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What is Aptivus
TipranavirThe Generic name of this drug
Treatment SummaryTipranavir is a medication used to treat HIV. It is a type of protease inhibitor, meaning that it blocks the enzyme HIV protease from allowing the virus to reproduce. Tipranavir is typically taken in combination with the drug ritonavir to increase its effectiveness.
Aptivusis the brand name
Aptivus Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Aptivus
Tipranavir
2005
2
Approved as Treatment by the FDA
Tipranavir, also known as Aptivus, is approved by the FDA for 3 uses which include multiprotease inhibitor-resistant and treatment experienced .multiprotease inhibitor-resistant
Used to treat multiprotease inhibitor-resistant in combination with Ritonavir
treatment experienced
Used to treat treatment experienced in combination with Ritonavir
HIV
Used to treat Human Immunodeficiency Virus Type 1 (HIV-1) Infection in combination with Ritonavir
Effectiveness
How Aptivus Affects PatientsTipranavir is an HIV drug that works by blocking the enzyme (protease) that HIV needs to spread. By stopping the enzyme, it prevents the virus from completing its life cycle and so, stops it from spreading. It usually needs to be taken with at least two other HIV drugs to be effective.
How Aptivus works in the bodyTipranavir is a drug that helps treat HIV. It stops the virus from forming mature, infectious particles. It does this by blocking the enzyme in the virus that processes its proteins into new, infectious particles. Tipranavir is especially effective against resistant viruses because it can fit into the enzyme's active site even if the virus has changed some of the amino acids. It also has a strong bond with an amino acid in the enzyme, making it harder for the virus to escape treatment.
When to interrupt dosage
The measure of Aptivus is dependant on the diagnosed affliction, including treatment experienced, HIV (Human Immunodeficiency Virus) and multiprotease inhibitor-resistant. The dosage fluctuates as per the strategy of delivery outlined in the below-enumerated table.Condition
Dosage
Administration
multiprotease inhibitor-resistant
250.0 mg, , 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral
treatment experienced
250.0 mg, , 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral
HIV
250.0 mg, , 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral
Warnings
There are 20 known major drug interactions with Aptivus.Common Aptivus Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Tipranavir.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Tipranavir.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Tipranavir.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be decreased when combined with Tipranavir.
7-ethyl-10-hydroxycamptothecin
Major
The metabolism of 7-ethyl-10-hydroxycamptothecin can be decreased when combined with Tipranavir.
Aptivus Toxicity & Overdose RiskThe highest dose of allopurinol that will not be toxic to rats is over 5,000 mg/kg. Side effects of overdosing on allopurinol include thirst, hunger, unexplained weight loss, frequent urination, feeling tired, and dry, itchy skin.
Aptivus Novel Uses: Which Conditions Have a Clinical Trial Featuring Aptivus?
43 active studies are examining the potential of Aptivus to address multiprotease inhibitor-resistant, treatment experienced and HIV (Human Immunodeficiency Virus) conditions.Condition
Clinical Trials
Trial Phases
HIV
41 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
treatment experienced
0 Actively Recruiting
multiprotease inhibitor-resistant
0 Actively Recruiting
Aptivus Reviews: What are patients saying about Aptivus?
5Patient Review
7/15/2008 This drug has been tremendously effective for me in terms of keeping my HIV levels undetectable. I have experienced no negative side effects that I am aware of, which is truly amazing.
Patient Q&A Section about aptivus
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long are tipranavir capsules good for?
"The medicine will remain effective for up to 60 days after you open the bottle. If you have any unused capsules after 60 days, you should discard them and get a new bottle of medicine."
Answered by AI
What is the brand name for ritonavir?
"Ritonavir is a prescription medicine that is approved by the FDA for the treatment of HIV in adults and children. It is always used in combination with other HIV medicines."
Answered by AI
What is Aptivus used for?
"Aptivus is a prescription medicine used to treat HIV infection. It is either used alone or with other medications. Aptivus is a part of a class of drugs called HIV protease inhibitors. Its effectiveness and safety have not been studied in children younger than 2 years old."
Answered by AI