What is Actoplus Met Xr
PioglitazoneThe Generic name of this drug
Treatment SummaryPioglitazone is a medication used to treat type 2 diabetes. It is often taken in combination with diet, exercise, and other diabetes medications. This drug works by increasing the body's sensitivity to insulin and helping to lower blood sugar levels. It is part of a class of drugs called thiazolidinediones, which also includes rosiglitazone and troglitazone. Although pioglitazone can be effective, it has been linked to side effects such as congestive heart failure and bladder cancer, so it is not as widely used as other treatments for type 2 diabetes.
Actosis the brand name
Actoplus Met Xr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Actos
Pioglitazone
1999
257
Effectiveness
How Actoplus Met Xr Affects PatientsPioglitazone helps your body respond better to insulin, allowing it to better manage glucose. This can help lower your blood glucose, insulin, and HbA1c levels. However, taking this medication can cause fluid retention and make existing heart failure worse, so it should not be used in those with heart failure or those at risk of developing heart failure. Additionally, there is evidence that pioglitazone may increase the risk of bladder cancer, so it should not be used in those with active bladder cancer and should be used with caution in those with a history of bladder cancer.
How Actoplus Met Xr works in the bodyPioglitazone helps make the body more sensitive to insulin, which helps lower blood sugar levels. It does this by activating PPAR-gamma, a protein in the body that helps control glucose and lipid production. This increases the body's response to insulin and decreases the amount of glucose produced by the liver. This helps with insulin resistance, a condition associated with type 2 diabetes.
When to interrupt dosage
The recommended measure of Actoplus Met Xr is contingent upon the identified condition, such as Diet, Physical Activity and Type 2 Diabetes. The quantity of dosage is contingent upon the mode of delivery (e.g. Tablet, film coated or Tablet, film coated - Oral) featured in the table underneath.Condition
Dosage
Administration
Diabetic Neuropathy
30.0 mg, 15.0 mg, , 45.0 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, Oral, , Tablet - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Diet
30.0 mg, 15.0 mg, , 45.0 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, Oral, , Tablet - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Physical Activity
30.0 mg, 15.0 mg, , 45.0 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, Oral, , Tablet - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Type 2 Diabetes
30.0 mg, 15.0 mg, , 45.0 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, Oral, , Tablet - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Type 2 Diabetes
30.0 mg, 15.0 mg, , 45.0 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, Oral, , Tablet - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Warnings
Actoplus Met Xr ContraindicationsCondition
Risk Level
Notes
Hypesthesia
Do Not Combine
Hypesthesia
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Urinary Bladder
Do Not Combine
Urinary Bladder
Do Not Combine
uninvestigated macroscopic hematuria
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Pioglitazone may interact with Toxoplasma Infections
Common Actoplus Met Xr Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Pioglitazone.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Pioglitazone.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Pioglitazone.
Fosphenytoin
Major
The metabolism of Fosphenytoin can be decreased when combined with Pioglitazone.
Paclitaxel
Major
The metabolism of Paclitaxel can be decreased when combined with Pioglitazone.
Actoplus Met Xr Toxicity & Overdose RiskIn mice, the lowest toxic dose of pioglitazone is 24mg/kg over a period of 4 days and in rats 3mg/kg over 6 days. In one instance of overdose, a patient ingested 120mg for 4 days and 180mg for 7 days without any reported adverse symptoms. In case of overdose, medical professionals should provide supportive care according to the patient's condition.
Actoplus Met Xr Novel Uses: Which Conditions Have a Clinical Trial Featuring Actoplus Met Xr?
300 active clinical trials are being conducted to assess the utility of Actoplus Met XR in managing Type 2 Diabetes, Type 2 Diabetes Mellitus and Physical Activity.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
99 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 2, Phase 3
Type 2 Diabetes
176 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Early Phase 1, Phase 1, Phase 3
Physical Activity
37 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1
Diet
4 Actively Recruiting
Not Applicable
Diabetic Neuropathy
24 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1
Actoplus Met Xr Reviews: What are patients saying about Actoplus Met Xr?
4.7Patient Review
10/20/20104Patient Review
3/8/2012 The price is unfortunately quite high.
Patient Q&A Section about actoplus met xr
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What type of drug is Actoplus Met?
"Actoplus MET is a prescription drug used to treat the symptoms of type 2 diabetes mellitus. It may be used alone or with other medications. It belongs to a class of drugs called antidiabetics and biguanides/thiazolidinediones. It is not known if it is safe and effective in children."
Answered by AI
What is the generic name for Actoplus Met?
"The drug Actos is available in both brand-name and generic form, with the latter being called pioglitazone. A generic drug is an exact replica of the active ingredient in a brand-name medication."
Answered by AI
What is Actoplus Met used for?
"Actoplus Met is a combination of two oral diabetes medicines, metformin and pioglitazone, that help control blood sugar levels. It is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus who do not use daily insulin injections."
Answered by AI
Is Actoplus Met XR discontinued?
"The ActoPlus Met XR brand will no longer be available in the United States. If the Food and Drug Administration has approved generic versions of this product, there may be generic equivalents available."
Answered by AI