Alocril

Eye, Asthma, Allergic Conjunctivitis (AC)
Treatment
20 Active Studies for Alocril

What is Alocril

NedocromilThe Generic name of this drug
Treatment SummaryZyflo is a medication that prevents the activation of immune cells related to asthma, such as eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets. It belongs to the pyranoquinolone family of drugs.
Tiladeis the brand name
image of different drug pills on a surface
Alocril Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tilade
Nedocromil
1992
3

Effectiveness

How Alocril Affects PatientsNedocromil is a drug that reduces inflammation. It is usually taken through the nose or mouth and can help lessen asthma symptoms such as early and late reactions to allergens, and difficulty breathing.
How Alocril works in the bodyNedocromil stops certain cells in the lungs from releasing substances that can cause asthma symptoms. These substances are normally released by eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets. Nedocromil also blocks nerve signals that cause bronchoconstriction, which is the tightening of the airways. It does not have any of the effects of bronchodilators, antihistamines, or corticosteroids.

When to interrupt dosage

The suggested dosage of Alocril is contingent upon the diagnosed situation, including Asthma, Allergic Conjunctivitis (AC) and Hay Fever. The extent of dosage is contingent upon the method of administration (e.g. Liquid or Solution / drops) exhibited in the table below.
Condition
Dosage
Administration
Eye
20.0 mg/mL, , 2.0 %, 2.0 mg, 2.0 mg/pump actuation, 2.0 mg/dose
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Liquid, Liquid - Ophthalmic, Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Aerosol, metered - Oral, Oral
Asthma
20.0 mg/mL, , 2.0 %, 2.0 mg, 2.0 mg/pump actuation, 2.0 mg/dose
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Liquid, Liquid - Ophthalmic, Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Aerosol, metered - Oral, Oral
Allergic Conjunctivitis (AC)
20.0 mg/mL, , 2.0 %, 2.0 mg, 2.0 mg/pump actuation, 2.0 mg/dose
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Liquid, Liquid - Ophthalmic, Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Aerosol, metered - Oral, Oral

Warnings

There are 20 known major drug interactions with Alocril.
Common Alocril Drug Interactions
Drug Name
Risk Level
Description
Abacavir
Minor
Nedocromil may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aclidinium
Minor
Nedocromil may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Nedocromil may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Nedocromil may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Allylestrenol
Minor
Nedocromil may decrease the excretion rate of Allylestrenol which could result in a higher serum level.
Alocril Toxicity & Overdose RiskSide effects of this drug include headache, stuffy nose, burning, itching, or stinging in the eyes, a bad taste in the mouth, coughing, difficulty breathing, wheezing, pink eye, blurry vision, trouble seeing at night, and being more sensitive to sunlight.
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Alocril Novel Uses: Which Conditions Have a Clinical Trial Featuring Alocril?

154 active clinical trials are presently studying the potential of Alocril in treating Asthma, Eye Conditions and Hay Fever.
Condition
Clinical Trials
Trial Phases
Asthma
92 Actively Recruiting
Phase 1, Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 3
Allergic Conjunctivitis (AC)
1 Actively Recruiting
Phase 2
Eye
0 Actively Recruiting

Alocril Reviews: What are patients saying about Alocril?

5Patient Review
5/10/2008
Alocril for Allergic Conjunctivitis
I highly recommend these eye drops! They work better than any other Drops or ointments I've tried in the past.
5Patient Review
4/12/2014
Alocril for Allergic Conjunctivitis
Alocril has been a godsend for my seasonal allergies. It's way more effective than Azelastine, and I only need to use it twice a day.
4.7Patient Review
10/26/2008
Alocril for Allergic Conjunctivitis
Alocril was, by far, the most effective of all the prescription eye drops I've tried for my allergies. Not only did it work well, but I also didn't experience any unpleasant side effects. This medication significantly reduced the number of allergy attacks I had while taking it.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about alocril

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the mechanism of action of nedocromil?

"Nedocromil's mechanism of action may be partly due to blocking of nerve impulses and release of neuropeptides such as substance P, neurokinin A, and calcitonin-geneñrelated peptides. This results in prevention of bronchoconstriction caused by bradykinin."

Answered by AI

What is Alocril used for?

"Alocril, or nedocromil, is a prescription eye drop used to treat itchy eyes related to allergies. Alocril was also available as an inhalation solution for treating asthma under the brand name Tilade, but that medication is no longer available."

Answered by AI

What type of drug is nedocromil?

"Nedocromil is used to treat itchy eyes that are caused by allergies. Allergy symptoms happen when cells in your body called mast cells release substances after you come in contact with something to which you are allergic. Nedocromil belongs to a class of drugs called mast cell stabilizers."

Answered by AI

How long to wait between eye drops?

"Be sure to space out your drops when taking multiple medications- waiting 5 to 10 minutes in between. This will ensure that each drop is effective and that you aren't rinsing the first drop out with the second."

Answered by AI

Clinical Trials for Alocril

Have you considered Alocril clinical trials? We made a collection of clinical trials featuring Alocril, we think they might fit your search criteria.Go to Trials
Image of Allergy Immunology Associates in Mayfield Heights, United States.

