What is Asacol Hd
MesalazineThe Generic name of this drug
Treatment SummaryMesalazine is an anti-inflammatory drug used to treat inflammatory bowel disease. It is related to aspirin and other non-steroidal anti-inflammatory drugs. It is the active ingredient in the medication Asacol and Pentasa, which are designed to make mesalazine more stable in the body. Studies have also suggested that it may help reduce the risk of colorectal cancer.
Rowasais the brand name
Asacol Hd Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rowasa
Mesalazine
1988
107
Approved as Treatment by the FDA
Mesalazine, otherwise called Rowasa, is approved by the FDA for 2 uses which include Ulcerative Colitis and Crohn Disease .Ulcerative Colitis
Helps manage Ulcerative Colitis Acute
Crohn Disease
Effectiveness
How Asacol Hd Affects PatientsMesalazine is an active ingredient in sulphasalazine, a drug used to treat ulcerative colitis. It works by reducing inflammation, stopping the production of certain chemicals that help leukocytes move around, and acting as an antioxidant. Mesalazine is more effective when taken directly to the affected area than when taken internally. Studies have shown that it works similarly to prednisolone or sulphasalazine in reducing colitis inflammation in mice and guinea pigs.
How Asacol Hd works in the bodyThe exact way mesalazine works to treat inflammatory bowel disease is not fully known, but it likely has anti-inflammatory effects. It appears to reduce the production of substances in the colon that cause inflammation, such as prostaglandins and leukotrienes. It may also block a cell protein called Nuclear Factor kappa B, which reduces the production of pro-inflammatory cytokines. Mesalazine also may reduce the movement of white blood cells to the inflamed area, decrease the production of substances like leukotriene B4, and reduce free radical formation.
When to interrupt dosage
The proposed measure of Asacol HD depends on the distinguished condition. The dosage fluctuates as per the technique of delivery outlined in the following table.Condition
Dosage
Administration
Crohn Disease
, 800.0 mg, 400.0 mg, 500.0 mg, 200.0 mg/mL, 40.0 mg/mL, 1000.0 mg/pump actuation, 20.0 mg/mL, 1000.0 mg, 0.4 mg/mg, 10.0 mg/mL, 400.0 mg/mL, 1200.0 mg, 250.0 mg, 375.0 mg, 0.2 mg/mg, 1600.0 mg
, Suppository - Rectal, Suspension, Rectal, Capsule, delayed release - Oral, Oral, Tablet, Delayed Release, Tablet, delayed release, Kit, Tablet, extended release, Capsule, delayed release, Enema; Liquid, Suppository, Capsule - Oral, Suspension - Rectal, Capsule, Tablet, delayed release - Oral, Tablet, Tablet, extended release - Oral, Capsule, extended release, Enema; Liquid - Rectal, Capsule, extended release - Oral, Tablet - Oral, Enema - Rectal, Tablet, Delayed Release - Oral, Enema; Kit, Enema, Kit - Rectal, Enema; Kit - Rectal
Ulcerative Colitis
, 800.0 mg, 400.0 mg, 500.0 mg, 200.0 mg/mL, 40.0 mg/mL, 1000.0 mg/pump actuation, 20.0 mg/mL, 1000.0 mg, 0.4 mg/mg, 10.0 mg/mL, 400.0 mg/mL, 1200.0 mg, 250.0 mg, 375.0 mg, 0.2 mg/mg, 1600.0 mg
, Suppository - Rectal, Suspension, Rectal, Capsule, delayed release - Oral, Oral, Tablet, Delayed Release, Tablet, delayed release, Kit, Tablet, extended release, Capsule, delayed release, Enema; Liquid, Suppository, Capsule - Oral, Suspension - Rectal, Capsule, Tablet, delayed release - Oral, Tablet, Tablet, extended release - Oral, Capsule, extended release, Enema; Liquid - Rectal, Capsule, extended release - Oral, Tablet - Oral, Enema - Rectal, Tablet, Delayed Release - Oral, Enema; Kit, Enema, Kit - Rectal, Enema; Kit - Rectal
Warnings
Asacol Hd ContraindicationsCondition
Risk Level
Notes
Severe Hepatic Impairment
Do Not Combine
Urinary tract obstruction
Do Not Combine
Anus Diseases
Do Not Combine
Curling Ulcer
Do Not Combine
Gastric Ulcer
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Mesalazine may interact with Anus Diseases
Severe Hypersensitivity Reactions
Do Not Combine
Mesalazine may interact with Anus Diseases
Severe Hypersensitivity Reactions
Do Not Combine
Mesalazine may interact with Toxoplasma Infections
Common Asacol Hd Drug Interactions
Drug Name
Risk Level
Description
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Mesalazine.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Mesalazine.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Neomycin.
