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What is Baraclude
EntecavirThe Generic name of this drug
Treatment SummaryEntecavir (marketed under the brand name Baraclude) is an oral antiviral medication used to treat hepatitis B infection. It works by stopping the virus from replicating and is more effective than other drugs used for the same purpose. Entecavir was approved by the U.S. FDA in 2005.
Baracludeis the brand name
Baraclude Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Baraclude
Entecavir
2005
53
Effectiveness
How Baraclude Affects PatientsEntecavir is a drug used to fight the hepatitis B virus. It works by blocking all three steps in the virus' replication process, which makes it more effective than the older hepatitis B drug, lamivudine.
How Baraclude works in the bodyEntecavir is a drug that blocks the HBV polymerase, which is responsible for replicating the virus. It does this by competing with the natural substrate deoxyguanosine triphosphate, preventing the polymerase from performing its 3 functions: base priming, reverse transcription of the negative strand, and synthesis of the positive strand of HBV DNA. When activated by kinases, entecavir can be incorporated into the DNA, making it impossible for the virus to replicate.
When to interrupt dosage
The amount of Baraclude is contingent upon the diagnosed disorder, including Chronic Hepatitis B, Viral Replication and Transaminases. The dosage likewise vacillates per the mode of administration highlighted in the table beneath.Condition
Dosage
Administration
Chronic Hepatitis B Infection
, 0.5 mg, 1.0 mg, 0.05 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral
Viral Replication
, 0.5 mg, 1.0 mg, 0.05 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral
Transaminases
, 0.5 mg, 1.0 mg, 0.05 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
There are 20 known major drug interactions with Baraclude.Common Baraclude Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Moderate
The metabolism of (R)-warfarin can be decreased when combined with Entecavir.
6-O-benzylguanine
Moderate
The metabolism of 6-O-benzylguanine can be decreased when combined with Entecavir.
8-azaguanine
Moderate
The metabolism of 8-azaguanine can be decreased when combined with Entecavir.
8-chlorotheophylline
Moderate
The metabolism of 8-chlorotheophylline can be decreased when combined with Entecavir.
9-Deazaguanine
Moderate
The metabolism of 9-Deazaguanine can be decreased when combined with Entecavir.
Baraclude Toxicity & Overdose RiskHealthy individuals have not experienced any adverse effects from taking up to 40 mg of entecavir in a single dose or up to 20 mg/day for up to 14 days. If an overdose occurs, the patient should be watched for signs of toxicity, and treated with the appropriate care if needed.
Baraclude Novel Uses: Which Conditions Have a Clinical Trial Featuring Baraclude?
Presently, three active studies are investigating the potential of Baraclude to inhibit Viral Replication, Chronic Hepatitis B and elevate Transaminase levels.Condition
Clinical Trials
Trial Phases
Viral Replication
0 Actively Recruiting
Chronic Hepatitis B Infection
7 Actively Recruiting
Phase 3, Phase 2, Phase 1
Transaminases
0 Actively Recruiting
Baraclude Reviews: What are patients saying about Baraclude?
5Patient Review
7/30/2011 Baraclude has been incredibly effective for me in managing my chronic Hepatitis B. I take it every morning and have had no issues with tolerance or side effects. My quarterly blood tests all come back normal, and I couldn't be happier with the results.
5Patient Review
10/8/2014 I've been taking baraclude for close to a year, and it's brought my viral load down from the billions to zero. I'm still dealing with the aftermath of Hep B, but I'm hopeful that this treatment will keep the virus at bay.
5Patient Review
4/7/2014 Baraclude has been a life-saving medication for me. My viral count went down to almost zero within a few months of starting treatment, and I'm still taking it according to my doctor's instructions.
5Patient Review
11/7/2014 It's good, but very expensive. The doctor says I need to take it for life, which is a bummer.
5Patient Review
6/18/2010 I've been taking this medication for three months now, and my DNA count has decreased from 6.4 billion to only 101,000 in that time. This is an amazing result! I'm hopeful for the next lab results in three months.
5Patient Review
1/6/2011 I was able to make a significant reduction in the number of my panic attacks within a year, and I credit this treatment for that.
5Patient Review
3/24/2010 This treatment really helped me. I'm grateful for modern medicine.
5Patient Review
12/10/2011 Baraclude has been a complete game-changer for me. I highly recommend it to anyone dealing with a similar virus.
5Patient Review
1/22/20105Patient Review
7/25/2011 After taking this medication for more than six months, my virus count went from four million to zero. I experienced no side effects and felt great the entire time!
4.7Patient Review
6/13/2010 I've been on this medication for three months and have already seen an improvement in my DNA count. I'm taking the 5 mg tablet before bed, and haven't experienced any negative side effects so far. I would recommend keeping the medication by your bedside to remind you to take it.
4.3Patient Review
3/12/2010 I saw a drastic reduction in my viral count within three months, and experienced no negative side effects.
4.3Patient Review
8/26/2011 I've been taking Baraclude for 24 days now, and I haven't experienced any negative side effects. I take the medication two hours after dinner.
4Patient Review
5/30/2014 It's so affordable in China! I got a pack of 7 pills for only $14. My virus count went down significantly after four months, but it's still not clear when I will be able to stop taking it. Haven't noticed any side effects.
4Patient Review
1/10/2018 I used this drug for four years, and it was effective until a few months ago when the virus came back. Now, my doctor is trying to find a new drug for me to use. I read that this drug's resistance can develop in as little as six years.
3Patient Review
3/16/2010 I'm on day seven of taking Baraclude, and I haven't experienced any negative side effects so far. I take it every night at 10pm, three hours after eating dinner. Does anyone know if this is the optimal time to take the medication?
2.7Patient Review
11/2/2010 my mother is a carrier.i have 305 virus count. prescribed lamivudine by my doctorin the pihilippines.undected after one month. as i arrive in the unitedstates my doctor changed to baraclude. for 2 years still a carrier. don't know when to stop taking this medication
Patient Q&A Section about baraclude
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Baraclude prescribed for?
"Baraclude contains the antiviral drug entecavir and is used to treat hepatitis b in adults."
Answered by AI
Can Baraclude cure hepatitis B?
"Entecavir is an antiviral drug used to treat chronic hepatitis b, especially patients with liver damage. Nov 22, 2020"
Answered by AI
What is entecavir Baraclude used for?
"This reduces liver damage and improves liver function.
Entecavir is used to treat long-term hepatitis b infection. Hepatitis B is an infection of the liver caused by the hepatitis B virus. Long-term infection can cause liver damage, liver cancer, and liver failure. Entecavir helps to decrease the amount of hepatitis B virus in your body, which reduces liver damage and improves liver function."
Answered by AI
What are the side effects of Baraclude?
"The symptoms of the Flu include: nausea, vomiting, diarrhea, upset stomach, temporary hair loss, headache, skin rash, and fatigue."
Answered by AI