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What is Aloprim
AllopurinolThe Generic name of this drug
Treatment SummaryGout is a medical condition caused by a build-up of uric acid crystals in the body, particularly in the joints. It is a very old disease that has been described in historical medical records. Allopurinol is a drug used to treat gout by reducing uric acid levels in the body. It was first approved by the FDA in 1966 and can now be bought from many different suppliers.
Zyloprimis the brand name
Aloprim Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zyloprim
Allopurinol
1966
270
Approved as Treatment by the FDA
Allopurinol, also called Zyloprim, is approved by the FDA for 12 uses such as Secondary gout and Primary Gout .Secondary gout
Primary Gout
Chemotherapy
Malignant Lymphomas
Symptomatic
Hyperuricemia
Leukemias
Gouty Arthritis
Used to treat Gouty Arthritis in combination with Lesinurad
failed previous allopurinol monotherapy
Used to treat failed previous allopurinol monotherapy in combination with Lesinurad
Recurrent calcium oxalate calculi
female patients with daily uric acid excretion that exceeds 750 mg/day
male patients with daily uric acid excretion that exceeds 800 mg/day
Effectiveness
How Aloprim Affects PatientsAllopurinol works by blocking the body's production of uric acid, which is the cause of gout symptoms like painful tophi, joint pain, inflammation, redness, reduced range of motion, and swelling.
How Aloprim works in the bodyAllopurinol works to reduce gout symptoms by blocking an enzyme that creates uric acid. The blocked enzyme then reuses hypoxanthine and xanthine for creating nucleotides and nucleic acid. This reduces the amount of uric acid in your blood, which helps reduce gout symptoms. Allopurinol also increases the amount of hypoxanthine and xanthine in your urine, but these substances are more soluble and are quickly taken away by the kidneys, so they won't form crystals in your body. As a result, allopurinol can help dissolve gout tophi.
When to interrupt dosage
The proposed dosage of Aloprim is reliant upon the identified condition, such as Gout Flares, Leukemias and Cancer. Dosage varies in accordance with the management technique (e.g. Injection, powder, lyophilized, for solution - Intravenous or Tablet, film coated - Oral) specified in the table below.Condition
Dosage
Administration
Hyperuricemia
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Chemotherapy
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Eczema
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Chronic Kidney Disease (CKD)
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Lesch-Nyhan Syndrome
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Leukemias
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Gouty Arthritis
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Metabolic Diseases
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Symptomatic
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Malignant Lymphomas
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Gout Flares
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Primary Gout
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Recurrent calcium oxalate calculi
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
female patients with daily uric acid excretion that exceeds 750 mg/day
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Secondary gout
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
male patients with daily uric acid excretion that exceeds 800 mg/day
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Urinary Bladder Calculi (disorder)
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
failed previous allopurinol monotherapy
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for solution, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Tablet, film coated, Tablet, film coated - Oral
Warnings
There are 20 known major drug interactions with Aloprim.Common Aloprim Drug Interactions
Drug Name
Risk Level
Description
Didanosine
Major
The serum concentration of Didanosine can be increased when it is combined with Allopurinol.
Oteracil
Major
The therapeutic efficacy of Oteracil can be decreased when used in combination with Allopurinol.
Pegloticase
Major
The risk or severity of adverse effects can be increased when Allopurinol is combined with Pegloticase.
Abacavir
Minor
Allopurinol may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aclidinium
Minor
Allopurinol may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Aloprim Toxicity & Overdose RiskThe lowest toxic dose of allopurinol in rats is 10mg/kg, and in mice is 78mg/kg. Studies in animals have found that taking up to 20 times the normal human dose (about 5mg/kg per day) does not impair fertility or cause harm to the fetus. There was one published report of a study in pregnant mice that was given 50 or 100mg/kg of allopurinol, which resulted in increased numbers of dead fetuses and malformations in the offspring. As there are no adequate studies of allopurinol in pregnant women, it should only be taken if
Aloprim Novel Uses: Which Conditions Have a Clinical Trial Featuring Aloprim?
