Asacol Hd

Q: What is Asacol HD used for?

<p>This medication helps to treat <a href="https://www.withpower.com/clinical-trials/ulcerative-colitis">ulcerative colitis</a>, which is a bowel disease. The drug works by reducing symptoms such as diarrhea, rectal bleeding, and stomach <a href="https://www.withpower.com/clinical-trials/pain">pain</a>. Mesalamine belongs to a class of drugs known as aminosalicylates, which work by decreasing swelling in the colon.</p>

Proctitis, Proctocolitis, Colitis, Ulcerative + 2 more

Treatment

1 FDA approval

0 Active Studies for Asacol Hd

Treatment for

Proctitis

What is Asacol Hd

Mesalazine

The Generic name of this drug

Treatment Summary

Mesalazine is an anti-inflammatory drug used to treat inflammatory bowel disease. It is related to aspirin and other non-steroidal anti-inflammatory drugs. It is the active ingredient in the medication Asacol and Pentasa, which are designed to make mesalazine more stable in the body. Studies have also suggested that it may help reduce the risk of colorectal cancer.

Rowasa

is the brand name

image of different drug pills on a surface

Asacol Hd Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Rowasa

Mesalazine

1988

107

Approved as Treatment by the FDA

Mesalazine, otherwise called Rowasa, is approved by the FDA for 1 uses which include Crohn Disease .

Crohn Disease

Effectiveness

How Asacol Hd Affects Patients

Mesalazine is an active ingredient in sulphasalazine, a drug used to treat ulcerative colitis. It works by reducing inflammation, stopping the production of certain chemicals that help leukocytes move around, and acting as an antioxidant. Mesalazine is more effective when taken directly to the affected area than when taken internally. Studies have shown that it works similarly to prednisolone or sulphasalazine in reducing colitis inflammation in mice and guinea pigs.

How Asacol Hd works in the body

The exact way mesalazine works to treat inflammatory bowel disease is not fully known, but it likely has anti-inflammatory effects. It appears to reduce the production of substances in the colon that cause inflammation, such as prostaglandins and leukotrienes. It may also block a cell protein called Nuclear Factor kappa B, which reduces the production of pro-inflammatory cytokines. Mesalazine also may reduce the movement of white blood cells to the inflamed area, decrease the production of substances like leukotriene B4, and reduce free radical formation.

When to interrupt dosage

The proposed measure of Asacol HD depends on the distinguished condition. The dosage fluctuates as per the technique of delivery outlined in the following table.

Condition

Dosage

Administration

Proctitis

400.0 mg, , 1200.0 mg, 800.0 mg, 400.0 mg/mL, 500.0 mg, 1000.0 mg, 375.0 mg, 250.0 mg, 10.0 mg/mL, 40.0 mg/mL, 0.4 mg/mg, 20.0 mg/mL, 200.0 mg/mL, 1000.0 mg/pump actuation, 0.2 mg/mg

, Tablet, delayed release, Oral, Tablet, delayed release - Oral, Capsule, delayed release - Oral, Capsule, delayed release, Enema, Tablet, Capsule - Oral, Tablet - Oral, Capsule, Rectal, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Enema; Liquid, Suspension, Suspension - Rectal, Enema - Rectal, Tablet, Delayed Release - Oral, Tablet, Delayed Release, Kit - Rectal, Enema; Liquid - Rectal, Kit

Ulcerative Colitis

400.0 mg, , 1200.0 mg, 800.0 mg, 400.0 mg/mL, 500.0 mg, 1000.0 mg, 375.0 mg, 250.0 mg, 10.0 mg/mL, 40.0 mg/mL, 0.4 mg/mg, 20.0 mg/mL, 200.0 mg/mL, 1000.0 mg/pump actuation, 0.2 mg/mg

Proctocolitis

400.0 mg, , 1200.0 mg, 800.0 mg, 400.0 mg/mL, 500.0 mg, 1000.0 mg, 375.0 mg, 250.0 mg, 10.0 mg/mL, 40.0 mg/mL, 0.4 mg/mg, 20.0 mg/mL, 200.0 mg/mL, 1000.0 mg/pump actuation, 0.2 mg/mg

Crohn Disease

400.0 mg, , 1200.0 mg, 800.0 mg, 400.0 mg/mL, 500.0 mg, 1000.0 mg, 375.0 mg, 250.0 mg, 10.0 mg/mL, 40.0 mg/mL, 0.4 mg/mg, 20.0 mg/mL, 200.0 mg/mL, 1000.0 mg/pump actuation, 0.2 mg/mg

Colitis, Ulcerative

400.0 mg, , 1200.0 mg, 800.0 mg, 400.0 mg/mL, 500.0 mg, 1000.0 mg, 375.0 mg, 250.0 mg, 10.0 mg/mL, 40.0 mg/mL, 0.4 mg/mg, 20.0 mg/mL, 200.0 mg/mL, 1000.0 mg/pump actuation, 0.2 mg/mg

Warnings

Asacol Hd Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Mesalazine may interact with Pulse Frequency

There are 20 known major drug interactions with Asacol Hd.

Common Asacol Hd Drug Interactions

Drug Name

Risk Level

Description

Macimorelin

Major

The therapeutic efficacy of Macimorelin can be decreased when used in combination with Mesalazine.

Methotrexate

Major

The serum concentration of Methotrexate can be increased when it is combined with Mesalazine.

Mifamurtide

Major

The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Mesalazine.

Neomycin

Major

The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Neomycin.

Omacetaxine mepesuccinate

Major

The risk or severity of bleeding can be increased when Mesalazine is combined with Omacetaxine mepesuccinate.

