Amlodipine Besylate And Benazepril Hydrochloride

Congestive Heart Failure, Primary Hypercholesterolemia, Coronary Artery Disease (CAD) + 13 more
Treatment
4 FDA approvals
20 Active Studies for Amlodipine Besylate And Benazepril Hydrochloride

What is Amlodipine Besylate And Benazepril Hydrochloride

AmlodipineThe Generic name of this drug
Treatment SummaryAmlodipine is a medication that lowers blood pressure and is used to treat hypertension and angina. It is part of a class of drugs called dihydropyridine calcium channel blockers, which are known to have fewer side effects than other types of blood pressure medications. Amlodipine is also known for its antioxidant properties and ability to increase the production of nitric oxide in the body, which is a natural vasodilator that helps reduce blood pressure. Amlodipine can be taken once a day, making it a convenient option for many patients.
Norvascis the brand name
image of different drug pills on a surface
Amlodipine Besylate And Benazepril Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norvasc
Amlodipine
1992
1199

Approved as Treatment by the FDA

Amlodipine, also known as Norvasc, is approved by the FDA for 4 uses like Coronary Artery Disease (CAD) and angiographically documented disease .
Coronary Artery Disease (CAD)
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin
angiographically documented disease
Used to treat angiographically documented disease in combination with Atorvastatin
Chronic Stable Angina Pectoris
Used to treat Chronic Stable Angina Pectoris in combination with Atorvastatin
Vasospastic Angina
Used to treat Vasospastic Angina in combination with Atorvastatin

Effectiveness

How Amlodipine Besylate And Benazepril Hydrochloride Affects PatientsAmlodipine helps to reduce high blood pressure by blocking certain calcium channels in the body. This blocking action helps to widen blood vessels, which in turn lowers blood pressure. Taking amlodipine on a regular basis can help to keep blood pressure levels in check for at least 24 hours. Taking amlodipine with beta-blockers has not been found to cause any significant changes in heart rate or blood pressure. Amlodipine also helps to relieve chest pain caused by angina and can increase exercise time, decrease the frequency of angina attacks, and reduce the need for nitroglycerin.
How Amlodipine Besylate And Benazepril Hydrochloride works in the bodyAmlodipine helps reduce blood pressure and angina by blocking calcium ions from entering the heart and blood vessels. This causes the vessels to relax and expand, which reduces the amount of pressure against which the heart has to work. This decreases the heart’s energy use and oxygen requirement. Amlodipine also causes the main coronary arteries and arterioles to widen, further reducing blood pressure and improving oxygen delivery in patients with coronary artery spasm.

When to interrupt dosage

The amount of Amlodipine Besylate And Benazepril Hydrochloride is dependent upon the diagnosed circumstance, including inadequate reaction to diet, High Cardiovascular Risk and Lifestyle Modification. Dosage fluctuates as per the delivery technique (e.g. Tablet, film coated or Tablet) detailed in the table beneath.
Condition
Dosage
Administration
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
angiographically documented disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Congestive Heart Failure
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Primary Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Coronary Artery Disease (CAD)
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Cardiovascular Events
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Lifestyle Modification
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Vasospastic Angina
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
High Cardiovascular Risk
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Dyslipidemias
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Chronic Stable Angina Pectoris
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
inadequate response to diet
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Mixed Dyslipidaemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Pharmacotherapy
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Homozygous Familial Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension

Warnings

Amlodipine Besylate And Benazepril Hydrochloride has one contraindication. It should not be ingested if any of the conditions in the following table are present.Amlodipine Besylate And Benazepril Hydrochloride Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Amlodipine may interact with Pulse Frequency
There are 20 known major drug interactions with Amlodipine Besylate And Benazepril Hydrochloride.
Common Amlodipine Besylate And Benazepril Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Amlodipine may increase the hypotensive activities of Amifostine.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Mobocertinib.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Ziprasidone.
Abafungin
Minor
The therapeutic efficacy of Abafungin can be increased when used in combination with Amlodipine.
Amlodipine Besylate And Benazepril Hydrochloride Toxicity & Overdose RiskA toxic dose of amlodipine in mice is 37mg/kg. Symptoms of an overdose may include high blood pressure, shock, and even death in extreme cases. Long-term tests in mice and rats have not shown any evidence of cancer or fertility issues. Amlodipine is considered a category C drug in pregnancy, so only take it if the potential benefits outweigh the risks. Nursing mothers should stop taking amlodipine while breastfeeding.
image of a doctor in a lab doing drug, clinical research

Amlodipine Besylate And Benazepril Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Amlodipine Besylate And Benazepril Hydrochloride?

