Accolate

Asthma, Chronic Urticaria
Treatment
2 FDA approvals
20 Active Studies for Accolate

What is Accolate

ZafirlukastThe Generic name of this drug
Treatment SummaryZafirlukast is a pill used to treat asthma. It works by blocking a certain type of molecule, called a leukotriene, which can cause your airways to become constricted, inflamed, and produce extra mucus. Zafirlukast is usually taken twice a day and is often used with an inhaled steroid and/or long-acting bronchodilator. Another similar medication is montelukast (Singulair), which is usually taken once daily.
Accolateis the brand name
image of different drug pills on a surface
Accolate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Accolate
Zafirlukast
1996
32

Approved as Treatment by the FDA

Zafirlukast, commonly known as Accolate, is approved by the FDA for 2 uses like Asthma and Asthma .
Asthma
Helps manage Asthma
Asthma
Helps manage Asthma

Effectiveness

How Accolate Affects PatientsZafirlukast is a medicine used to prevent and treat asthma. People with asthma are more sensitive to the effects of leukotriene D4 (LTD<sub>4</sub>) than non-asthmatic people. Tests have shown that zafirlukast helps block the effects of LTD<sub>4</sub>, LTC<sub>4</sub>, and LTE<sub>4</sub> on airways and skin, as well as preventing LTD<sub>4</sub> from increasing the permeability of the skin and stopping it from causing eosinophils to enter
How Accolate works in the bodyZafirlukast blocks leukotriene D4 and E4 from attaching to their receptors in the body. These molecules are associated with asthma, causing swelling, tightening of airways, and inflammation. By preventing them from binding, zafirlukast helps to reduce the signs and symptoms of asthma.

When to interrupt dosage

The measure of Accolate is contingent upon the diagnosed state. The amount of dosage differs, as per the mode of delivery (e.g. Tablet, film coated or Tablet) indicated in the table beneath.
Condition
Dosage
Administration
Asthma
, 10.0 mg, 20.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral
Chronic Urticaria
, 10.0 mg, 20.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral

Warnings

Accolate Contraindications
Condition
Risk Level
Notes
Cirrhosis
Do Not Combine
Liver Disease
Do Not Combine
There are 20 known major drug interactions with Accolate.
Common Accolate Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Zafirlukast.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Zafirlukast.
Albendazole
Major
The metabolism of Albendazole can be decreased when combined with Zafirlukast.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Zafirlukast.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Zafirlukast.
Accolate Toxicity & Overdose RiskPossible side effects of this medication include skin rash and stomach discomfort.

Accolate Novel Uses: Which Conditions Have a Clinical Trial Featuring Accolate?

160 active studies are currently underway to evaluate the potential of Accolate to provide therapeutic benefit in cases of Chronic Urticaria.
Condition
Clinical Trials
Trial Phases
Chronic Urticaria
0 Actively Recruiting
Asthma
93 Actively Recruiting
Phase 1, Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 3

Accolate Reviews: What are patients saying about Accolate?

5Patient Review
10/1/2008
Accolate for Chronic Obstructive Asthma
This drug has been a miracle for me. If I could only take one medication, this would be it. I've experienced fewer headaches and ear aches since taking it, and I no longer have to take my inhaler to bed with me at night.
5Patient Review
10/7/2008
Accolate for Asthma Prevention
Marax was an older drug I used to take that worked well for me, but this newer medication is even better.
5Patient Review
6/29/2010
Accolate for Asthma Prevention
I have severe muscle spasms around my lungs whenever I miss two doses of this medication, similar to pleurisy. It took me a while to figure out what was causing the pain, but when I did some research and discovered pleurisy, it perfectly described my symptoms. The pain is unbearable, and my doctors have always just shrugged their shoulders.
5Patient Review
1/27/2011
Accolate for Chronic Obstructive Asthma
This medication has been a lifesaver for me. I've been taking it since 1993, and it's helped me immensely. I'm so grateful that it's available to people who need it.
5Patient Review
6/26/2017
Accolate for Chronic Obstructive Asthma
I've been taking ACCOLATE for 25 years with great success and no side effects. I've tried other medications in the past, but this is by far the most effective with the least amount of negatives.
5Patient Review
9/23/2009
Accolate for Asthma
Accolate was the only thing that worked for me. Singular was a total waste of money in comparison because it did nothing to address my breathing problems.
5Patient Review
6/18/2009
Accolate for Asthma
This medication has been great! I hardly ever have to use my inhaler now.
4Patient Review
9/21/2009
Accolate for Asthma
My daughter's headaches were actually being caused by Accolate. We didn't make the connection until she forgot to take her medication while on vacation and her headaches disappeared after a few days.
3.3Patient Review
2/26/2009
Accolate for Asthma
I was recently advised to discontinue this medication after using it for 15 years. I didn't experience any adverse effects while taking it, but since stopping the medicine my headaches, muscle aches and fatigue are slowly starting to improve.
3Patient Review
8/18/2009
Accolate for Asthma
I developed an extreme itch after just one month of using this medication. I had to stop taking it as a result.
2.7Patient Review
8/3/2009
Accolate for Asthma
It's not the most convenient medication, having to wait a few hours after taking it to eat anything.
2.3Patient Review
4/28/2011
Accolate for Asthma
I was hospitalized due to liver problems, even though I don't drink. The staff kept asking me about my drinking habits, which was really frustrating.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about accolate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic name for Accolate?