Asacol Hd Toxicity & Overdose Risk

In animal tests, up to 320mg/kg of mesalazine did not increase cancer risk, and the drug was not found to be mutagenic. It also did not affect fertility or reproduction in male and female rats. Symptoms of mesalazine toxicity include nausea, vomiting, shortness of breath, ringing in the ears, headaches, dizziness, confusion, and seizures. In the event of an overdose, there is no specific antidote but treatment may involve decontaminating the stomach and balancing fluids and electrolytes. People with impaired kidney function or a history of kidney problems should be monitored carefully while taking mesalazine.

image of a doctor in a lab doing drug, clinical research

Asacol Hd Novel Uses: Which Conditions Have a Clinical Trial Featuring Asacol Hd?

96 active clinical trials are presently evaluating the potential of Asacol Hd in providing relief for Ulcerative Colitis.

Condition

Clinical Trials

Trial Phases

Proctocolitis

0 Actively Recruiting

Proctitis

0 Actively Recruiting

Crohn Disease

0 Actively Recruiting

Colitis, Ulcerative

0 Actively Recruiting

Ulcerative Colitis

0 Actively Recruiting

Asacol Hd Reviews: What are patients saying about Asacol Hd?

Patient Review

10/26/2013

Asacol Hd for Ulcerative Colitis currently Without Symptoms

When I first started taking this medication, I got headaches. However, after talking to my doctor and making some adjustments, like changing the dose and how often I take it, that problem has gone away for the most part. Plus, I have fewer flare-ups now too!

Patient Review

8/4/2014

Asacol Hd for Ulcerative Colitis currently Without Symptoms

I've been taking this medication for two months now, three times a day as directed. I haven't found it to be effective at all; in fact, the only thing that seems to help is staying hydrated.

Patient Review

2/10/2016

Asacol Hd for Ulcerative Colitis currently Without Symptoms

This treatment was effective immediately.

Patient Review

5/9/2011

Asacol Hd for Ulcerative Colitis currently Without Symptoms

I highly recommend this medication to anyone struggling with chronic pain. It's been incredibly effective for me, as long as I remember to take it regularly.

Patient Review

12/26/2013

Asacol Hd for Ulcerative Colitis currently Without Symptoms

I am experiencing hair loss

4.7

Patient Review

10/13/2013

Asacol Hd for Ulcerated Colon

It's tough to remember to take this medication three times a day when I'm always on the go, but it's worth it. I also have to take it with food because otherwise I get an upset stomach, which is just another inconvenience. But hopefully this will help keep the colon cancer away!

4.7

Patient Review

10/22/2009

Asacol Hd for Ulcerated Colon

4.3

Patient Review

1/13/2014

Asacol Hd for Ulcerated Colon

This drug has been really effective in preventing me from having any flare-ups of my ulcerative colitis. However, I have noticed some stiffness in my joints as well as gas and fatigue after taking it for a while now.

Patient Review

9/7/2011

Asacol Hd for Ulcerative Colitis currently Without Symptoms

I saw a big change when I switched from Asacol 400mg 3 pills 3 times a day to AsacolHD 2 pills 800mg 2 times a day. This new treatment works just as well or even better than the old one.

Patient Review

3/11/2010

Asacol Hd for Crohn's Disease

2.3

Patient Review

5/10/2016

Asacol Hd for Crohn's Disease

I've been taking this medication for a long time, and it's definitely helped lower the frequency of my flare-ups.

1.7

Patient Review

6/19/2011

Asacol Hd for Ulcerative Colitis currently Without Symptoms

After being hospitalized for Crohn's a second time, I started taking this medication. At first, it made my Crohn's worse, but after a few days it began to work great. However, if you miss a dose, the symptoms come back quickly. I appreciate that you don't have to take as many pills with this version of Asacol because the mg is greater.

1.7

Patient Review

9/27/2015

Asacol Hd for Ulcerated Colon

This medication has helped me by reducing the number of flare ups I experience.

1.7

Patient Review

2/4/2014

Asacol Hd for Ulcerated Colon

I still have this problem occasionally, but this medication generally keeps it under control.

Patient Review

1/5/2014

Asacol Hd for Ulcerative Colitis currently Without Symptoms

I started this treatment 9 years ago with 8 pills (800mg). After a year or so, I decreased the dosage to 6 pills, and then 4 pills at breakfast. This works for me and it's easy to remember. If I travel and forget to take my pills, there are consequences... I start seeing pink mucus and then blood in the stools.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about asacol hd

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Asacol HD used for?

"This medication helps to treat ulcerative colitis, which is a bowel disease. The drug works by reducing symptoms such as diarrhea, rectal bleeding, and stomach pain. Mesalamine belongs to a class of drugs known as aminosalicylates, which work by decreasing swelling in the colon."

Answered by AI

What is the difference between Asacol and Asacol HD?

"Asacol HD is a delayed-release (DR) version of mesalamine that's FDA-approved to treat moderately active UC in adults. It's available as 800 mg DR tablets. There was another brand-name product called Asacol, which was available as 400 mg DR tablets, but it is no longer on the market."

Answered by AI

Is there a generic for Asacol HD?

"The generic form of Asacol HD is mesalamine tablet, delayed release. A generic drug is an exact copy of the active drug in a brand-name medication and is considered to be as safe and effective as the original drug."

Answered by AI

What are the side effects of taking Asacol?

"The following are potential side effects of the medication: burping, constipation, nausea, vomiting, stomach pain, diarrhea, gas, dizziness, cold symptoms such as stuffy nose, sneezing, sore throat, back pain, headache, rash, or abnormal liver function tests."

Answered by AI