Aloprim

Hyperuricemia, Lesch-Nyhan Syndrome, Chemotherapy + 15 more

Treatment

16 FDA approvals

20 Active Studies for Aloprim

What is Aloprim

Allopurinol

The Generic name of this drug

Treatment Summary

Gout is a medical condition caused by a build-up of uric acid crystals in the body, particularly in the joints. It is a very old disease that has been described in historical medical records. Allopurinol is a drug used to treat gout by reducing uric acid levels in the body. It was first approved by the FDA in 1966 and can now be bought from many different suppliers.

Zyloprim

is the brand name

image of different drug pills on a surface

Aloprim Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Zyloprim

Allopurinol

1966

270

Approved as Treatment by the FDA

Allopurinol, also called Zyloprim, is approved by the FDA for 16 uses such as female patients with daily uric acid excretion that exceeds 750 mg/day and Cancer .

female patients with daily uric acid excretion that exceeds 750 mg/day

Cancer

Kidney Calculi

Hyperuricemia

Leukemias

Malignant Lymphomas

Arthritis, Gouty

Used to treat Gouty Arthritis in combination with Lesinurad

failed previous allopurinol monotherapy

Used to treat failed previous allopurinol monotherapy in combination with Lesinurad

Hyperuricemia

Hyperuricemia

Chemotherapy

Lymphoma, Non-Hodgkin

Leukemia

Symptomatic

Secondary gout

Primary Gout

Effectiveness

How Aloprim Affects Patients

Allopurinol works by blocking the body's production of uric acid, which is the cause of gout symptoms like painful tophi, joint pain, inflammation, redness, reduced range of motion, and swelling.

How Aloprim works in the body

Allopurinol works to reduce gout symptoms by blocking an enzyme that creates uric acid. The blocked enzyme then reuses hypoxanthine and xanthine for creating nucleotides and nucleic acid. This reduces the amount of uric acid in your blood, which helps reduce gout symptoms. Allopurinol also increases the amount of hypoxanthine and xanthine in your urine, but these substances are more soluble and are quickly taken away by the kidneys, so they won't form crystals in your body. As a result, allopurinol can help dissolve gout tophi.

When to interrupt dosage

The proposed dosage of Aloprim is reliant upon the identified condition, such as Gout Flares, Leukemias and Cancer. Dosage varies in accordance with the management technique (e.g. Injection, powder, lyophilized, for solution - Intravenous or Tablet, film coated - Oral) specified in the table below.

Condition

Dosage

Administration

Symptomatic

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Chemotherapy

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Chronic Kidney Disease (CKD)

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Metabolic Diseases

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Gout Flares

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Eczema

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Leukemia

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Primary Gout

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Hyperuricemia

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Lesch-Nyhan Syndrome

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Arthritis, Gouty

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Kidney Calculi

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

female patients with daily uric acid excretion that exceeds 750 mg/day

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

failed previous allopurinol monotherapy

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Hyperuricemia

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Urinary Bladder Calculi (disorder)

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Lymphoma, Non-Hodgkin

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Secondary gout

, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral

Warnings

There are 20 known major drug interactions with Aloprim.

Common Aloprim Drug Interactions

Drug Name

Risk Level

Description

Didanosine

Major

The serum concentration of Didanosine can be increased when it is combined with Allopurinol.

Oteracil

Major

The therapeutic efficacy of Oteracil can be decreased when used in combination with Allopurinol.

Pegloticase

Major

The risk or severity of adverse effects can be increased when Allopurinol is combined with Pegloticase.

Abacavir

Minor

Allopurinol may decrease the excretion rate of Abacavir which could result in a higher serum level.

Aclidinium

Minor

Allopurinol may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Aloprim Toxicity & Overdose Risk

The lowest toxic dose of allopurinol in rats is 10mg/kg, and in mice is 78mg/kg. Studies in animals have found that taking up to 20 times the normal human dose (about 5mg/kg per day) does not impair fertility or cause harm to the fetus. There was one published report of a study in pregnant mice that was given 50 or 100mg/kg of allopurinol, which resulted in increased numbers of dead fetuses and malformations in the offspring. As there are no adequate studies of allopurinol in pregnant women, it should only be taken if

image of a doctor in a lab doing drug, clinical research

Aloprim Novel Uses: Which Conditions Have a Clinical Trial Featuring Aloprim?

560 active clinical trials are currently in progress to determine the effectiveness of Aloprim in treating Renal Disease, Chemotherapeutic Agents and Metabolic Pathologies.