"Zafirlukast is used to prevent asthma attacks in adults and children as young as 5 years old.

Zafirlukast is a medication that is used to prevent asthma attacks in adults and children as young as 5 years old."

Answered by AI

What is the drug Accolate used for?

"This medication is used to control and prevent the symptoms of asthma, such as wheezing and shortness of breath. By controlling these symptoms, it allows you to keep up with your normal activities and prevents you from having to miss work or school. In order to be effective, this medication must be used on a regular basis."

Answered by AI

What is the most common side effect of Accolate?

"Side effects that are common may include: feeling nauseous, having diarrhea, stomach pain; a headache; or. having cold symptoms like a stuffy nose, sneezing, or a sore throat."

Answered by AI

Clinical Trials for Accolate

Have you considered Accolate clinical trials? We made a collection of clinical trials featuring Accolate, we think they might fit your search criteria.Go to Trials
Image of Allergy Immunology Associates in Mayfield Heights, United States.

Osteopathic Manipulative Treatment for Asthma

18 - 60
All Sexes
Mayfield Heights, OH
Asthma is a common respiratory condition that can be difficult to control despite the use of medications such as inhalers, oral steroids or even injectable medications. Osteopathic Manipulative Treatment (OMT) is a hands-on technique used to improve the chest structure and function and may help in improving breathing. Previous research showed that OMT in asthma patients, can improve the movement of the ribs and improve the "peak flow" which is the maximum rate at which a person can exhale air after taking a deep breath. However, no studies have evaluated the impact of OMT on lung inflammation. This single-site research study at University Hospitals aims to evaluate whether Osteopathic Manipulative Treatment (OMT) can reduce lung inflammation and improve breathing and lung function in adult patients with asthma. The lung function will be evaluated by Spirometry which is a test that measures how much air you can breathe in and out of your lungs, as well as how quickly and easily you can exhale air. The lung inflammation will be measured using a device that can detect how much you are breathing out Nitric Oxide which is a gas produced by inflamed cells in the lungs, this test is called: Fractional exhaled Nitric Oxide or FeNO. Approximately 100 participants will be enrolled.
Waitlist Available
Has No Placebo
Allergy Immunology AssociatesNancy Wasserbauer-Kingston, DO
Image of DARTNet Institute in Aurora, United States.

Inhaled Corticosteroids + Azithromycin for Asthma

13 - 75
All Sexes
Aurora, CO
While asthma therapy is becoming more individualized based on asthma phenotypes, more research is needed to tailor newer therapies to individuals. Inhaled corticosteroid (ICS) medications are the foundation of care for all individuals with persistent asthma. But ICS use is not without possible long term side effects. This study will compare two currently available approaches to reduce AEX in primary care patients: (1) use of inhaled corticosteroids (ICS) as part of rescue therapy, also known as MART (Maintenance And Reliever Therapy) or PARTICS (Patient Activated Reliever Trigger Inhaled Corticosteriods) therapy - either of these therapies will be called Rescue-Inhaled Corticosteroids or R-ICS pronounced "Ricks," and (2) use of azithromycin (AZ) as a preventive therapy. These treatments will be studied both individually and in combination.
Phase 4
Recruiting
DARTNet Institute (+12 Sites)Wilson D Pace, MD, FAAFP
Image of Medical Place Pharmacy in Ajax, Canada.