Omacetaxine mepesuccinate
Major
The risk or severity of bleeding can be increased when Mesalazine is combined with Omacetaxine mepesuccinate.
Probenecid
Major
The therapeutic efficacy of Probenecid can be decreased when used in combination with Mesalazine.
Asacol Hd Toxicity & Overdose RiskIn animal tests, up to 320mg/kg of mesalazine did not increase cancer risk, and the drug was not found to be mutagenic. It also did not affect fertility or reproduction in male and female rats. Symptoms of mesalazine toxicity include nausea, vomiting, shortness of breath, ringing in the ears, headaches, dizziness, confusion, and seizures. In the event of an overdose, there is no specific antidote but treatment may involve decontaminating the stomach and balancing fluids and electrolytes. People with impaired kidney function or a history of kidney problems should be monitored carefully while taking mesalazine.
Asacol Hd Novel Uses: Which Conditions Have a Clinical Trial Featuring Asacol Hd?
96 active clinical trials are presently evaluating the potential of Asacol Hd in providing relief for Ulcerative Colitis.Condition
Clinical Trials
Trial Phases
Ulcerative Colitis
99 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Phase 4, Early Phase 1
Crohn Disease
0 Actively Recruiting
Asacol Hd Reviews: What are patients saying about Asacol Hd?
5Patient Review
10/26/2013 When I first started taking this medication, I got headaches. However, after talking to my doctor and making some adjustments, like changing the dose and how often I take it, that problem has gone away for the most part. Plus, I have fewer flare-ups now too!
5Patient Review
8/4/2014 I've been taking this medication for two months now, three times a day as directed. I haven't found it to be effective at all; in fact, the only thing that seems to help is staying hydrated.
5Patient Review
2/10/2016 This treatment was effective immediately.
5Patient Review
5/9/2011 I highly recommend this medication to anyone struggling with chronic pain. It's been incredibly effective for me, as long as I remember to take it regularly.
5Patient Review
12/26/2013 I am experiencing hair loss
4.7Patient Review
10/13/2013 It's tough to remember to take this medication three times a day when I'm always on the go, but it's worth it. I also have to take it with food because otherwise I get an upset stomach, which is just another inconvenience. But hopefully this will help keep the colon cancer away!
4.7Patient Review
10/22/20094.3Patient Review
1/13/2014 This drug has been really effective in preventing me from having any flare-ups of my ulcerative colitis. However, I have noticed some stiffness in my joints as well as gas and fatigue after taking it for a while now.
4Patient Review
9/7/2011 I saw a big change when I switched from Asacol 400mg 3 pills 3 times a day to AsacolHD 2 pills 800mg 2 times a day. This new treatment works just as well or even better than the old one.
4Patient Review
3/11/20102.3Patient Review
5/10/2016 I've been taking this medication for a long time, and it's definitely helped lower the frequency of my flare-ups.
1.7Patient Review
6/19/2011 After being hospitalized for Crohn's a second time, I started taking this medication. At first, it made my Crohn's worse, but after a few days it began to work great. However, if you miss a dose, the symptoms come back quickly. I appreciate that you don't have to take as many pills with this version of Asacol because the mg is greater.
1.7Patient Review
9/27/2015 This medication has helped me by reducing the number of flare ups I experience.
1.7Patient Review
2/4/2014 I still have this problem occasionally, but this medication generally keeps it under control.
1Patient Review
1/5/2014 I started this treatment 9 years ago with 8 pills (800mg). After a year or so, I decreased the dosage to 6 pills, and then 4 pills at breakfast. This works for me and it's easy to remember. If I travel and forget to take my pills, there are consequences... I start seeing pink mucus and then blood in the stools.
Patient Q&A Section about asacol hd
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Asacol HD used for?
"This medication helps to treat ulcerative colitis, which is a bowel disease. The drug works by reducing symptoms such as diarrhea, rectal bleeding, and stomach pain. Mesalamine belongs to a class of drugs known as aminosalicylates, which work by decreasing swelling in the colon."
Answered by AI
What is the difference between Asacol and Asacol HD?
"Asacol HD is a delayed-release (DR) version of mesalamine that's FDA-approved to treat moderately active UC in adults. It's available as 800 mg DR tablets. There was another brand-name product called Asacol, which was available as 400 mg DR tablets, but it is no longer on the market."
Answered by AI
Is there a generic for Asacol HD?
"The generic form of Asacol HD is mesalamine tablet, delayed release. A generic drug is an exact copy of the active drug in a brand-name medication and is considered to be as safe and effective as the original drug."
Answered by AI
What are the side effects of taking Asacol?
"The following are potential side effects of the medication: burping, constipation, nausea, vomiting, stomach pain, diarrhea, gas, dizziness, cold symptoms such as stuffy nose, sneezing, sore throat, back pain, headache, rash, or abnormal liver function tests."
Answered by AI