Condition

Clinical Trials

Trial Phases

Chronic Kidney Disease (CKD)

28 Actively Recruiting

Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4

failed previous allopurinol monotherapy

0 Actively Recruiting

Secondary gout

0 Actively Recruiting

Lymphoma, Non-Hodgkin

1 Actively Recruiting

Phase 1

Leukemia

1 Actively Recruiting

Not Applicable

Eczema

9 Actively Recruiting

Phase 2, Early Phase 1, Not Applicable, Phase 3

Lesch-Nyhan Syndrome

0 Actively Recruiting

Arthritis, Gouty

0 Actively Recruiting

Hyperuricemia

0 Actively Recruiting

Chemotherapy

4 Actively Recruiting

Phase 1, Phase 3, Not Applicable

female patients with daily uric acid excretion that exceeds 750 mg/day

0 Actively Recruiting

Kidney Calculi

0 Actively Recruiting

Metabolic Diseases

1 Actively Recruiting

Not Applicable

Hyperuricemia

3 Actively Recruiting

Phase 3, Phase 1

Urinary Bladder Calculi (disorder)

0 Actively Recruiting

Primary Gout

0 Actively Recruiting

Gout Flares

1 Actively Recruiting

Phase 2

Symptomatic

0 Actively Recruiting

Aloprim Reviews: What are patients saying about Aloprim?

5

Patient Review

3/11/2021

Aloprim for Gout

I had several flares annually for ten years, and it really impacted my mobility and quality of life. I decided to take allopurinol 100mg daily, and I haven't had a flare in the past three years. I wish I had made the decision to take it sooner.

5

Patient Review

5/2/2019

Aloprim for Gout

Allopurinol has been a lifesaver for me. I used to suffer from gout really badly, but since I've been taking it every day, I haven't had an attack in over 14 years.

5

Patient Review

1/6/2022

Aloprim for High Amount of Uric Acid in the Blood

I've been taking this medication for over ten years to prevent gout flare-ups, and I can't remember the last time I had one.

5

Patient Review

10/18/2022

Aloprim for High Amount of Uric Acid in the Blood

I started taking this in 1976 and have found it really helpful in preventing gout attacks. I'm now only taking it every other day.

5

Patient Review

10/17/2021

Aloprim for Prevention of Calcium-Containing Kidney Stones

I've been using this medication for 30 years and I find it helps with my overall health.

5

Patient Review

1/14/2020

Aloprim for Gout

I've been taking this medication for twelve years to treat my gout, and it's worked great. I was also able to get rid of my kidney stones.

5

Patient Review

7/15/2021

Aloprim for Gout

This has been an absolute godsend. I was symptom-free for close to a decade and only had one relatively mild attack about six months ago.

5

Patient Review

6/6/2021

Aloprim for High Amount of Uric Acid in the Blood

This medication does a great job of preventing high uric acid levels.

5

Patient Review

5/2/2019

Aloprim for Gout

Allopurinol has really helped me manage my gout. I've been taking it every day for 14 years with no issues.

5

Patient Review

10/18/2022

Aloprim for High Amount of Uric Acid in the Blood

I started with a 300mg dose daily in 1976. Subsequently, I reduced the size to 100mg and took it every day. Eventually, my doctor told me that it was ineffective at such a small dose and increased it back to 300mg. Now, I take it every other day and have not had any gout attacks since using Allopurinol.

5

Patient Review

7/15/2021

Aloprim for Gout

This drug has been nothing short of a miracle for me. I was symptom-free for close to a decade and then had only one mild attack about six months ago.

5

Patient Review

6/6/2021

Aloprim for High Amount of Uric Acid in the Blood

This medication has been really effective in preventing gout attacks by keeping uric acid levels low.

5

Patient Review

3/11/2021

Aloprim for Gout

I had a really tough decade, flare-ups wise, before I decided to start taking allopurinol. It's been three years since then and I haven't experienced a single one. I only wish I had started sooner!

5

Patient Review

1/14/2020

Aloprim for Gout

I've been taking this medication for 12 years to manage my gout, and it's worked great. I was also pleasantly surprised when it got rid of my kidney stones!

5

Patient Review

1/11/2020

Aloprim for Gout

This is an excellent preventative treatment for gout.

5

Patient Review

10/17/2021

Aloprim for Prevention of Calcium-Containing Kidney Stones

I've been using this medication for 30 years and I find it really helpful in keeping me healthy.

