Aloprim

Hyperuricemia, Lesch-Nyhan Syndrome, Chemotherapy + 15 more
Treatment
16 FDA approvals
20 Active Studies for Aloprim

What is Aloprim

AllopurinolThe Generic name of this drug
Treatment SummaryGout is a medical condition caused by a build-up of uric acid crystals in the body, particularly in the joints. It is a very old disease that has been described in historical medical records. Allopurinol is a drug used to treat gout by reducing uric acid levels in the body. It was first approved by the FDA in 1966 and can now be bought from many different suppliers.
Zyloprimis the brand name
image of different drug pills on a surface
Aloprim Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zyloprim
Allopurinol
1966
270

Approved as Treatment by the FDA

Allopurinol, also called Zyloprim, is approved by the FDA for 16 uses such as Kidney Calculi and female patients with daily uric acid excretion that exceeds 750 mg/day .
Kidney Calculi
female patients with daily uric acid excretion that exceeds 750 mg/day
Cancer
Hyperuricemia
Leukemias
Malignant Lymphomas
Arthritis, Gouty
Used to treat Gouty Arthritis in combination with Lesinurad
failed previous allopurinol monotherapy
Used to treat failed previous allopurinol monotherapy in combination with Lesinurad
Hyperuricemia
Hyperuricemia
Chemotherapy
Lymphoma, Non-Hodgkin
Leukemia
Symptomatic
Secondary gout
Primary Gout

Effectiveness

How Aloprim Affects PatientsAllopurinol works by blocking the body's production of uric acid, which is the cause of gout symptoms like painful tophi, joint pain, inflammation, redness, reduced range of motion, and swelling.
How Aloprim works in the bodyAllopurinol works to reduce gout symptoms by blocking an enzyme that creates uric acid. The blocked enzyme then reuses hypoxanthine and xanthine for creating nucleotides and nucleic acid. This reduces the amount of uric acid in your blood, which helps reduce gout symptoms. Allopurinol also increases the amount of hypoxanthine and xanthine in your urine, but these substances are more soluble and are quickly taken away by the kidneys, so they won't form crystals in your body. As a result, allopurinol can help dissolve gout tophi.

When to interrupt dosage

The proposed dosage of Aloprim is reliant upon the identified condition, such as Gout Flares, Leukemias and Cancer. Dosage varies in accordance with the management technique (e.g. Injection, powder, lyophilized, for solution - Intravenous or Tablet, film coated - Oral) specified in the table below.
Condition
Dosage
Administration
Symptomatic
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Chemotherapy
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Chronic Kidney Disease (CKD)
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Metabolic Diseases
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Gout Flares
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Eczema
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Leukemia
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Primary Gout
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Hyperuricemia
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Lesch-Nyhan Syndrome
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Arthritis, Gouty
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Kidney Calculi
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
female patients with daily uric acid excretion that exceeds 750 mg/day
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
failed previous allopurinol monotherapy
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Hyperuricemia
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Urinary Bladder Calculi (disorder)
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Lymphoma, Non-Hodgkin
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Secondary gout
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Warnings

There are 20 known major drug interactions with Aloprim.
Common Aloprim Drug Interactions
Drug Name
Risk Level
Description
Didanosine
Major
The serum concentration of Didanosine can be increased when it is combined with Allopurinol.
Oteracil
Major
The therapeutic efficacy of Oteracil can be decreased when used in combination with Allopurinol.
Pegloticase
Major
The risk or severity of adverse effects can be increased when Allopurinol is combined with Pegloticase.
Abacavir
Minor
Allopurinol may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aclidinium
Minor
Allopurinol may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Aloprim Toxicity & Overdose RiskThe lowest toxic dose of allopurinol in rats is 10mg/kg, and in mice is 78mg/kg. Studies in animals have found that taking up to 20 times the normal human dose (about 5mg/kg per day) does not impair fertility or cause harm to the fetus. There was one published report of a study in pregnant mice that was given 50 or 100mg/kg of allopurinol, which resulted in increased numbers of dead fetuses and malformations in the offspring. As there are no adequate studies of allopurinol in pregnant women, it should only be taken if
image of a doctor in a lab doing drug, clinical research

Aloprim Novel Uses: Which Conditions Have a Clinical Trial Featuring Aloprim?

