Apresoline

Hypertensive crisis, Congestive Heart Failure, Severe Hypertension + 1 more

Treatment

1 FDA approval

20 Active Studies for Apresoline

Treatment for

Hypertensive crisis

What is Apresoline

HydralazineThe Generic name of this drug

Treatment SummaryHydralazine is a medication used to treat high blood pressure and heart failure. It was originally developed in the 1950s as a malaria treatment, but was later discovered to reduce hypertension. It is no longer used as a first line treatment for hypertension, as newer medications are available. Hydralazine hydrochloride was approved by the FDA in 1953.

Apresoline hydrochlorideis the brand name

image of different drug pills on a surface

Apresoline Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Apresoline hydrochloride

Hydralazine

1953

300

Approved as Treatment by the FDA

Hydralazine, also called Apresoline hydrochloride, is approved by the FDA for 1 uses which include Hypertensive disease .

Hypertensive disease

Helps manage Hypertension, Essential Hypertension

Effectiveness

How Apresoline Affects PatientsHydralazine helps to relax the small muscles of the arteries, which reduces blood pressure. The effects of the drug usually last 2-6 hours. It is generally safe and can be taken in doses of up to 300mg. However, people should be aware of the risk of developing systemic lupus erythematosus syndrome when taking this drug.

How Apresoline works in the bodyHydralazine works to lower blood pressure by blocking calcium from entering cells in vascular smooth muscle. This reduces the resistance in the blood vessels and increases the heart rate, stroke volume, and cardiac output. Hydralazine also prevents a protein called protocollagen prolyl hydroxylase from binding to free iron. This stops the breakdown of HIF-1α, which encourages the growth of new blood vessels and helps them regenerate.

When to interrupt dosage

The proposed measure of Apresoline is contingent upon the specified condition, including Hypertensive crisis, Hypertensive disease and Pregnancy. The quantity of dosage is dependent upon the technique of delivery (e.g. Tablet, coated - Oral or Tablet) detailed in the table beneath.

Condition

Dosage

Administration

Severe Hypertension

, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg

, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intramuscular; Intravascular

Hypertensive disease

, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg

Hypertensive crisis

, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg

Congestive Heart Failure

, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg

Warnings

Apresoline Contraindications

Condition

Risk Level

Notes

Coronary Artery Disease (CAD)

Do Not Combine

Rheumatic Heart Disease

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Hydralazine may interact with Pulse Frequency

There are 20 known major drug interactions with Apresoline.

Common Apresoline Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Hydralazine.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Hydralazine.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Hydralazine.

Alpelisib

Major

The metabolism of Alpelisib can be decreased when combined with Hydralazine.

Amifostine

Major

Hydralazine may increase the hypotensive activities of Amifostine.

Apresoline Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats is 173-187mg/kg, and the highest known dose an adult human has survived is 10g. Symptoms of an overdose may include low blood pressure, rapid heart rate, headache, redness of the skin, lack of oxygen to the heart, heart attack, abnormal heart rhythm, and shock. Treatment for overdose includes emptying the stomach contents and administering activated charcoal, though this can lead to further arrhythmias and shock. Patients should receive supportive and symptomatic care.

image of a doctor in a lab doing drug, clinical research

Apresoline Novel Uses: Which Conditions Have a Clinical Trial Featuring Apresoline?

352 active clinical trials are presently exploring the potential of Apresoline to mitigate Hypertensive disease, Congestive Heart Failure and Hypertensive crisis.

Condition

Clinical Trials

Trial Phases

Hypertensive crisis

0 Actively Recruiting

Severe Hypertension

0 Actively Recruiting

Hypertensive disease

2 Actively Recruiting

Not Applicable

Congestive Heart Failure

315 Actively Recruiting

Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4