Pharmacy Support System for Asthma

Any Age
All Sexes
Ajax, Canada
The goal of this study is to assess the effect of an electronic asthma management system in pharmacies (eAMS-Pharm) on asthma control assessment, asthma medication adjustment, asthma action plan delivery, and prompting for specialist referral in severe asthma. The study assesses the differences on pharmacy processes (affecting both the pharmacy team and patients) and pharmacy-delivered care using an interrupted time-series analysis (six-months before vs. six-months after the introduction of eAMS-Pharm in study pharmacy sites). The eAMS-Pharm uses patient data (asthma control, asthma flare-up risk, and current medications) to provide clinical decision support to pharmacists, empowering them to bridge existing gaps between guideline-recommended asthma care and patient care received.
Waitlist Available
Has No Placebo
Medical Place Pharmacy (+2 Sites)
Image of St. Paul's Hospital in Vancouver, Canada.

Salbutamol for Athletic Performance

18 - 55
All Sexes
Vancouver, Canada
β2-Agonists, commonly used to treat asthma, have also been used by athletes to enhance performance, leading to their ban by the International Olympic Committee in 1972. Research has shown non-asthmatics receive no benefit from these drugs at therapeutic dosages; however, many elite athletes still use them, and asthmatic athletes often win more Olympic medals. In some non-asthmatics, β2-agonists may improve breathing limitations during high intensity exercise, which may improve performance. Therefore, we aim to examine if there is a select group of non-asthmatic individuals who experience breathing limitations that may receive benefit from β2-agonists.
Waitlist Available
Paid Trial
St. Paul's HospitalJordan A Guenette, PhD
Have you considered Accolate clinical trials? We made a collection of clinical trials featuring Accolate, we think they might fit your search criteria.Go to Trials
Image of Velocity Clinical Research, Mobile in Mobile, United States.

PF-07275315 for Asthma

18 - 70
All Sexes
Mobile, AL
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07275315) for the potential treatment of moderate-to-severe asthma. Asthma is a condition that makes it challenging to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 18 to 70 years old * Have had moderate-to-severe asthma for at least 12 months that is not well controlled * Have been taking their regular maintenance treatment(s) for asthma over the last 12 months All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 12 weeks. We will compare the experiences of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective. Participants will be involved in this study for about 9.5 months. During this time, they will have 10 visits at the study clinic.
Phase 2
Recruiting
Velocity Clinical Research, Mobile (+10 Sites)Pfizer CT.gov Call CenterPfizer
Image of St. Joseph's Healthcare Hamilton in Hamilton, Canada.

Corticosteroids for Asthma

18+
All Sexes
Hamilton, Canada
Most individuals with asthma can effectively manage their symptoms and maintain normal lung function using inhaled medications, unfortunately, there is a subset of asthma sufferers whose symptoms, lung function, and risk of asthma attacks remain unimproved despite conventional inhaled medications. There could be several reasons for this. One possibility is that inhaled medications fail to reach the intended areas within the lungs, due to structural abnormalities within the airways themselves. Much like road conditions or closures can impede the speed and efficiency of vehicle travel, factors such as airway narrowing or mucus blockages, which are common in asthma, can obstruct the passage of inhaled medications through the airways. Our team has now optimized advanced medical imaging techniques, including magnetic resonance imaging (MRI) and computed tomography (CT), required to investigate this. This study will use these imaging methods to visually assess and measure individual patients' airways and determine whether abnormal airway structures impact how well they respond to inhaled and orally delivered medications. We anticipate finding that abnormal airway structures make inhaled medications less effective, but that they do not affect the response to oral medications.
Phase 4
Recruiting
St. Joseph's Healthcare Hamilton (+1 Sites)
Have you considered Accolate clinical trials? We made a collection of clinical trials featuring Accolate, we think they might fit your search criteria.Go to Trials
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Terms of Service·Privacy Policy·Cookies·Security