5

Patient Review

1/6/2022

Aloprim for High Amount of Uric Acid in the Blood

I've been on this medication for over 10 years to prevent gout, and I can't even remember the last time I had a flare-up. It's really effective, and I would recommend it to anyone who is struggling with gout or elevated uric acid levels.

5

Patient Review

1/11/2020

Aloprim for Gout

This treatment is very effective in preventing gout.

4.3

Patient Review

12/2/2018

Aloprim for Gout

I've been taking this drug for over three years to manage my uric acid levels and the occasional flare-up. In that time, I've only had one attack.

4.3

Patient Review

12/2/2018

Aloprim for Gout

I've been taking this medication for over three years to keep my uric acid levels in check and prevent hour-long flareups. In that time, I've only had one attack.

4

Patient Review

7/19/2021

Aloprim for Gout

This medication was very effective at treating my gout.

4

Patient Review

4/15/2021

Aloprim for High Amount of Uric Acid in the Blood

I used to have gout attacks a few times per year, and would take the expensive colchicine as well as pain medication. My doctor then prescribed Alopurinol; I now take it 3-4 times per week, and haven't had an attack in over five years.

4

Patient Review

4/15/2021

Aloprim for High Amount of Uric Acid in the Blood

I used to have gout attacks a couple times per year, and would take colchicine as well as pain medication. My doctor later prescribed Alopurinol, which I now take 3-4 times per week. This has effectively eliminated my gout attacks for over five years.

4

Patient Review

7/19/2021

Aloprim for Gout

This treatment effectively stopped my gout.

3.7

Patient Review

4/13/2021

Aloprim for High Amount of Uric Acid in the Blood

I've been taking this medication for the past two years to help with my gout. It's been successful in keeping the swelling down, and I haven't had any problems as long as I stay on the drug.

3.7

Patient Review

4/13/2021

Aloprim for High Amount of Uric Acid in the Blood

I've been taking this medication for two years to manage my gout. It's been effective in keeping the swelling down, and I haven't had any issues as long as I stay on the drug.

2.3

Patient Review

4/8/2019

Aloprim for Gout

I've had gout for a decade now and have been taking this medication on and off for the past few years. However, my doctor said that I wasn't being consistent enough with it and my gout came back as a result. They bumped up my dosage to 300mg, but ever since then I've been having issues like gas, itchy skin, rash, and bloody stool. I'm writing this review because I think something's really wrong.

2.3

Patient Review

11/27/2018

Aloprim for Gout

I'm really disappointed with this medication. I've been taking it for 40 days now, and my gout attacks are more frequent, more severe, and last longer than before. It's gotten to the point where I can't walk or sleep because of the pain.

2.3

Patient Review

11/27/2018

Aloprim for Gout

After forty days of taking this medication, my gout attacks have become more frequent and more severe. I can't walk or sleep because the pain is so bad. I'm amazed that the FDA would approve this drug.

2.3

Patient Review

4/8/2019

Aloprim for Gout

I've had gout for 10 years and I've been taking this medication on and off for the past few years. Unfortunately, because I wasn't consistent with my dosage, the gout came back. When I was bumped up to 300mg, I started experiencing a lot of side effects like gas, itchy skin, rash, and bloody stool. I'm writing this review because I'm concerned that these could be serious problems.

1.7

Patient Review

1/7/2019

Aloprim for Gout

I've been taking Allopurinal for the past four months, and I've experienced gout almost monthly since. When one flare-up starts to resolve, a new one begins. Colchicine is my preferred method of controlling gout.

1.7

Patient Review

1/7/2019

Aloprim for Gout

Allopurinal hasn't been working for me these past four months. I get gout almost monthly, and it's just one flare up after another. Colchicine seems to work better for me in controlling the gout.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aloprim

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of aloprim?

"The most common side effects are injection site reactions, rash, hives, allergic reaction, itching, diarrhea, nausea, vomiting, or."

Answered by AI

What is aloprim used for?

"These crystals can cause pain, swelling, or a red, hot, and swollen joint.

Allopurinol is a medicine used to lower levels of uric acid in your blood. If you produce too much uric acid or your kidneys do not filter enough out, it can build up and cause tiny, sharp crystals to form in and around your joints. These crystals can cause pain, swelling, or a red, hot, and swollen joint."

Answered by AI

What does allopurinol do to your body?

"Allopurinol is used to either prevent or lower high uric acid levels in the blood. It can also be used to prevent or lower excess uric acid levels that are caused by cancer medicines or in patients with kidney stones. Having a high uric acid level can cause gout or gouty arthritis (which is joint pain and inflammation)."