Condition
Clinical Trials
Trial Phases
Hypertensive disease
2 Actively Recruiting
Not Applicable
inadequate response to diet
0 Actively Recruiting
Primary Hypercholesterolemia
16 Actively Recruiting
Early Phase 1, Not Applicable, Phase 3, Phase 2
Hypertensive disease
18 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Mixed Dyslipidaemia
0 Actively Recruiting
Congestive Heart Failure
317 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Homozygous Familial Hypercholesterolemia
4 Actively Recruiting
Phase 3, Phase 2
Vasospastic Angina
0 Actively Recruiting
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
High Cardiovascular Risk
1 Actively Recruiting
Phase 2
Pharmacotherapy
0 Actively Recruiting
Dyslipidemias
1 Actively Recruiting
Phase 2
Cardiovascular Events
3 Actively Recruiting
Not Applicable
angiographically documented disease
0 Actively Recruiting
Lifestyle Modification
1 Actively Recruiting
Not Applicable
Chronic Stable Angina Pectoris
1 Actively Recruiting
Not Applicable

Amlodipine Besylate And Benazepril Hydrochloride Reviews: What are patients saying about Amlodipine Besylate And Benazepril Hydrochloride?

5Patient Review
6/8/2017
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
I've been managing my hypertension for a long time now, and I've tried many different medications. When the amlodipine stopped working, I was worried. But this treatment not only lowered my blood pressure, but it also got rid of the swelling in my feet. No more diuretic needed!
5Patient Review
2/11/2017
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
My blood pressure decreased significantly overnight after starting this treatment.
5Patient Review
6/20/2017
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
I saw a very quick and effective decrease in my blood pressure levels. Within days, it went from 160 to 115-120. My doctor and I are both pleased with how well this medication is working for me.
5Patient Review
1/11/2016
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
I have experienced lower leg swelling (pindli) as a result of taking amlodipine besilate (lodopine 10 mg). Please advise.
5Patient Review
8/16/2014
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
5Patient Review
11/14/2014
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
5Patient Review
4/20/2017
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
I've been using this drug for 25 years and I'm very happy with it.
5Patient Review
1/12/2017
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
While this treatment effectively lowered my blood pressure, I unfortunately experience painful swelling in my ankles and feet.
4.3Patient Review
4/4/2021
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
Amlodipine-Benazepril 10-20 mg has been great for managing my blood pressure. The only downside is that it's changed the consistency of my stool and I'm gassier than usual.
4Patient Review
11/6/2017
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
Although my blood pressure has significantly lowered since taking this medication, I have noticed some significant drawbacks. I've been feeling tired a lot more, and after 2-3 months my erections just aren't what they used to be. Additionally, it's become much harder for me to get aroused. This is incredibly disappointing as I still consider myself to be very sexually active.
4Patient Review
6/17/2016
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
I sometimes feel a little lightheaded after taking this medication, but lying down usually helps. Just make sure you eat something with it.
3.7Patient Review
9/1/2016
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
My blood pressure has lowered a lot since I started this medication, but unfortunately it comes with a harsh dry cough that's been keeping me up at night.
3.3Patient Review
11/7/2015
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
Can this drug be used to regulate blood pressure and heart rate? I'm out of metoprolol.
2.7Patient Review
3/30/2019
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
I take 5mg. once a day for high BP with other BP pills it has cause swelling in ankles, feet, hands and upper body, also weight gain!
2Patient Review
11/14/2019
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
I had to urinate constantly and felt very tired and flu-like after taking this medication. Not a good experience for me.
1Patient Review
2/16/2018
Amlodipine Besylate And Benazepril Hydrochloride for High Blood Pressure
I was taking Avapro for my high blood pressure, but suddenly started getting dizzy spells and high readings. My doctor prescribed this new medication to take at bedtime in order to help me sleep and lower my BP. Unfortunately, it did neither; I was awake all night and my reading this morning was only slightly lower. Needless to say, I won't be using this again.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about amlodipine besylate and benazepril hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are side effects of amlodipine benazepril?

"The symptoms of a cold include a cough, headache, dizziness, and swelling of the hands, feet, ankles, or lower legs."

Answered by AI

What are amlodipine and benazepril used for?

"Amlodipine and benazepril is a combination of medicines that are used to treat high blood pressure (hypertension). High blood pressure causes the heart and arteries to work harder."

Answered by AI

Can I take benazepril and amlodipine together?

"The study concluded that high doses of amlodipine/benazepril are an effective, safe, and well-tolerated treatment option for hypertensive patients who do not respond adequately to benazepril alone."

Answered by AI

Clinical Trials for Amlodipine Besylate And Benazepril Hydrochloride

Have you considered Amlodipine Besylate And Benazepril Hydrochloride clinical trials? We made a collection of clinical trials featuring Amlodipine Besylate And Benazepril Hydrochloride, we think they might fit your search criteria.
Have you considered Amlodipine Besylate And Benazepril Hydrochloride clinical trials? We made a collection of clinical trials featuring Amlodipine Besylate And Benazepril Hydrochloride, we think they might fit your search criteria.
Have you considered Amlodipine Besylate And Benazepril Hydrochloride clinical trials? We made a collection of clinical trials featuring Amlodipine Besylate And Benazepril Hydrochloride, we think they might fit your search criteria.