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What is Anectine
SuccinylcholineThe Generic name of this drug
Treatment SummarySuccinylcholine is a muscle relaxant made up of two molecules of the neurotransmitter acetylcholine linked by their acetyl groups. It has been used in medical procedures for over 50 years, usually in the form of its chloride salt. Succinylcholine is injected intravenously and has a fast onset and offset, taking effect in 60 seconds and lasting between 4-6 minutes. This makes it useful for short medical procedures requiring temporary muscle relaxation.
Anectineis the brand name
Anectine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Anectine
Succinylcholine
1952
58
Effectiveness
How Anectine Affects PatientsSuccinylcholine is an intravenous drug that causes muscle paralysis within 60 seconds of being administered. It does not affect consciousness or pain threshold, so it must be used with anesthetics. Succinylcholine usually affects the muscles of the face and glottis first, then the intercostals and diaphragm, then other skeletal muscles. In rare cases, succinylcholine has been linked to cardiac arrest and death in pediatric patients with undiagnosed muscular diseases. Because of this, its use in pediatric patients should be restricted to emergency situations where no other alternatives are available.
How Anectine works in the bodySuccinylcholine blocks nerve signals from reaching muscle cells. It does this by attaching to the cholinergic receptors on the nerves. This prevents the nerves from sending out signals, leading to paralysis of the muscles.
When to interrupt dosage
The amount of Anectine is contingent upon the diagnosed disorder, including Skeletal muscle structure, General Anesthesia and Tracheal Intubation. The dosage of drug is subject to the method of application (e.g. Injection, solution - Intramuscular; Intravenous; Parenteral or Liquid - Intravenous) outlined in the table below.Condition
Dosage
Administration
General Anesthesia
, 20.0 mg/mL, 500.0 mg, 100.0 mg/mL
Intramuscular; Intravenous; Parenteral, , Injection, solution, Injection, solution - Intramuscular; Intravenous; Parenteral, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Parenteral, Injection - Parenteral, Injection, Injection - Intramuscular; Intravenous
Tracheal Intubation
, 20.0 mg/mL, 500.0 mg, 100.0 mg/mL
Intramuscular; Intravenous; Parenteral, , Injection, solution, Injection, solution - Intramuscular; Intravenous; Parenteral, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Parenteral, Injection - Parenteral, Injection, Injection - Intramuscular; Intravenous
Skeletal muscle structure
, 20.0 mg/mL, 500.0 mg, 100.0 mg/mL
Intramuscular; Intravenous; Parenteral, , Injection, solution, Injection, solution - Intramuscular; Intravenous; Parenteral, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Parenteral, Injection - Parenteral, Injection, Injection - Intramuscular; Intravenous
Warnings
Anectine has eight contraindications, meaning it should not be administered while exhibiting any of the conditions shown in the table below.Anectine ContraindicationsCondition
Risk Level
Notes
Wounds and Injuries
Do Not Combine
Family history of malignant hyperthermia
Do Not Combine
Muscle Tissue
Do Not Combine
Severe Burns
Do Not Combine
Malignant hyperpyrexia due to anesthesia
Do Not Combine
upper motor neuron lesion
Do Not Combine
Denervation
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Succinylcholine may interact with Pulse Frequency
Common Anectine Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Succinylcholine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Succinylcholine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Succinylcholine is combined with Oliceridine.
Thalidomide
Major
Succinylcholine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Acebutolol
Minor
The risk or severity of hyperkalemia can be increased when Succinylcholine is combined with Acebutolol.
Anectine Toxicity & Overdose RiskTaking too much succinylcholine may cause the effects of the drug to last longer than necessary and cause intense muscle weakness, difficulty breathing, shallow breathing, or even stop breathing altogether. Treatment for succinylcholine overdose includes providing airway and respiratory support until normal breathing is restored. If a large amount or prolonged dose is taken, the drug may cause severe muscle paralysis or weakness in the respiratory muscles.
Anectine Novel Uses: Which Conditions Have a Clinical Trial Featuring Anectine?
Anectine is currently being investigated in 4 active studies to examine its potential to induce General Anesthesia, affect Skeletal Muscle Structure, and facilitate Tracheal Intubation.Condition
Clinical Trials
Trial Phases
Tracheal Intubation
0 Actively Recruiting
General Anesthesia
3 Actively Recruiting
Not Applicable, Phase 3
Skeletal muscle structure
0 Actively Recruiting
Anectine Reviews: What are patients saying about Anectine?
1Patient Review
2/21/2013 I had a severe allergic reaction to this medication (I'm 7 years old and was having my tonsils removed). Please be sure to get tested for allergies before taking this, as it could be life-threatening.
Patient Q&A Section about anectine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Anectine used for?
"Anectine is a drug that is given through a vein in order to help with anesthesia. It is also used to help with intubation and to provide muscle relaxation during surgery or when a person is on a mechanical ventilation machine."
Answered by AI
Is Anectine the same as succinylcholine?
"ANECTINE is a depolarizing-type, skeletal muscle relaxant that works very quickly and is given intravenously (IV). Succinylcholine is a depolarizing skeletal muscle relaxant that works in a similar way to acetylcholine by combining with the cholinergic receptors of the motor end plate to cause depolarization."
Answered by AI
What is the drug succinylcholine used for?
"Succinylcholine is a muscle relaxant that can rapidly induce muscle relaxation, and has been used for this purpose since the late 1950s. However, the drug also has serious side effects and a number of contraindications."
Answered by AI
What type of drug is Anectine?
"An ultra-short acting depolarizing-type skeletal muscle relaxant, Anectine (succinylcholine chloride) is administered through intravenous means."
Answered by AI