Answered by AI

What is Loric used for?

"This medicine requires a prescription because it is used to treat and prevent gout. Gout is a condition that occurs when there is too much uric acid in your body. When this happens, uric acid can form crystals around your joints and kidneys, which can cause pain. This medicine helps to keep uric acid levels low, which can help to prevent gout."

Answered by AI

Clinical Trials for Aloprim

Image of UPMC Hillman Cancer Center in Pittsburgh, United States.

Mobile App for Cancer

18+
All Sexes
Pittsburgh, PA

The goal of this study is to determine whether a mobile application that combines real-time sensor data and patient-reported symptoms to trigger care-team contact recommendations is feasible and beneficial for patients receiving chemotherapy. The main questions it aims to answer are: * Is the mobile application feasible and acceptable to patients? * Do the alerts and guidance improve symptom management, quality of life, and engagement with the care team during treatment? Participants will: * Complete a demographic questionnaire at the beginning of the study and quality-of-life and health questionnaires at the beginning, midpoint, and end of study. * Complete daily symptom ratings via study application. * Wear a Fitbit activity tracker for 90 days. * At the end of the study, complete a semi-structured interview to provide feedback on the study. * Optional: At the beginning and end of the study, complete an in-person physical function assessment measuring balance (Short Physical Performance Battery).

Waitlist Available
Has No Placebo

UPMC Hillman Cancer Center

Carissa A Low

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Image of South Florida Research Institute in Lauderdale Lakes, United States.

Mezagitamab for Berger's Disease

18+
All Sexes
Lauderdale Lakes, FL

Immunoglobulin A nephropathy (IgAN) is a kidney condition. It happens when the body's immune system creates groups of proteins (called immune complexes) that build-up in the kidneys causing swelling (inflammation). Over time, this inflammation may lead to kidney damage and cause the kidneys to no longer work properly. The main aim of this study is to check how well mezagitamab changes protein levels in the urine (proteinuria) compared to placebo in adults with primary IgAN. A placebo looks like medicine but doesn't have any active ingredients in it. Other aims are to check how safe mezagitamab is and how well participants with primary IgAN can tolerate it compared to placebo, and to find out if and how well mezagitamab continues to maintain kidney function over the long term compared to placebo. Participants will be placed in 1 of the 2 treatment groups; the main group and the open-label group. In the main group, participants will be placed in 1 of the 2 treatment groups by chance (either mezagitamab or placebo) at a 2:1 ratio. This means that out of 3 participants, 2 will receive mezagitamab and 1 will receive placebo. The participants will receive either mezagitamab or placebo for almost half a year in two 1-year cycles. They will be observed for another half year in each 1-year cycle and will have check-ups about every month during this time. In the open-label group, a small number of participants who have lower levels of protein in their urine or have kidneys that do not filter the blood well, will receive mezagitamab treatment. This will include participants who have previously received mezagitamab in another study, TAK-079-1006. Every participant will receive mezagitamab in the same way as those in the main group receiving mezagitamab. During the study, participants will visit their study clinic several times.

Phase 3
Recruiting

South Florida Research Institute (+20 Sites)

Study Director

Takeda

Image of PAREXEL International - Early Phase Clinical Unit Baltimore in Baltimore, United States.

NNC4004-0002 for High Uric Acid

35 - 75
All Sexes
Baltimore, MD

This study will evaluate an investigational drug called NNC4004-0002. "Investigational" means NNC4004-0002 has not been approved for sale/ for clinical use or for the use described in this study/ by any regulatory authority. Its use in this study is experimental. This will be the first time that NNC4004-0002 will be given to human. This study will be testing the ability of the study medicine to lower serum uric acid. The main aim of this study will be to see if the new study medicine is safe and tolerated by the body after a single dose of study medicine in adults with asymptomatic hyperuricemia. Participants will either get NNC4004-0002 (the study medicine), or saline. Which treatment the participant get will be decided by chance. The participant will get the medicine as an injection under their skin. Depending on the dose they will receive, participant may need more than one injection. The study will last for about 19 months in total. The participant will take part in the study for about 7 months. Participant will have approximately 14 visits to the clinic and one of them will be a 4 night in-house stay.

Phase 1
Recruiting

PAREXEL International - Early Phase Clinical Unit Baltimore (+2 Sites)

Clinical Transparency (dept. 2834)

Novo Nordisk A/S

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