle control difficulties, and balance issues. It is also used to treat tremors caused by other medical problems or medications."
Answered by AI
Can Benztropine be used for anxiety?
"Benztropine (Cogentin) will not alleviate symptoms of anxiety, and in some cases may cause psychosis. Benztropine (Cogentin) functions similarly to atropine, which is also associated with these effects."
Answered by AI