Anectine

General Anesthesia, Tracheal Intubation, Skeletal muscle structure

Treatment

1 Active Study for Anectine

Treatment for

General Anesthesia

What is Anectine

Succinylcholine

The Generic name of this drug

Treatment Summary

Succinylcholine is a muscle relaxant made up of two molecules of the neurotransmitter acetylcholine linked by their acetyl groups. It has been used in medical procedures for over 50 years, usually in the form of its chloride salt. Succinylcholine is injected intravenously and has a fast onset and offset, taking effect in 60 seconds and lasting between 4-6 minutes. This makes it useful for short medical procedures requiring temporary muscle relaxation.

Anectine

is the brand name

image of different drug pills on a surface

Anectine Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Anectine

Succinylcholine

1952

Effectiveness

How Anectine Affects Patients

Succinylcholine is an intravenous drug that causes muscle paralysis within 60 seconds of being administered. It does not affect consciousness or pain threshold, so it must be used with anesthetics. Succinylcholine usually affects the muscles of the face and glottis first, then the intercostals and diaphragm, then other skeletal muscles. In rare cases, succinylcholine has been linked to cardiac arrest and death in pediatric patients with undiagnosed muscular diseases. Because of this, its use in pediatric patients should be restricted to emergency situations where no other alternatives are available.

How Anectine works in the body

Succinylcholine blocks nerve signals from reaching muscle cells. It does this by attaching to the cholinergic receptors on the nerves. This prevents the nerves from sending out signals, leading to paralysis of the muscles.

When to interrupt dosage

The amount of Anectine is contingent upon the diagnosed disorder, including Skeletal muscle structure, General Anesthesia and Tracheal Intubation. The dosage of drug is subject to the method of application (e.g. Injection, solution - Intramuscular; Intravenous; Parenteral or Liquid - Intravenous) outlined in the table below.

Condition

Dosage

Administration

General Anesthesia

, 20.0 mg/mL, 500.0 mg, 100.0 mg/mL

, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Injection, solution, Intravenous, Injection, solution - Intravenous, Solution, Solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Parenteral, Injection - Parenteral, Liquid, Injection - Intramuscular; Intravenous, Liquid - Intravenous, Injection

Tracheal Intubation

, 20.0 mg/mL, 500.0 mg, 100.0 mg/mL

Skeletal muscle structure

, 20.0 mg/mL, 500.0 mg, 100.0 mg/mL

Warnings

Anectine has eight contraindications, meaning it should not be administered while exhibiting any of the conditions shown in the table below.

Anectine Contraindications

Condition

Risk Level

Notes

Wounds and Injuries

Do Not Combine

Malignant Hyperthermia

Do Not Combine

Muscle Tissue

Do Not Combine

Burns

Do Not Combine

Malignant hyperpyrexia due to anesthesia

Do Not Combine

upper motor neuron lesion

Do Not Combine

Denervation

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Succinylcholine may interact with Pulse Frequency

There are 20 known major drug interactions with Anectine.

Common Anectine Drug Interactions

Drug Name

Risk Level

Description

Azelastine

Major

Succinylcholine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Ethanol

Major

Succinylcholine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.

Oliceridine

Major

The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Succinylcholine is combined with Oliceridine.

Thalidomide

Major

Succinylcholine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.

Acebutolol

Minor

The risk or severity of hyperkalemia can be increased when Succinylcholine is combined with Acebutolol.

Anectine Toxicity & Overdose Risk

Taking too much succinylcholine may cause the effects of the drug to last longer than necessary and cause intense muscle weakness, difficulty breathing, shallow breathing, or even stop breathing altogether. Treatment for succinylcholine overdose includes providing airway and respiratory support until normal breathing is restored. If a large amount or prolonged dose is taken, the drug may cause severe muscle paralysis or weakness in the respiratory muscles.

image of a doctor in a lab doing drug, clinical research

Anectine Novel Uses: Which Conditions Have a Clinical Trial Featuring Anectine?

Anectine is currently being investigated in 4 active studies to examine its potential to induce General Anesthesia, affect Skeletal Muscle Structure, and facilitate Tracheal Intubation.

Condition

Clinical Trials

Trial Phases

General Anesthesia

1 Actively Recruiting

Phase 4

Tracheal Intubation

0 Actively Recruiting

Skeletal muscle structure

0 Actively Recruiting

Anectine Reviews: What are patients saying about Anectine?

Patient Review

2/21/2013

Anectine for Skeletal Muscle Relaxation for Tube Insertion Into Trachea

I had a severe allergic reaction to this medication (I'm 7 years old and was having my tonsils removed). Please be sure to get tested for allergies before taking this, as it could be life-threatening.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about anectine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Anectine used for?

"Anectine is a drug that is given through a vein in order to help with anesthesia. It is also used to help with intubation and to provide muscle relaxation during surgery or when a person is on a mechanical ventilation machine."

Answered by AI

Is Anectine the same as succinylcholine?

"ANECTINE is a depolarizing-type, skeletal muscle relaxant that works very quickly and is given intravenously (IV). Succinylcholine is a depolarizing skeletal muscle relaxant that works in a similar way to acetylcholine by combining with the cholinergic receptors of the motor end plate to cause depolarization."

Answered by AI

What is the drug succinylcholine used for?

"Succinylcholine is a muscle relaxant that can rapidly induce muscle relaxation, and has been used for this purpose since the late 1950s. However, the drug also has serious side effects and a number of contraindications."

Answered by AI