560 active clinical trials are currently in progress to determine the effectiveness of Aloprim in treating Renal Disease, Chemotherapeutic Agents and Metabolic Pathologies.
Condition
Clinical Trials
Trial Phases
Chronic Kidney Disease (CKD)
27 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1
Secondary gout
0 Actively Recruiting
Lymphoma, Non-Hodgkin
2 Actively Recruiting
Phase 1
Leukemia
0 Actively Recruiting
failed previous allopurinol monotherapy
0 Actively Recruiting
Eczema
10 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 3
Lesch-Nyhan Syndrome
0 Actively Recruiting
Arthritis, Gouty
4 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Hyperuricemia
0 Actively Recruiting
Chemotherapy
3 Actively Recruiting
Phase 1, Phase 3, Not Applicable
female patients with daily uric acid excretion that exceeds 750 mg/day
0 Actively Recruiting
Kidney Calculi
0 Actively Recruiting
Metabolic Diseases
2 Actively Recruiting
Not Applicable
Hyperuricemia
4 Actively Recruiting
Phase 3, Phase 1
Urinary Bladder Calculi (disorder)
0 Actively Recruiting
Primary Gout
0 Actively Recruiting
Gout Flares
0 Actively Recruiting
Symptomatic
0 Actively Recruiting

Aloprim Reviews: What are patients saying about Aloprim?

5Patient Review
3/11/2021
Aloprim for Gout
I had several flares annually for ten years, and it really impacted my mobility and quality of life. I decided to take allopurinol 100mg daily, and I haven't had a flare in the past three years. I wish I had made the decision to take it sooner.
5Patient Review
5/2/2019
Aloprim for Gout
Allopurinol has been a lifesaver for me. I used to suffer from gout really badly, but since I've been taking it every day, I haven't had an attack in over 14 years.
5Patient Review
1/6/2022
Aloprim for High Amount of Uric Acid in the Blood
I've been taking this medication for over ten years to prevent gout flare-ups, and I can't remember the last time I had one.
5Patient Review
10/18/2022
Aloprim for High Amount of Uric Acid in the Blood
I started taking this in 1976 and have found it really helpful in preventing gout attacks. I'm now only taking it every other day.
5Patient Review
10/17/2021
Aloprim for Prevention of Calcium-Containing Kidney Stones
I've been using this medication for 30 years and I find it helps with my overall health.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aloprim

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of aloprim?

"The most common side effects are injection site reactions, rash, hives, allergic reaction, itching, diarrhea, nausea, vomiting, or."

Answered by AI

What is aloprim used for?

"These crystals can cause pain, swelling, or a red, hot, and swollen joint.

Allopurinol is a medicine used to lower levels of uric acid in your blood. If you produce too much uric acid or your kidneys do not filter enough out, it can build up and cause tiny, sharp crystals to form in and around your joints. These crystals can cause pain, swelling, or a red, hot, and swollen joint."

Answered by AI

What does allopurinol do to your body?

"Allopurinol is used to either prevent or lower high uric acid levels in the blood. It can also be used to prevent or lower excess uric acid levels that are caused by cancer medicines or in patients with kidney stones. Having a high uric acid level can cause gout or gouty arthritis (which is joint pain and inflammation)."

Answered by AI

What is Loric used for?

"This medicine requires a prescription because it is used to treat and prevent gout. Gout is a condition that occurs when there is too much uric acid in your body. When this happens, uric acid can form crystals around your joints and kidneys, which can cause pain. This medicine helps to keep uric acid levels low, which can help to prevent gout."

Answered by AI

Clinical Trials for Aloprim

Have you considered Aloprim clinical trials? We made a collection of clinical trials featuring Aloprim, we think they might fit your search criteria.
Have you considered Aloprim clinical trials? We made a collection of clinical trials featuring Aloprim, we think they might fit your search criteria.
Have you considered Aloprim clinical trials? We made a collection of clinical trials featuring Aloprim, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top