Osteopathic Manipulative Treatment for Asthma

18 - 60
All Sexes
Mayfield Heights, OH
Asthma is a common respiratory condition that can be difficult to control despite the use of medications such as inhalers, oral steroids or even injectable medications. Osteopathic Manipulative Treatment (OMT) is a hands-on technique used to improve the chest structure and function and may help in improving breathing. Previous research showed that OMT in asthma patients, can improve the movement of the ribs and improve the "peak flow" which is the maximum rate at which a person can exhale air after taking a deep breath. However, no studies have evaluated the impact of OMT on lung inflammation. This single-site research study at University Hospitals aims to evaluate whether Osteopathic Manipulative Treatment (OMT) can reduce lung inflammation and improve breathing and lung function in adult patients with asthma. The lung function will be evaluated by Spirometry which is a test that measures how much air you can breathe in and out of your lungs, as well as how quickly and easily you can exhale air. The lung inflammation will be measured using a device that can detect how much you are breathing out Nitric Oxide which is a gas produced by inflamed cells in the lungs, this test is called: Fractional exhaled Nitric Oxide or FeNO. Approximately 100 participants will be enrolled.
Waitlist Available
Has No Placebo
Allergy Immunology AssociatesNancy Wasserbauer-Kingston, DO
Image of DARTNet Institute in Aurora, United States.

Inhaled Corticosteroids + Azithromycin for Asthma

13 - 75
All Sexes
Aurora, CO
While asthma therapy is becoming more individualized based on asthma phenotypes, more research is needed to tailor newer therapies to individuals. Inhaled corticosteroid (ICS) medications are the foundation of care for all individuals with persistent asthma. But ICS use is not without possible long term side effects. This study will compare two currently available approaches to reduce AEX in primary care patients: (1) use of inhaled corticosteroids (ICS) as part of rescue therapy, also known as MART (Maintenance And Reliever Therapy) or PARTICS (Patient Activated Reliever Trigger Inhaled Corticosteriods) therapy - either of these therapies will be called Rescue-Inhaled Corticosteroids or R-ICS pronounced "Ricks," and (2) use of azithromycin (AZ) as a preventive therapy. These treatments will be studied both individually and in combination.
Phase 4
Recruiting
DARTNet Institute (+12 Sites)Wilson D Pace, MD, FAAFP
Image of Medical Place Pharmacy in Ajax, Canada.

Pharmacy Support System for Asthma

Any Age
All Sexes
Ajax, Canada
The goal of this study is to assess the effect of an electronic asthma management system in pharmacies (eAMS-Pharm) on asthma control assessment, asthma medication adjustment, asthma action plan delivery, and prompting for specialist referral in severe asthma. The study assesses the differences on pharmacy processes (affecting both the pharmacy team and patients) and pharmacy-delivered care using an interrupted time-series analysis (six-months before vs. six-months after the introduction of eAMS-Pharm in study pharmacy sites). The eAMS-Pharm uses patient data (asthma control, asthma flare-up risk, and current medications) to provide clinical decision support to pharmacists, empowering them to bridge existing gaps between guideline-recommended asthma care and patient care received.
Waitlist Available
Has No Placebo
Medical Place Pharmacy (+2 Sites)
Have you considered Alocril clinical trials? We made a collection of clinical trials featuring Alocril, we think they might fit your search criteria.Go to Trials
Image of Velocity Clinical Research, Mobile in Mobile, United States.

PF-07275315 for Asthma

18 - 70
All Sexes
Mobile, AL
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07275315) for the potential treatment of moderate-to-severe asthma. Asthma is a condition that makes it challenging to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 18 to 70 years old * Have had moderate-to-severe asthma for at least 12 months that is not well controlled * Have been taking their regular maintenance treatment(s) for asthma over the last 12 months All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 12 weeks. We will compare the experiences of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective. Participants will be involved in this study for about 9.5 months. During this time, they will have 10 visits at the study clinic.
Phase 2
Recruiting
Velocity Clinical Research, Mobile (+10 Sites)Pfizer CT.gov Call CenterPfizer
Image of St. Joseph's Healthcare Hamilton in Hamilton, Canada.

Corticosteroids for Asthma

18+
All Sexes
Hamilton, Canada
Most individuals with asthma can effectively manage their symptoms and maintain normal lung function using inhaled medications, unfortunately, there is a subset of asthma sufferers whose symptoms, lung function, and risk of asthma attacks remain unimproved despite conventional inhaled medications. There could be several reasons for this. One possibility is that inhaled medications fail to reach the intended areas within the lungs, due to structural abnormalities within the airways themselves. Much like road conditions or closures can impede the speed and efficiency of vehicle travel, factors such as airway narrowing or mucus blockages, which are common in asthma, can obstruct the passage of inhaled medications through the airways. Our team has now optimized advanced medical imaging techniques, including magnetic resonance imaging (MRI) and computed tomography (CT), required to investigate this. This study will use these imaging methods to visually assess and measure individual patients' airways and determine whether abnormal airway structures impact how well they respond to inhaled and orally delivered medications. We anticipate finding that abnormal airway structures make inhaled medications less effective, but that they do not affect the response to oral medications.
Phase 4
Recruiting
St. Joseph's Healthcare Hamilton (+1 Sites)
Have you considered Alocril clinical trials? We made a collection of clinical trials featuring Alocril, we think they might fit your search criteria.Go to Trials
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