560 active clinical trials are currently in progress to determine the effectiveness of Aloprim in treating Renal Disease, Chemotherapeutic Agents and Metabolic Pathologies.Condition
Clinical Trials
Trial Phases
Chronic Kidney Disease (CKD)
246 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Eczema
25 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 4, Early Phase 1, Phase 3
Leukemias
0 Actively Recruiting
Secondary gout
0 Actively Recruiting
Hyperuricemia
2 Actively Recruiting
Phase 2, Phase 3
failed previous allopurinol monotherapy
0 Actively Recruiting
Gout Flares
0 Actively Recruiting
Gouty Arthritis
1 Actively Recruiting
Phase 2, Phase 3
Urinary Bladder Calculi (disorder)
0 Actively Recruiting
Primary Gout
0 Actively Recruiting
Malignant Lymphomas
3 Actively Recruiting
Phase 1
Recurrent calcium oxalate calculi
0 Actively Recruiting
Metabolic Diseases
3 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Lesch-Nyhan Syndrome
0 Actively Recruiting
male patients with daily uric acid excretion that exceeds 800 mg/day
0 Actively Recruiting
Chemotherapy
2 Actively Recruiting
Not Applicable
female patients with daily uric acid excretion that exceeds 750 mg/day
0 Actively Recruiting
Symptomatic
0 Actively Recruiting
Aloprim Reviews: What are patients saying about Aloprim?
5Patient Review
3/11/2021 I had several flares annually for ten years, and it really impacted my mobility and quality of life. I decided to take allopurinol 100mg daily, and I haven't had a flare in the past three years. I wish I had made the decision to take it sooner.
5Patient Review
5/2/2019 Allopurinol has been a lifesaver for me. I used to suffer from gout really badly, but since I've been taking it every day, I haven't had an attack in over 14 years.
5Patient Review
1/6/2022 I've been taking this medication for over ten years to prevent gout flare-ups, and I can't remember the last time I had one.
5Patient Review
10/18/2022 I started taking this in 1976 and have found it really helpful in preventing gout attacks. I'm now only taking it every other day.
5Patient Review
10/17/2021 I've been using this medication for 30 years and I find it helps with my overall health.
5Patient Review
1/14/2020 I've been taking this medication for twelve years to treat my gout, and it's worked great. I was also able to get rid of my kidney stones.
5Patient Review
7/15/2021 This has been an absolute godsend. I was symptom-free for close to a decade and only had one relatively mild attack about six months ago.
5Patient Review
6/6/2021 This medication does a great job of preventing high uric acid levels.
5Patient Review
5/2/2019 Allopurinol has really helped me manage my gout. I've been taking it every day for 14 years with no issues.
5Patient Review
10/18/2022 I started with a 300mg dose daily in 1976. Subsequently, I reduced the size to 100mg and took it every day. Eventually, my doctor told me that it was ineffective at such a small dose and increased it back to 300mg. Now, I take it every other day and have not had any gout attacks since using Allopurinol.
5Patient Review
7/15/2021 This drug has been nothing short of a miracle for me. I was symptom-free for close to a decade and then had only one mild attack about six months ago.
5Patient Review
6/6/2021 This medication has been really effective in preventing gout attacks by keeping uric acid levels low.
5Patient Review
3/11/2021 I had a really tough decade, flare-ups wise, before I decided to start taking allopurinol. It's been three years since then and I haven't experienced a single one. I only wish I had started sooner!
5Patient Review
1/14/2020 I've been taking this medication for 12 years to manage my gout, and it's worked great. I was also pleasantly surprised when it got rid of my kidney stones!
5Patient Review
1/11/2020 This is an excellent preventative treatment for gout.
5Patient Review
10/17/2021 I've been using this medication for 30 years and I find it really helpful in keeping me healthy.
5Patient Review
1/6/2022 I've been on this medication for over 10 years to prevent gout, and I can't even remember the last time I had a flare-up. It's really effective, and I would recommend it to anyone who is struggling with gout or elevated uric acid levels.
5Patient Review
1/11/2020 This treatment is very effective in preventing gout.
4.3Patient Review
12/2/2018 I've been taking this drug for over three years to manage my uric acid levels and the occasional flare-up. In that time, I've only had one attack.
4.3Patient Review
12/2/2018 I've been taking this medication for over three years to keep my uric acid levels in check and prevent hour-long flareups. In that time, I've only had one attack.
4Patient Review
7/19/2021 This medication was very effective at treating my gout.
4Patient Review
4/15/2021 I used to have gout attacks a few times per year, and would take the expensive colchicine as well as pain medication. My doctor then prescribed Alopurinol; I now take it 3-4 times per week, and haven't had an attack in over five years.
4Patient Review
4/15/2021 I used to have gout attacks a couple times per year, and would take colchicine as well as pain medication. My doctor later prescribed Alopurinol, which I now take 3-4 times per week. This has effectively eliminated my gout attacks for over five years.
4Patient Review
7/19/2021 This treatment effectively stopped my gout.
3.7Patient Review
4/13/2021 I've been taking this medication for the past two years to help with my gout. It's been successful in keeping the swelling down, and I haven't had any problems as long as I stay on the drug.
3.7Patient Review
4/13/2021 I've been taking this medication for two years to manage my gout. It's been effective in keeping the swelling down, and I haven't had any issues as long as I stay on the drug.
2.3Patient Review
4/8/2019 I've had gout for a decade now and have been taking this medication on and off for the past few years. However, my doctor said that I wasn't being consistent enough with it and my gout came back as a result. They bumped up my dosage to 300mg, but ever since then I've been having issues like gas, itchy skin, rash, and bloody stool. I'm writing this review because I think something's really wrong.
2.3Patient Review
11/27/2018 I'm really disappointed with this medication. I've been taking it for 40 days now, and my gout attacks are more frequent, more severe, and last longer than before. It's gotten to the point where I can't walk or sleep because of the pain.
2.3Patient Review
11/27/2018 After forty days of taking this medication, my gout attacks have become more frequent and more severe. I can't walk or sleep because the pain is so bad. I'm amazed that the FDA would approve this drug.
2.3Patient Review
4/8/2019 I've had gout for 10 years and I've been taking this medication on and off for the past few years. Unfortunately, because I wasn't consistent with my dosage, the gout came back. When I was bumped up to 300mg, I started experiencing a lot of side effects like gas, itchy skin, rash, and bloody stool. I'm writing this review because I'm concerned that these could be serious problems.
1.7Patient Review
1/7/2019 I've been taking Allopurinal for the past four months, and I've experienced gout almost monthly since. When one flare-up starts to resolve, a new one begins. Colchicine is my preferred method of controlling gout.
1.7Patient Review
1/7/2019 Allopurinal hasn't been working for me these past four months. I get gout almost monthly, and it's just one flare up after another. Colchicine seems to work better for me in controlling the gout.
Patient Q&A Section about aloprim
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of aloprim?
"The most common side effects are injection site reactions, rash, hives, allergic reaction, itching, diarrhea, nausea, vomiting, or."
Answered by AI
What is aloprim used for?
"These crystals can cause pain, swelling, or a red, hot, and swollen joint.
Allopurinol is a medicine used to lower levels of uric acid in your blood. If you produce too much uric acid or your kidneys do not filter enough out, it can build up and cause tiny, sharp crystals to form in and around your joints. These crystals can cause pain, swelling, or a red, hot, and swollen joint."
Answered by AI
What does allopurinol do to your body?
"Allopurinol is used to either prevent or lower high uric acid levels in the blood. It can also be used to prevent or lower excess uric acid levels that are caused by cancer medicines or in patients with kidney stones. Having a high uric acid level can cause gout or gouty arthritis (which is joint pain and inflammation)."
Answered by AI
What is Loric used for?
"This medicine requires a prescription because it is used to treat and prevent gout. Gout is a condition that occurs when there is too much uric acid in your body. When this happens, uric acid can form crystals around your joints and kidneys, which can cause pain. This medicine helps to keep uric acid levels low, which can help to prevent gout."
Answered by AI